DK0765321T3 - 2-amino-3-aroylbenzo-beta-thiophener og fremgangsmåde til fremstilling deraf - Google Patents

2-amino-3-aroylbenzo-beta-thiophener og fremgangsmåde til fremstilling deraf

Info

Publication number
DK0765321T3
DK0765321T3 DK95922292T DK95922292T DK0765321T3 DK 0765321 T3 DK0765321 T3 DK 0765321T3 DK 95922292 T DK95922292 T DK 95922292T DK 95922292 T DK95922292 T DK 95922292T DK 0765321 T3 DK0765321 T3 DK 0765321T3
Authority
DK
Denmark
Prior art keywords
beta
amino
thiophenes
benzo
aroylbenzo
Prior art date
Application number
DK95922292T
Other languages
Danish (da)
English (en)
Inventor
Alexander Glenn Godfrey
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0765321T3 publication Critical patent/DK0765321T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Cephalosporin Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK95922292T 1994-06-10 1995-06-07 2-amino-3-aroylbenzo-beta-thiophener og fremgangsmåde til fremstilling deraf DK0765321T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/257,859 US5466810A (en) 1994-06-10 1994-06-10 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
PCT/US1995/007397 WO1995034557A1 (fr) 1994-06-10 1995-06-07 2-AMINO-3-AROYL-BENZO[β]THIOPHENES ET PROCEDE DE PRODUCTION DE CES COMPOSES

Publications (1)

Publication Number Publication Date
DK0765321T3 true DK0765321T3 (da) 2001-05-07

Family

ID=22978079

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95922292T DK0765321T3 (da) 1994-06-10 1995-06-07 2-amino-3-aroylbenzo-beta-thiophener og fremgangsmåde til fremstilling deraf

Country Status (14)

Country Link
US (3) US5466810A (fr)
EP (1) EP0765321B1 (fr)
JP (1) JPH10502057A (fr)
AT (1) ATE200671T1 (fr)
AU (1) AU2702995A (fr)
BR (1) BR9507956A (fr)
CA (1) CA2192097A1 (fr)
DE (1) DE69520738T2 (fr)
DK (1) DK0765321T3 (fr)
ES (1) ES2155891T3 (fr)
FI (1) FI964914A (fr)
GR (1) GR3036028T3 (fr)
PT (1) PT765321E (fr)
WO (1) WO1995034557A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
AU6277396A (en) 1995-06-07 1996-12-30 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
US5606075A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
CA2207141A1 (fr) * 1996-07-15 1998-01-15 David Thompson Berg Composes de benzothiophene,formulations et utilisations de ceux-ci
US5792798A (en) * 1996-07-29 1998-08-11 Eli Lilly And Company Method for inhibiting plasminogen activator inhibitor 1
ZA9710262B (en) * 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
AU6959898A (en) * 1997-04-11 1998-11-11 David J. Grainger Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
CA2372720C (fr) 1999-05-04 2007-09-11 John Antony Kanis Glycosides d'androgenes et activite androgenique desdits glycosides
US6232260B1 (en) 1999-10-14 2001-05-15 Equistar Chemicals, L.P. Single-site catalysts for olefin polymerization
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
KR20040094720A (ko) * 2002-02-22 2004-11-10 바이엘 파마슈티칼스 코포레이션 과다증식성 질환 치료에 유용한 접합 3환계 헤테로사이클
US7144885B2 (en) * 2002-02-22 2006-12-05 Bayer Pharmaceuticals Corporation Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
US20100125073A1 (en) * 2006-09-01 2010-05-20 Olaf Weber Benzofuran and benzothiophene derivatives useful in the treatment of cancers of the central nervous system
WO2011109679A2 (fr) * 2010-03-05 2011-09-09 Amira Pharmaceuticals, Inc. Inhibiteurs de la 5-lipoxygénase
CN102653520A (zh) * 2012-04-10 2012-09-05 苏州大学 一种2-羟基-2-芳基硫代乙酰胺的制备方法
US11400639B2 (en) * 2016-09-27 2022-08-02 Dsm Ip Assets B.V. Transparent drawn article

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US5420349A (en) * 1994-06-10 1995-05-30 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[β]thiophenes

Also Published As

Publication number Publication date
DE69520738D1 (de) 2001-05-23
GR3036028T3 (en) 2001-09-28
PT765321E (pt) 2001-07-31
JPH10502057A (ja) 1998-02-24
US5554755A (en) 1996-09-10
EP0765321A4 (fr) 1997-05-02
ATE200671T1 (de) 2001-05-15
BR9507956A (pt) 1997-08-12
EP0765321B1 (fr) 2001-04-18
EP0765321A1 (fr) 1997-04-02
FI964914A0 (fi) 1996-12-09
US5792870A (en) 1998-08-11
WO1995034557A1 (fr) 1995-12-21
ES2155891T3 (es) 2001-06-01
DE69520738T2 (de) 2001-09-13
FI964914A (fi) 1996-12-09
CA2192097A1 (fr) 1995-12-21
US5466810A (en) 1995-11-14
AU2702995A (en) 1996-01-05

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