DK0935607T3 - Oplöselige monovalente og multivalente MHC klasse II-fusionsproteiner samt anvendelser deraf - Google Patents

Oplöselige monovalente og multivalente MHC klasse II-fusionsproteiner samt anvendelser deraf

Info

Publication number
DK0935607T3
DK0935607T3 DK97938386T DK97938386T DK0935607T3 DK 0935607 T3 DK0935607 T3 DK 0935607T3 DK 97938386 T DK97938386 T DK 97938386T DK 97938386 T DK97938386 T DK 97938386T DK 0935607 T3 DK0935607 T3 DK 0935607T3
Authority
DK
Denmark
Prior art keywords
fusion proteins
applications
mhc class
soluble monovalent
multivalent mhc
Prior art date
Application number
DK97938386T
Other languages
Danish (da)
English (en)
Inventor
Jack L Strominger
Kai W Wucherpfennig
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of DK0935607T3 publication Critical patent/DK0935607T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK97938386T 1996-08-16 1997-08-15 Oplöselige monovalente og multivalente MHC klasse II-fusionsproteiner samt anvendelser deraf DK0935607T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2407796P 1996-08-16 1996-08-16
EP97938386A EP0935607B1 (de) 1996-08-16 1997-08-15 Lösliche monovalente und multivalente mhc klasse ii fusionsproteine und deren verwendungen

Publications (1)

Publication Number Publication Date
DK0935607T3 true DK0935607T3 (da) 2004-12-06

Family

ID=21818743

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97938386T DK0935607T3 (da) 1996-08-16 1997-08-15 Oplöselige monovalente og multivalente MHC klasse II-fusionsproteiner samt anvendelser deraf

Country Status (11)

Country Link
EP (1) EP0935607B1 (de)
JP (1) JP2000516470A (de)
AT (1) ATE272070T1 (de)
AU (1) AU730457B2 (de)
CA (1) CA2263195A1 (de)
DE (1) DE69730038T2 (de)
DK (1) DK0935607T3 (de)
ES (1) ES2221065T3 (de)
NZ (1) NZ333915A (de)
PT (1) PT935607E (de)
WO (1) WO1998006749A2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458354B1 (en) 1996-03-28 2002-10-01 The Johns Hopkins University Molecular complexes which modify immune responses
US6015884A (en) 1996-03-28 2000-01-18 The Johns Hopkins University Soluble divalent and multivalent heterodimeric analogs of proteins
US6268411B1 (en) 1997-09-11 2001-07-31 The Johns Hopkins University Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
JP2002504342A (ja) * 1998-02-19 2002-02-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 一価ｍｈｃ結合ドメイン融合タンパク質および接合体、多価ｍｈｃ結合ドメイン融合タンパク質および接合体、ならびに多量体ｍｈｃ結合ドメイン融合タンパク質および接合体、そしてそれらのための使用
FR2778669B1 (fr) * 1998-05-14 2002-06-14 Centre Nat Rech Scient Procede d'expression d'un complexe forme d'au moins un produit du complexe majeur d'histocompatibilite et d'un peptide chez un phage, phages et complexes ainsi obtenus et leurs applications
SK17332000A3 (sk) * 1998-05-19 2001-06-11 Avidex Limited Preskladaný rekombinantný t bunkový receptor-tcr, sekvencie nukleových kyselín, ktoré kódujú rekombinantné tcr reťazce rekombinantného tcr, a spôsob jeho výroby
FR2796953B1 (fr) * 1999-07-29 2003-10-10 Centre Nat Rech Scient Proteines recombinantes, et complexes moleculaires derives de ces proteines, analogues a des molecules impliquees dans les reponses immunitaires
US7521202B2 (en) 1999-12-17 2009-04-21 The Board Of Regents Of The University Of Oklahoma Method and apparatus for the production of soluble MHC antigens and uses thereof
WO2002030964A2 (en) 2000-10-10 2002-04-18 The Board Of Regents Of The University Of Oklahoma Comparative ligand mapping from mhc positive cells
EP1353950A2 (de) * 2000-12-18 2003-10-22 William H. Hildebrand Verfahren und vorrichtung zur herstellung von antigene und deren verwendungen
US20070026433A1 (en) 2001-03-09 2007-02-01 Hildebrand William H Epitope testing using soluble HLA
CA2440474A1 (en) 2001-04-05 2002-10-17 Virginia Mason Research Center Methods of mhc class ii epitope mapping, detection of autoimmune t cells and antigens, and autoimmune treatment
GB2392158B (en) * 2002-08-21 2005-02-16 Proimmune Ltd Chimeric MHC protein and oligomer thereof
ES2559763T3 (es) * 2002-09-10 2016-02-15 Affimed Gmbh Anticuerpo humano específico de CD3 con propiedades inmunosupresoras
CA2532966C (en) * 2003-07-15 2012-12-04 Chugai Seiyaku Kabushiki Kaisha Igm production by transformed cells and methods for quantifying said igm production
ATE518888T1 (de) 2003-10-09 2011-08-15 Chugai Pharmaceutical Co Ltd Stabilisierte lösung mit hoher igm-konzentration
GB2409456B (en) * 2003-10-30 2006-01-04 Proimmune Ltd Oligomeric receptor ligand pair member complexes
EP2361930A3 (de) 2007-03-26 2011-10-26 Dako Denmark A/S Multimere von peptide-mhc komplexen und deren verwendung in borrelia infektionskrankheiten
EP3023436A1 (de) 2007-07-03 2016-05-25 Dako Denmark A/S Verbesserte verfahren zur herstellung, markierung und verwendung von mhc-multimeren
WO2009039854A2 (en) 2007-09-27 2009-04-02 Dako Denmark A/S Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
US10722562B2 (en) 2008-07-23 2020-07-28 Immudex Aps Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
GB201002730D0 (en) 2010-02-18 2010-04-07 Uni I Oslo Product
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
MX2014008146A (es) * 2012-01-06 2016-02-03 Univ Oregon Health & Science Constructos de mhc parciales y metodos de uso.
WO2013124474A2 (en) 2012-02-23 2013-08-29 Stage Cell Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
US10988516B2 (en) 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
US9603948B2 (en) 2012-10-11 2017-03-28 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
GB201309469D0 (en) 2013-05-28 2013-07-10 Imcyse Sa Detection of CD4+ T lymphocytes
WO2015051330A1 (en) 2013-10-03 2015-04-09 Oregon Health & Science University RECOMBINANT POLYPEPTIDES COMPRISING MHC CLASS II α1 DOMAINS
EP3065771B1 (de) 2013-11-04 2019-03-20 UTI Limited Partnership Verfahren und zusammensetzungen für retard-immuntherapie
WO2015148960A1 (en) 2014-03-28 2015-10-01 The Board Of Regents Of The University Of Oklahoma Compositions comprising soluble hla/m. tuberculosis-specific ligand complexes and methods of production and use thereof
RU2718692C2 (ru) 2014-05-29 2020-04-13 Мэкроудженикс, Инк. Триспецифичные связывающие молекулы, которые специфически связывают антигены множества злокачественных опухолей, и способы их применения
EP3155426B1 (de) 2014-06-13 2023-07-19 Immudex ApS Allgemeiner nachweis und isolierung spezifischer zellen durch binden markierter moleküle
US12011480B2 (en) 2015-05-06 2024-06-18 Uti Limited Partnership Nanoparticle compositions for sustained therapy
GEP20217317B (en) 2015-10-08 2021-11-10 Macrogenics Inc Combination therapy for the treatment of cancer
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
BR112019009477A2 (pt) * 2016-11-09 2019-07-30 Uti Lp moléculas de classe ii de pmhc recombinantes
CN111032850B (zh) 2017-04-27 2024-08-13 朱诺治疗学有限公司 寡聚粒子试剂及其使用方法
US20220275043A1 (en) * 2018-07-17 2022-09-01 Massachusetts Institute Of Technology Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof
GB201909509D0 (en) * 2019-07-02 2019-08-14 Immunocore Ltd Peptide-MHC complexes
CN112816595A (zh) * 2021-01-06 2021-05-18 海默斯（重庆）医学生物技术有限公司 一种重组角蛋白液体制剂及其纯度检测方法
WO2022216974A1 (en) * 2021-04-07 2022-10-13 Repertoire Immune Medicines, Inc. Peptide-mhc-immunoglobulin multimers and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010220A1 (en) * 1991-11-19 1993-05-27 Anergen, Inc. Soluble mhc molecules and their uses
JPH10503379A (ja) * 1994-07-29 1998-03-31 デイド・インターナショナル・インコーポレーテッド Ｍｈｃ複合体およびその用途

Also Published As

Publication number Publication date
NZ333915A (en) 2000-11-24
WO1998006749A2 (en) 1998-02-19
PT935607E (pt) 2004-12-31
DE69730038T2 (de) 2004-11-25
ATE272070T1 (de) 2004-08-15
CA2263195A1 (en) 1998-02-19
WO1998006749A3 (en) 1998-06-11
EP0935607A2 (de) 1999-08-18
EP0935607B1 (de) 2004-07-28
DE69730038D1 (de) 2004-09-02
AU730457B2 (en) 2001-03-08
ES2221065T3 (es) 2004-12-16
JP2000516470A (ja) 2000-12-12
AU4072397A (en) 1998-03-06

Similar Documents

Publication Publication Date Title
DK0935607T3 (da) Oplöselige monovalente og multivalente MHC klasse II-fusionsproteiner samt anvendelser deraf
CY1107706T1 (el) Πεπτιδια ανταγωνιστες καρκινοεμβρυονικου αντιγονου (cea)
MA23065A1 (fr) Microspheres de proteines vegetales modifies hydrolysees et leurs procedes de preparation et d'utilisation.
DK0700445T3 (da) Stressproteiner og anvendelser deraf
ATE328068T1 (de) Papillomavirus vakzine
DE69933216D1 (de) Erythropoietin-analog-menschliches serum-albumin fusionsprotein
DK0719340T3 (da) Klonet glutaminsyre-decarboxylase
NO20000850L (no) Vaksine
ATE159299T1 (de) Cd4-spezifischer rekombinanter antikörper
DE68917323D1 (de) Expressions-Vektor für Fusions-Proteine und Immunogen-Proteine.
DK0538300T3 (da) O-Glycosyleret IFN-alfa
DK1053256T3 (da) Antistoffer mod Dødsreceptor 4 (DR4) og anvendelser deraf
FR2576774B1 (fr) Dispositif de positionnement tridimensionnel de deux pieces quelconques, en particulier de deux parties d'os, et permettant de modifier ledit positionnement
ATE80792T1 (de) Shampoo-praeparate.
AR016389A1 (es) Composicion cosmetica que contiene una dispersion acuosa de polimero y una emulsion de silicona disilanol y procedimiento.
BG101295A (en) Modified human c3 proteins
ATE218616T1 (de) Humanes zirkulierendes cytokin cc-1
DK0538341T3 (da) EHV-4-gycoproteinvaccine.
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
TR199800575T1 (en) Kemokin �-8'in k�sa formlar�.
HUP0300997A2 (hu) A MIA-fehérje alkalmazása immunterápiában
CY1106740T1 (el) Παραλλαγες του μειζονος αλλεργιογονου par j 2 του φυτου περδικακι
DK1431391T3 (da) RANTES-mutanter og terapeutiske anvendelser heraf
FI953257A0 (fi) Rekombinanttinen ihmisen prostaspesifinen antigeenRekombinanttinen ihmisen prostaspesifinen antigeeni ja sen käytöt i ja sen käytöt
DK0952771T3 (da) Hidtil ukendte saponinpræparater og anvendelser deraf