DK0787726T3 - Ny forbindelse, fremgangsmåde til fremstilling deraf og antitumor-middel - Google Patents

Ny forbindelse, fremgangsmåde til fremstilling deraf og antitumor-middel

Info

Publication number
DK0787726T3
DK0787726T3 DK95920265T DK95920265T DK0787726T3 DK 0787726 T3 DK0787726 T3 DK 0787726T3 DK 95920265 T DK95920265 T DK 95920265T DK 95920265 T DK95920265 T DK 95920265T DK 0787726 T3 DK0787726 T3 DK 0787726T3
Authority
DK
Denmark
Prior art keywords
hydrogen atom
preparation
group
lower alkyl
alkyl group
Prior art date
Application number
DK95920265T
Other languages
Danish (da)
English (en)
Inventor
Kyoji Tomita
Katsumi Chiba
Shigeki Kashimoto
Koh-Ichiro Shibamori
Yasunori Tsuzuki
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Application granted granted Critical
Publication of DK0787726T3 publication Critical patent/DK0787726T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK95920265T 1994-06-14 1995-06-06 Ny forbindelse, fremgangsmåde til fremstilling deraf og antitumor-middel DK0787726T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP15657894 1994-06-14
JP19792194 1994-07-28
JP30691494 1994-11-15
JP33995694 1994-12-28
JP8170595 1995-03-13
PCT/JP1995/001110 WO1995034559A1 (en) 1994-06-14 1995-06-06 Novel compound, process for producing the same, and antitumor agent

Publications (1)

Publication Number Publication Date
DK0787726T3 true DK0787726T3 (da) 2002-02-11

Family

ID=27524935

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95920265T DK0787726T3 (da) 1994-06-14 1995-06-06 Ny forbindelse, fremgangsmåde til fremstilling deraf og antitumor-middel

Country Status (27)

Country Link
US (1) US5817669A (cs)
EP (1) EP0787726B1 (cs)
JP (1) JP3391796B2 (cs)
KR (1) KR100350921B1 (cs)
CN (1) CN1053668C (cs)
AT (1) ATE209645T1 (cs)
AU (1) AU679859B2 (cs)
BR (1) BR9508037A (cs)
CA (1) CA2192824C (cs)
CZ (1) CZ292631B6 (cs)
DE (1) DE69524251T2 (cs)
DK (1) DK0787726T3 (cs)
ES (1) ES2163512T3 (cs)
FI (1) FI112485B (cs)
HK (1) HK1000495A1 (cs)
HU (1) HU220072B (cs)
MX (1) MX9606331A (cs)
NO (1) NO307255B1 (cs)
NZ (1) NZ287139A (cs)
PL (1) PL181867B1 (cs)
PT (1) PT787726E (cs)
RO (1) RO117793B1 (cs)
RU (1) RU2151770C1 (cs)
SI (1) SI0787726T1 (cs)
SK (1) SK281341B6 (cs)
TW (1) TW319769B (cs)
WO (1) WO1995034559A1 (cs)

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WO2004091627A2 (en) * 2003-04-07 2004-10-28 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs
BRPI0413964B8 (pt) * 2003-09-10 2021-05-25 Kyorin Seiyaku Kk ácido derivado do ácido carboxílico quinolona, sua composição e agente antibacterial
DE10352979A1 (de) * 2003-11-13 2005-06-09 Merck Patent Gmbh Pyridopyrimidinone
AU2013201203C1 (en) * 2004-03-15 2015-04-23 Sumitomo Dainippon Pharma Co., Ltd. Sns-595 and methods of using the same
SI1725233T1 (sl) * 2004-03-15 2011-04-29 Sunesis Pharmaceuticals Inc Farmacevtski sestavek, ki obsega SNS-595 in uporabe le-tega
EP1802614A1 (en) * 2004-10-14 2007-07-04 F. Hoffmann-Roche AG Quinazolinylmethylenethiazolinones as cdk1 inhibitors
AU2005293835A1 (en) * 2004-10-14 2006-04-20 F. Hoffmann-La Roche Ag 1,5-Naphthyridine azolidinones having CDK1 antiproliferative activity
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
WO2007022474A2 (en) * 2005-08-19 2007-02-22 Cylene Pharmaceuticals, Inc. HUMAN RIBOSOMAL DNA(rDNA) AND RIBOSOMAL RNA (rRNA) NUCLEIC ACIDS AND USES THEREOF
AU2013219242C1 (en) * 2005-09-02 2016-09-22 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
WO2007028171A1 (en) * 2005-09-02 2007-03-08 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
CN104873502A (zh) * 2005-09-02 2015-09-02 逊尼希思制药公司 使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸治疗癌症的方法
US8580814B2 (en) * 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
CA2620915C (en) * 2005-09-02 2014-03-25 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
RU2428983C2 (ru) * 2005-09-02 2011-09-20 Санесис Фармасьютикалз, Инк. Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака
US7642270B2 (en) 2005-09-14 2010-01-05 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
EP1937681A1 (en) * 2005-09-14 2008-07-02 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase
TW200800983A (en) 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
EP2043645A2 (en) * 2006-06-12 2009-04-08 Sunesis Pharmaceuticals, Inc. Compounds and compositions for treatment of cancer
WO2008016678A2 (en) * 2006-08-01 2008-02-07 Sunesis Pharmaceuticals, Inc. Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
HUE026693T2 (hu) * 2006-08-02 2016-07-28 Sunesis Pharmaceuticals Inc (+)-1,4-dihidro-7-[(3S,4S)-3-metoxi-4-(metilamino)-1-pirrolidinil]-4-oxo-1-(2-tiazolil) -1,8-naftiridin-3-karbonsav és cytarabin (Ara-C) kombinált alkalmazása leukémia kezelésére
AU2008317400B2 (en) * 2007-10-22 2014-10-02 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino) -1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3- carboxylic acid in combination therapy
US20110008371A1 (en) * 2007-12-10 2011-01-13 Sunesis Pharmaceuticals, Inc Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
EP2382214B1 (en) 2008-12-31 2017-07-19 Sunesis Pharmaceuticals, Inc. Method of preparing (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
US20120148564A1 (en) 2009-02-27 2012-06-14 Hawtin Rachael E Methods of using sns-595 for treatment of cancer subjects with reduced brca2 activity
UA110465C2 (en) * 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
TW201120037A (en) * 2009-10-26 2011-06-16 Sunesis Pharmaceuticals Inc Compounds and methods for treatment of cancer
UA114711C2 (uk) * 2011-05-13 2017-07-25 Еррей Біофарма Інк. Сполуки піролідинілсечовини й піролідинілтіосечовини як інгібітори кінази trka
CN103497186B (zh) * 2013-09-24 2015-02-25 浙江司太立制药股份有限公司 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法
ES2988457T3 (es) * 2017-03-24 2024-11-20 Wakunaga Pharma Co Ltd Derivado novedoso del ácido piridona carboxílico o sal del mismo

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US3988463A (en) * 1974-05-06 1976-10-26 Merck & Co., Inc. Method of preventing metastasis of H. Ep. No. 3
US4384001A (en) * 1978-12-21 1983-05-17 Gosalvez Mario Treatment of tumors with thiazolidine-4-carboxylic acid
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
EP0154780B1 (en) * 1984-01-26 1990-04-11 Abbott Laboratories Quinoline antibacterial compounds
JPS61152682A (ja) * 1984-12-27 1986-07-11 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体、そのエステルおよびその塩
JPS61251667A (ja) * 1985-04-30 1986-11-08 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
IL79110A0 (en) * 1985-06-13 1986-09-30 Schering Corp Polycyclic quinoline,naphthyridine and pyrazinopyridine derivatives
EP0226624A1 (en) * 1985-06-14 1987-07-01 The Upjohn Company Cyclopentapyrazole and tetrahydroindazole compounds
JPS6233176A (ja) * 1985-08-05 1987-02-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
JP2704428B2 (ja) * 1988-06-15 1998-01-26 富山化学工業株式会社 キノロンカルボン酸誘導体またはその塩
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
JPH06233176A (ja) * 1993-01-29 1994-08-19 Sony Corp ビデオカメラ

Also Published As

Publication number Publication date
PL181867B1 (pl) 2001-09-28
NZ287139A (en) 1997-07-27
FI965020A7 (fi) 1996-12-16
HUT75777A (en) 1997-05-28
CA2192824A1 (en) 1995-12-21
DE69524251T2 (de) 2002-07-11
KR100350921B1 (ko) 2002-11-18
HK1000495A1 (en) 2002-07-19
RO117793B1 (ro) 2002-07-30
NO307255B1 (no) 2000-03-06
AU2576795A (en) 1996-01-05
HU9603455D0 (en) 1997-02-28
CN1053668C (zh) 2000-06-21
DE69524251D1 (de) 2002-01-10
US5817669A (en) 1998-10-06
CA2192824C (en) 2006-11-07
BR9508037A (pt) 1997-09-16
JP3391796B2 (ja) 2003-03-31
NO965305D0 (no) 1996-12-11
TW319769B (cs) 1997-11-11
CZ292631B6 (cs) 2003-11-12
HU220072B (hu) 2001-10-28
SK157496A3 (en) 1997-08-06
CN1158614A (zh) 1997-09-03
SK281341B6 (sk) 2001-02-12
EP0787726A1 (en) 1997-08-06
EP0787726A4 (cs) 1997-08-06
PT787726E (pt) 2002-04-29
CZ364396A3 (en) 1997-06-11
FI112485B (fi) 2003-12-15
FI965020A0 (fi) 1996-12-13
AU679859B2 (en) 1997-07-10
ATE209645T1 (de) 2001-12-15
RU2151770C1 (ru) 2000-06-27
WO1995034559A1 (en) 1995-12-21
SI0787726T1 (en) 2002-04-30
NO965305L (no) 1997-02-04
EP0787726B1 (en) 2001-11-28
MX9606331A (es) 1997-03-29
PL317726A1 (en) 1997-04-28
ES2163512T3 (es) 2002-02-01

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