DK0831938T3 - Radiomærkede peptidsammensætninger til stedspecifik målsögninger - Google Patents
Radiomærkede peptidsammensætninger til stedspecifik målsögningerInfo
- Publication number
- DK0831938T3 DK0831938T3 DK96922403T DK96922403T DK0831938T3 DK 0831938 T3 DK0831938 T3 DK 0831938T3 DK 96922403 T DK96922403 T DK 96922403T DK 96922403 T DK96922403 T DK 96922403T DK 0831938 T3 DK0831938 T3 DK 0831938T3
- Authority
- DK
- Denmark
- Prior art keywords
- somatostatin
- peptide
- radiolabeled peptide
- radiolabeled
- site
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/480,373 US5830431A (en) | 1995-06-07 | 1995-06-07 | Radiolabeled peptide compositions for site-specific targeting |
PCT/US1996/009384 WO1996040291A1 (fr) | 1995-06-07 | 1996-06-06 | Compositions de peptides radiomarques pour le ciblage specifique d'un site |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0831938T3 true DK0831938T3 (da) | 2008-07-21 |
Family
ID=23907713
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96922403T DK0831938T3 (da) | 1995-06-07 | 1996-06-06 | Radiomærkede peptidsammensætninger til stedspecifik målsögninger |
DK07019899.9T DK1872800T3 (da) | 1995-06-07 | 1996-06-06 | Radiomærkede peptidsammensætninger til stedsspecifik målsøgning |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07019899.9T DK1872800T3 (da) | 1995-06-07 | 1996-06-06 | Radiomærkede peptidsammensætninger til stedsspecifik målsøgning |
Country Status (10)
Country | Link |
---|---|
US (2) | US5830431A (fr) |
EP (2) | EP1872800B1 (fr) |
JP (2) | JP4236282B2 (fr) |
AT (1) | ATE395938T1 (fr) |
CA (1) | CA2224153C (fr) |
DE (1) | DE69637535D1 (fr) |
DK (2) | DK0831938T3 (fr) |
ES (2) | ES2308778T3 (fr) |
PT (1) | PT831938E (fr) |
WO (1) | WO1996040291A1 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
MY133346A (en) * | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
US6358491B1 (en) | 1999-08-27 | 2002-03-19 | Berlex Laboratories, Inc. | Somatostatin analogs |
US7067111B1 (en) * | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
EP1286704B1 (fr) | 2000-06-02 | 2014-07-23 | Board of Regents, The University of Texas System | CONJUGUES D'ETHYLENEDICYSTEINE (EC) ET D'UN analogue de la glucose, COMPOSITIONS ET PROCEDES POUR L'IMAGERIE DE MALADIES A SPECIFICITE TISSULAIRE |
US20020197261A1 (en) * | 2001-04-26 | 2002-12-26 | Chun Li | Therapeutic agent/ligand conjugate compositions, their methods of synthesis and use |
US7261875B2 (en) * | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
US20040166058A1 (en) * | 2002-11-07 | 2004-08-26 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
CA2518406A1 (fr) * | 2003-03-10 | 2004-09-23 | Biogen Idec Ma Inc. | Fixation de medicament a mediation de thiol a des peptides de ciblage |
US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
EP1861127A1 (fr) * | 2005-03-10 | 2007-12-05 | Bayer Schering Pharma Aktiengesellschaft | Chelateurs pour des conjugues radioactivement marques comprenant une chaine laterale stabilisante |
US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
WO2011075678A1 (fr) | 2009-12-18 | 2011-06-23 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibiteurs spécifiques et sondes de site actif pour la légumaïne |
US8791121B2 (en) | 2010-08-12 | 2014-07-29 | New York University | Oligooxopiperazines and methods of making and using them |
JP2015508779A (ja) | 2012-02-16 | 2015-03-23 | ニューヨーク・ユニバーシティ | 低酸素状態で誘導可能な遺伝子発現の、オリゴオキソピペラジン非ペプチド性へリックス模倣体による制御 |
US10994032B2 (en) | 2012-05-08 | 2021-05-04 | Trt Innovations Aps | 177-Lu labeled peptide for site-specific uPAR-targeting |
CN108137690A (zh) | 2015-06-25 | 2018-06-08 | 高级催化剂应用品有限公司 | 治疗过度表达生长抑素受体的神经内分泌肿瘤的方法 |
EP3568205B1 (fr) | 2017-01-12 | 2023-08-16 | Radiomedix Inc. | Traitement de cellules cancéreuses exprimant recepteurs de la somatostatine en excès avec des dérivés de l'octréotide chelé avec des radioisotopes |
US10596278B2 (en) | 2018-07-25 | 2020-03-24 | Advanced Accelerator Applications (Italy) S.R.L. | Stable, concentrated radionuclide complex solutions |
US10596276B2 (en) | 2018-07-25 | 2020-03-24 | Advanced Accelerator Applications (Italy) S.R.L. | Stable, concentrated radionuclide complex solutions |
US11357874B2 (en) | 2018-09-11 | 2022-06-14 | Stanley Satz | Tumor targeted radionuclide therapy and molecular imaging of HER2+ cancers and other neoplasms |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3062075D1 (en) * | 1979-11-27 | 1983-03-24 | Sandoz Ag | Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use |
US4282143A (en) * | 1980-06-13 | 1981-08-04 | American Home Products Corporation | Octapeptides lowering growth hormone |
US4440904A (en) * | 1983-01-31 | 1984-04-03 | American Home Products Corporation | Nonapeptide anti-secretory agents |
US4725577A (en) * | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
US4585755A (en) * | 1985-04-29 | 1986-04-29 | Merck & Co., Inc. | Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents |
MY106120A (en) * | 1988-12-05 | 1995-03-31 | Novartis Ag | Peptide derivatives. |
GB9111199D0 (en) * | 1991-05-23 | 1991-07-17 | Sandoz Ltd | Improvements in or relating to organic compounds |
US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
JPH04236282A (ja) * | 1991-01-18 | 1992-08-25 | Aica Kogyo Co Ltd | 接着剤組成物 |
EP0600992B1 (fr) * | 1991-08-29 | 2000-09-20 | Mallinckrodt Medical, Inc. | Utilisation de l'acide gentisique ou de l'alcool gentisyle pour stabiliser des peptides et proteines radiomarques |
US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
US5411943A (en) * | 1992-02-25 | 1995-05-02 | Biomeasure, Inc. | Hepatoma treatment with somatostatin analogs |
CA2113121A1 (fr) * | 1993-01-12 | 1994-07-13 | Rainer Albert | Peptides |
US5650134A (en) * | 1993-01-12 | 1997-07-22 | Novartis Ag (Formerly Sandoz Ltd.) | Peptides |
CA2168113C (fr) * | 1993-08-09 | 2002-10-01 | Sun Hyuk Kim | Derives de peptides, agents therapeutiques |
WO1995013832A1 (fr) * | 1993-11-16 | 1995-05-26 | Resolution Pharmaceuticals Inc. | Procede de marquage fixe |
WO1995019187A1 (fr) * | 1994-01-12 | 1995-07-20 | Amersham International Plc | Agents biologiques de ciblage |
EP0835662B1 (fr) * | 1996-10-08 | 2001-11-14 | National Institute of Immunology | Médicament pour le traitement du cancer |
-
1995
- 1995-06-07 US US08/480,373 patent/US5830431A/en not_active Expired - Lifetime
-
1996
- 1996-06-06 DE DE69637535T patent/DE69637535D1/de not_active Expired - Lifetime
- 1996-06-06 AT AT96922403T patent/ATE395938T1/de active
- 1996-06-06 EP EP07019899A patent/EP1872800B1/fr not_active Expired - Lifetime
- 1996-06-06 CA CA2224153A patent/CA2224153C/fr not_active Expired - Lifetime
- 1996-06-06 ES ES96922403T patent/ES2308778T3/es not_active Expired - Lifetime
- 1996-06-06 ES ES07019899T patent/ES2395961T3/es not_active Expired - Lifetime
- 1996-06-06 EP EP96922403A patent/EP0831938B1/fr not_active Expired - Lifetime
- 1996-06-06 WO PCT/US1996/009384 patent/WO1996040291A1/fr active Application Filing
- 1996-06-06 DK DK96922403T patent/DK0831938T3/da active
- 1996-06-06 JP JP50171497A patent/JP4236282B2/ja not_active Expired - Lifetime
- 1996-06-06 PT PT96922403T patent/PT831938E/pt unknown
- 1996-06-06 DK DK07019899.9T patent/DK1872800T3/da active
-
1997
- 1997-12-12 US US08/989,434 patent/US5804157A/en not_active Expired - Lifetime
-
2008
- 2008-05-12 JP JP2008125326A patent/JP2008266342A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2224153A1 (fr) | 1996-12-19 |
DE69637535D1 (de) | 2008-07-03 |
EP1872800A3 (fr) | 2008-03-19 |
EP0831938A4 (fr) | 2001-12-05 |
US5830431A (en) | 1998-11-03 |
ES2395961T3 (es) | 2013-02-18 |
JP2008266342A (ja) | 2008-11-06 |
WO1996040291A1 (fr) | 1996-12-19 |
US5804157A (en) | 1998-09-08 |
CA2224153C (fr) | 2010-08-17 |
ATE395938T1 (de) | 2008-06-15 |
JP4236282B2 (ja) | 2009-03-11 |
EP1872800B1 (fr) | 2012-10-17 |
EP0831938B1 (fr) | 2008-05-21 |
DK1872800T3 (da) | 2013-02-04 |
PT831938E (pt) | 2008-08-26 |
ES2308778T3 (es) | 2008-12-01 |
EP1872800A2 (fr) | 2008-01-02 |
JPH11507342A (ja) | 1999-06-29 |
EP0831938A1 (fr) | 1998-04-01 |
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