DK0785252T3 - Antisense-oligonukleotider mod den alfa-regulatoriske subunit af den cAMP-afhængige proteinkinase til behandling af cancer - Google Patents

Antisense-oligonukleotider mod den alfa-regulatoriske subunit af den cAMP-afhængige proteinkinase til behandling af cancer

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Publication number
DK0785252T3
DK0785252T3 DK97100277T DK97100277T DK0785252T3 DK 0785252 T3 DK0785252 T3 DK 0785252T3 DK 97100277 T DK97100277 T DK 97100277T DK 97100277 T DK97100277 T DK 97100277T DK 0785252 T3 DK0785252 T3 DK 0785252T3
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Denmark
Prior art keywords
antisense oligonucleotides
camp
cancer
treatment
protein kinase
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Application number
DK97100277T
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Danish (da)
English (en)
Inventor
Yoon S Cho-Chung
Original Assignee
Cho Chung Yoon S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Cho Chung Yoon S filed Critical Cho Chung Yoon S
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Publication of DK0785252T3 publication Critical patent/DK0785252T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK97100277T 1990-11-02 1991-10-31 Antisense-oligonukleotider mod den alfa-regulatoriske subunit af den cAMP-afhængige proteinkinase til behandling af cancer DK0785252T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60711390A 1990-11-02 1990-11-02
US68019891A 1991-04-05 1991-04-05
US07/702,163 US5271941A (en) 1990-11-02 1991-05-20 Antisense oligonucleotides of human regulatory subunit RI.sub.α of cAMP-dependent protein kinases

Publications (1)

Publication Number Publication Date
DK0785252T3 true DK0785252T3 (da) 2000-10-02

Family

ID=27416969

Family Applications (2)

Application Number Title Priority Date Filing Date
DK97100277T DK0785252T3 (da) 1990-11-02 1991-10-31 Antisense-oligonukleotider mod den alfa-regulatoriske subunit af den cAMP-afhængige proteinkinase til behandling af cancer
DK91118628.6T DK0490077T3 (da) 1990-11-02 1991-10-31 Antisense-oligonukleotider til behandling af cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK91118628.6T DK0490077T3 (da) 1990-11-02 1991-10-31 Antisense-oligonukleotider til behandling af cancer

Country Status (9)

Country Link
US (3) US5271941A (fr)
EP (3) EP0785252B1 (fr)
KR (1) KR0171210B1 (fr)
AT (2) ATE156517T1 (fr)
CA (2) CA2488792A1 (fr)
DE (2) DE69132299T2 (fr)
DK (2) DK0785252T3 (fr)
ES (2) ES2148838T3 (fr)
GR (2) GR3024673T3 (fr)

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Publication number Publication date
CA2054325A1 (fr) 1992-05-03
GR3034535T3 (en) 2001-01-31
CA2488792A1 (fr) 1992-05-03
CA2054325C (fr) 2005-03-15
DE69132299D1 (de) 2000-08-10
KR0171210B1 (ko) 1999-02-01
ES2148838T3 (es) 2000-10-16
ATE156517T1 (de) 1997-08-15
US5271941A (en) 1993-12-21
ATE194383T1 (de) 2000-07-15
US5691317A (en) 1997-11-25
DE69127175T2 (de) 1998-03-12
EP0490077A1 (fr) 1992-06-17
DE69127175D1 (de) 1997-09-11
US5627158A (en) 1997-05-06
EP0490077B1 (fr) 1997-08-06
EP0972831A1 (fr) 2000-01-19
EP0785252A1 (fr) 1997-07-23
DK0490077T3 (da) 1998-01-26
GR3024673T3 (en) 1997-12-31
EP0785252B1 (fr) 2000-07-05
ES2104644T3 (es) 1997-10-16
DE69132299T2 (de) 2001-02-15

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