DK0804456T3 - Peptid-nukleinsyre-konjugater - Google Patents
Peptid-nukleinsyre-konjugaterInfo
- Publication number
- DK0804456T3 DK0804456T3 DK95938726T DK95938726T DK0804456T3 DK 0804456 T3 DK0804456 T3 DK 0804456T3 DK 95938726 T DK95938726 T DK 95938726T DK 95938726 T DK95938726 T DK 95938726T DK 0804456 T3 DK0804456 T3 DK 0804456T3
- Authority
- DK
- Denmark
- Prior art keywords
- peptide
- nucleic acid
- acid conjugates
- nucleic acids
- peptide nucleic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/319,411 US7223833B1 (en) | 1991-05-24 | 1994-10-06 | Peptide nucleic acid conjugates |
PCT/US1995/012931 WO1996011205A1 (en) | 1994-10-06 | 1995-10-06 | Peptide nucleic acid conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0804456T3 true DK0804456T3 (da) | 2002-12-02 |
Family
ID=23242149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95938726T DK0804456T3 (da) | 1994-10-06 | 1995-10-06 | Peptid-nukleinsyre-konjugater |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0804456B1 (de) |
JP (1) | JP3307945B2 (de) |
AT (1) | ATE222589T1 (de) |
AU (1) | AU3999495A (de) |
DE (1) | DE69527857T2 (de) |
DK (1) | DK0804456T3 (de) |
ES (1) | ES2181799T3 (de) |
PT (1) | PT804456E (de) |
WO (1) | WO1996011205A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8071737B2 (en) | 1995-05-04 | 2011-12-06 | Glead Sciences, Inc. | Nucleic acid ligand complexes |
JPH11504926A (ja) * | 1995-05-04 | 1999-05-11 | ネクスター ファーマスーティカルズ,インコーポレイテッド | 核酸リガンド複合体 |
SE506700C2 (sv) | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
US7812149B2 (en) | 1996-06-06 | 2010-10-12 | Isis Pharmaceuticals, Inc. | 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations |
US9096636B2 (en) | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
US5908845A (en) * | 1996-10-30 | 1999-06-01 | Segev; David | Polyether nucleic acids |
EP0863150A1 (de) * | 1997-02-08 | 1998-09-09 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung einer Nukleinsäure-bindende Substanz |
DE19712530A1 (de) * | 1997-03-25 | 1998-10-01 | Boehringer Mannheim Gmbh | Neue Monomerbausteine zur Markierung von peptidischen Nukleinsäuren |
AU745309B2 (en) * | 1997-05-28 | 2002-03-21 | Peter E. Nielsen | Conjugated peptide nucleic acids having enhanced cellular uptake |
JPH11332595A (ja) * | 1997-07-09 | 1999-12-07 | Masao Karube | プローブpnaによるdnaの検出方法 |
US6025140A (en) * | 1997-07-24 | 2000-02-15 | Perseptive Biosystems, Inc. | Membrane-permeable constructs for transport across a lipid membrane |
AU9570898A (en) * | 1997-09-18 | 1999-04-05 | Gene Therapy Systems, Inc. | Chemical modification of dna using peptide nucleic acid conjugates |
DE19757516A1 (de) * | 1997-12-23 | 1999-06-24 | Roche Diagnostics Gmbh | Modifizierte Nukleinsäureanaloga |
DE69900462T2 (de) | 1998-02-11 | 2002-07-11 | Pe Corp Ny Foster City | Konjugate von dns und pns und verfahren zu deren herstellung |
US20040186071A1 (en) * | 1998-04-13 | 2004-09-23 | Bennett C. Frank | Antisense modulation of CD40 expression |
JP2002520008A (ja) | 1998-07-09 | 2002-07-09 | バイオセプト インコーポレイテッド | Dna配列ハイブリッド形成を最適化するための改良されたペプチド核酸汎用ライブラリーの使用法 |
SE9803099D0 (sv) | 1998-09-13 | 1998-09-13 | Karolinska Innovations Ab | Nucleic acid transfer |
HUP0203465A2 (hu) * | 1998-11-11 | 2003-01-28 | Pantheco A/S | Peptidek és nukleinsav-analóg, mint például PNS, LNS vagy morfolino közötti konjugátumok |
US6548651B1 (en) | 1998-11-11 | 2003-04-15 | Pantheco A/S | Modified peptide nucleic acid (PNA) molecules |
DE10019136A1 (de) | 2000-04-18 | 2001-10-31 | Aventis Pharma Gmbh | Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung |
DE10019135A1 (de) | 2000-04-18 | 2001-10-31 | Aventis Pharma Gmbh | Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung |
DE10201862A1 (de) | 2002-01-18 | 2003-08-07 | Deutsches Krebsforsch | Konjugat zur Behandlung prokaryontischer Infektionen |
WO2004044132A2 (en) | 2002-11-05 | 2004-05-27 | Isis Pharmaceuticals, Inc. | Modified oligonucleotides for use in rna interference |
US8569474B2 (en) | 2004-03-09 | 2013-10-29 | Isis Pharmaceuticals, Inc. | Double stranded constructs comprising one or more short strands hybridized to a longer strand |
US20050260131A1 (en) * | 2004-05-20 | 2005-11-24 | General Electric Company | Pharmaceuticals for enhanced delivery to disease targets |
US8394947B2 (en) | 2004-06-03 | 2013-03-12 | Isis Pharmaceuticals, Inc. | Positionally modified siRNA constructs |
US7884086B2 (en) | 2004-09-08 | 2011-02-08 | Isis Pharmaceuticals, Inc. | Conjugates for use in hepatocyte free uptake assays |
WO2009067243A2 (en) | 2007-11-20 | 2009-05-28 | Isis Pharmaceuticals Inc. | Modulation of cd40 expression |
KR102238317B1 (ko) | 2012-05-17 | 2021-04-12 | 익스텐드 바이오사이언시즈, 인크. | 개선된 약물 전달용 캐리어 |
AU2013346767B2 (en) | 2012-11-15 | 2019-04-11 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
RU2018108405A (ru) | 2013-01-30 | 2019-02-26 | Ф. Хоффманн-Ля Рош Аг | Конъюгаты углевода и lna-олигонуклеотида |
WO2014118272A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Antimir-122 oligonucleotide carbohydrate conjugates |
PE20160158A1 (es) | 2013-06-27 | 2016-03-18 | Roche Innovation Ct Copenhagen As | Oligomeros antisentido y conjugados con diana en pcsk9 |
CR20160316A (es) | 2014-01-10 | 2016-09-19 | Glaxosmithkline Intellectual Property (No 2) Ltd | Compuestos derivados de hidroxiformamida y usos del mismo |
GB201408623D0 (en) | 2014-05-15 | 2014-07-02 | Santaris Pharma As | Oligomers and oligomer conjugates |
US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
JP6748219B2 (ja) | 2016-03-14 | 2020-08-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Pd−l1発現低減用のオリゴヌクレオチド |
CN114146187B (zh) * | 2021-11-12 | 2022-11-22 | 中山大学 | 一种PDGFR-β基因表达抑制剂及其用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3650699T2 (de) * | 1985-03-15 | 1999-04-15 | Antivirals Inc | Immunotestmittel für Polynukleotid und Verfahren |
DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
MX9207334A (es) * | 1991-12-18 | 1993-08-01 | Glaxo Inc | Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene |
GB2289677A (en) * | 1993-12-06 | 1995-11-29 | Pna Diagnostics As | Labelling of nucleic acid analogue-peptide chimerae |
JPH10500310A (ja) * | 1994-05-19 | 1998-01-13 | ダコ アクティーゼルスカブ | 淋菌及びトラコーマ クラミジアの検出のためのpna プローブ |
-
1995
- 1995-10-06 EP EP95938726A patent/EP0804456B1/de not_active Expired - Lifetime
- 1995-10-06 AU AU39994/95A patent/AU3999495A/en not_active Abandoned
- 1995-10-06 ES ES95938726T patent/ES2181799T3/es not_active Expired - Lifetime
- 1995-10-06 WO PCT/US1995/012931 patent/WO1996011205A1/en active IP Right Grant
- 1995-10-06 PT PT95938726T patent/PT804456E/pt unknown
- 1995-10-06 AT AT95938726T patent/ATE222589T1/de not_active IP Right Cessation
- 1995-10-06 JP JP51266996A patent/JP3307945B2/ja not_active Expired - Fee Related
- 1995-10-06 DK DK95938726T patent/DK0804456T3/da active
- 1995-10-06 DE DE69527857T patent/DE69527857T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69527857D1 (de) | 2002-09-26 |
EP0804456A1 (de) | 1997-11-05 |
PT804456E (pt) | 2003-01-31 |
EP0804456A4 (de) | 1999-05-19 |
ES2181799T3 (es) | 2003-03-01 |
AU3999495A (en) | 1996-05-02 |
EP0804456B1 (de) | 2002-08-21 |
WO1996011205A1 (en) | 1996-04-18 |
JPH10503524A (ja) | 1998-03-31 |
ATE222589T1 (de) | 2002-09-15 |
DE69527857T2 (de) | 2003-05-28 |
JP3307945B2 (ja) | 2002-07-29 |
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