DK0915884T3 - Fremstilling af narkotiske analgetika - Google Patents
Fremstilling af narkotiske analgetikaInfo
- Publication number
- DK0915884T3 DK0915884T3 DK97932926T DK97932926T DK0915884T3 DK 0915884 T3 DK0915884 T3 DK 0915884T3 DK 97932926 T DK97932926 T DK 97932926T DK 97932926 T DK97932926 T DK 97932926T DK 0915884 T3 DK0915884 T3 DK 0915884T3
- Authority
- DK
- Denmark
- Prior art keywords
- narcotic analgesics
- preparation
- hydromorphone
- hydrocodone
- disclosed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9616253.2A GB9616253D0 (en) | 1996-08-01 | 1996-08-01 | Preparation of narcotic analgesics |
PCT/GB1997/001977 WO1998005667A1 (en) | 1996-08-01 | 1997-07-18 | Preparation of narcotic analgesics |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0915884T3 true DK0915884T3 (da) | 2002-07-01 |
Family
ID=10797912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97932926T DK0915884T3 (da) | 1996-08-01 | 1997-07-18 | Fremstilling af narkotiske analgetika |
Country Status (15)
Country | Link |
---|---|
US (1) | US5847142A (zh) |
EP (1) | EP0915884B1 (zh) |
JP (2) | JP4316674B2 (zh) |
CN (1) | CN1105721C (zh) |
AT (1) | ATE215955T1 (zh) |
AU (1) | AU3629197A (zh) |
DE (1) | DE69711883T2 (zh) |
DK (1) | DK0915884T3 (zh) |
ES (1) | ES2175438T3 (zh) |
GB (1) | GB9616253D0 (zh) |
MY (1) | MY117858A (zh) |
PL (1) | PL186307B1 (zh) |
TW (1) | TW396157B (zh) |
WO (1) | WO1998005667A1 (zh) |
ZA (1) | ZA976853B (zh) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9616253D0 (en) * | 1996-08-01 | 1996-09-11 | Johnson Matthey Plc | Preparation of narcotic analgesics |
EP2003134B1 (en) * | 1999-11-09 | 2011-03-02 | Abbott Laboratories | Hydromorphinone compositions |
MXPA04011327A (es) * | 2002-05-17 | 2005-08-15 | Jenken Biosciences Inc | Opioides y compuestos similares a opioides y usos de los mismos. |
US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
US7323565B2 (en) * | 2002-11-11 | 2008-01-29 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
US7399858B2 (en) * | 2002-11-11 | 2008-07-15 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof |
AU2003290629B8 (en) * | 2002-11-11 | 2008-11-27 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
US7321038B2 (en) * | 2002-11-11 | 2008-01-22 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
SK286047B6 (sk) * | 2004-04-13 | 2008-01-07 | Zentiva, A. S. | Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu |
JP2007537144A (ja) * | 2004-05-13 | 2007-12-20 | マリンクロッド・インコーポレイテッド | ヒドロコドンおよびヒドロモルホンの触媒的製法 |
US6946556B1 (en) | 2004-05-21 | 2005-09-20 | Acura Pharmaceuticals, Inc. | Preparation of opioid analgesics by a one-pot process |
US7348430B2 (en) * | 2005-01-21 | 2008-03-25 | Acura Pharmaceuticals, Inc. | Production of opioid analgesics |
EP1871774A1 (en) | 2005-03-28 | 2008-01-02 | Mallinckrodt, Inc. | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof |
WO2006138020A2 (en) * | 2005-06-16 | 2006-12-28 | Mallinckrodt Inc. | A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
US7399859B1 (en) | 2007-02-06 | 2008-07-15 | Cody Laboratories Inc. | Method for catalytic preparation of hydromorphone and hydrocodone |
WO2008137672A1 (en) * | 2007-05-04 | 2008-11-13 | Mallinckrodt Inc. | Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates |
US8962841B2 (en) | 2007-06-29 | 2015-02-24 | Brock University | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids |
US7999104B2 (en) | 2007-06-29 | 2011-08-16 | Brock University | Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids |
EP2167505B1 (en) * | 2007-07-17 | 2012-11-28 | Mallinckrodt LLC | Preparation of n-alkylated opiates by reductive amination |
NZ607842A (en) | 2008-09-30 | 2013-12-20 | Mallinckrodt Llc | Processes for the selective amination of ketomorphinans |
US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
US8293907B2 (en) * | 2009-04-09 | 2012-10-23 | Mallinckrodt Inc. | Preparation of saturated ketone morphinan compounds by catalytic isomerization |
US9040705B2 (en) * | 2009-04-09 | 2015-05-26 | Mallinckrodt Llc | Preparation of saturated ketone morphinan compounds |
US20100261906A1 (en) * | 2009-04-09 | 2010-10-14 | Mallinckrodt Inc. | Preparation of 6-Keto, 3-Alkoxy Morphinans |
ES2598496T3 (es) * | 2009-06-11 | 2017-01-27 | Mallinckrodt Llc | Preparación de 6-alfa-amino morfinanos N-sustituidos por transferencia de hidrógeno catalítico |
US8471023B2 (en) * | 2009-06-11 | 2013-06-25 | Mallinckrodt Llc | Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer |
NZ600379A (en) | 2009-12-04 | 2014-05-30 | Alkermes Pharma Ireland Ltd | Morphinan derivatives for the treatment of drug overdose |
WO2011154827A2 (en) | 2010-06-11 | 2011-12-15 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
CA2802294C (en) | 2010-06-11 | 2016-05-10 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
WO2012003468A1 (en) | 2010-07-02 | 2012-01-05 | Johnson Matthey Public Limited Company | Process for the synthesis and purification of oxycodone |
WO2012005795A1 (en) * | 2010-07-08 | 2012-01-12 | Alkermes, Inc. | Process for the synthesis of substituted morphinans |
SI2608670T1 (sl) | 2010-08-23 | 2019-04-30 | Alkermes Pharma Ireland Limited | Postopki za zdravljenje pridobivanja teže, ki je posledica uporabe antipsihotičnih zdravil |
ES2613403T3 (es) | 2011-05-06 | 2017-05-24 | Brock University | Proceso de preparación de análogos de la morfina mediante N-desmetilación/funcionalización catalizada por metal y transferencia de grupo intramolecular |
BR112013031420A2 (pt) | 2011-06-09 | 2016-08-16 | Mallinckrodt Llc | "processo para preparar um 6-amino morfinano, composição que o compreende e composição compreendendo um composto intermediário" |
CN103917543A (zh) | 2011-09-08 | 2014-07-09 | 马林克罗特有限公司 | 在不分离中间体的情况下制备生物碱 |
US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
EP3003311A2 (en) | 2013-05-24 | 2016-04-13 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
AU2014268361B2 (en) | 2013-05-24 | 2018-09-06 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
GB201313211D0 (en) | 2013-07-24 | 2013-09-04 | Cambrex Karlskoga Ab | New process |
EP3255051A1 (en) | 2016-06-09 | 2017-12-13 | Siegfried AG | Supported metal catalyst for the production of hydrocodon and hydromorphon |
US10081636B2 (en) | 2016-07-08 | 2018-09-25 | Cody Laboratories, Inc. | Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates |
EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
US20240043447A1 (en) | 2020-11-13 | 2024-02-08 | Ferrer Internacional, S.A. | Synthesis of hydromorphone base |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2654756A (en) * | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
US2628962A (en) * | 1949-10-20 | 1953-02-17 | Mallinckrodt Chemical Works | Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone |
US2715626A (en) * | 1950-07-05 | 1955-08-16 | Merck & Co Inc | Process of preparing dihydrocodeinone |
FR1290174A (fr) * | 1961-01-25 | 1962-04-13 | S E M P A Chemie | Préparation de la codéïnone à partir de la thébaïne |
GB9616253D0 (en) * | 1996-08-01 | 1996-09-11 | Johnson Matthey Plc | Preparation of narcotic analgesics |
-
1996
- 1996-08-01 GB GBGB9616253.2A patent/GB9616253D0/en active Pending
-
1997
- 1997-04-03 US US08/825,744 patent/US5847142A/en not_active Expired - Lifetime
- 1997-07-18 CN CN97198338A patent/CN1105721C/zh not_active Expired - Lifetime
- 1997-07-18 EP EP97932926A patent/EP0915884B1/en not_active Expired - Lifetime
- 1997-07-18 ES ES97932926T patent/ES2175438T3/es not_active Expired - Lifetime
- 1997-07-18 AU AU36291/97A patent/AU3629197A/en not_active Abandoned
- 1997-07-18 DK DK97932926T patent/DK0915884T3/da active
- 1997-07-18 AT AT97932926T patent/ATE215955T1/de active
- 1997-07-18 DE DE69711883T patent/DE69711883T2/de not_active Expired - Lifetime
- 1997-07-18 PL PL97331525A patent/PL186307B1/pl unknown
- 1997-07-18 WO PCT/GB1997/001977 patent/WO1998005667A1/en active IP Right Grant
- 1997-07-18 JP JP50769898A patent/JP4316674B2/ja not_active Expired - Lifetime
- 1997-07-24 TW TW086110548A patent/TW396157B/zh active
- 1997-07-28 MY MYPI97003431A patent/MY117858A/en unknown
- 1997-07-31 ZA ZA9706853A patent/ZA976853B/xx unknown
-
2009
- 2009-03-12 JP JP2009059906A patent/JP2009161557A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1231667A (zh) | 1999-10-13 |
JP2009161557A (ja) | 2009-07-23 |
ES2175438T3 (es) | 2002-11-16 |
DE69711883D1 (de) | 2002-05-16 |
JP4316674B2 (ja) | 2009-08-19 |
US5847142A (en) | 1998-12-08 |
ATE215955T1 (de) | 2002-04-15 |
EP0915884A1 (en) | 1999-05-19 |
ZA976853B (en) | 1998-02-11 |
EP0915884B1 (en) | 2002-04-10 |
PL186307B1 (pl) | 2003-12-31 |
CN1105721C (zh) | 2003-04-16 |
WO1998005667A1 (en) | 1998-02-12 |
DE69711883T2 (de) | 2002-10-31 |
JP2001500846A (ja) | 2001-01-23 |
TW396157B (en) | 2000-07-01 |
PL331525A1 (en) | 1999-07-19 |
AU3629197A (en) | 1998-02-25 |
MY117858A (en) | 2004-08-30 |
GB9616253D0 (en) | 1996-09-11 |
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