DK0814084T3 - Indolderivat som 5HT-1A-antagonist og som inhibitor af serotoningenoptagelse - Google Patents

Indolderivat som 5HT-1A-antagonist og som inhibitor af serotoningenoptagelse

Info

Publication number
DK0814084T3
DK0814084T3 DK97304280T DK97304280T DK0814084T3 DK 0814084 T3 DK0814084 T3 DK 0814084T3 DK 97304280 T DK97304280 T DK 97304280T DK 97304280 T DK97304280 T DK 97304280T DK 0814084 T3 DK0814084 T3 DK 0814084T3
Authority
DK
Denmark
Prior art keywords
serotonin
antagonist
inhibitor
indole derivative
serotonin uptake
Prior art date
Application number
DK97304280T
Other languages
Danish (da)
English (en)
Inventor
Daniel James Koch
Vincent Patrick Rocco
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0814084T3 publication Critical patent/DK0814084T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
DK97304280T 1996-06-20 1997-06-18 Indolderivat som 5HT-1A-antagonist og som inhibitor af serotoningenoptagelse DK0814084T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2013196P 1996-06-20 1996-06-20

Publications (1)

Publication Number Publication Date
DK0814084T3 true DK0814084T3 (da) 2001-10-08

Family

ID=21796938

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97304280T DK0814084T3 (da) 1996-06-20 1997-06-18 Indolderivat som 5HT-1A-antagonist og som inhibitor af serotoningenoptagelse

Country Status (13)

Country Link
US (1) US5912256A (fr)
EP (1) EP0814084B1 (fr)
JP (1) JP2000513358A (fr)
AT (1) ATE203990T1 (fr)
AU (1) AU3401797A (fr)
CA (1) CA2257962A1 (fr)
DE (1) DE69706000T2 (fr)
DK (1) DK0814084T3 (fr)
ES (1) ES2160894T3 (fr)
GR (1) GR3037072T3 (fr)
HK (1) HK1008525A1 (fr)
PT (1) PT814084E (fr)
WO (1) WO1997048698A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399618B1 (en) 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
CA2330452A1 (fr) * 1998-04-29 1999-11-04 American Home Products Corporation Derives d'indolyl psychotiques
SI1113797T1 (sl) * 1998-09-15 2010-02-26 Lilly Co Eli Uporaba duloksetina pri zdravljenju fibromialgije
FR2788772B1 (fr) * 1999-01-26 2001-03-02 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR100799134B1 (ko) 1999-05-24 2008-01-29 미츠비시 웰파마 가부시키가이샤 페녹시프로필아민 화합물
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
BR0014166A (pt) * 1999-09-03 2002-05-14 Lilly Co Eli Método de utilização de inibidores de reabsorção de serotonina seletivo de rápido ataque para tratamento de disfunção sexual
JP2003510266A (ja) * 1999-09-28 2003-03-18 ハー・ルンドベック・アクチエゼルスカベット 溶融顆粒化された調合物及びこの調合物から製造された、放出が調節された投薬形
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
AU1018801A (en) * 1999-10-29 2001-05-14 Novo Nordisk A/S Use of 3,4-substituted piperidines
WO2001046187A1 (fr) * 1999-12-20 2001-06-28 Eli Lilly And Company Derives d'azabicyclo[3.2.1]octane
ES2220582T3 (es) * 1999-12-20 2004-12-16 Eli Lilly And Company Derivados de piperidina y su uso como antagonistas de receptor de serotonina.
US7144898B2 (en) * 1999-12-20 2006-12-05 Eli Lilly And Company Indole derivatives for the treatment of depression and anxiety
UA76130C2 (en) * 2000-11-20 2006-07-17 Merck Patent Gmbh Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
DE10117184A1 (de) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen
TW589312B (en) 2001-05-25 2004-06-01 Wyeth Corp Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
EP1482921A1 (fr) * 2002-02-12 2004-12-08 Cypress Bioscience, Inc. Methodes de traitement du trouble d'hyperactivite avec deficit de l'attention (thada)
EP1558231A4 (fr) * 2002-10-03 2010-09-08 Cypress Bioscience Inc Escalade posologique et dose quotidienne fractionnee d'antidepresseurs pour traiter des troubles neurologiques
AU2003287024A1 (en) * 2002-11-05 2004-06-03 Eli Lilly And Company 3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norephinephrine reuptake
WO2004069339A1 (fr) * 2003-01-29 2004-08-19 Psychogenics Inc. Traitement du trouble d'hyperactivite avec deficit de l'attention
US20040192730A1 (en) * 2003-03-13 2004-09-30 Dynogen Pharmaceuticals, Inc. Methods of using compounds with combined 5-HT1A and SSRI activities as-needed to treat sexual dysfunction
SI1626720T1 (sl) 2003-04-04 2008-12-31 Lundbeck & Co As H Derivati 4-(2-fenilsulfanil-fenil)-piperidina kotzaviralci ponovnega vnosa serotonina
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
KR100872023B1 (ko) * 2003-12-23 2008-12-05 하. 룬트벡 아크티에 셀스카브 Ｓｓｒｉ로서 2-(1ｈ-인돌릴술파닐)-벤질 아민 유도체
PT1701940E (pt) 2003-12-23 2008-07-30 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-benzil-amina como ssri
TWI347183B (en) * 2003-12-23 2011-08-21 Lundbeck & Co As H 2-(1h-indolylsulfanyl)-benzyl amine derivatives
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
US7994220B2 (en) * 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
ZA200901739B (en) * 2006-09-28 2010-06-30 Lundbeck & Co As H [2-(6-flouro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders
WO2014078568A1 (fr) 2012-11-14 2014-05-22 The Johns Hopkins University Méthodes et compositions pour le traitement de la schizophrénie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013761A (en) * 1988-06-03 1991-05-07 Eli Lilly And Company Serotonin antagonists
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5627196A (en) * 1995-01-17 1997-05-06 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5614523A (en) * 1995-01-17 1997-03-25 Eli Lilly And Company Compounds having effects on serotonin-related systems

Also Published As

Publication number Publication date
US5912256A (en) 1999-06-15
EP0814084A1 (fr) 1997-12-29
CA2257962A1 (fr) 1997-12-24
DE69706000T2 (de) 2002-04-04
EP0814084B1 (fr) 2001-08-08
AU3401797A (en) 1998-01-07
GR3037072T3 (en) 2002-01-31
WO1997048698A1 (fr) 1997-12-24
JP2000513358A (ja) 2000-10-10
DE69706000D1 (de) 2001-09-13
ATE203990T1 (de) 2001-08-15
HK1008525A1 (en) 1999-05-14
PT814084E (pt) 2001-11-30
ES2160894T3 (es) 2001-11-16

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