DK0957903T3 - Norbornen- og norbornandiolforbindelser til behandling af pigmenteringslidelser, neurodegenerative sygdomme eller proliferative hudlidelser - Google Patents
Norbornen- og norbornandiolforbindelser til behandling af pigmenteringslidelser, neurodegenerative sygdomme eller proliferative hudlidelserInfo
- Publication number
- DK0957903T3 DK0957903T3 DK97944319T DK97944319T DK0957903T3 DK 0957903 T3 DK0957903 T3 DK 0957903T3 DK 97944319 T DK97944319 T DK 97944319T DK 97944319 T DK97944319 T DK 97944319T DK 0957903 T3 DK0957903 T3 DK 0957903T3
- Authority
- DK
- Denmark
- Prior art keywords
- disorders
- norbornanediol
- norbornene
- compounds
- treatment
- Prior art date
Links
- 208000012641 Pigmentation disease Diseases 0.000 title 1
- WZZPVFWYFOZMQS-UHFFFAOYSA-N bicyclo[2.2.1]heptane-3,4-diol Chemical class C1CC2(O)C(O)CC1C2 WZZPVFWYFOZMQS-UHFFFAOYSA-N 0.000 title 1
- 230000004770 neurodegeneration Effects 0.000 title 1
- 208000015122 neurodegenerative disease Diseases 0.000 title 1
- JFNLZVQOOSMTJK-KNVOCYPGSA-N norbornene Chemical compound C1[C@@H]2CC[C@H]1C=C2 JFNLZVQOOSMTJK-KNVOCYPGSA-N 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- 208000017520 skin disease Diseases 0.000 title 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 6
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 3
- 102000004654 Cyclic GMP-Dependent Protein Kinases Human genes 0.000 abstract 3
- 108010003591 Cyclic GMP-Dependent Protein Kinases Proteins 0.000 abstract 3
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 150000004072 triols Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2657796P | 1996-09-18 | 1996-09-18 | |
US3594797P | 1997-01-21 | 1997-01-21 | |
US3686397P | 1997-02-04 | 1997-02-04 | |
US4859797P | 1997-06-04 | 1997-06-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0957903T3 true DK0957903T3 (da) | 2005-11-21 |
Family
ID=27487517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97944319T DK0957903T3 (da) | 1996-09-18 | 1997-09-18 | Norbornen- og norbornandiolforbindelser til behandling af pigmenteringslidelser, neurodegenerative sygdomme eller proliferative hudlidelser |
Country Status (9)
Country | Link |
---|---|
US (2) | US6294585B1 (de) |
EP (1) | EP0957903B1 (de) |
AT (1) | ATE301459T1 (de) |
AU (1) | AU740783B2 (de) |
CA (1) | CA2266496A1 (de) |
DE (1) | DE69733968T2 (de) |
DK (1) | DK0957903T3 (de) |
ES (1) | ES2245465T3 (de) |
WO (1) | WO1998011882A1 (de) |
Families Citing this family (53)
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US6214888B1 (en) | 1996-09-18 | 2001-04-10 | Applied Genetics Incorporated | Dermatological compounds |
US6623724B2 (en) * | 1996-09-18 | 2003-09-23 | Applied Genetics Incorporated Dermatics | Dermatological compositions and methods |
ES2245465T3 (es) | 1996-09-18 | 2006-01-01 | Applied Genetics Incorporated Dermatics | Dioles de compuestos de norborneno y norbornano para el tratamiento de trastornos de la pigmentacion, enfermedades neurodegenerativas o enfermedades proliferativas de la piel. |
JP2001511151A (ja) * | 1997-02-04 | 2001-08-07 | ザ ジェネラル ホスピタル コーポレイション | 表皮又は皮膚疾患部の処理方法と形質転換動物 |
CA2238283C (en) | 1997-05-30 | 2002-08-20 | Cell Pathways, Inc. | Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions |
US6267948B1 (en) * | 1998-04-06 | 2001-07-31 | Applied Genetics Incorporated Dermatics | Dermatological formulations and methods |
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EP1261572A4 (de) * | 2000-03-10 | 2004-05-26 | Applied Genetics Inc Dermatics | Dermatologische verbindungen |
US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
DE10111050A1 (de) * | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigenOrganismus ihre Wirkung entfaltet, zur Herstellung von kosmetischewn oder dermatologischen Zubereitungen zur Behandlung und/oder Prophylaxe unerwünschter Hautpigmentierung |
US6682753B2 (en) * | 2001-03-23 | 2004-01-27 | Neuronz Limited | Methods for promoting weight gain using GPE-related compounds |
US20070004641A1 (en) * | 2001-05-24 | 2007-01-04 | Neuren Pharmaceuticals Limited | Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate |
US7605177B2 (en) * | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
DE60232880D1 (de) | 2001-05-24 | 2009-08-20 | Neuren Pharmaceuticals Ltd | Gpe-analoga und peptidomimetika |
US7714020B2 (en) * | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
EP1408757A4 (de) * | 2001-07-02 | 2006-12-27 | Wisconsin Alumni Res Found | Verfahren und zusammensetzung zur verlängerung der verweilzeit von arzneistoffenim darm |
US20040192638A1 (en) * | 2001-07-02 | 2004-09-30 | Oaks John A. | Method and composition for prolonging the residence time of drugs in the gut |
US6723755B2 (en) | 2002-06-12 | 2004-04-20 | Piotr Chomczynski | Method of treating rosacea |
FR2840530B1 (fr) * | 2002-06-11 | 2004-12-24 | Oreal | Composition cosmetique comprenant un agent inducteur de l'expression de la dopachrome tautomerase (trp-2) pour lutter contre la canitie |
AU2004242507B2 (en) * | 2002-06-12 | 2009-02-19 | Piotr Chomczynski | Method of treating rosacea |
US20040047919A1 (en) * | 2002-06-13 | 2004-03-11 | Board Of Regents, The University Of Texas System | Methods and compositions involving aldose reductase inhibitors |
FR2856926B1 (fr) * | 2003-07-02 | 2005-09-30 | Centre Nat Rech Scient | Utilisation des n-alkanols comme activateurs du canal cftr |
US9440089B2 (en) | 2003-12-05 | 2016-09-13 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurological injury or condition caused by a stroke |
US9433797B2 (en) | 2003-12-05 | 2016-09-06 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurodegenerative conditions |
US8961385B2 (en) | 2003-12-05 | 2015-02-24 | Ivivi Health Sciences, Llc | Devices and method for treatment of degenerative joint diseases with electromagnetic fields |
US10350428B2 (en) | 2014-11-04 | 2019-07-16 | Endonovo Therapetics, Inc. | Method and apparatus for electromagnetic treatment of living systems |
US9656096B2 (en) | 2003-12-05 | 2017-05-23 | Rio Grande Neurosciences, Inc. | Method and apparatus for electromagnetic enhancement of biochemical signaling pathways for therapeutics and prophylaxis in plants, animals and humans |
US9415233B2 (en) | 2003-12-05 | 2016-08-16 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurological pain |
EP1740107B1 (de) | 2004-04-19 | 2020-03-04 | Ivivi Health Sciences, LLC | Elektromagnetisches behandlungsgerät |
JP2008500368A (ja) * | 2004-05-27 | 2008-01-10 | ミジェニックス コーポレイション | 細胞保護のための2置換17−イミノエストロゲン化合物 |
US7812057B2 (en) * | 2004-08-25 | 2010-10-12 | Molecular Research Center, Inc. | Cosmetic compositions |
US20110092566A1 (en) * | 2004-11-19 | 2011-04-21 | Srivastava Satish K | Treatment of cancer with aldose reductase inhibitors |
US9579298B2 (en) * | 2004-12-02 | 2017-02-28 | Piotr Chomczynski | Antioxidant dietary supplement compositions and methods for maintaining healthy skin |
FR2889808B1 (fr) | 2005-08-17 | 2011-07-22 | Oreal | Utilisation de l'acide 8-hexadecene-1,16-dicarboxylique comme agent de soin destine a favoriser la cohesion de la couche cornee |
WO2007048034A2 (en) * | 2005-10-21 | 2007-04-26 | Caritas St. Elizabeth Medical Center Of Boston, Inc. | Use of androgens for the treatment of parkinson' s disease |
KR101111020B1 (ko) * | 2006-07-04 | 2012-03-13 | 주식회사 알엔에스 | 신규한 사이클릭 화합물의 유도체 및 그의 용도 |
EP2066393A1 (de) * | 2006-09-20 | 2009-06-10 | IVIVI Technologies, Inc. | Elektromagnetische vorrichtung zur behandlung von atmungserkrankungen und verwendungsverfahren dafür |
US20080229371A1 (en) * | 2007-02-22 | 2008-09-18 | Mick Colin K | Digital multimedia network including method and apparatus for high speed user download of digital files |
WO2008118844A1 (en) | 2007-03-23 | 2008-10-02 | The Board Of Regents Of The University Of Texas System | Methods involving aldose reductase inhibitors |
US8026217B2 (en) * | 2007-10-03 | 2011-09-27 | Florida Atlantic University | Compositions and methods for treating neural anoxia and spreading depression |
US20090270490A1 (en) * | 2008-04-24 | 2009-10-29 | The Board Of Regents Of The University Of Texas System | Methods involving aldose reductase inhibition |
KR101050429B1 (ko) * | 2009-03-18 | 2011-07-19 | 연세대학교 산학협력단 | 캠펜을 유효성분으로 포함하는 비만, 이상지방혈증, 지방간또는 인슐린 저항성 증후군의 예방 또는 치료용 조성물 |
CN101797243B (zh) * | 2010-03-23 | 2012-01-18 | 广东药学院 | 一种含有左旋多巴和冰片的组合物及其应用 |
AU2011258553B2 (en) * | 2010-05-27 | 2014-08-14 | Targacept, Inc. | Nicotinic receptor non-competitive antagonists |
WO2012045079A2 (en) | 2010-10-01 | 2012-04-05 | Ivivi Health Sciences, Llc | Method and apparatus for electromagnetic treatment of head cerebral and neural injury in animals and humans |
ITMI20111260A1 (it) * | 2011-07-06 | 2013-01-07 | Carmelo Cutrupi | Composizioni topiche per l'uso nella prevenzione e/o nel trattamento di dermatiti |
US8343027B1 (en) | 2012-01-30 | 2013-01-01 | Ivivi Health Sciences, Llc | Methods and devices for providing electromagnetic treatment in the presence of a metal-containing implant |
US9457003B2 (en) * | 2013-03-12 | 2016-10-04 | Bio-Pharm Solutions Co., Ltd. | Phenyl carbamate compound and a composition for preventing or treating a nerve gas-induced disease comprising the same |
US9320913B2 (en) | 2014-04-16 | 2016-04-26 | Rio Grande Neurosciences, Inc. | Two-part pulsed electromagnetic field applicator for application of therapeutic energy |
CN105693817B (zh) * | 2014-11-27 | 2020-06-05 | 西北大学 | 一类三肽化合物及其制备方法与应用 |
WO2018089795A1 (en) | 2016-11-10 | 2018-05-17 | Qoravita LLC | System and method for applying a low frequency magnetic field to biological tissues |
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AT279052B (de) | 1968-08-08 | 1970-02-25 | Dragoco Gerberding Co Gmbh | Lichtschutzmittel |
DE2350315C2 (de) * | 1973-10-06 | 1984-01-12 | Johnson & Johnson GmbH, 4000 Düsseldorf | Pharmazeutische und kosmetische Präparate zur äußerlichen Anwendung |
US3956361A (en) | 1974-05-23 | 1976-05-11 | Ciba-Geigy Corporation | Hindered phenolic derivatives of norbornane thioalcohols |
US4102995A (en) * | 1976-05-13 | 1978-07-25 | Westwood Pharmaceuticals Inc. | Tar gel formulation |
DE3025187A1 (de) * | 1980-07-03 | 1982-02-11 | Henkel KGaA, 4000 Düsseldorf | Neue riechstoffe, deren herstellung sowie diese enthaltende riechstoffkompositionen |
US4647585A (en) | 1984-11-08 | 1987-03-03 | E. R. Squibb & Sons, Inc. | Bicycloheptane substituted ethers |
US5525635A (en) * | 1986-02-04 | 1996-06-11 | Moberg; Sven | Pharmaceutical compositions containing propylene glycol and/or polyethylene glycol and urea as active main components and use thereof |
SE462139B (sv) * | 1986-02-04 | 1990-05-14 | Sven Moberg | Farmaceutisk komposition, innehaallande propylenglykol och karbamid, foer behandling av bl.a. nagelsvamp och seborroiskt eksem |
DE3724691C2 (de) * | 1987-07-25 | 1999-03-18 | Konrad Minninger | Pharmazeutisches Mittel zur lokalen Therapie von schuppenden Hautkrankheiten |
US5700450A (en) * | 1988-03-30 | 1997-12-23 | The Trustees Of Boston University | Methods for enhancing melanin synthesis in melanocytes using diacyglycerols and uses thereof |
US5352440A (en) * | 1988-03-30 | 1994-10-04 | Trustees Of Boston University | Methods for increasing melanin content in melanocytes using diacylglycerols and uses thereof |
DE3925634A1 (de) * | 1989-08-03 | 1991-02-07 | Bayer Ag | Stabilisatordispersionen |
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US5190798A (en) * | 1992-01-09 | 1993-03-02 | Gilbert Bloch | Paper-plastic film, fiberglass-reinforced sealing tape |
US5587402A (en) | 1992-04-09 | 1996-12-24 | Wisconsin Alumni Research Foundation | Regression of mammalian leukemia cell tumors |
US5414019A (en) | 1992-04-09 | 1995-05-09 | Wisconsin Alumni Research Foundation | Regression of mammalian carcinomas |
US5602184A (en) | 1993-03-03 | 1997-02-11 | The United States Of America As Represented By Department Of Health And Human Services | Monoterpenes, sesquiterpenes and diterpenes as cancer therapy |
US5470577A (en) * | 1993-07-07 | 1995-11-28 | Trustees Of Boston University | Stimulation of tanning by DNA fragments or single-stranded DNA |
DE69331232T2 (de) * | 1993-09-09 | 2002-07-25 | Du Pont | Wässrige Tintenzusammensetzung, die Mittel gegen das Einrollen von Papier enthält |
US5434144A (en) * | 1994-03-04 | 1995-07-18 | The Procter & Gamble Company | Methods of using cyclic polyanionic polyol derivatives for regulating skin wrinkles |
US5626839A (en) * | 1994-11-08 | 1997-05-06 | Scales-Medeiros; Virginia | Light responsive self-tanning products and methods for use |
BR9609820A (pt) * | 1995-07-11 | 1999-07-06 | Procter & Gamble | Composições amaciantes de tecidos concentrados dispersíveis em água e estáveis |
US5747532A (en) * | 1995-11-21 | 1998-05-05 | Medinox, Inc. | Combinational therapeutic methods employing nitric oxide scavengers and compositions useful therefor |
AU2099397A (en) * | 1996-02-21 | 1997-09-10 | Stoa S.A. | Cosmetic, dermopharmaceutical or veterinary compositions for disinfecting human or animal skin |
ES2245465T3 (es) | 1996-09-18 | 2006-01-01 | Applied Genetics Incorporated Dermatics | Dioles de compuestos de norborneno y norbornano para el tratamiento de trastornos de la pigmentacion, enfermedades neurodegenerativas o enfermedades proliferativas de la piel. |
WO1998055085A1 (en) * | 1997-06-04 | 1998-12-10 | Codon Pharmaceuticals, Inc. | Pharmaceutical compositions and methods |
CA2301016A1 (en) * | 1997-08-21 | 1999-02-25 | Johnson & Johnson Consumer Companies, Inc. | Use of 17-.alpha.-estradiol for the treatment of aged or sundamaged ski n and/or skin atrophy |
-
1997
- 1997-09-18 ES ES97944319T patent/ES2245465T3/es not_active Expired - Lifetime
- 1997-09-18 CA CA002266496A patent/CA2266496A1/en not_active Abandoned
- 1997-09-18 US US08/933,145 patent/US6294585B1/en not_active Expired - Lifetime
- 1997-09-18 DE DE69733968T patent/DE69733968T2/de not_active Expired - Lifetime
- 1997-09-18 US US08/933,144 patent/US5990177A/en not_active Expired - Fee Related
- 1997-09-18 AT AT97944319T patent/ATE301459T1/de not_active IP Right Cessation
- 1997-09-18 WO PCT/US1997/016642 patent/WO1998011882A1/en active IP Right Grant
- 1997-09-18 DK DK97944319T patent/DK0957903T3/da active
- 1997-09-18 EP EP97944319A patent/EP0957903B1/de not_active Expired - Lifetime
- 1997-09-18 AU AU45842/97A patent/AU740783B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE69733968D1 (de) | 2005-09-15 |
EP0957903B1 (de) | 2005-08-10 |
AU740783B2 (en) | 2001-11-15 |
EP0957903A1 (de) | 1999-11-24 |
AU4584297A (en) | 1998-04-14 |
US5990177A (en) | 1999-11-23 |
EP0957903A4 (de) | 2002-10-09 |
US6294585B1 (en) | 2001-09-25 |
ATE301459T1 (de) | 2005-08-15 |
WO1998011882A1 (en) | 1998-03-26 |
ES2245465T3 (es) | 2006-01-01 |
DE69733968T2 (de) | 2006-06-01 |
CA2266496A1 (en) | 1998-03-26 |
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