DK0948483T3 - Farnesyltransferaseinhibitorer - Google Patents

Farnesyltransferaseinhibitorer

Info

Publication number
DK0948483T3
DK0948483T3 DK97953000T DK97953000T DK0948483T3 DK 0948483 T3 DK0948483 T3 DK 0948483T3 DK 97953000 T DK97953000 T DK 97953000T DK 97953000 T DK97953000 T DK 97953000T DK 0948483 T3 DK0948483 T3 DK 0948483T3
Authority
DK
Denmark
Prior art keywords
farnesyl transferase
farnesyl
transferase
Prior art date
Application number
DK97953000T
Other languages
Danish (da)
English (en)
Inventor
Jean-Dominique Bourzat
Alain Commercon
Norbert Dereu
Patrick Mailliet
Fabienne Sounigo-Thompson
Jean-Paul Martin
Marc Capet
Michel Cheve
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of DK0948483T3 publication Critical patent/DK0948483T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/58[b]- or [c]-condensed
    • C07D209/724,7-Endo-alkylene-iso-indoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
DK97953000T 1996-12-30 1997-12-23 Farnesyltransferaseinhibitorer DK0948483T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9616206A FR2757855B1 (fr) 1996-12-30 1996-12-30 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1997/002407 WO1998029390A1 (fr) 1996-12-30 1997-12-23 Inhibiteurs de farnesyle transferase

Publications (1)

Publication Number Publication Date
DK0948483T3 true DK0948483T3 (da) 2002-07-01

Family

ID=9499293

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97953000T DK0948483T3 (da) 1996-12-30 1997-12-23 Farnesyltransferaseinhibitorer

Country Status (32)

Country Link
EP (1) EP0948483B1 (enExample)
JP (1) JP2001509147A (enExample)
KR (1) KR20000062391A (enExample)
AR (1) AR008950A1 (enExample)
AT (1) ATE214367T1 (enExample)
AU (1) AU741921B2 (enExample)
BR (1) BR9714498A (enExample)
CA (1) CA2275943A1 (enExample)
CO (1) CO4920252A1 (enExample)
CZ (1) CZ233599A3 (enExample)
DE (1) DE69711081T2 (enExample)
DK (1) DK0948483T3 (enExample)
DZ (1) DZ2389A1 (enExample)
EA (1) EA002114B1 (enExample)
ES (1) ES2172033T3 (enExample)
FR (1) FR2757855B1 (enExample)
HU (1) HUP0001747A3 (enExample)
ID (1) ID22922A (enExample)
IL (1) IL130453A0 (enExample)
MA (1) MA26460A1 (enExample)
NO (1) NO993225L (enExample)
NZ (1) NZ336042A (enExample)
PE (1) PE28199A1 (enExample)
PL (1) PL334345A1 (enExample)
PT (1) PT948483E (enExample)
SK (1) SK88399A3 (enExample)
TN (1) TNSN97214A1 (enExample)
TR (1) TR199901502T2 (enExample)
UY (1) UY24832A1 (enExample)
WO (1) WO1998029390A1 (enExample)
YU (1) YU30299A (enExample)
ZA (1) ZA9711734B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2787327B1 (fr) * 1998-12-21 2003-01-17 Aventis Pharma Sa Compositions contenant des inhibiteurs de farnesyle transferase
FR2796641B1 (fr) * 1999-07-22 2001-09-21 Aventis Pharma Sa Nouveau procede de preparation de composes benzoperhydroisoindole
FR2796640A1 (fr) * 1999-07-22 2001-01-26 Aventis Pharma Sa Nouveaux inhibiteurs de farnesyle transferase, leur preparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour la preparation de medicaments
FR2845994B1 (fr) * 2002-10-18 2006-05-19 Servier Lab Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2005089504A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ras相關疾病或病症之組合療法
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012612A1 (en) * 1993-11-05 1995-05-11 Warner-Lambert Company Substituted di- and tripeptide inhibitors of protein:farnesyl transferase
FR2736641B1 (fr) * 1995-07-10 1997-08-22 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
NO993225L (no) 1999-08-24
FR2757855A1 (fr) 1998-07-03
SK88399A3 (en) 2000-05-16
DZ2389A1 (fr) 2002-12-28
FR2757855B1 (fr) 1999-01-29
AU5669498A (en) 1998-07-31
TNSN97214A1 (fr) 2005-03-15
PE28199A1 (es) 1999-06-05
JP2001509147A (ja) 2001-07-10
KR20000062391A (ko) 2000-10-25
ATE214367T1 (de) 2002-03-15
ID22922A (enExample) 1999-12-16
MA26460A1 (fr) 2004-12-20
NZ336042A (en) 2000-12-22
CA2275943A1 (fr) 1998-07-09
HUP0001747A2 (hu) 2000-09-28
DE69711081T2 (de) 2002-08-01
HUP0001747A3 (en) 2000-10-30
CZ233599A3 (cs) 1999-09-15
IL130453A0 (en) 2000-06-01
EP0948483B1 (fr) 2002-03-13
PT948483E (pt) 2002-08-30
TR199901502T2 (xx) 1999-09-21
YU30299A (sh) 2002-03-18
ES2172033T3 (es) 2002-09-16
UY24832A1 (es) 2001-08-27
PL334345A1 (en) 2000-02-28
EA199900608A1 (ru) 2000-02-28
DE69711081D1 (de) 2002-04-18
ZA9711734B (en) 1998-06-25
WO1998029390A1 (fr) 1998-07-09
EP0948483A1 (fr) 1999-10-13
CO4920252A1 (es) 2000-05-29
BR9714498A (pt) 2000-03-21
AR008950A1 (es) 2000-02-23
EA002114B1 (ru) 2001-12-24
AU741921B2 (en) 2001-12-13
NO993225D0 (no) 1999-06-29

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