DE69723639D1 - Benzothiophenverbindungen, Zubereitungen und Verfahren - Google Patents
Benzothiophenverbindungen, Zubereitungen und VerfahrenInfo
- Publication number
- DE69723639D1 DE69723639D1 DE69723639T DE69723639T DE69723639D1 DE 69723639 D1 DE69723639 D1 DE 69723639D1 DE 69723639 T DE69723639 T DE 69723639T DE 69723639 T DE69723639 T DE 69723639T DE 69723639 D1 DE69723639 D1 DE 69723639D1
- Authority
- DE
- Germany
- Prior art keywords
- methods
- preparations
- benzothiophene compounds
- compounds
- benzothiophene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2744996P | 1996-09-27 | 1996-09-27 | |
US27449P | 1996-09-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69723639D1 true DE69723639D1 (de) | 2003-08-28 |
DE69723639T2 DE69723639T2 (de) | 2004-04-15 |
Family
ID=21837814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69723639T Expired - Fee Related DE69723639T2 (de) | 1996-09-27 | 1997-09-22 | Benzothiophenverbindungen, Zubereitungen und Verfahren |
Country Status (7)
Country | Link |
---|---|
US (1) | US5981570A (de) |
EP (1) | EP0832888B1 (de) |
JP (1) | JPH10109984A (de) |
AT (1) | ATE245637T1 (de) |
CA (1) | CA2214922A1 (de) |
DE (1) | DE69723639T2 (de) |
ES (1) | ES2203758T3 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090843A (en) * | 1997-08-11 | 2000-07-18 | Eli Lilly And Company | Benzothiophenes compounds which have useful pharmaceutical activity |
DE19751956A1 (de) * | 1997-11-24 | 1999-06-02 | Ilt International Licence Trad | Verfahren und Schaltungsanordnung zur Umwandlung einer Wechselhochspannung in eine Gleichniederspannung |
WO2000059897A2 (en) * | 1999-04-06 | 2000-10-12 | Akzo Nobel N.V. | Esters and carbonates of 2-(4-hydroxyphenyl)-6(or 5)-hydroxy-benzothiophene derivatives as selective estrogenic compounds |
US7056931B2 (en) | 2001-05-22 | 2006-06-06 | Eli Lilly And Company | 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods |
EP1401446B1 (de) * | 2001-05-22 | 2005-02-09 | Eli Lilly And Company | Tetrahydrochinolin-derivate zur behandlung von krankheiten ausgelöst durch zu hohem oder zu niedrigem oestrogenspiegel |
CN116813603A (zh) * | 2023-06-02 | 2023-09-29 | 成都市第三人民医院 | 一种选择性雌激素受体α降解化合物及其制备方法和应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US553238A (en) * | 1896-01-21 | Isaac harrison | ||
DE1300575B (de) * | 1965-05-21 | 1969-08-07 | Bristol Myers Co | Benzo[b]thiophene |
US3394125A (en) * | 1965-10-23 | 1968-07-23 | Bristol Myers Co | 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group |
US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
AU555658B2 (en) * | 1981-04-03 | 1986-10-02 | Eli Lilly And Company | Benzothiophene compounds |
US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
US4358593A (en) * | 1981-04-03 | 1982-11-09 | Eli Lilly And Company | Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes |
US4916126A (en) * | 1987-09-25 | 1990-04-10 | Ciba-Geigy Corporation | Diacyl derivatives of 4-(trialkylbenzyl)-piperazinyl compounds |
US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
DE4117512A1 (de) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
CA2145614A1 (en) * | 1994-03-31 | 1995-10-01 | Jeffrey A. Dodge | Intermediates and processes for preparing benzothiophene compounds |
US5596106A (en) * | 1994-07-15 | 1997-01-21 | Eli Lilly And Company | Cannabinoid receptor antagonists |
IL115582A0 (en) * | 1994-10-14 | 1996-01-19 | Lilly Co Eli | Methods for treating resistant tumors |
US5514703A (en) * | 1995-03-13 | 1996-05-07 | Eli Lilly And Company | Benzothiophene compounds useful for inhibiting lipoxygenase |
US5532382A (en) * | 1995-03-13 | 1996-07-02 | Eli Lilly And Company | Benzothiophenes substituted at the 3-carbonyl |
-
1997
- 1997-09-02 CA CA002214922A patent/CA2214922A1/en not_active Abandoned
- 1997-09-22 US US08/935,374 patent/US5981570A/en not_active Expired - Fee Related
- 1997-09-22 EP EP97307339A patent/EP0832888B1/de not_active Expired - Lifetime
- 1997-09-22 DE DE69723639T patent/DE69723639T2/de not_active Expired - Fee Related
- 1997-09-22 AT AT97307339T patent/ATE245637T1/de not_active IP Right Cessation
- 1997-09-22 ES ES97307339T patent/ES2203758T3/es not_active Expired - Lifetime
- 1997-09-25 JP JP9259950A patent/JPH10109984A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JPH10109984A (ja) | 1998-04-28 |
ATE245637T1 (de) | 2003-08-15 |
DE69723639T2 (de) | 2004-04-15 |
EP0832888B1 (de) | 2003-07-23 |
EP0832888A1 (de) | 1998-04-01 |
US5981570A (en) | 1999-11-09 |
CA2214922A1 (en) | 1998-03-27 |
ES2203758T3 (es) | 2004-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |