DK0841922T3 - 1H-4(5)-substituerede imidazolderivater - Google Patents
1H-4(5)-substituerede imidazolderivaterInfo
- Publication number
- DK0841922T3 DK0841922T3 DK96920543T DK96920543T DK0841922T3 DK 0841922 T3 DK0841922 T3 DK 0841922T3 DK 96920543 T DK96920543 T DK 96920543T DK 96920543 T DK96920543 T DK 96920543T DK 0841922 T3 DK0841922 T3 DK 0841922T3
- Authority
- DK
- Denmark
- Prior art keywords
- ring structure
- methyl
- hydrogen
- imidazole derivatives
- taken together
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Luminescent Compositions (AREA)
- Liquid Crystal Substances (AREA)
- Epoxy Resins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45452295A | 1995-05-30 | 1995-05-30 | |
PCT/US1996/007873 WO1996038142A1 (en) | 1995-05-30 | 1996-05-29 | 1h-4(5)-substituted imidazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0841922T3 true DK0841922T3 (da) | 2002-06-03 |
Family
ID=23804951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96920543T DK0841922T3 (da) | 1995-05-30 | 1996-05-29 | 1H-4(5)-substituerede imidazolderivater |
Country Status (16)
Country | Link |
---|---|
US (1) | US6166060A (fi) |
EP (1) | EP0841922B1 (fi) |
JP (1) | JPH11506106A (fi) |
KR (1) | KR19990022136A (fi) |
CN (1) | CN1192144A (fi) |
AT (1) | ATE213412T1 (fi) |
AU (1) | AU721325B2 (fi) |
CA (1) | CA2222099A1 (fi) |
DE (1) | DE69619381T2 (fi) |
DK (1) | DK0841922T3 (fi) |
ES (1) | ES2170859T3 (fi) |
FI (1) | FI974364A0 (fi) |
NO (1) | NO975483D0 (fi) |
NZ (1) | NZ308931A (fi) |
PT (1) | PT841922E (fi) |
WO (1) | WO1996038142A1 (fi) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5932590A (en) * | 1996-12-05 | 1999-08-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
GB2344588B (en) * | 1997-07-25 | 2001-11-14 | Black James Foundation | 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands |
GB9715814D0 (en) * | 1997-07-25 | 1997-10-01 | Black James Foundation | Histamine H3 receptor ligands |
WO2000042023A1 (en) | 1999-01-18 | 2000-07-20 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
US6908926B1 (en) | 1999-04-16 | 2005-06-21 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
US6610721B2 (en) | 2000-03-17 | 2003-08-26 | Novo Nordisk A/S | Imidazo heterocyclic compounds |
US6437147B1 (en) | 2000-03-17 | 2002-08-20 | Novo Nordisk | Imidazole compounds |
AU2001285442A1 (en) | 2000-08-17 | 2002-02-25 | Gliatech, Inc. | Novel alicyclic imidazoles as H3 agents |
FR2827863A1 (fr) * | 2001-07-27 | 2003-01-31 | Sanofi Synthelabo | Derives d'aminoalkylimidazole, leur preparation et leur utilisation en therapeutique |
MXPA04005557A (es) * | 2002-03-01 | 2005-05-17 | Warner Lambert Co | Metodo para tratar la osteoartritis. |
CN1784220B (zh) * | 2003-05-05 | 2011-08-03 | 前体生物药物股份公司 | 谷氨酰胺酰基和谷氨酸环化酶效应物的应用 |
ZA200603165B (en) * | 2003-11-03 | 2007-07-25 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
US7902191B2 (en) | 2004-02-25 | 2011-03-08 | Eli Lilly And Company | Histamine H3 receptor antagonists, preparation and therapeutic uses |
PL1735278T3 (pl) | 2004-04-01 | 2010-06-30 | Lilly Co Eli | Związki receptora histaminowego H3, wytwarzanie i zastosowania terapeutyczne |
BRPI0511642A (pt) | 2004-06-02 | 2008-01-02 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para inibir o receptor h3 da histamina em um mamìfero, para tratamento ou prevenção de um distúrbio do sistema nervoso ou outro distúrbio associado com o receptor h3 da histamina, para tratamento ou prevenção da obesidade, para tratamento ou prevenção de um distúrbio ou doença, e, uso de um composto ou um sal do mesmo |
GB0413605D0 (en) | 2004-06-17 | 2004-07-21 | Addex Pharmaceuticals Sa | Novel compounds |
JP4942654B2 (ja) | 2004-08-23 | 2012-05-30 | イーライ リリー アンド カンパニー | ヒスタミンh3受容体薬剤、製剤及び治療的使用 |
DE602005011988D1 (de) | 2004-10-18 | 2009-02-05 | Lilly Co Eli | Histamin-h3-rezeptor inhibitoren, ihre herstellung und therapeutische anwendungen |
WO2006058023A2 (en) * | 2004-11-23 | 2006-06-01 | Merck & Co., Inc. | Treatment of stroke with histamine h3 inverse agonists or histamine h3 antagonists |
JP5052497B2 (ja) * | 2005-03-17 | 2012-10-17 | イーライ リリー アンド カンパニー | ヒスタミンh3受容体アンタゴニストとしてのピロリジン誘導体 |
CN101151244B (zh) | 2005-04-01 | 2014-09-03 | 伊莱利利公司 | 组胺h3受体活性剂、制备和治疗用途 |
EP1707203A1 (en) | 2005-04-01 | 2006-10-04 | Bioprojet | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine H3- receptor ligands |
EP1717235A3 (en) | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
EP1717233A1 (en) | 2005-04-29 | 2006-11-02 | Bioprojet | Histamine H3-receptor ligands and their therapeutic application |
WO2007063385A2 (en) * | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Spirocyclic amine histamine-3 receptor antagonists |
WO2008104942A2 (en) * | 2007-02-28 | 2008-09-04 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
WO2018053222A1 (en) * | 2016-09-16 | 2018-03-22 | Research Traingle Institute | Tetrahydroisoquinoline kappa opioid antagonists |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2069481B (en) * | 1980-02-13 | 1983-07-27 | Farmos Oy | Substituted imidazole derivatives |
GB2110663B (en) * | 1981-12-04 | 1985-08-07 | Farmos Group Ltd | Imidazole derivatives |
FR2579596B1 (fr) * | 1985-03-26 | 1987-11-20 | Inst Nat Sante Rech Med | (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique |
NL8601585A (nl) * | 1986-06-19 | 1988-01-18 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | N-(2-gesubstitueerde alkyl)-n-imidazol-4-yl alkyl guanidine. |
US4996221A (en) * | 1987-01-13 | 1991-02-26 | The Board Of Trustees Of The Leland Stanford Junior University | Histamine derivatives as immune modulators |
FI91159C (fi) * | 1988-12-07 | 1994-05-25 | Tanabe Seiyaku Co | Menetelmä imidatsolipitoisten peptidien ja niiden farmaseuttisesti sopivien suolojen valmistamiseksi |
US5248689A (en) * | 1989-11-06 | 1993-09-28 | Smithkline Beecham Corporation | Substituted N-(imidazolyl)alkyl alanine derivatives |
FR2669030B1 (fr) * | 1990-11-14 | 1992-12-31 | Adir | Nouveaux derives d'imidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2671083B1 (fr) * | 1990-12-31 | 1994-12-23 | Inst Nat Sante Rech Med | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. |
DE69222757T2 (de) * | 1991-02-27 | 1998-02-12 | Seed Capital Investments | Imidazol-derivate mit antagonistischer aktivität auf den histamin-h3-receptor |
FR2686084B1 (fr) * | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
US5217986A (en) * | 1992-03-26 | 1993-06-08 | Harbor Branch Oceanographic Institution, Inc. | Anti-allergy agent |
FR2711990B1 (fr) * | 1993-11-05 | 1995-12-08 | Exsymol Sa | Produit pseudodipeptide possédant un groupement imidazole, et applications thérapeutiques, cosmétologiques et agroalimentaires. |
FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
-
1996
- 1996-05-29 CA CA002222099A patent/CA2222099A1/en not_active Abandoned
- 1996-05-29 EP EP96920543A patent/EP0841922B1/en not_active Expired - Lifetime
- 1996-05-29 DE DE69619381T patent/DE69619381T2/de not_active Expired - Fee Related
- 1996-05-29 AT AT96920543T patent/ATE213412T1/de not_active IP Right Cessation
- 1996-05-29 WO PCT/US1996/007873 patent/WO1996038142A1/en not_active Application Discontinuation
- 1996-05-29 NZ NZ308931A patent/NZ308931A/en unknown
- 1996-05-29 KR KR1019970708615A patent/KR19990022136A/ko not_active Application Discontinuation
- 1996-05-29 ES ES96920543T patent/ES2170859T3/es not_active Expired - Lifetime
- 1996-05-29 PT PT96920543T patent/PT841922E/pt unknown
- 1996-05-29 DK DK96920543T patent/DK0841922T3/da active
- 1996-05-29 AU AU58817/96A patent/AU721325B2/en not_active Ceased
- 1996-05-29 JP JP8536607A patent/JPH11506106A/ja not_active Ceased
- 1996-05-29 CN CN96195926A patent/CN1192144A/zh active Pending
-
1997
- 1997-10-10 US US08/948,801 patent/US6166060A/en not_active Expired - Fee Related
- 1997-11-28 FI FI974364A patent/FI974364A0/fi not_active IP Right Cessation
- 1997-11-28 NO NO975483A patent/NO975483D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
JPH11506106A (ja) | 1999-06-02 |
DE69619381T2 (de) | 2002-11-21 |
EP0841922A4 (en) | 1999-03-10 |
DE69619381D1 (de) | 2002-03-28 |
US6166060A (en) | 2000-12-26 |
NZ308931A (en) | 2001-10-26 |
ES2170859T3 (es) | 2002-08-16 |
CN1192144A (zh) | 1998-09-02 |
PT841922E (pt) | 2002-07-31 |
AU721325B2 (en) | 2000-06-29 |
KR19990022136A (ko) | 1999-03-25 |
EP0841922B1 (en) | 2002-02-20 |
WO1996038142A1 (en) | 1996-12-05 |
FI974364A (fi) | 1997-11-28 |
AU5881796A (en) | 1996-12-18 |
ATE213412T1 (de) | 2002-03-15 |
FI974364A0 (fi) | 1997-11-28 |
CA2222099A1 (en) | 1996-12-05 |
EP0841922A1 (en) | 1998-05-20 |
NO975483D0 (no) | 1997-11-28 |
MX9709210A (es) | 1998-07-31 |
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