DK0831100T3 - Nye peptidderivater - Google Patents

Nye peptidderivater

Info

Publication number
DK0831100T3
DK0831100T3 DK96908363T DK96908363T DK0831100T3 DK 0831100 T3 DK0831100 T3 DK 0831100T3 DK 96908363 T DK96908363 T DK 96908363T DK 96908363 T DK96908363 T DK 96908363T DK 0831100 T3 DK0831100 T3 DK 0831100T3
Authority
DK
Denmark
Prior art keywords
group
peptide derivatives
new peptide
chem
salts
Prior art date
Application number
DK96908363T
Other languages
Danish (da)
English (en)
Inventor
Kyoichi Sakakibara
Masaaki - Sunstage-Ryoku Gondo
Koichi Miyazaki
Takeshi Ito
Akihiro Sugimura
Motohiro Kobayashi
Original Assignee
Teikoku Hormone Mfg Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Mfg Co Ltd filed Critical Teikoku Hormone Mfg Co Ltd
Application granted granted Critical
Publication of DK0831100T3 publication Critical patent/DK0831100T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK96908363T 1995-04-21 1996-04-08 Nye peptidderivater DK0831100T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11909095 1995-04-21
JP11909195 1995-04-21
PCT/JP1996/000949 WO1996033212A1 (fr) 1995-04-21 1996-04-08 Nouveaux derives peptidiques

Publications (1)

Publication Number Publication Date
DK0831100T3 true DK0831100T3 (da) 2001-01-02

Family

ID=26456890

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96908363T DK0831100T3 (da) 1995-04-21 1996-04-08 Nye peptidderivater

Country Status (13)

Country Link
US (1) US5840699A (pt)
EP (1) EP0831100B1 (pt)
KR (1) KR100408909B1 (pt)
CN (1) CN1113066C (pt)
AT (1) ATE196913T1 (pt)
AU (1) AU704973B2 (pt)
CA (1) CA2218606A1 (pt)
DE (1) DE69610627T2 (pt)
DK (1) DK0831100T3 (pt)
ES (1) ES2150664T3 (pt)
GR (1) GR3034924T3 (pt)
PT (1) PT831100E (pt)
WO (1) WO1996033212A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69434136T2 (de) * 1993-10-01 2005-12-01 Teikoku Hormone Mfg. Co., Ltd. Dolastatin-derivate
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
EP1545613B9 (en) 2002-07-31 2012-01-25 Seattle Genetics, Inc. Auristatin conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
CN107213469A (zh) * 2003-11-06 2017-09-29 西雅图基因公司 能够与配体偶联的单甲基缬氨酸化合物
JP2008519863A (ja) * 2004-11-12 2008-06-12 シアトル ジェネティクス インコーポレイティッド Ｎ末端にアミノ安息香酸単位を有するオーリスタチン
CA2614436C (en) 2005-07-07 2016-05-17 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
US8871720B2 (en) * 2005-07-07 2014-10-28 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
AU2008276128B2 (en) 2007-07-16 2013-10-10 Genentech, Inc. Humanized anti-CD79b antibodies and immunoconjugates and methods of use
ES2381788T3 (es) 2007-07-16 2012-05-31 Genentech, Inc. Anticuerpos anti-CD79b e inmunoconjugados y métodos de uso
IL287292B (en) 2008-01-31 2022-09-01 Genentech Inc and fusion antibody-drug-cd79b engineered antibodies cysteine-
WO2009117531A1 (en) * 2008-03-18 2009-09-24 Seattle Genetics, Inc. Auristatin drug linker conjugates
MY168297A (en) 2011-11-17 2018-10-23 Pfizer Cytotoxic Peptides and Antibody Drug Conjugates Thereof
EP3539563A1 (en) 2012-07-19 2019-09-18 Redwood Bioscience, Inc. Antibody specific for cd22 and methods of use thereof
WO2014072897A1 (en) 2012-11-07 2014-05-15 Pfizer Inc. Anti-notch3 antibodies and antibody-drug conjugates
JP2016500058A (ja) 2012-11-12 2016-01-07 レッドウッド バイオサイエンス， インコーポレイテッド 化合物および抱合体を生成するための方法
EP2922818B1 (en) 2012-11-24 2018-09-05 Hangzhou Dac Biotech Co., Ltd Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
KR102320019B1 (ko) 2013-11-27 2021-11-01 레드우드 바이오사이언스 인코포레이티드 히드라지닐-피롤로 화합물 및 콘쥬게이트 제조 방법
MX2016007865A (es) 2013-12-17 2017-01-11 Novartis Ag Peptidos citotoxicos y conjugados de los mismos.
DK3122757T3 (da) 2014-02-28 2023-10-09 Hangzhou Dac Biotech Co Ltd Ladede linkere og anvendelse deraf til konjugering
AU2015273098B2 (en) 2014-06-13 2018-05-10 Novartis Ag Auristatin derivatives and conjugates thereof
RS60349B8 (sr) 2014-09-23 2022-10-31 Hoffmann La Roche Postupak upotrebe anti-cd79b imunokonjugata
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
EP3373977A4 (en) 2015-11-12 2019-07-17 The Board of Trustees of the Leland Stanford Junior University CELLULAR PENETRATION-RICH GUANIDINIC OLIGOPHOSPHOTRIESTERS FOR THE DELIVERY OF MEDICATION AND PROBE
EP3448885A4 (en) 2016-04-26 2020-01-08 R.P. Scherer Technologies, LLC ANTIBODY CONJUGATES AND METHODS OF MAKING AND USING SAME
LT3463308T (lt) 2016-06-01 2022-02-10 Servier IP UK Limited Polialkilenoksido-asparaginazės vaisto formos ir jų gamybos būdai bei panaudojimas
CA3042442C (en) 2016-11-14 2024-01-02 Hangzhou Dac Biotech Co., Ltd Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses of such conjugates with the linkers
IL302338A (en) 2017-09-08 2023-06-01 Univ Leland Stanford Junior ENPP1 inhibitors and their use for cancer treatment
US20230174537A1 (en) 2020-06-18 2023-06-08 The Board Of Trustees Of The Leland Stanford Junior University Isoform-Specific Aldehyde Dehydrogenase Inhibitors
WO2023033129A1 (ja) 2021-09-03 2023-03-09 東レ株式会社 癌の治療及び／又は予防用医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4978744A (en) * 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
WO1993003054A1 (en) * 1991-08-09 1993-02-18 Teikoku Hormone Mfg. Co., Ltd. Novel tetrapeptide derivative
US5635483A (en) * 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
DE69434136T2 (de) * 1993-10-01 2005-12-01 Teikoku Hormone Mfg. Co., Ltd. Dolastatin-derivate
US5741892A (en) * 1996-07-30 1998-04-21 Basf Aktiengesellschaft Pentapeptides as antitumor agents

Also Published As

Publication number Publication date
DE69610627T2 (de) 2001-02-15
ES2150664T3 (es) 2000-12-01
AU704973B2 (en) 1999-05-13
CA2218606A1 (en) 1996-10-24
US5840699A (en) 1998-11-24
AU5162796A (en) 1996-11-07
DE69610627D1 (de) 2000-11-16
WO1996033212A1 (fr) 1996-10-24
EP0831100A1 (en) 1998-03-25
KR100408909B1 (ko) 2004-04-29
ATE196913T1 (de) 2000-10-15
KR19980703203A (ko) 1998-10-15
EP0831100B1 (en) 2000-10-11
CN1182434A (zh) 1998-05-20
GR3034924T3 (en) 2001-02-28
EP0831100A4 (en) 1998-07-29
PT831100E (pt) 2001-01-31
CN1113066C (zh) 2003-07-02

Similar Documents

Publication Publication Date Title
DK0831100T3 (da) Nye peptidderivater
ES2172069T3 (es) Derivado tetrapeptidico.
MY132671A (en) Substituted 6,6-hetero-bicyclic derivatives
MY133647A (en) Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates
MY113806A (en) Antiparasitic marcfortines and paraherquamides
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
DK1200418T3 (da) Nematodicide trifluorbutener
ATE241643T1 (de) Therapeutisch wirksame peptidderivate
BG102162A (en) Substituted (sulpphinic acid, sulphonic acid, sulphonylamino or sulphinylamino)n-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylam ide compounds
FI933568A (fi) 9-((substituerad glycyl)amido)-6-demetyl-6-deoxitetracykliner
DK0977741T3 (da) Substituerede phenylderivater, deres fremstilling og anvendelse
DE69716810T2 (de) 2,3-Disubstituierte-(5,6)-heteroarylkondensierte-pyrimidin-4-one
ATE184009T1 (de) Halichondrine: zytotoxische polyäther-makrolide
MX9602806A (es) Derivados del 1,2,4-oxadiazol y su uso como parasiticidas para animales.
ATE206708T1 (de) Benzimidazolonderivate mit zentraler dopaminerger aktivität
TR200000272T2 (tr) Antitümör ve antimetastaz maddeleri olarak o-ikameli hidrosikumaranon türevleri.
MX9709398A (es) N-aril-1,2,4-triazolin-5-onas.
EA200000204A1 (ru) Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов
MD1560G2 (ro) Compuşi ciclici, compoziţii farmaceutice pe baza lor şi metode de tratament al infecţiilor sau bolilor provocate de retrovirusuri
MD502G2 (ro) Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
ATE242220T1 (de) Benzimidazolderivate mit dopaminerger wirkung
TR200000697T2 (tr) İkame edilmiş 1,2,3,4,5,6-Heksahidro-2,6-Metano-3-Benzazosin-10-OL'ler, üretim yöntemleri ve farmasötik preparat olarak kullanımları.
DE69601451D1 (de) UCK14-Verbindungen
TR200302031T4 (tr) İkame edilmiş 1,2,3,4,5,6-Heksahidro-2,6-Metano-3-Benzazosin'ler ve farmasotik preparat olarak kullanımları
RO116896B1 (ro) Derivaţi pseudocarbaciclinici şi procedeu pentru prepararea acestora