GR3036028T3 - 2-amino-3-aroyl-benzo beta thiophenes and method of making the same - Google Patents

2-amino-3-aroyl-benzo beta thiophenes and method of making the same

Info

Publication number
GR3036028T3
GR3036028T3 GR20010400881T GR20010400881T GR3036028T3 GR 3036028 T3 GR3036028 T3 GR 3036028T3 GR 20010400881 T GR20010400881 T GR 20010400881T GR 20010400881 T GR20010400881 T GR 20010400881T GR 3036028 T3 GR3036028 T3 GR 3036028T3
Authority
GR
Greece
Prior art keywords
benzo
beta
amino
thiophenes
aroyl
Prior art date
Application number
GR20010400881T
Other languages
English (en)
Inventor
Alexander Glenn Godfrey
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of GR3036028T3 publication Critical patent/GR3036028T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
GR20010400881T 1994-06-10 2001-06-13 2-amino-3-aroyl-benzo beta thiophenes and method of making the same GR3036028T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/257,859 US5466810A (en) 1994-06-10 1994-06-10 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
PCT/US1995/007397 WO1995034557A1 (en) 1994-06-10 1995-06-07 2-AMINO-3-AROYL-BENZO[β]THIOPHENES AND METHOD OF MAKING THE SAME

Publications (1)

Publication Number Publication Date
GR3036028T3 true GR3036028T3 (en) 2001-09-28

Family

ID=22978079

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010400881T GR3036028T3 (en) 1994-06-10 2001-06-13 2-amino-3-aroyl-benzo beta thiophenes and method of making the same

Country Status (14)

Country Link
US (3) US5466810A (el)
EP (1) EP0765321B1 (el)
JP (1) JPH10502057A (el)
AT (1) ATE200671T1 (el)
AU (1) AU2702995A (el)
BR (1) BR9507956A (el)
CA (1) CA2192097A1 (el)
DE (1) DE69520738T2 (el)
DK (1) DK0765321T3 (el)
ES (1) ES2155891T3 (el)
FI (1) FI964914A0 (el)
GR (1) GR3036028T3 (el)
PT (1) PT765321E (el)
WO (1) WO1995034557A1 (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US5606075A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
CA2223595C (en) 1995-06-07 2008-08-05 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
CA2207141A1 (en) * 1996-07-15 1998-01-15 David Thompson Berg Benzothiophene compounds, and uses and formulations thereof
US5792798A (en) * 1996-07-29 1998-08-11 Eli Lilly And Company Method for inhibiting plasminogen activator inhibitor 1
ZA9710262B (en) * 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
US6117911A (en) * 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
HUP0200871A3 (en) 1999-05-04 2004-04-28 Strakan Int Ltd Androgen glycosides and androgenic activity thereof
US6232260B1 (en) 1999-10-14 2001-05-15 Equistar Chemicals, L.P. Single-site catalysts for olefin polymerization
HUP0600156A2 (en) * 2002-02-22 2006-06-28 Bayer Pharmaceuticals Corp Benzofuran and benzothiophene deruvatives useful in the treatment of hyper-proliferative disorders
US7144885B2 (en) * 2002-02-22 2006-12-05 Bayer Pharmaceuticals Corporation Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
EP2056817A1 (en) * 2006-09-01 2009-05-13 Bayer HealthCare AG Benzofuran and benzothiophene derivatives useful in the treatment of cancers of the central nervous system
WO2011109679A2 (en) * 2010-03-05 2011-09-09 Amira Pharmaceuticals, Inc. Inhibitors of 5-lipoxygenase
CN102653520A (zh) * 2012-04-10 2012-09-05 苏州大学 一种2-羟基-2-芳基硫代乙酰胺的制备方法
CN109789651B (zh) * 2016-09-27 2021-12-14 帝斯曼知识产权资产管理有限公司 透明拉伸制品

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US5420349A (en) * 1994-06-10 1995-05-30 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[β]thiophenes

Also Published As

Publication number Publication date
US5554755A (en) 1996-09-10
FI964914A (fi) 1996-12-09
CA2192097A1 (en) 1995-12-21
DK0765321T3 (da) 2001-05-07
EP0765321A1 (en) 1997-04-02
DE69520738D1 (de) 2001-05-23
US5466810A (en) 1995-11-14
US5792870A (en) 1998-08-11
PT765321E (pt) 2001-07-31
EP0765321B1 (en) 2001-04-18
ES2155891T3 (es) 2001-06-01
DE69520738T2 (de) 2001-09-13
ATE200671T1 (de) 2001-05-15
EP0765321A4 (el) 1997-05-02
BR9507956A (pt) 1997-08-12
JPH10502057A (ja) 1998-02-24
FI964914A0 (fi) 1996-12-09
WO1995034557A1 (en) 1995-12-21
AU2702995A (en) 1996-01-05

Similar Documents

Publication Publication Date Title
GR3036028T3 (en) 2-amino-3-aroyl-benzo beta thiophenes and method of making the same
UA42716C2 (uk) ГЕМІСОЛЬВАТИ 6-ГІДРОКСИ-2-(4-ГІДРОКСИФЕНІЛ)-3-[4-(ПІПЕРИДИНОЕТОКСИ)БЕНЗОЇЛ]БЕНЗО[b]ТІОФЕНГІДРОХЛОРИДУ
MY112481A (en) Synthesis of 3-[4-(2-aminoethoxy)-benzoyl] -2-aryl-6-hydroxybenzo [b] thiophenes
CA2344057A1 (en) Treatment of persistent pain
HUT76000A (en) 2-amino-3-aroyl-benzo[beta]thiophenes and method of making the same
MX9606140A (es) 2-AMINO-3-AROIL-BENZO[ beta]TIOFENOS Y METODO PARA LA ELABORACION DE LOS MISMOS.
MY131787A (en) An improved process for preparing 3-(4-aminoethoxy- benzoyl) benzo (b) - thiophenes
MX9606177A (es) 2-AMINO-3-AROIL-BENZO[ beta]TIOFENOS Y METODOS PARA PREPARAR Y USAR LOS MISMOS PARA PRODUCIR 6-HIDROXI-2-(4-HIDROXIFENIL)3-[4-(2-AMINOETOXI)-BENZOIL]BENZO[ beta]TIOFENOS
HUT40647A (en) Process for preparing 2-/azolyl-methyl/-3-/difluor-benzyloxy/-2,3-dihydro-fluor-benzo(b) thiophenes
WO1995034536B1 (en) Production of hydroxythioacetamides and use thereof in the synthesis of benzothiophenes
ZA867610B (en) Thiophene ring-substituted alpha-(alkylaminopropionyl)-thiophene derivatives,a process for preparing them and pharmaceutical composition containing them
FR2751651B1 (fr) Derives de 3-(benzo[b]thien-3-yl)oxazolidin-2-one, leur procede de preparation et leur application en therapeutique
JO1890B1 (en) New pharmaceutical product

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees