ATE395938T1 - Mittel auf basis radiomarkierter peptide zur ortsspezifischen verabreichung - Google Patents

Mittel auf basis radiomarkierter peptide zur ortsspezifischen verabreichung

Info

Publication number
ATE395938T1
ATE395938T1 AT96922403T AT96922403T ATE395938T1 AT E395938 T1 ATE395938 T1 AT E395938T1 AT 96922403 T AT96922403 T AT 96922403T AT 96922403 T AT96922403 T AT 96922403T AT E395938 T1 ATE395938 T1 AT E395938T1
Authority
AT
Austria
Prior art keywords
somatostatin
peptide
diagnostic
site
amino acid
Prior art date
Application number
AT96922403T
Other languages
English (en)
Inventor
Ananthachari Srinivasan
Mary Dyszlewski
Joseph Bugaj
Jack L Erion
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23907713&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE395938(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE395938T1 publication Critical patent/ATE395938T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
AT96922403T 1995-06-07 1996-06-06 Mittel auf basis radiomarkierter peptide zur ortsspezifischen verabreichung ATE395938T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/480,373 US5830431A (en) 1995-06-07 1995-06-07 Radiolabeled peptide compositions for site-specific targeting

Publications (1)

Publication Number Publication Date
ATE395938T1 true ATE395938T1 (de) 2008-06-15

Family

ID=23907713

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96922403T ATE395938T1 (de) 1995-06-07 1996-06-06 Mittel auf basis radiomarkierter peptide zur ortsspezifischen verabreichung

Country Status (10)

Country Link
US (2) US5830431A (de)
EP (2) EP1872800B1 (de)
JP (2) JP4236282B2 (de)
AT (1) ATE395938T1 (de)
CA (1) CA2224153C (de)
DE (1) DE69637535D1 (de)
DK (2) DK0831938T3 (de)
ES (2) ES2308778T3 (de)
PT (1) PT831938E (de)
WO (1) WO1996040291A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US6358491B1 (en) 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
CN1292798C (zh) * 2000-06-02 2007-01-03 德克萨斯州立大学董事会 乙二半胱氨酸(ec)－药物缀合物
CA2444483A1 (en) * 2001-04-26 2002-11-07 Board Of Regents, The University Of Texas System Diagnostic imaging compositions, their methods of synthesis and use
US7261875B2 (en) * 2001-12-21 2007-08-28 Board Of Regents, The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
EP2316493A3 (de) * 2002-11-07 2011-08-10 Board of Regents, The University of Texas System Ethylendicystein(ec)-Aarzneimittelkonjugate, Zusammensetzungen und Verfahren für die gewebsspezifische Darstellung von Krankheiten
WO2004081031A2 (en) * 2003-03-10 2004-09-23 Biogen Idec Inc. Thiol-mediated drug attachment to targeting peptides
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
WO2006094725A1 (en) * 2005-03-10 2006-09-14 Bayer Schering Pharma Aktiengesellschaft Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US10925977B2 (en) * 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
US9345789B2 (en) 2009-12-18 2016-05-24 The Board Of Trustees Of The Leland Stanford Junior University Specific inhibitors and active site probes for legumain
WO2012021144A1 (en) 2010-08-12 2012-02-16 New York University Oligooxopiperazines and methods of making and using them
US9255086B2 (en) 2012-02-16 2016-02-09 New York University Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics
CA2905172C (en) 2012-05-08 2021-07-20 Andreas Kjaer 177-lu labeled peptide for site-specific upar-targeting
KR20180041623A (ko) 2015-06-25 2018-04-24 어드밴스드 엑셀러레이터 어플리케이션즈 에스.에이. 소마토스타타틴 수용체를 과발현하는 신경내분비 종양의 치료방법
WO2018132751A1 (en) 2017-01-12 2018-07-19 Radiomedix Inc. Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes
US10596278B2 (en) 2018-07-25 2020-03-24 Advanced Accelerator Applications (Italy) S.R.L. Stable, concentrated radionuclide complex solutions
US10596276B2 (en) 2018-07-25 2020-03-24 Advanced Accelerator Applications (Italy) S.R.L. Stable, concentrated radionuclide complex solutions
EP3923952A4 (de) 2018-09-11 2023-08-30 Stanley Satz Auf tumor abzielende radionuklidtherapie und molekulare bildgebung von her2+-krebs und anderen neoplasmen sowie präzisionsmedizin

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029579B1 (de) * 1979-11-27 1983-02-16 Sandoz Ag Polypeptide, Verfahren zu ihrer Herstellung, pharmazeutische Zusammensetzungen, die diese Polypeptide enthalten, und ihre Verwendung
US4282143A (en) * 1980-06-13 1981-08-04 American Home Products Corporation Octapeptides lowering growth hormone
US4440904A (en) * 1983-01-31 1984-04-03 American Home Products Corporation Nonapeptide anti-secretory agents
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4585755A (en) * 1985-04-29 1986-04-29 Merck & Co., Inc. Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
JPH04236282A (ja) * 1991-01-18 1992-08-25 Aica Kogyo Co Ltd 接着剤組成物
ES2150916T3 (es) * 1991-08-29 2000-12-16 Mallinckrodt Medical Inc Utilizacion del acido gentisico o del alcohol gentisilico para estabilizar peptidos y proteinas radiomarcados.
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5411943A (en) * 1992-02-25 1995-05-02 Biomeasure, Inc. Hepatoma treatment with somatostatin analogs
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
NZ250653A (en) * 1993-01-12 1995-12-21 Sandoz Ltd Somatostatin derivatives and pharmaceutical or diagnostic imaging compositions
RO117259B1 (ro) * 1993-08-09 2001-12-28 Biomeasure Inc. Derivaţi peptidici, terapeutici
EP0730472B1 (de) * 1993-11-16 2006-08-02 Bracco International B.V. Immobilisiertes markierungsverfahren
US5705143A (en) * 1994-01-12 1998-01-06 Amersham International Plc Biological targeting agents
EP0835662B1 (de) * 1996-10-08 2001-11-14 National Institute of Immunology Arzneimittel zur Behandlung von Krebs

Also Published As

Publication number Publication date
DK0831938T3 (da) 2008-07-21
EP0831938A1 (de) 1998-04-01
EP1872800A2 (de) 2008-01-02
WO1996040291A1 (en) 1996-12-19
PT831938E (pt) 2008-08-26
CA2224153A1 (en) 1996-12-19
ES2395961T3 (es) 2013-02-18
JP2008266342A (ja) 2008-11-06
US5804157A (en) 1998-09-08
DE69637535D1 (de) 2008-07-03
JP4236282B2 (ja) 2009-03-11
ES2308778T3 (es) 2008-12-01
CA2224153C (en) 2010-08-17
EP1872800B1 (de) 2012-10-17
EP0831938B1 (de) 2008-05-21
JPH11507342A (ja) 1999-06-29
DK1872800T3 (da) 2013-02-04
EP1872800A3 (de) 2008-03-19
EP0831938A4 (de) 2001-12-05
US5830431A (en) 1998-11-03

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