DK0939632T3 - Non-peptidyl vasopressin V1a antagonister - Google Patents
Non-peptidyl vasopressin V1a antagonisterInfo
- Publication number
- DK0939632T3 DK0939632T3 DK97907895T DK97907895T DK0939632T3 DK 0939632 T3 DK0939632 T3 DK 0939632T3 DK 97907895 T DK97907895 T DK 97907895T DK 97907895 T DK97907895 T DK 97907895T DK 0939632 T3 DK0939632 T3 DK 0939632T3
- Authority
- DK
- Denmark
- Prior art keywords
- antagonists
- vasopressin
- peptidyl
- peptidyl vasopressin
- azetidin
- Prior art date
Links
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 title 1
- 102000002852 Vasopressins Human genes 0.000 title 1
- 108010004977 Vasopressins Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 229960003726 vasopressin Drugs 0.000 title 1
- RZRRJTZLVKZGRN-UHFFFAOYSA-N 2-(2-oxoazetidin-1-yl)acetic acid Chemical class OC(=O)CN1CCC1=O RZRRJTZLVKZGRN-UHFFFAOYSA-N 0.000 abstract 1
- 102000004136 Vasopressin Receptors Human genes 0.000 abstract 1
- 108090000643 Vasopressin Receptors Proteins 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1214996P | 1996-02-23 | 1996-02-23 | |
| US1218896P | 1996-02-23 | 1996-02-23 | |
| US1221596P | 1996-02-23 | 1996-02-23 | |
| GBGB9605046.3A GB9605046D0 (en) | 1996-03-09 | 1996-03-09 | Method for antagonism of the tachykinin receptor with non-peptide agents |
| GBGB9605045.5A GB9605045D0 (en) | 1996-03-09 | 1996-03-09 | Method and non-peptidyl agents for modulation of the oxytocin receptor |
| GBGB9605044.8A GB9605044D0 (en) | 1996-03-09 | 1996-03-09 | Method and non-peptidyl agents for modulation of the vasopressin v1a receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0939632T3 true DK0939632T3 (da) | 2006-01-30 |
Family
ID=27547258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97907895T DK0939632T3 (da) | 1996-02-23 | 1997-02-20 | Non-peptidyl vasopressin V1a antagonister |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6204260B1 (en:Method) |
| EP (1) | EP0939632B1 (en:Method) |
| JP (1) | JP4212112B2 (en:Method) |
| AT (1) | ATE305781T1 (en:Method) |
| AU (1) | AU1977997A (en:Method) |
| CA (1) | CA2246753C (en:Method) |
| DE (1) | DE69734321T2 (en:Method) |
| DK (1) | DK0939632T3 (en:Method) |
| ES (1) | ES2248840T3 (en:Method) |
| WO (1) | WO1997030707A1 (en:Method) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6426342B2 (en) * | 1999-08-16 | 2002-07-30 | Revaax Pharmaceuticals, Llc | Use of β-lactamase inhibitors as neuroprotectants |
| CA2383522C (en) * | 1999-08-16 | 2011-12-06 | Revaax Pharmaceuticals, Llc | Neurotherapeutic composition and method |
| US6489319B2 (en) * | 1999-08-16 | 2002-12-03 | Revaax Pharmaceuticals, Llc | Neurotherapeutic use of carboxypeptidase inhibitors |
| MXPA02004513A (es) | 1999-11-04 | 2004-09-10 | Johnson & Johnson | Benzotiazefinas sustituidas no peptidicas como antagonistas de vasopresina. |
| AR036053A1 (es) | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
| DE60219630T2 (de) | 2001-06-15 | 2007-12-27 | Vicuron Pharmaceuticals, Inc., Fremont | Bicyclische pyrrolidinverbindungen |
| JP4494015B2 (ja) * | 2001-10-12 | 2010-06-30 | アゼヴァン ファーマスーティカルズ，インコーポレイテッド | β−ラクタミル・バソプレッシンＶ１ａ拮抗剤 |
| US7179907B2 (en) * | 2001-12-18 | 2007-02-20 | Bruce Eaton | Antibiotic compounds |
| US20050282814A1 (en) * | 2002-10-03 | 2005-12-22 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
| HK1079789A1 (zh) * | 2002-10-03 | 2006-04-13 | Targegen, Inc. | 血管静态毒性试剂及其使用方法 |
| WO2005035492A1 (en) * | 2003-10-03 | 2005-04-21 | Serenix Pharmaceuticals, Llc. | 3-SUBSTITUTED β-LACTAMYL VASOPRESSIN V1A ANTAGONISTS |
| EP1809614B1 (en) * | 2004-04-08 | 2014-05-07 | TargeGen, Inc. | Benzotriazine inhibitors of kinases |
| EP2532653A1 (en) | 2004-08-25 | 2012-12-12 | Targegen, Inc. | Benzo[1,2,4]triazines as protein kinase modulators |
| CN104922117A (zh) * | 2005-03-22 | 2015-09-23 | 阿泽范药品公司 | 用于治疗月经前病症的β-内酰氨基链烷酸 |
| AU2013206201B2 (en) * | 2005-03-22 | 2016-06-16 | Azevan Pharmaceuticals, Inc. | Beta-lactamylalkanoic acids for treating premenstrual disorders |
| CA2611720A1 (en) * | 2005-06-08 | 2006-12-14 | Targegen, Inc. | Methods and compositions for the treatment of ocular disorders |
| BRPI0613664B1 (pt) | 2005-07-19 | 2021-08-24 | Azevan Pharmaceuticals, Inc | Compostos antagonistas de beta-lactamil fenilalanina, cisteína e serina vasopressina, composição farmacêutica que compreende ditos compostos e usos terapêuticos dos mesmos |
| US8604042B2 (en) * | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| US8133900B2 (en) * | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| CA2628283C (en) * | 2005-11-01 | 2017-06-27 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| WO2007127366A2 (en) * | 2006-04-25 | 2007-11-08 | Targegen, Inc. | Kinase inhibitors and methods of use thereof |
| US20100016274A1 (en) * | 2006-09-14 | 2010-01-21 | Koppel Gary A | Beta-lactam cannabinoid receptor modulators |
| CN102413814A (zh) * | 2009-04-29 | 2012-04-11 | 瑞恩药品公司 | 用于神经保护和治疗神经变性病症的克拉维酸类物质制剂 |
| ES2858499T3 (es) | 2010-07-01 | 2021-09-30 | Azevan Pharmaceuticals Inc | Compuestos para su uso en el tratamiento de trastorno explosivo intermitente |
| AU2010363329A1 (en) | 2010-11-07 | 2013-05-09 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
| JP7255967B2 (ja) | 2014-03-28 | 2023-04-11 | アゼヴァン ファーマスーティカルズ，インコーポレイテッド | 神経変性疾患を治療するための組成物および方法 |
| TW201919625A (zh) | 2017-09-15 | 2019-06-01 | 美商愛治凡製藥公司 | 用於治療腦損傷之組合物及方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751299A (en) | 1983-11-18 | 1988-06-14 | Takeda Chemical Industries, Ltd. | Optically active β-lactams and method of their production |
| US4665171A (en) | 1985-07-17 | 1987-05-12 | Harvard University | Process and intermediates for β-lactam antibiotics |
| US4673737A (en) | 1985-08-02 | 1987-06-16 | Harvard University | 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof |
| DE3687870T2 (de) | 1985-09-09 | 1993-08-19 | Otsuka Pharma Co Ltd | 2-oxa-isocephemverbindungen, sie enthaltende zusammensetzungen und verfahren zu deren herstellung. |
| US4734498A (en) | 1986-07-10 | 1988-03-29 | Eli Lilly And Company | 3β-succinimidoazetidinones as chiral intermediates |
| US4772694A (en) | 1986-07-24 | 1988-09-20 | Eli Lilly And Company | Chiral 3-(1,2,5-trisubstituted imidazolidinone) azetidinone antibiotic intermediates |
| KR960002856B1 (ko) | 1987-03-09 | 1996-02-27 | 오쓰까 세이야꾸 가부시끼가이샤 | 2-옥사-이소세펨 화합물, 이를 함유하는 조성물 및 이의 제조방법 |
| US5373089A (en) | 1988-09-02 | 1994-12-13 | Northwestern University | Oxytocin antagonist |
| US5068232A (en) * | 1990-04-10 | 1991-11-26 | American Cyanamid Company | Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them |
| US5521307A (en) * | 1992-02-18 | 1996-05-28 | Eli Lilly And Company | Methods and compounds for the preparation of carbacephems |
| JPH08502752A (ja) * | 1992-10-27 | 1996-03-26 | メルク エンド カンパニー インコーポレーテッド | 抗炎症剤及び抗変性剤としての新規の置換アゼチジノン |
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| AU4368896A (en) * | 1994-11-23 | 1996-06-17 | Affymax Technologies N.V. | Methods for synthesizing diverse collections of beta-lactam compounds |
| JPH11503728A (ja) * | 1995-03-31 | 1999-03-30 | シンファー ラボラトリーズ，インコーポレーティッド | システイン・プロテイナーゼ阻害剤として有用な新規な４−置換−３−ペプチジル−アゼチジン−２−オン誘導体 |
| WO1996035122A1 (en) * | 1995-05-03 | 1996-11-07 | Eli Lilly And Company | Combinatorial process for synthesizing azetidinone analogs |
-
1997
- 1997-02-20 JP JP52964797A patent/JP4212112B2/ja not_active Expired - Lifetime
- 1997-02-20 DE DE69734321T patent/DE69734321T2/de not_active Expired - Lifetime
- 1997-02-20 ES ES97907895T patent/ES2248840T3/es not_active Expired - Lifetime
- 1997-02-20 DK DK97907895T patent/DK0939632T3/da active
- 1997-02-20 EP EP97907895A patent/EP0939632B1/en not_active Expired - Lifetime
- 1997-02-20 WO PCT/US1997/003039 patent/WO1997030707A1/en not_active Ceased
- 1997-02-20 AU AU19779/97A patent/AU1977997A/en not_active Abandoned
- 1997-02-20 AT AT97907895T patent/ATE305781T1/de active
- 1997-02-20 US US09/125,737 patent/US6204260B1/en not_active Expired - Lifetime
- 1997-02-20 CA CA002246753A patent/CA2246753C/en not_active Expired - Lifetime
-
2000
- 2000-12-08 US US09/733,430 patent/US6521611B2/en not_active Expired - Lifetime
-
2002
- 2002-12-20 US US10/327,240 patent/US6610680B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2246753A1 (en) | 1997-08-28 |
| WO1997030707A1 (en) | 1997-08-28 |
| ATE305781T1 (de) | 2005-10-15 |
| EP0939632B1 (en) | 2005-10-05 |
| EP0939632A1 (en) | 1999-09-08 |
| US6204260B1 (en) | 2001-03-20 |
| US6521611B2 (en) | 2003-02-18 |
| ES2248840T3 (es) | 2006-03-16 |
| JP4212112B2 (ja) | 2009-01-21 |
| DE69734321D1 (de) | 2006-02-16 |
| US20020049187A1 (en) | 2002-04-25 |
| EP0939632A4 (en) | 2002-09-25 |
| JP2000504731A (ja) | 2000-04-18 |
| CA2246753C (en) | 2005-05-10 |
| DE69734321T2 (de) | 2006-08-10 |
| AU1977997A (en) | 1997-09-10 |
| US6610680B1 (en) | 2003-08-26 |
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