PT804456E - Conjugados de acidos nucleicos dos peptidos - Google Patents

Conjugados de acidos nucleicos dos peptidos

Info

Publication number
PT804456E
PT804456E PT95938726T PT95938726T PT804456E PT 804456 E PT804456 E PT 804456E PT 95938726 T PT95938726 T PT 95938726T PT 95938726 T PT95938726 T PT 95938726T PT 804456 E PT804456 E PT 804456E
Authority
PT
Portugal
Prior art keywords
nucleic acids
conjugates
peptides
peptide nucleic
attached
Prior art date
Application number
PT95938726T
Other languages
English (en)
Inventor
Muthiah Manoharan
Peter Nielsen
Michael Egholm
Kelly Sprankle
Ole Di Buchardt
Soren Holst Sonnechsen
Jesper Lohse
John Kiely
Michael Griffith
Original Assignee
Peter Eigil Nielsen
Isis Pharmaceuticals Inc
Dorte Buchardt
Michael Egholm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/319,411 external-priority patent/US7223833B1/en
Application filed by Peter Eigil Nielsen, Isis Pharmaceuticals Inc, Dorte Buchardt, Michael Egholm filed Critical Peter Eigil Nielsen
Publication of PT804456E publication Critical patent/PT804456E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT95938726T 1994-10-06 1995-10-06 Conjugados de acidos nucleicos dos peptidos PT804456E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/319,411 US7223833B1 (en) 1991-05-24 1994-10-06 Peptide nucleic acid conjugates

Publications (1)

Publication Number Publication Date
PT804456E true PT804456E (pt) 2003-01-31

Family

ID=23242149

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95938726T PT804456E (pt) 1994-10-06 1995-10-06 Conjugados de acidos nucleicos dos peptidos

Country Status (9)

Country Link
EP (1) EP0804456B1 (pt)
JP (1) JP3307945B2 (pt)
AT (1) ATE222589T1 (pt)
AU (1) AU3999495A (pt)
DE (1) DE69527857T2 (pt)
DK (1) DK0804456T3 (pt)
ES (1) ES2181799T3 (pt)
PT (1) PT804456E (pt)
WO (1) WO1996011205A1 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071737B2 (en) 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
CA2219119C (en) * 1995-05-04 2012-10-23 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
SE506700C2 (sv) * 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US5908845A (en) * 1996-10-30 1999-06-01 Segev; David Polyether nucleic acids
EP0863150A1 (en) * 1997-02-08 1998-09-09 Boehringer Mannheim Gmbh A method for the preparation of nucleic acid binding compound
DE19712530A1 (de) * 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Neue Monomerbausteine zur Markierung von peptidischen Nukleinsäuren
CA2291839A1 (en) * 1997-05-28 1998-12-03 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
JPH11332595A (ja) * 1997-07-09 1999-12-07 Masao Karube プローブｐｎａによるｄｎａの検出方法
AU741546B2 (en) * 1997-07-24 2001-12-06 Perseptive Biosystems, Inc. Conjugates of transporter peptides and nucleic acid analogs, and their use
CA2303908A1 (en) * 1997-09-18 1999-03-25 Gene Therapy Systems, Inc. Chemical modification of dna using peptide nucleic acid conjugates
DE19757516A1 (de) * 1997-12-23 1999-06-24 Roche Diagnostics Gmbh Modifizierte Nukleinsäureanaloga
WO1999041273A2 (en) 1998-02-11 1999-08-19 Perkin-Elmer Corporation Pna and dna conjugates and methods for preparation thereof
US20040186071A1 (en) * 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
WO2000002899A1 (en) 1998-07-09 2000-01-20 Biocept, Inc. Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation
SE9803099D0 (sv) 1998-09-13 1998-09-13 Karolinska Innovations Ab Nucleic acid transfer
EP1220902A2 (en) * 1998-11-11 2002-07-10 Pantheco A/S Conjugates between a peptide and a nucleic acid analog, such as a pna, lna or a morpholino
US6548651B1 (en) 1998-11-11 2003-04-15 Pantheco A/S Modified peptide nucleic acid (PNA) molecules
DE10019136A1 (de) * 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
DE10019135A1 (de) 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
DE10201862A1 (de) * 2002-01-18 2003-08-07 Deutsches Krebsforsch Konjugat zur Behandlung prokaryontischer Infektionen
EP1560840B1 (en) 2002-11-05 2015-05-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
US20050260131A1 (en) * 2004-05-20 2005-11-24 General Electric Company Pharmaceuticals for enhanced delivery to disease targets
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
US8916531B2 (en) 2007-11-20 2014-12-23 Isis Pharmaceuticals, Inc. Modulation of CD40 expression
AU2013263349B2 (en) 2012-05-17 2016-09-08 Extend Biosciences, Inc Carriers for improved drug delivery
PL2920304T3 (pl) 2012-11-15 2019-07-31 Roche Innovation Center Copenhagen A/S Koniugaty oligonukleotydowe
EP2951305B1 (en) 2013-01-30 2018-08-15 F.Hoffmann-La Roche Ag Lna oligonucleotide carbohydrate conjugates
WO2014118272A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
PT3013959T (pt) 2013-06-27 2020-02-04 Roche Innovation Ct Copenhagen As Oligómeros antissentido e conjugados dirigidos para pcsk9
CR20160316A (es) 2014-01-10 2016-09-19 Glaxosmithkline Intellectual Property (No 2) Ltd Compuestos derivados de hidroxiformamida y usos del mismo
GB201408623D0 (en) 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
CA2964463C (en) 2014-10-22 2024-02-13 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
US20170283496A1 (en) 2016-03-14 2017-10-05 Roche Innovation Center Copenhagen A/S Oligonucleotides for reduction of pd-l1 expression
CN114146187B (zh) * 2021-11-12 2022-11-22 中山大学 一种PDGFR-β基因表达抑制剂及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5698186A (en) * 1985-03-15 1986-10-13 Summerton, J. Polynucleotide assay reagent and method
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
MX9207334A (es) * 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
GB2289677A (en) * 1993-12-06 1995-11-29 Pna Diagnostics As Labelling of nucleic acid analogue-peptide chimerae
US6169169B1 (en) * 1994-05-19 2001-01-02 Dako A/S PNA probes for detection of Neisseria gonorrhoeae and Chlamydia trachomatis

Also Published As

Publication number Publication date
JP3307945B2 (ja) 2002-07-29
ATE222589T1 (de) 2002-09-15
JPH10503524A (ja) 1998-03-31
DK0804456T3 (da) 2002-12-02
EP0804456A1 (en) 1997-11-05
DE69527857T2 (de) 2003-05-28
WO1996011205A1 (en) 1996-04-18
EP0804456A4 (en) 1999-05-19
AU3999495A (en) 1996-05-02
ES2181799T3 (es) 2003-03-01
DE69527857D1 (de) 2002-09-26
EP0804456B1 (en) 2002-08-21

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