ES2155891T3 - 2-amino-3-aroil-benzo(beta)tiofenos y procedimiento de preparacion de los mismos. - Google Patents
2-amino-3-aroil-benzo(beta)tiofenos y procedimiento de preparacion de los mismos.Info
- Publication number
- ES2155891T3 ES2155891T3 ES95922292T ES95922292T ES2155891T3 ES 2155891 T3 ES2155891 T3 ES 2155891T3 ES 95922292 T ES95922292 T ES 95922292T ES 95922292 T ES95922292 T ES 95922292T ES 2155891 T3 ES2155891 T3 ES 2155891T3
- Authority
- ES
- Spain
- Prior art keywords
- benzo
- beta
- amino
- thiophenes
- aroil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Cephalosporin Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE PREPARA UN GRUPO DE 2-AMINO-3-AROIL-BENZO[ BE ]TIOFENOS, MEDIANTE TRATAMIENTO DE UN ALDEHIDO CON UN ANION DE DIMETILAMINO TIOFORMAMIDA, CICLANDO LA {AL}-HIDROXI TIOAMIDA, Y ACICLANDO POSTERIORMENTE EL BENZO[{BE}]TIOFENO, PARA PRODUCIR EL DERIVADO 2-AMINO-3-ARILO. DICHOS COMPUESTOS SE PUEDEN TRATAR CON REACTIVOS DE GRIGNARD FENILADOS ADECUADOS, Y, TRAS DESPROTEGERLOS, PRODUCEN 6-HIDROXI-2-(4-HIDROXIFENIL)-3-[4-(2PIPERIDINOETOXI)BENZO[{BE}]TIOFENO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/257,859 US5466810A (en) | 1994-06-10 | 1994-06-10 | 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2155891T3 true ES2155891T3 (es) | 2001-06-01 |
Family
ID=22978079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95922292T Expired - Lifetime ES2155891T3 (es) | 1994-06-10 | 1995-06-07 | 2-amino-3-aroil-benzo(beta)tiofenos y procedimiento de preparacion de los mismos. |
Country Status (14)
Country | Link |
---|---|
US (3) | US5466810A (es) |
EP (1) | EP0765321B1 (es) |
JP (1) | JPH10502057A (es) |
AT (1) | ATE200671T1 (es) |
AU (1) | AU2702995A (es) |
BR (1) | BR9507956A (es) |
CA (1) | CA2192097A1 (es) |
DE (1) | DE69520738T2 (es) |
DK (1) | DK0765321T3 (es) |
ES (1) | ES2155891T3 (es) |
FI (1) | FI964914A (es) |
GR (1) | GR3036028T3 (es) |
PT (1) | PT765321E (es) |
WO (1) | WO1995034557A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5770609A (en) | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5595722A (en) | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
AU6277396A (en) | 1995-06-07 | 1996-12-30 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies with tamoxifen analogues |
US5606075A (en) * | 1995-06-07 | 1997-02-25 | Eli Lilly And Company | Process for the synthesis of benzo[b]thiophenes |
CA2207141A1 (en) * | 1996-07-15 | 1998-01-15 | David Thompson Berg | Benzothiophene compounds, and uses and formulations thereof |
US5792798A (en) * | 1996-07-29 | 1998-08-11 | Eli Lilly And Company | Method for inhibiting plasminogen activator inhibitor 1 |
ZA9710262B (en) * | 1996-11-19 | 1999-05-13 | Lilly Co Eli | Process for the synthesis of benzothiophenes |
AU6959898A (en) * | 1997-04-11 | 1998-11-11 | David J. Grainger | Compounds and therapies for the prevention of vascular and non-vascular pathol ogies |
CA2372720C (en) | 1999-05-04 | 2007-09-11 | John Antony Kanis | Androgen glycosides and androgenic activity thereof |
US6232260B1 (en) | 1999-10-14 | 2001-05-15 | Equistar Chemicals, L.P. | Single-site catalysts for olefin polymerization |
IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
KR20040094720A (ko) * | 2002-02-22 | 2004-11-10 | 바이엘 파마슈티칼스 코포레이션 | 과다증식성 질환 치료에 유용한 접합 3환계 헤테로사이클 |
US7144885B2 (en) * | 2002-02-22 | 2006-12-05 | Bayer Pharmaceuticals Corporation | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders |
US20100125073A1 (en) * | 2006-09-01 | 2010-05-20 | Olaf Weber | Benzofuran and benzothiophene derivatives useful in the treatment of cancers of the central nervous system |
WO2011109679A2 (en) * | 2010-03-05 | 2011-09-09 | Amira Pharmaceuticals, Inc. | Inhibitors of 5-lipoxygenase |
CN102653520A (zh) * | 2012-04-10 | 2012-09-05 | 苏州大学 | 一种2-羟基-2-芳基硫代乙酰胺的制备方法 |
US11400639B2 (en) * | 2016-09-27 | 2022-08-02 | Dsm Ip Assets B.V. | Transparent drawn article |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
US5420349A (en) * | 1994-06-10 | 1995-05-30 | Eli Lilly And Company | 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[β]thiophenes |
-
1994
- 1994-06-10 US US08/257,859 patent/US5466810A/en not_active Expired - Lifetime
-
1995
- 1995-03-15 US US08/404,659 patent/US5554755A/en not_active Expired - Lifetime
- 1995-06-07 PT PT95922292T patent/PT765321E/pt unknown
- 1995-06-07 DK DK95922292T patent/DK0765321T3/da active
- 1995-06-07 BR BR9507956A patent/BR9507956A/pt not_active IP Right Cessation
- 1995-06-07 ES ES95922292T patent/ES2155891T3/es not_active Expired - Lifetime
- 1995-06-07 AT AT95922292T patent/ATE200671T1/de not_active IP Right Cessation
- 1995-06-07 DE DE69520738T patent/DE69520738T2/de not_active Expired - Fee Related
- 1995-06-07 AU AU27029/95A patent/AU2702995A/en not_active Abandoned
- 1995-06-07 CA CA002192097A patent/CA2192097A1/en not_active Abandoned
- 1995-06-07 JP JP8502364A patent/JPH10502057A/ja active Pending
- 1995-06-07 WO PCT/US1995/007397 patent/WO1995034557A1/en active IP Right Grant
- 1995-06-07 EP EP95922292A patent/EP0765321B1/en not_active Expired - Lifetime
-
1996
- 1996-09-10 US US08/710,070 patent/US5792870A/en not_active Expired - Lifetime
- 1996-12-09 FI FI964914A patent/FI964914A/fi unknown
-
2001
- 2001-06-13 GR GR20010400881T patent/GR3036028T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69520738D1 (de) | 2001-05-23 |
GR3036028T3 (en) | 2001-09-28 |
PT765321E (pt) | 2001-07-31 |
JPH10502057A (ja) | 1998-02-24 |
US5554755A (en) | 1996-09-10 |
EP0765321A4 (es) | 1997-05-02 |
DK0765321T3 (da) | 2001-05-07 |
ATE200671T1 (de) | 2001-05-15 |
BR9507956A (pt) | 1997-08-12 |
EP0765321B1 (en) | 2001-04-18 |
EP0765321A1 (en) | 1997-04-02 |
FI964914A0 (fi) | 1996-12-09 |
US5792870A (en) | 1998-08-11 |
WO1995034557A1 (en) | 1995-12-21 |
DE69520738T2 (de) | 2001-09-13 |
FI964914A (fi) | 1996-12-09 |
CA2192097A1 (en) | 1995-12-21 |
US5466810A (en) | 1995-11-14 |
AU2702995A (en) | 1996-01-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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