DK0861068T3 - Fremgangsmåde og apparat til fremstilling af et lægemiddel til parenteral indgivelse - Google Patents

Fremgangsmåde og apparat til fremstilling af et lægemiddel til parenteral indgivelse

Info

Publication number
DK0861068T3
DK0861068T3 DK96938066T DK96938066T DK0861068T3 DK 0861068 T3 DK0861068 T3 DK 0861068T3 DK 96938066 T DK96938066 T DK 96938066T DK 96938066 T DK96938066 T DK 96938066T DK 0861068 T3 DK0861068 T3 DK 0861068T3
Authority
DK
Denmark
Prior art keywords
homogenizer
bar
drug
preparing
predispersion
Prior art date
Application number
DK96938066T
Other languages
Danish (da)
English (en)
Inventor
Bernd Klinksiek
Said Mahiout
Ricarda-Christine Nothelle
Hans-Juergen Hamann
Juergen Sdebik
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK0861068T3 publication Critical patent/DK0861068T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/46—Homogenising or emulsifying nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/70—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming
    • B01F33/71—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming working at super-atmospheric pressure, e.g. in pressurised vessels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
DK96938066T 1995-11-15 1996-11-04 Fremgangsmåde og apparat til fremstilling af et lægemiddel til parenteral indgivelse DK0861068T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19542499A DE19542499A1 (de) 1995-11-15 1995-11-15 Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung
PCT/EP1996/004795 WO1997017946A2 (de) 1995-11-15 1996-11-04 Verfahren und vorrichtung zur herstellung einer parenteralen arzneistoff-zubereitung

Publications (1)

Publication Number Publication Date
DK0861068T3 true DK0861068T3 (da) 2002-12-02

Family

ID=7777475

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96938066T DK0861068T3 (da) 1995-11-15 1996-11-04 Fremgangsmåde og apparat til fremstilling af et lægemiddel til parenteral indgivelse

Country Status (11)

Country Link
US (1) US6331314B1 (cg-RX-API-DMAC7.html)
EP (1) EP0861068B1 (cg-RX-API-DMAC7.html)
JP (1) JP4049391B2 (cg-RX-API-DMAC7.html)
AT (1) ATE222097T1 (cg-RX-API-DMAC7.html)
CA (1) CA2237554C (cg-RX-API-DMAC7.html)
DE (2) DE19542499A1 (cg-RX-API-DMAC7.html)
DK (1) DK0861068T3 (cg-RX-API-DMAC7.html)
ES (1) ES2180807T3 (cg-RX-API-DMAC7.html)
MX (1) MX9803633A (cg-RX-API-DMAC7.html)
PT (1) PT861068E (cg-RX-API-DMAC7.html)
WO (1) WO1997017946A2 (cg-RX-API-DMAC7.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1008380B1 (en) 1998-12-07 2004-03-10 F. Hoffmann-La Roche Ag Method and device for mixing or dispersing liquids
US20020119188A1 (en) * 2000-02-08 2002-08-29 Susan Niemiec Method of manufacturing liposomes
EP1222957A1 (en) * 2000-12-22 2002-07-17 Société des Produits Nestlé S.A. Process and device for producing a food grade oil-in-water emulsion
DE102004055507A1 (de) * 2004-11-17 2006-05-18 Basf Ag Verfahren zur Herstellung feinteiliger flüssig-flüssig Formulierungen und Vorrichtung zur Herstellung feinteiliger flüssig-flüssig Formulierungen
WO2007111937A1 (en) * 2006-03-23 2007-10-04 Applera Corporation Directed enrichment of genomic dna for high-throughput sequencing
US7985058B2 (en) * 2007-01-12 2011-07-26 Mark Gray Method and apparatus for making uniformly sized particles
US8304584B2 (en) * 2007-06-27 2012-11-06 H R D Corporation Method of making alkylene glycols
US7479576B1 (en) 2007-06-27 2009-01-20 H R D Corporation Method of hydrogenating aldehydes and ketones
US7652175B2 (en) * 2007-06-27 2010-01-26 H R D Corporation High shear process for the production of acetaldehyde
US7491856B2 (en) * 2007-06-27 2009-02-17 H R D Corporation Method of making alkylene glycols
CA2794102C (en) * 2007-06-28 2014-08-19 The Procter & Gamble Company Apparatus and method for mixing by producing shear and/or cavitation, and components for apparatus
US8322910B2 (en) 2008-07-25 2012-12-04 The Procter & Gamble Company Apparatus and method for mixing by producing shear and/or cavitation, and components for apparatus
CN101617990B (zh) * 2009-07-31 2013-01-23 中国人民解放军第三军医大学 脂质体制备装置以及使用该装置制备脂质体的方法
JP5771366B2 (ja) * 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
DE102009056884B4 (de) 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
PL2356983T3 (pl) 2009-12-03 2013-08-30 Novartis Ag Cyrkulacja komponentów w czasie homogenizacji emulsji
DE102009056883B4 (de) 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CL2012001399A1 (es) 2009-12-03 2013-03-08 Novartis Ag Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
DE102009056871A1 (de) 2009-12-03 2011-06-22 Novartis AG, 4056 Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
EP2601933B1 (en) 2009-12-03 2015-10-07 Novartis AG Hydrophilic filtration during manufacture of vaccine adjuvants
CN120529961A (zh) * 2023-01-17 2025-08-22 帝斯曼知识产权资产管理有限公司 液体分散体制备工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
EP0082877A1 (en) 1981-07-06 1983-07-06 Rush-Presbyterian-St.Luke's Medical Center Preparation of synthetic erythrocytes
CA1264668C (en) * 1984-06-20 1990-01-23 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES
DE3515335C2 (de) 1985-04-27 1995-01-26 Bayer Ag Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung
DE4207481A1 (de) 1992-03-10 1993-09-16 Bayer Ag Liposomale wirkstoff-formulierungen und verfahren zu ihrer herstellung
CA2146963A1 (en) * 1992-10-16 1994-04-28 Andreas Sachse Process and device for producing liquid, dispersed systems
DE4328331A1 (de) * 1993-08-18 1995-02-23 Andreas Dr Sachse Kontinuierliches Hochdruckextrusionsverfahren zur Herstellung von Liposomen und Emulsionen

Also Published As

Publication number Publication date
DE59609564D1 (de) 2002-09-19
PT861068E (pt) 2002-12-31
ES2180807T3 (es) 2003-02-16
CA2237554A1 (en) 1997-05-22
JP2000500146A (ja) 2000-01-11
CA2237554C (en) 2007-01-09
WO1997017946A2 (de) 1997-05-22
US6331314B1 (en) 2001-12-18
JP4049391B2 (ja) 2008-02-20
EP0861068B1 (de) 2002-08-14
DE19542499A1 (de) 1997-05-22
EP0861068A2 (de) 1998-09-02
MX9803633A (es) 1998-09-30
WO1997017946A3 (de) 1997-09-12
ATE222097T1 (de) 2002-08-15

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