DK0832883T3 - Tetrahydrobenzo(a)fluorenforbindelser og fremgangsmåder til anvendelse - Google Patents
Tetrahydrobenzo(a)fluorenforbindelser og fremgangsmåder til anvendelseInfo
- Publication number
- DK0832883T3 DK0832883T3 DK97307498T DK97307498T DK0832883T3 DK 0832883 T3 DK0832883 T3 DK 0832883T3 DK 97307498 T DK97307498 T DK 97307498T DK 97307498 T DK97307498 T DK 97307498T DK 0832883 T3 DK0832883 T3 DK 0832883T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- tetrahydrobenzo
- fluorene compounds
- compounds
- tetrahydrobenzoäaüfluorene
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- NLEJQXRCWFYJCV-UHFFFAOYSA-N 2,3,4,11-tetrahydro-1h-benzo[a]fluorene Chemical class C1CCCC2=C3CC4=CC=CC=C4C3=CC=C21 NLEJQXRCWFYJCV-UHFFFAOYSA-N 0.000 title 1
- 208000006386 Bone Resorption Diseases 0.000 abstract 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 230000024279 bone resorption Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2675296P | 1996-09-26 | 1996-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0832883T3 true DK0832883T3 (da) | 2002-06-17 |
Family
ID=21833596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97307498T DK0832883T3 (da) | 1996-09-26 | 1997-09-25 | Tetrahydrobenzo(a)fluorenforbindelser og fremgangsmåder til anvendelse |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5821253A (enExample) |
| EP (1) | EP0832883B1 (enExample) |
| JP (1) | JPH10109965A (enExample) |
| AT (1) | ATE215538T1 (enExample) |
| CA (1) | CA2214931A1 (enExample) |
| DE (1) | DE69711529T2 (enExample) |
| DK (1) | DK0832883T3 (enExample) |
| ES (1) | ES2175279T3 (enExample) |
| PT (1) | PT832883E (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19937394A1 (de) * | 1999-08-07 | 2001-02-08 | Merck Patent Gmbh | Fluorenderivate |
| EP1458728A1 (en) * | 2001-12-13 | 2004-09-22 | Ranbaxy Laboratories Limited | Crystalline cefdinir potassium dihydrate |
| US20040092735A1 (en) * | 2002-11-08 | 2004-05-13 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of cefuroxime sodium |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274213A (en) * | 1961-09-05 | 1966-09-20 | Upjohn Co | Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes |
| DE1300575B (de) * | 1965-05-21 | 1969-08-07 | Bristol Myers Co | Benzo[b]thiophene |
| US3394125A (en) * | 1965-10-23 | 1968-07-23 | Bristol Myers Co | 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group |
| US3974186A (en) * | 1970-05-14 | 1976-08-10 | Richardson-Merrell Inc. | Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones |
| CH564513A5 (en) * | 1971-05-24 | 1975-07-31 | Richardson Merrell Inc | Basically substd fluoranthene derivs - with antiviral activity |
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US4358593A (en) * | 1981-04-03 | 1982-11-09 | Eli Lilly And Company | Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| IL65404A0 (en) * | 1981-04-03 | 1982-07-30 | Lilly Co Eli | Benzothiophene compounds and process for preparing them |
| AU621811B2 (en) * | 1987-09-25 | 1992-03-26 | Ciba-Geigy Ag | Diacyl derivatives of 4-(trialkylbenzyl)-piperazinyl compounds |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| DE4117512A1 (de) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| US5147880A (en) * | 1991-07-22 | 1992-09-15 | Eli Lilly And Company | Benzo[a]fluorene compounds |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
| GB9220735D0 (en) * | 1992-10-02 | 1992-11-18 | British Tech Group | Heterocyclic amines |
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US7501441B1 (en) * | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
| US5998401A (en) * | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
| GB2303628A (en) * | 1995-07-27 | 1997-02-26 | Lilly Co Eli | 5-Hydroxy- and 5-phenyl-substituted 1-[4-(aminoalkoxy)phenyl]-2-phenylbenzene derivatives for the treatment of post menopausal symptoms and intermediates |
| US5811421A (en) * | 1995-07-31 | 1998-09-22 | Eli Lilly And Company | Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods |
-
1997
- 1997-09-02 CA CA002214931A patent/CA2214931A1/en not_active Abandoned
- 1997-09-24 US US08/937,646 patent/US5821253A/en not_active Expired - Fee Related
- 1997-09-24 JP JP9258351A patent/JPH10109965A/ja not_active Withdrawn
- 1997-09-25 EP EP97307498A patent/EP0832883B1/en not_active Expired - Lifetime
- 1997-09-25 ES ES97307498T patent/ES2175279T3/es not_active Expired - Lifetime
- 1997-09-25 DE DE69711529T patent/DE69711529T2/de not_active Expired - Fee Related
- 1997-09-25 DK DK97307498T patent/DK0832883T3/da active
- 1997-09-25 AT AT97307498T patent/ATE215538T1/de not_active IP Right Cessation
- 1997-09-25 PT PT97307498T patent/PT832883E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10109965A (ja) | 1998-04-28 |
| EP0832883B1 (en) | 2002-04-03 |
| EP0832883A1 (en) | 1998-04-01 |
| US5821253A (en) | 1998-10-13 |
| ES2175279T3 (es) | 2002-11-16 |
| PT832883E (pt) | 2002-08-30 |
| DE69711529T2 (de) | 2002-10-31 |
| CA2214931A1 (en) | 1998-03-26 |
| DE69711529D1 (de) | 2002-05-08 |
| ATE215538T1 (de) | 2002-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE394082T1 (de) | Vorrichtung zur verbindung von wirbeln der wirbelsäule | |
| DK0871631T3 (da) | Antiparasitære marcfortiner og paraherquamider | |
| IS4812A (is) | Samsett meðferð fyrir beingisnun | |
| NO20004626D0 (no) | Bicyclo(2.2.1)heptaner og beslektede forbindelser | |
| PL332541A1 (en) | D-olanzapin dihydrate | |
| DK0980250T3 (da) | Planteekstrakter til behandling af forøget knogleresorption | |
| DE69724062D1 (de) | Benzothiophenderivate, Zwischenprodukte, Verfahren, Zubereitungen und Methoden | |
| DE69730796D1 (de) | Naphthylverbindungen, Zusammensetzungen und Verfahren | |
| ATE278684T1 (de) | Benzo(b)thiophen-verbindungen, zwischenprodukte, verfahren und zusammensetzungen | |
| ZA9810215B (en) | 2-Aryl-3-Aroylbenzo[b]thiophenes useful for the treatment of estrogen deprivation syndrome. | |
| DE69723639D1 (de) | Benzothiophenverbindungen, Zubereitungen und Verfahren | |
| IL136720A0 (en) | Indole derivatives useful a.o. for the treatment of osteoporosis | |
| DK0832883T3 (da) | Tetrahydrobenzo(a)fluorenforbindelser og fremgangsmåder til anvendelse | |
| ATE248830T1 (de) | Substituierte 2,3-aryl-benzothiophene und ihre östrogene aktivität | |
| DK0601152T3 (da) | Osteosyntesehjælpemiddel til fiksering af knogler. | |
| DE69723187D1 (de) | Dihydrobenzofluorenverbindungen, Zwischenprodukte, Zusammensetzungen und Methode | |
| DK0832882T3 (da) | Naphthofluorenforbindelser, mellemprodukter, præparater og fremgangsmåder | |
| DE69723188D1 (de) | Benzo[B]indeno[2,1-D]thiophenverbindungen, Zwischenprodukte, Verfahren, Zusammensetzungen und Methoden | |
| DE69727529D1 (de) | Benzothiophenverbindungen, Zwischenprodukte, Zusammensetzungen und Methode | |
| MXPA03007242A (es) | Delta-1-pirrolinas para control de pestes. | |
| ES2136443T3 (es) | Limpieza in situ. | |
| DE69723790D1 (de) | Dihydrobenzo(b)indeno(2,1-D)thiophen-Derivate, Zwischenprodukte, Verfahren, Zubereitungen und Methoden | |
| TH32978A (enExample) | ||
| IT1295187B1 (it) | Placca per chirurgia ortopedica. | |
| ECSP961890A (es) | Benzotiofenos lipofilos (caso x- 10395) |