DK0804413T3 - Prodrugs af nitrogen-sennepsgasforbindelser med nye lipofile beskyttelsesgrupper og fremgangsmåder til fremstilling heraf - Google Patents
Prodrugs af nitrogen-sennepsgasforbindelser med nye lipofile beskyttelsesgrupper og fremgangsmåder til fremstilling herafInfo
- Publication number
- DK0804413T3 DK0804413T3 DK96900627T DK96900627T DK0804413T3 DK 0804413 T3 DK0804413 T3 DK 0804413T3 DK 96900627 T DK96900627 T DK 96900627T DK 96900627 T DK96900627 T DK 96900627T DK 0804413 T3 DK0804413 T3 DK 0804413T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- nitrogen mustard
- independently
- prodrugs
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9501052.6A GB9501052D0 (en) | 1995-01-19 | 1995-01-19 | Improvements relating to prodrugs |
| PCT/GB1996/000112 WO1996022277A1 (en) | 1995-01-19 | 1996-01-19 | Nitrogen mustard prodrugs with novel lipophilic protecting groups, and processes for their production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0804413T3 true DK0804413T3 (da) | 2000-09-25 |
Family
ID=10768261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96900627T DK0804413T3 (da) | 1995-01-19 | 1996-01-19 | Prodrugs af nitrogen-sennepsgasforbindelser med nye lipofile beskyttelsesgrupper og fremgangsmåder til fremstilling heraf |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6005002A (da) |
| EP (1) | EP0804413B1 (da) |
| JP (1) | JPH10512565A (da) |
| AT (1) | ATE193012T1 (da) |
| AU (1) | AU709251B2 (da) |
| CA (1) | CA2210347A1 (da) |
| DE (1) | DE69608412T2 (da) |
| DK (1) | DK0804413T3 (da) |
| ES (1) | ES2149445T3 (da) |
| GB (1) | GB9501052D0 (da) |
| GR (1) | GR3034196T3 (da) |
| NZ (1) | NZ298847A (da) |
| PT (1) | PT804413E (da) |
| WO (1) | WO1996022277A1 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2312975C (en) | 1997-12-17 | 2012-08-21 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US6410328B1 (en) | 1998-02-03 | 2002-06-25 | Protiva Biotherapeutics Inc. | Sensitizing cells to compounds using lipid-mediated gene and compound delivery |
| WO1999039741A2 (en) | 1998-02-03 | 1999-08-12 | Inex Pharmaceuticals Corporation | Systemic delivery of serum stable plasmid lipid particles for cancer therapy |
| US5969133A (en) * | 1998-05-22 | 1999-10-19 | Shiongi Bioresearch Corp. | Bioreductive cytotoxic agents |
| CA2332806A1 (en) * | 1998-05-22 | 1999-12-02 | Natalie Dales | Bioreductive cytotoxic agents |
| US6433199B1 (en) | 1998-05-22 | 2002-08-13 | Shionogi Bioresearch Corporation | Quinone derivatives |
| GB9907414D0 (en) | 1999-03-31 | 1999-05-26 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| US6656718B2 (en) | 2000-07-07 | 2003-12-02 | Cancer Research Technology Limited | Modified carboxypeptidase enzymes and their use |
| JP2004518776A (ja) * | 2000-12-01 | 2004-06-24 | エンゾン，インコーポレーテッド | テトラパルテートプロドラッグ |
| DK1362053T3 (da) * | 2001-02-20 | 2008-03-10 | Enzon Inc | Terminalt forgrenede polymere linkere og polymere konjugater indeholdende disse |
| GB0220319D0 (en) * | 2002-09-02 | 2002-10-09 | Cancer Res Campaign Tech | Enzyme activated self-immolative nitrogen mustard drugs |
| JP4723380B2 (ja) * | 2003-09-25 | 2011-07-13 | テルモ株式会社 | ポリエチレングリコール誘導体及びこれを膜構成成分とする薬物担体 |
| PT103030A (pt) * | 2003-10-17 | 2005-04-29 | Bruno Manuel Nunes Ra Carvalho | Vestuario autonomo, alimentado por paineis solares e com controlo activo da temperatura |
| US20110039943A1 (en) * | 2005-03-14 | 2011-02-17 | Robert Alonso | Methods for treating skin disorders with topical nitrogen mustard compositions |
| US8501818B2 (en) * | 2005-03-14 | 2013-08-06 | Ceptaris Therapeutics, Inc. | Stabilized compositions of alkylating agents and methods of using same |
| US7872050B2 (en) * | 2005-03-14 | 2011-01-18 | Yaupon Therapeutics Inc. | Stabilized compositions of volatile alkylating agents and methods of using thereof |
| US20070119950A1 (en) * | 2005-11-30 | 2007-05-31 | Auslander Judith D | Document edge encoding using multi-spectral encoding tags |
| US7926730B2 (en) * | 2005-11-30 | 2011-04-19 | Pitney Bowes Inc. | Combined multi-spectral document markings |
| WO2008041059A1 (en) * | 2006-10-03 | 2008-04-10 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates |
| JP5167699B2 (ja) * | 2007-06-12 | 2013-03-21 | 宇部興産株式会社 | Ｎ−グルコノ−グルタミン酸エステル及びその製造方法、並びにその中間体 |
| LT2273876T (lt) * | 2008-03-27 | 2019-05-27 | Helsinn Healthcare Sa | Stabilizuotos alkilinimo medžiagų kompozicijos ir jų panaudojimo būdai |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB915454A (en) * | 1960-06-28 | 1963-01-16 | Nat Res Dev | Nitrogen mustards |
| GB8705477D0 (en) * | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| JP4115514B2 (ja) * | 1991-10-23 | 2008-07-09 | キャンサー・リサーチ・キヤンペーン・テクノロジー・リミテツド | Ｃｂ １９５４およびその類似体を細胞障害性の形態に還元するための細菌のニトロリダクターゼ |
| GB9314960D0 (en) * | 1992-07-23 | 1993-09-01 | Zeneca Ltd | Chemical compounds |
| AU691820B2 (en) * | 1993-07-15 | 1998-05-28 | Cancer Research Campaign Technology Limited | Prodrugs of protein tyrosine kinase inhibitors |
| GB9315494D0 (en) * | 1993-07-27 | 1993-09-08 | Springer Caroline | Improvements relating to prodrugs |
-
1995
- 1995-01-19 GB GBGB9501052.6A patent/GB9501052D0/en active Pending
-
1996
- 1996-01-19 JP JP8522127A patent/JPH10512565A/ja not_active Ceased
- 1996-01-19 PT PT96900627T patent/PT804413E/pt unknown
- 1996-01-19 NZ NZ298847A patent/NZ298847A/xx unknown
- 1996-01-19 AU AU44535/96A patent/AU709251B2/en not_active Ceased
- 1996-01-19 DK DK96900627T patent/DK0804413T3/da active
- 1996-01-19 CA CA002210347A patent/CA2210347A1/en not_active Abandoned
- 1996-01-19 WO PCT/GB1996/000112 patent/WO1996022277A1/en active IP Right Grant
- 1996-01-19 AT AT96900627T patent/ATE193012T1/de not_active IP Right Cessation
- 1996-01-19 ES ES96900627T patent/ES2149445T3/es not_active Expired - Lifetime
- 1996-01-19 US US08/875,099 patent/US6005002A/en not_active Expired - Fee Related
- 1996-01-19 EP EP96900627A patent/EP0804413B1/en not_active Expired - Lifetime
- 1996-01-19 DE DE69608412T patent/DE69608412T2/de not_active Expired - Fee Related
-
2000
- 2000-08-14 GR GR20000401890T patent/GR3034196T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE193012T1 (de) | 2000-06-15 |
| GB9501052D0 (en) | 1995-03-08 |
| EP0804413B1 (en) | 2000-05-17 |
| PT804413E (pt) | 2001-03-30 |
| JPH10512565A (ja) | 1998-12-02 |
| NZ298847A (en) | 1999-06-29 |
| EP0804413A1 (en) | 1997-11-05 |
| ES2149445T3 (es) | 2000-11-01 |
| GR3034196T3 (en) | 2000-11-30 |
| DE69608412D1 (de) | 2000-06-21 |
| AU4453596A (en) | 1996-08-07 |
| WO1996022277A1 (en) | 1996-07-25 |
| AU709251B2 (en) | 1999-08-26 |
| US6005002A (en) | 1999-12-21 |
| DE69608412T2 (de) | 2000-10-26 |
| CA2210347A1 (en) | 1996-07-25 |
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