DK0939632T3 - Non-peptidyl vasopressin V1a antagonister - Google Patents

Non-peptidyl vasopressin V1a antagonister

Info

Publication number
DK0939632T3
DK0939632T3 DK97907895T DK97907895T DK0939632T3 DK 0939632 T3 DK0939632 T3 DK 0939632T3 DK 97907895 T DK97907895 T DK 97907895T DK 97907895 T DK97907895 T DK 97907895T DK 0939632 T3 DK0939632 T3 DK 0939632T3
Authority
DK
Denmark
Prior art keywords
antagonists
vasopressin
peptidyl
peptidyl vasopressin
azetidin
Prior art date
Application number
DK97907895T
Other languages
Danish (da)
English (en)
Inventor
Robert F Bruns Jr
Gary A Koppel
Robin D G Cooper
Bruce A Dressman
David C Hunden
Stephen W Kaldor
John R Rizzo
Jeffrey James Skelton
Mitchell I Steinberg
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605044.8A external-priority patent/GB9605044D0/en
Priority claimed from GBGB9605045.5A external-priority patent/GB9605045D0/en
Priority claimed from GBGB9605046.3A external-priority patent/GB9605046D0/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0939632T3 publication Critical patent/DK0939632T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
DK97907895T 1996-02-23 1997-02-20 Non-peptidyl vasopressin V1a antagonister DK0939632T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US1214996P 1996-02-23 1996-02-23
US1221596P 1996-02-23 1996-02-23
US1218896P 1996-02-23 1996-02-23
GBGB9605044.8A GB9605044D0 (en) 1996-03-09 1996-03-09 Method and non-peptidyl agents for modulation of the vasopressin v1a receptor
GBGB9605045.5A GB9605045D0 (en) 1996-03-09 1996-03-09 Method and non-peptidyl agents for modulation of the oxytocin receptor
GBGB9605046.3A GB9605046D0 (en) 1996-03-09 1996-03-09 Method for antagonism of the tachykinin receptor with non-peptide agents

Publications (1)

Publication Number Publication Date
DK0939632T3 true DK0939632T3 (da) 2006-01-30

Family

ID=27547258

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97907895T DK0939632T3 (da) 1996-02-23 1997-02-20 Non-peptidyl vasopressin V1a antagonister

Country Status (10)

Country Link
US (3) US6204260B1 (fr)
EP (1) EP0939632B1 (fr)
JP (1) JP4212112B2 (fr)
AT (1) ATE305781T1 (fr)
AU (1) AU1977997A (fr)
CA (1) CA2246753C (fr)
DE (1) DE69734321T2 (fr)
DK (1) DK0939632T3 (fr)
ES (1) ES2248840T3 (fr)
WO (1) WO1997030707A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU781218B2 (en) * 1999-08-16 2005-05-12 Revaax Pharmaceuticals, Llc Pharmaceutical compositions comprising clavulanic acid or derivative thereof for the treatment of behavioral diseases
US6426342B2 (en) * 1999-08-16 2002-07-30 Revaax Pharmaceuticals, Llc Use of β-lactamase inhibitors as neuroprotectants
US6489319B2 (en) * 1999-08-16 2002-12-03 Revaax Pharmaceuticals, Llc Neurotherapeutic use of carboxypeptidase inhibitors
CZ20021492A3 (cs) 1999-11-04 2003-06-18 Ortho-Mcneil Pharmaceutical, Inc. Nepeptidové substituované benzothiazepiny jako antagonisté vazopresinu
EP1406893B1 (fr) 2001-06-15 2007-04-18 Vicuron Pharmaceuticals, Inc. COMPOSeS BICYCLIQUES DE PYRROLIDINE
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
EP1434763B1 (fr) 2001-10-12 2018-01-17 Azevan Pharmaceuticals, Inc. Antagonistes v1a de vasopressine beta-lactamyl
WO2003051314A2 (fr) * 2001-12-18 2003-06-26 Medallion Biomedical, Llc Composes antibiotiques
WO2004030635A2 (fr) * 2002-10-03 2004-04-15 Targegen, Inc. Agents vasculo-statiques et procedes d'utilisation de ceux-ci
US20050282814A1 (en) * 2002-10-03 2005-12-22 Targegen, Inc. Vasculostatic agents and methods of use thereof
US20060281728A1 (en) * 2003-10-03 2006-12-14 Guillon Christophe D 3-Substituted beta-lactamyl vasopressin v1a antagonists
AU2005231507B2 (en) * 2004-04-08 2012-03-01 Targegen, Inc. Benzotriazine inhibitors of kinases
US7652051B2 (en) 2004-08-25 2010-01-26 Targegen, Inc. Heterocyclic compounds and methods of use
JP2008534504A (ja) * 2005-03-22 2008-08-28 アゼヴァン ファーマスーティカルズ，インコーポレイテッド 月経前障害を治療するためのβラクタミルアルカン酸
AU2013206201B2 (en) * 2005-03-22 2016-06-16 Azevan Pharmaceuticals, Inc. Beta-lactamylalkanoic acids for treating premenstrual disorders
EP1893216A4 (fr) * 2005-06-08 2012-08-08 Targegen Inc Methodes et preparations pour le traitement de troubles oculaires
SI1910346T1 (sl) * 2005-07-19 2019-08-30 Azevan Pharmaceuticals, Inc. Antagonist beta-laktamil fenilalalina, cisteina in serin vasopresina
US8604042B2 (en) * 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
US8133900B2 (en) * 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
BR122021011787B1 (pt) * 2005-11-01 2022-01-25 Impact Biomedicines, Inc Inibidores de biaril meta pirimidina de cinases, composição farmacêutica e processo para preparar uma composição farmacêutica
WO2007127366A2 (fr) * 2006-04-25 2007-11-08 Targegen, Inc. Inhibiteurs de kinases et leurs procédés d'utilisation
US20100016274A1 (en) * 2006-09-14 2010-01-21 Koppel Gary A Beta-lactam cannabinoid receptor modulators
BRPI1013901A2 (pt) * 2009-04-29 2019-09-24 Rexahn Pharmaceuticals Inc formulação de clavulanato para neuroproteção e tratamento de distúrbios neurodegenerativos
US9376424B2 (en) 2010-07-01 2016-06-28 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
WO2012060847A1 (fr) 2010-11-07 2012-05-10 Targegen, Inc. Compositions et procédés de traitement de la myélofibrose
US9802925B2 (en) 2014-03-28 2017-10-31 Azevan Pharmaceuticals, Inc. Compositions and methods for treating neurodegenerative diseases
AU2018333051B2 (en) 2017-09-15 2024-03-21 Azevan Pharmaceuticals, Inc. Compositions and methods for treating brain injury

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751299A (en) 1983-11-18 1988-06-14 Takeda Chemical Industries, Ltd. Optically active β-lactams and method of their production
US4665171A (en) 1985-07-17 1987-05-12 Harvard University Process and intermediates for β-lactam antibiotics
US4673737A (en) 1985-08-02 1987-06-16 Harvard University 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof
ES2000907A6 (es) 1985-09-09 1988-03-16 Otsuka Pharma Co Ltd Procedimiento de preparar compuestos 2-oxaisocefen microbiologicamente activos
US4734498A (en) 1986-07-10 1988-03-29 Eli Lilly And Company 3β-succinimidoazetidinones as chiral intermediates
US4772694A (en) * 1986-07-24 1988-09-20 Eli Lilly And Company Chiral 3-(1,2,5-trisubstituted imidazolidinone) azetidinone antibiotic intermediates
KR960002856B1 (ko) 1987-03-09 1996-02-27 오쓰까 세이야꾸 가부시끼가이샤 2-옥사-이소세펨 화합물, 이를 함유하는 조성물 및 이의 제조방법
US5373089A (en) 1988-09-02 1994-12-13 Northwestern University Oxytocin antagonist
US5068232A (en) * 1990-04-10 1991-11-26 American Cyanamid Company Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them
US5521307A (en) * 1992-02-18 1996-05-28 Eli Lilly And Company Methods and compounds for the preparation of carbacephems
CA2147129A1 (fr) * 1992-10-27 1994-05-11 James B. Doherty Nouvelles azetidinones substituees utilisees comme agents anti-inflammatoires et anti-degeneratifs
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
AU4368896A (en) * 1994-11-23 1996-06-17 Affymax Technologies N.V. Methods for synthesizing diverse collections of beta-lactam compounds
WO1996032408A1 (fr) * 1995-03-31 1996-10-17 Synphar Laboratories, Inc. Nouveaux derives 3-peptidyl-azetidin-2-one substituee en 4 utiles en tant qu'inhibiteur des cysteines proteinases
AU5487496A (en) * 1995-05-03 1996-11-21 Eli Lilly And Company Combinatorial process for synthesizing azetidinone analogs

Also Published As

Publication number Publication date
WO1997030707A1 (fr) 1997-08-28
US6521611B2 (en) 2003-02-18
ES2248840T3 (es) 2006-03-16
US20020049187A1 (en) 2002-04-25
EP0939632A1 (fr) 1999-09-08
AU1977997A (en) 1997-09-10
US6610680B1 (en) 2003-08-26
EP0939632A4 (fr) 2002-09-25
CA2246753A1 (fr) 1997-08-28
CA2246753C (fr) 2005-05-10
JP2000504731A (ja) 2000-04-18
EP0939632B1 (fr) 2005-10-05
DE69734321D1 (de) 2006-02-16
ATE305781T1 (de) 2005-10-15
US6204260B1 (en) 2001-03-20
DE69734321T2 (de) 2006-08-10
JP4212112B2 (ja) 2009-01-21

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