DK0960881T3 - Syntese af taxol og derivater deraf - Google Patents

Syntese af taxol og derivater deraf

Info

Publication number
DK0960881T3
DK0960881T3 DK99116028T DK99116028T DK0960881T3 DK 0960881 T3 DK0960881 T3 DK 0960881T3 DK 99116028 T DK99116028 T DK 99116028T DK 99116028 T DK99116028 T DK 99116028T DK 0960881 T3 DK0960881 T3 DK 0960881T3
Authority
DK
Denmark
Prior art keywords
taxol
synthesis
derivatives
tricyclic
intermediates
Prior art date
Application number
DK99116028T
Other languages
English (en)
Inventor
Robert J Holton
Carmen Somoza
Hyeong B C O Dupont Agricu Kim
Mitsuro C O Prof K Koga Shindo
Ronald J Texas Biotec Biediger
Douglas P Boatman
Chase Smith
Feng Liang
Krishna C O Univ Of Vir Murthi
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State filed Critical Univ Florida State
Application granted granted Critical
Publication of DK0960881T3 publication Critical patent/DK0960881T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
DK99116028T 1993-07-20 1994-07-20 Syntese af taxol og derivater deraf DK0960881T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9516193A 1993-07-20 1993-07-20
US13822993A 1993-10-15 1993-10-15
US08/189,058 US5405972A (en) 1993-07-20 1994-01-27 Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes

Publications (1)

Publication Number Publication Date
DK0960881T3 true DK0960881T3 (da) 2003-08-11

Family

ID=27377903

Family Applications (2)

Application Number Title Priority Date Filing Date
DK94923998T DK0710223T3 (da) 1993-07-20 1994-07-20 Syntese af taxol og derivater deraf
DK99116028T DK0960881T3 (da) 1993-07-20 1994-07-20 Syntese af taxol og derivater deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK94923998T DK0710223T3 (da) 1993-07-20 1994-07-20 Syntese af taxol og derivater deraf

Country Status (15)

Country Link
US (4) US5405972A (da)
EP (2) EP0710223B1 (da)
JP (2) JP3564135B2 (da)
KR (3) KR100323273B1 (da)
CN (1) CN1046261C (da)
AT (2) ATE238289T1 (da)
AU (1) AU687428B2 (da)
CA (1) CA2167718C (da)
DE (2) DE69424939T2 (da)
DK (2) DK0710223T3 (da)
ES (2) ES2149883T3 (da)
GR (1) GR3034343T3 (da)
PT (2) PT710223E (da)
SG (2) SG44727A1 (da)
WO (1) WO1995003265A1 (da)

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US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US6005138A (en) 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US6011056A (en) * 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US6339164B1 (en) 1993-01-29 2002-01-15 Florida State University C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them
CA2157114C (en) * 1993-03-05 2003-12-16 Robert A. Holton Process for the preparation of 9-desoxotaxanes
US6710191B2 (en) 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
FR2718137B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation de trialcoylsilyl-7 baccatine III.
DE4416374A1 (de) * 1994-05-05 1995-11-09 Schering Ag Neue Borneolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US5508447A (en) * 1994-05-24 1996-04-16 Board Of Regents, The University Of Texas System Short synthetic route to taxol and taxol derivatives
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
WO1997042181A1 (en) * 1996-05-06 1997-11-13 Florida State University 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
CA2188190A1 (en) 1996-10-18 1998-04-18 Sarala Balachandran The semi-synthesis of a protected bacatin iii compound
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
NZ503206A (en) * 1997-08-21 2002-05-31 Univ Florida State Method of taxane synthesis by treating with a base (potassium hydride or potassium hexamethyldisilazide) and a silylating agent (trialkylsilyl halide)
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
WO2002024179A2 (en) 2000-09-22 2002-03-28 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
CA2426762A1 (en) 2000-11-02 2002-05-10 Sloan-Kettering Institute For Cancer Research Methods for enhancing the efficacy of cytotoxic agents through the use of hsp90 inhibitors
ATE431343T1 (de) * 2002-10-09 2009-05-15 Chatham Biotec Ltd Thio-analoga von paclitaxel und deren vorprodukte
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
EP1613269B1 (en) 2003-04-04 2015-02-25 Incyte Corporation Compositions, methods and kits relating to her-2 cleavage
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
WO2006102758A1 (en) * 2005-03-31 2006-10-05 Bioxel Pharma Inc. Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii
CA2627943C (en) * 2005-11-04 2013-12-31 Bioxel Pharma Inc. New methods for the preparation of taxanes using chiral auxiliaries
CA2672940A1 (en) 2006-12-20 2008-07-10 Schering Corporation Novel jnk inhibitors
AU2010300925A1 (en) 2009-09-30 2012-03-29 Merck Sharp & Dohme Corp. Novel compounds that are ERK inhibitors
AU2011293612B2 (en) 2010-08-23 2015-11-26 Syntrix Biosystems Inc. Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators
JP5859000B2 (ja) * 2011-06-07 2016-02-10 株式会社クレハ オキセタン化合物の製造方法、アゾリルメチルシクロペンタノール化合物の製造方法、および中間体化合物
US8969365B2 (en) 2013-08-02 2015-03-03 Syntrix Biosystems, Inc. Thiopyrimidinecarboxamides as CXCR1/2 modulators
US10046002B2 (en) 2013-08-02 2018-08-14 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
US10561676B2 (en) 2013-08-02 2020-02-18 Syntrix Biosystems Inc. Method for treating cancer using dual antagonists of CXCR1 and CXCR2
DK3027627T3 (da) 2013-08-02 2018-05-22 Syntrix Biosystems Inc 2-[5-[n-(4-fluorphenyl)carbamoyl]pyrimidin-2-ylsulfanylmethyl]-4-(trifluormethoxy)phenyl]boronsyre
CN110201717B (zh) * 2019-05-21 2021-11-23 南京工业大学 一种铜基金属有机多面体复合材料的制备方法与应用
JP2022549156A (ja) 2019-09-19 2022-11-24 リープ セラピューティクス，インコーポレイテッド 癌を治療するためのｄｋｋ－１阻害剤の使用
EP4061419A1 (en) 2019-11-22 2022-09-28 Leap Therapeutics, Inc. Methods of treating cancer using dkk-1-inhibitors

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
USRE34277E (en) * 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
FR2662441B1 (fr) * 1990-05-22 1992-10-23 Rhone Poulenc Sante Procede de preparation enantioselective de derives de la phenylisoserine.
FR2662440B1 (fr) * 1990-05-22 1992-07-31 Rhone Poulenc Sante Procede de preparation stereoselective de derives de la phenylisoserine.
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
WO1993002064A1 (fr) * 1991-07-16 1993-02-04 Centre National De La Recherche Scientifique (Cnrs) Nouveau derive de la 7-desacetoxy baccatine iv, sa preparation et son emploi
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5597931A (en) * 1992-03-30 1997-01-28 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol and analogues thereof
US5488116A (en) * 1992-03-30 1996-01-30 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol and analogues thereof
US5416225A (en) * 1992-03-30 1995-05-16 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol
US5254703A (en) * 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
US5248796A (en) * 1992-06-18 1993-09-28 Bristol-Myers Squibb Company Taxol derivatives
US5274137A (en) * 1992-06-23 1993-12-28 Nicolaou K C Intermediates for preparation of taxols
US5481007A (en) * 1992-06-23 1996-01-02 The Scripps Research Institute Taxoid synthesis
US5461169A (en) * 1992-06-23 1995-10-24 The Scripps Research Institute Total synthesis of taxol and taxol analogs
PT668762E (pt) * 1992-11-13 2004-02-27 Univ Florida State Taxanos substituidos com isobutenilo e suas composicoes farmaceuticas
US5508447A (en) * 1994-05-24 1996-04-16 Board Of Regents, The University Of Texas System Short synthetic route to taxol and taxol derivatives

Also Published As

Publication number Publication date
EP0710223A4 (en) 1996-08-21
EP0710223A1 (en) 1996-05-08
US5760252A (en) 1998-06-02
WO1995003265A1 (en) 1995-02-02
KR100323273B1 (ko) 2002-03-15
KR100353666B1 (ko) 2002-09-23
CN1137789A (zh) 1996-12-11
ES2149883T3 (es) 2000-11-16
AU7404294A (en) 1995-02-20
CA2167718A1 (en) 1995-02-02
CA2167718C (en) 2006-10-03
AU687428B2 (en) 1998-02-26
DE69424939T2 (de) 2000-11-02
ATE238289T1 (de) 2003-05-15
DE69432569T2 (de) 2003-11-27
EP0960881A1 (en) 1999-12-01
JPH09501153A (ja) 1997-02-04
EP0960881B1 (en) 2003-04-23
JP3564135B2 (ja) 2004-09-08
US5637732A (en) 1997-06-10
DE69432569D1 (de) 2003-05-28
JP2004115526A (ja) 2004-04-15
PT710223E (pt) 2000-12-29
EP0710223B1 (en) 2000-06-14
US5618952A (en) 1997-04-08
ES2198827T3 (es) 2004-02-01
KR100325791B1 (ko) 2002-10-11
SG97813A1 (en) 2003-08-20
KR960703837A (ko) 1996-08-31
DK0710223T3 (da) 2000-09-11
DE69424939D1 (de) 2000-07-20
CN1046261C (zh) 1999-11-10
SG44727A1 (en) 1997-12-19
ATE193880T1 (de) 2000-06-15
PT960881E (pt) 2003-09-30
US5405972A (en) 1995-04-11
GR3034343T3 (en) 2000-12-29

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