DK0761681T3 - Fremgangsmåde til fremstilling af substituerede N-ethyl-glycinderivater - Google Patents

Fremgangsmåde til fremstilling af substituerede N-ethyl-glycinderivater

Info

Publication number
DK0761681T3
DK0761681T3 DK96113530T DK96113530T DK0761681T3 DK 0761681 T3 DK0761681 T3 DK 0761681T3 DK 96113530 T DK96113530 T DK 96113530T DK 96113530 T DK96113530 T DK 96113530T DK 0761681 T3 DK0761681 T3 DK 0761681T3
Authority
DK
Denmark
Prior art keywords
acid
formula
protecting
labile
base
Prior art date
Application number
DK96113530T
Other languages
Danish (da)
English (en)
Inventor
Gerhard Breipohl
Eugen Uhlmann
David William Will
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0761681T3 publication Critical patent/DK0761681T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK96113530T 1995-09-04 1996-08-22 Fremgangsmåde til fremstilling af substituerede N-ethyl-glycinderivater DK0761681T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19532553A DE19532553A1 (de) 1995-09-04 1995-09-04 Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate

Publications (1)

Publication Number Publication Date
DK0761681T3 true DK0761681T3 (da) 2002-07-08

Family

ID=7771182

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96113530T DK0761681T3 (da) 1995-09-04 1996-08-22 Fremgangsmåde til fremstilling af substituerede N-ethyl-glycinderivater

Country Status (11)

Country Link
US (1) US5817811A (fr)
EP (1) EP0761681B1 (fr)
JP (1) JP3934708B2 (fr)
AT (1) ATE214398T1 (fr)
AU (1) AU708034B2 (fr)
CA (1) CA2184681C (fr)
DE (2) DE19532553A1 (fr)
DK (1) DK0761681T3 (fr)
ES (1) ES2173230T3 (fr)
NO (1) NO313833B1 (fr)
PT (1) PT761681E (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710164B1 (en) 1993-11-22 2004-03-23 Peter E. Nielsen Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5855911A (en) * 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
US6043353A (en) * 1995-12-22 2000-03-28 University Technologies International, Inc. Reusable solid support for oligonucleotide synthesis, process for production thereof and process for use thereof
WO1997023497A1 (fr) * 1995-12-22 1997-07-03 University Technologies International Inc. Bras de liaison pour la synthese d'oligonucleotides sur un support solide et procede pour le former
ATE311402T1 (de) * 1996-07-24 2005-12-15 Buchardt Dorte Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeit
DE19640974A1 (de) * 1996-10-04 1998-04-16 Bayer Ag Bausteine für DNA/PNA-Cooligomere
US6977244B2 (en) * 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
HU226867B1 (en) * 1997-05-14 2009-12-28 Morphochem Ag Method for producing polymers having nucleo-bases as side-groups
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
US7285288B1 (en) 1997-10-03 2007-10-23 Board Of Regents, The University Of Texas System Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US7135564B1 (en) * 1998-07-02 2006-11-14 University Technologies International Inc. Reusable solid support for oligonucleotide synthesis
JP2002520008A (ja) 1998-07-09 2002-07-09 バイオセプト インコーポレイテッド Ｄｎａ配列ハイブリッド形成を最適化するための改良されたペプチド核酸汎用ライブラリーの使用法
SK14102001A3 (sk) * 1999-04-13 2002-07-02 Basf Aktiengesellschaft Ligandy integrínového receptora
ATE346950T1 (de) 2001-03-09 2006-12-15 Boston Probes Inc Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen
US6541626B2 (en) * 2001-04-17 2003-04-01 Isis Pharmaceuticals, Inc. Process for selective N-acylation of purine nucleosides
KR20030084444A (ko) * 2002-04-26 2003-11-01 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
US7413857B2 (en) 2002-11-21 2008-08-19 Epicentre Technologies Methods for using riboprimers for strand displacement replication of target sequences
KR101354692B1 (ko) * 2010-11-26 2014-02-06 서울대학교산학협력단 올리고머 및 그 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
DE4421536A1 (de) * 1994-06-20 1995-12-21 Hoechst Ag Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE69632324T2 (de) * 1995-06-07 2005-06-16 PerSeptive Biosystems, Inc., Framingham Pna-dna-chimäre und pna-synthone zu deren herstellung

Also Published As

Publication number Publication date
EP0761681A2 (fr) 1997-03-12
ATE214398T1 (de) 2002-03-15
NO963677D0 (no) 1996-09-03
DE19532553A1 (de) 1997-03-06
PT761681E (pt) 2002-08-30
NO313833B1 (no) 2002-12-09
EP0761681A3 (fr) 1997-07-09
CA2184681A1 (fr) 1997-03-05
ES2173230T3 (es) 2002-10-16
CA2184681C (fr) 2010-01-05
NO963677L (no) 1997-03-05
EP0761681B1 (fr) 2002-03-13
DE59608867D1 (de) 2002-04-18
JP3934708B2 (ja) 2007-06-20
AU6440896A (en) 1997-03-06
JPH09124572A (ja) 1997-05-13
US5817811A (en) 1998-10-06
AU708034B2 (en) 1999-07-29

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