DK0884051T3 - Cancröse metastaseinhibitorer indeholdende uracilderivater - Google Patents
Cancröse metastaseinhibitorer indeholdende uracilderivaterInfo
- Publication number
- DK0884051T3 DK0884051T3 DK97940448T DK97940448T DK0884051T3 DK 0884051 T3 DK0884051 T3 DK 0884051T3 DK 97940448 T DK97940448 T DK 97940448T DK 97940448 T DK97940448 T DK 97940448T DK 0884051 T3 DK0884051 T3 DK 0884051T3
- Authority
- DK
- Denmark
- Prior art keywords
- unsubstituted
- inhibitors containing
- substituted
- uracil derivatives
- containing uracil
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25130396 | 1996-09-24 | ||
PCT/JP1997/003355 WO1998013045A1 (fr) | 1996-09-24 | 1997-09-22 | Inhibiteurs de metastases cancereuses contenant des derives d'uracile |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0884051T3 true DK0884051T3 (da) | 2005-01-24 |
Family
ID=17220808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97940448T DK0884051T3 (da) | 1996-09-24 | 1997-09-22 | Cancröse metastaseinhibitorer indeholdende uracilderivater |
Country Status (12)
Country | Link |
---|---|
US (1) | US6255314B1 (fr) |
EP (1) | EP0884051B1 (fr) |
JP (1) | JP3088758B2 (fr) |
KR (1) | KR100284413B1 (fr) |
AT (1) | ATE284694T1 (fr) |
AU (1) | AU699728B2 (fr) |
CA (1) | CA2238331C (fr) |
DE (1) | DE69731940T2 (fr) |
DK (1) | DK0884051T3 (fr) |
ES (1) | ES2235249T3 (fr) |
PT (1) | PT884051E (fr) |
WO (1) | WO1998013045A1 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4049477B2 (ja) * | 1999-03-23 | 2008-02-20 | 大鵬薬品工業株式会社 | 副作用軽減剤 |
FR2796945B1 (fr) * | 1999-07-30 | 2002-06-28 | Sod Conseils Rech Applic | Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments |
NZ523970A (en) * | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
US8415315B2 (en) | 2004-05-06 | 2013-04-09 | University Of Central Florida Research Foundation, Inc. | Methods and compositions for inhibiting the proliferation of cancer cells |
RU2394581C2 (ru) * | 2005-01-26 | 2010-07-20 | Тайхо Фармасьютикал Ко., Лтд. | ПРОТИВОРАКОВОЕ ЛЕКАРСТВЕННОЕ СРЕДСТВО, СОДЕРЖАЩЕЕ α,α,α-ТРИФТОРТИМИДИН И ИНГИБИТОР ТИМИДИНФОСФОРИЛАЗЫ |
US7799783B2 (en) | 2005-01-26 | 2010-09-21 | Taiho Pharmaceutical Co., Ltd. | Method of administrating an anticancer drug containing α, α, α-trifluorothymidine and thymidine phosphorylase inhibitor |
ES2382673T3 (es) | 2006-04-13 | 2012-06-12 | Taiho Pharmaceutical Co., Ltd. | Agente terapéutico para la enfermedad inflamatoria intestinal |
JP4852605B2 (ja) | 2006-06-30 | 2012-01-11 | 大鵬薬品工業株式会社 | 放射線治療増強剤 |
TWI435725B (zh) * | 2007-10-11 | 2014-05-01 | Taiho Pharmaceutical Co Ltd | The use of a uracil compound for a prophylactic or therapeutic composition for the preparation of cystitis and hepatitis |
TWI429439B (zh) | 2007-10-11 | 2014-03-11 | Taiho Pharmaceutical Co Ltd | And a therapeutic agent for inflammatory bowel disease using a uracil derivative as an active ingredient |
JP2010202591A (ja) * | 2009-03-04 | 2010-09-16 | Hokkaido Univ | 増殖性疾患の内用放射線治療剤 |
KR101928618B1 (ko) | 2013-05-17 | 2018-12-12 | 다이호야쿠힌고교 가부시키가이샤 | Tk1 단백질의 발현이 항진된 결장직장암 환자에 대한 치료효과 예측 방법 |
GEP20186841B (en) | 2013-06-17 | 2018-04-10 | Pharmaceutical Co Ltd Taiho | Stabilized crystal of tipiracil hydrochloride, and crystallization method for same |
CN105906573A (zh) * | 2015-12-23 | 2016-08-31 | 嘉实(湖南)医药科技有限公司 | 一种替吡嘧啶中间体的制备方法 |
EP3526199B1 (fr) * | 2016-10-14 | 2022-04-13 | Tes Pharma S.r.l. | Inhibiteurs de la semialdéhyde décarboxylase de l'acide alpha-amino-bêta-carboxymuconique |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3450399B2 (ja) * | 1993-12-28 | 2003-09-22 | 大鵬薬品工業株式会社 | 血管新生阻害剤 |
DK0763529T3 (da) * | 1995-03-29 | 2003-11-10 | Taiho Pharmaceutical Co Ltd | Uracilderivater og antitumorvirkningspotentiator og antitumormiddel indeholdende samme |
-
1997
- 1997-09-22 AU AU42225/97A patent/AU699728B2/en not_active Ceased
- 1997-09-22 US US09/077,209 patent/US6255314B1/en not_active Expired - Lifetime
- 1997-09-22 KR KR1019980703452A patent/KR100284413B1/ko not_active IP Right Cessation
- 1997-09-22 AT AT97940448T patent/ATE284694T1/de active
- 1997-09-22 WO PCT/JP1997/003355 patent/WO1998013045A1/fr active IP Right Grant
- 1997-09-22 JP JP10503999A patent/JP3088758B2/ja not_active Expired - Fee Related
- 1997-09-22 DK DK97940448T patent/DK0884051T3/da active
- 1997-09-22 PT PT97940448T patent/PT884051E/pt unknown
- 1997-09-22 CA CA002238331A patent/CA2238331C/fr not_active Expired - Fee Related
- 1997-09-22 EP EP97940448A patent/EP0884051B1/fr not_active Expired - Lifetime
- 1997-09-22 ES ES97940448T patent/ES2235249T3/es not_active Expired - Lifetime
- 1997-09-22 DE DE69731940T patent/DE69731940T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0884051B1 (fr) | 2004-12-15 |
US6255314B1 (en) | 2001-07-03 |
ES2235249T3 (es) | 2005-07-01 |
WO1998013045A1 (fr) | 1998-04-02 |
DE69731940D1 (de) | 2005-01-20 |
ATE284694T1 (de) | 2005-01-15 |
EP0884051A1 (fr) | 1998-12-16 |
DE69731940T2 (de) | 2005-05-25 |
JP3088758B2 (ja) | 2000-09-18 |
KR100284413B1 (ko) | 2001-03-02 |
CA2238331C (fr) | 2003-02-25 |
KR19990067441A (ko) | 1999-08-16 |
CA2238331A1 (fr) | 1998-04-02 |
EP0884051A4 (fr) | 2001-06-13 |
PT884051E (pt) | 2005-03-31 |
AU4222597A (en) | 1998-04-17 |
AU699728B2 (en) | 1998-12-10 |
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