DK0841344T3 - 1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner - Google Patents

1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner

Info

Publication number
DK0841344T3
DK0841344T3 DK97916633T DK97916633T DK0841344T3 DK 0841344 T3 DK0841344 T3 DK 0841344T3 DK 97916633 T DK97916633 T DK 97916633T DK 97916633 T DK97916633 T DK 97916633T DK 0841344 T3 DK0841344 T3 DK 0841344T3
Authority
DK
Denmark
Prior art keywords
arabinofuranosyl
cytosines
deoxy
thio
fluoro
Prior art date
Application number
DK97916633T
Other languages
Danish (da)
English (en)
Inventor
Yuichi Yoshimura
Kenji Kitano
Shinji Miura
Haruhiko Machida
Mikari Watanabe
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of DK0841344T3 publication Critical patent/DK0841344T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK97916633T 1996-04-09 1997-04-09 1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner DK0841344T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP11196896 1996-04-09
JP21508296 1996-07-26
JP27863196 1996-09-30
PCT/JP1997/001206 WO1997038001A1 (en) 1996-04-09 1997-04-09 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES

Publications (1)

Publication Number Publication Date
DK0841344T3 true DK0841344T3 (da) 2002-12-23

Family

ID=27312140

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97916633T DK0841344T3 (da) 1996-04-09 1997-04-09 1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner

Country Status (10)

Country Link
US (1) US6147058A (member.php)
EP (1) EP0841344B1 (member.php)
JP (1) JP3657008B2 (member.php)
AT (1) ATE224909T1 (member.php)
CA (1) CA2224155C (member.php)
DE (1) DE69715774T2 (member.php)
DK (1) DK0841344T3 (member.php)
ES (1) ES2182061T3 (member.php)
PT (1) PT841344E (member.php)
WO (1) WO1997038001A1 (member.php)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
ATE344271T1 (de) * 1998-02-25 2006-11-15 Univ Emory 2'-fluoronukleoside
AU2004274021B2 (en) * 2003-09-18 2009-08-13 Isis Pharmaceuticals, Inc. 4'-thionucleosides and oligomeric compounds
US7524831B2 (en) * 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
EP2388257A1 (en) * 2010-05-20 2011-11-23 LibraMedicina, Inc. Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-ß-D-arabinofuranoses
SG181745A1 (en) * 2009-12-18 2012-07-30 Libramedicina Inc PROCESS FOR PREPARING SUBSTITUTED 1-O-ACYL-2-DEOXY-2-FLUORO-4-THIO-ß-D-ARABINOFURANOSES
CA2865742C (en) 2012-03-28 2017-04-18 Fujifilm Corporation Salt of 1-(2-deoxy-2-fluoro-4-thio-.beta.-d-arabinofuranosyl)cytosine
HRP20190572T1 (hr) 2012-08-13 2019-05-17 Fujifilm Corporation POSREDNIK ZA SINTEZU 1-(2-DEOKSI-2 FLUORO-4-TIO-beta-D-ARABINOFURANOZIL) CITOZINA, POSREDNIK ZA SINTEZU TIONUKLEOZIDA, I METODE ZA PROIZVODNJU OVIH POSREDNIKA
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
JP6175553B2 (ja) * 2014-02-18 2017-08-09 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6351107B2 (ja) * 2014-02-18 2018-07-04 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) * 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
CA2975990A1 (en) * 2015-04-03 2016-10-06 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Novel compound of 4'-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof
JP6450356B2 (ja) * 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
EP3508205B1 (en) * 2016-08-31 2022-05-18 FUJIFILM Corporation Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit
CA3041420A1 (en) 2016-12-22 2018-06-28 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Solid form of 4'-thio-2'-fluoronucleoside phosphamide compound and preparation method therefor and use thereof
EP3677267A4 (en) 2017-09-01 2021-06-02 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF TUMORS, METHOD AND USES THEREOF
AU2018404329B2 (en) 2018-01-29 2021-09-09 Fujifilm Corporation Antitumor agent for biliary tract cancer and method for treating biliary tract cancer
TW201932120A (zh) * 2018-01-29 2019-08-16 日商富士軟片股份有限公司 用於具有異檸檬酸脫氫酶突變的腫瘤的藥物組成物與抗腫瘤劑及其應用
WO2019164010A1 (ja) * 2018-02-26 2019-08-29 富士フイルム株式会社 膀胱がん用抗腫瘍剤および膀胱がんの処置方法
CA3093794C (en) * 2018-03-13 2023-03-14 Fujifilm Corporation Antitumor enhancer agent comprising 1-(2-deoxy-2-fluoro-4-thio-b-d-arabinofuranosyl)cytosine and an antitumor platinum complex
WO2020068657A1 (en) * 2018-09-25 2020-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
CN112770731A (zh) * 2018-11-28 2021-05-07 四川科伦博泰生物医药股份有限公司 以4’-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途
CN114341149A (zh) * 2019-07-30 2022-04-12 匹诺生物股份有限公司 用于治疗癌症的二核苷酸化合物及其医学用途
WO2023008511A1 (ja) 2021-07-29 2023-02-02 富士フイルム株式会社 Ｂａｐ１およびｐｂｒｍ１の少なくとも１つの機能低下を有する腫瘍に対する医薬組成物および抗腫瘍剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE74701B1 (en) * 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
WO1996001834A1 (en) * 1994-07-12 1996-01-25 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted methylidene)-4'-thionucleoside
JPH0853490A (ja) * 1994-08-09 1996-02-27 Yamasa Shoyu Co Ltd ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド

Also Published As

Publication number Publication date
ATE224909T1 (de) 2002-10-15
WO1997038001A1 (en) 1997-10-16
EP0841344B1 (en) 2002-09-25
US6147058A (en) 2000-11-14
PT841344E (pt) 2003-02-28
ES2182061T3 (es) 2003-03-01
JP3657008B2 (ja) 2005-06-08
EP0841344A1 (en) 1998-05-13
EP0841344A4 (member.php) 1998-05-13
CA2224155A1 (en) 1997-10-16
DE69715774D1 (de) 2002-10-31
DE69715774T2 (de) 2003-05-15
CA2224155C (en) 2004-10-26

Similar Documents

Publication Publication Date Title
DK0841344T3 (da) 1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner
IL159418A0 (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
AU5211686A (en) Pyrazolesulfonamide derivative, process for its production and herbicide containing it
ES2195510T3 (es) Derivados de imidazopiridina y procedimiento para prepararlos.
ATE201195T1 (de) Tricyclische verbindungen
EP1385518A4 (en) Benzimidazolone CONNECTIONS
BG103778A (en) Process for preparing pyrazole derivatives
EP0714900A3 (de) Alkylhydrogenchlorsilane, Verfahren zu deren Herstellung und deren Verwendung
DE60013994D1 (de) 1,2-Disubstituierte 1,4-Dihydro-4-oxochinolin-Verbindungen
ES2192852T3 (es) Proceso de obtencion de 3-aril-benzofuranonas.
YU76500A (sh) Hemijska sinzeza morfolinskih derivata
AU2001282297A1 (en) Catalysts
FI955954A0 (fi) Thiolyhdisteitä
EP0782996A4 (en) METHOD FOR PRODUCING N-BIPHENYLMETHYLTHIADIAZOLINE DERIVATIVES OR THEIR SALTS, AND INTERMEDIATE COMPOUNDS REQUIRED THEREFOR
ATE223414T1 (de) Prozess zur herstellung von zwischebprodukten für imidazodeazepinen
EP0747350A4 (en) PROCESS FOR THE MANUFACTURE OF BIS (4-ALKYLTHIOPHENYLE) BISULFIDE
ATE206125T1 (de) Furoindolizine
EP0551632A3 (en) Process for the preparation of halogenoanthranilic acid
AU2407597A (en) Eyedrops
ATE176242T1 (de) Uck14-verbindungen
ATE206699T1 (de) Uch-15-verbindungen
AU2007601A (en) Method for production of 1,3-disubstituted 2-nitroguanidines
FI904981A0 (fi) Nya inosin/guanosinderivat.
EP1007511A4 (en) PRODUCTION OF BETA MEHTYLCARBAPENEM INTERMEDIATE PRODUCTS