DK0760819T3 - Tricykliske dicarbonylderivater - Google Patents
Tricykliske dicarbonylderivaterInfo
- Publication number
- DK0760819T3 DK0760819T3 DK95920816T DK95920816T DK0760819T3 DK 0760819 T3 DK0760819 T3 DK 0760819T3 DK 95920816 T DK95920816 T DK 95920816T DK 95920816 T DK95920816 T DK 95920816T DK 0760819 T3 DK0760819 T3 DK 0760819T3
- Authority
- DK
- Denmark
- Prior art keywords
- lower alkyl
- pct
- disease
- amino
- signify
- Prior art date
Links
- 125000004989 dicarbonyl group Chemical group 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000004429 atom Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010003805 Autism Diseases 0.000 abstract 1
- 208000020706 Autistic disease Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 208000036626 Mental retardation Diseases 0.000 abstract 1
- 208000001089 Multiple system atrophy Diseases 0.000 abstract 1
- 208000008238 Muscle Spasticity Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 206010047163 Vasospasm Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000035987 intoxication Effects 0.000 abstract 1
- 231100000566 intoxication Toxicity 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 208000031237 olivopontocerebellar atrophy Diseases 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000018198 spasticity Diseases 0.000 abstract 1
- 208000020431 spinal cord injury Diseases 0.000 abstract 1
- 125000005505 thiomorpholino group Chemical group 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH160294 | 1994-05-24 | ||
| CH47795 | 1995-02-17 | ||
| PCT/EP1995/001856 WO1995032205A1 (fr) | 1994-05-24 | 1995-05-16 | Derives dicarbonyliques tricycliques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0760819T3 true DK0760819T3 (da) | 2000-10-09 |
Family
ID=25684688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95920816T DK0760819T3 (da) | 1994-05-24 | 1995-05-16 | Tricykliske dicarbonylderivater |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5688803A (fr) |
| EP (1) | EP0760819B1 (fr) |
| JP (1) | JP2828506B2 (fr) |
| CN (1) | CN1044245C (fr) |
| AT (1) | ATE194841T1 (fr) |
| AU (1) | AU688515B2 (fr) |
| BR (1) | BR9507672A (fr) |
| CA (1) | CA2189776A1 (fr) |
| DE (1) | DE69518075T2 (fr) |
| DK (1) | DK0760819T3 (fr) |
| ES (1) | ES2149989T3 (fr) |
| GR (1) | GR3034625T3 (fr) |
| NZ (1) | NZ287413A (fr) |
| PT (1) | PT760819E (fr) |
| RU (1) | RU2145606C1 (fr) |
| WO (1) | WO1995032205A1 (fr) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5243049A (en) * | 1992-01-22 | 1993-09-07 | Neurogen Corporation | Certain pyrroloquinolinones: a new class of GABA brain receptor ligands |
| US5955465A (en) * | 1996-03-22 | 1999-09-21 | Neurogen Corporation | 1,2,4-triazolo 4,3-c!quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones |
| GB2346883B (en) * | 1996-09-02 | 2001-02-14 | Lilly Industries Ltd | GluR5 receptor binding assay |
| FR2773153A1 (fr) * | 1997-12-29 | 1999-07-02 | Rhone Poulenc Agrochimie | Nouveaux composes fongicides |
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| WO2001046190A1 (fr) * | 1999-12-22 | 2001-06-28 | Kyorin Pharmaceutical Co., Ltd. | Composes tricycliques et sels d'addition de ceux-ci |
| DE10004572A1 (de) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| GB0223730D0 (en) * | 2002-10-11 | 2002-11-20 | Novartis Ag | Organic compounds |
| WO2005080392A1 (fr) | 2004-02-19 | 2005-09-01 | Takeda Pharmaceutical Company Limited | Dérive de pyrazoloquinolone et utilisation de celui-ci |
| JO3077B1 (ar) * | 2005-07-28 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينولين مضادة للبكتيريا |
| TW200806670A (en) * | 2006-04-25 | 2008-02-01 | Merck & Co Inc | Inhibitors of checkpoint kinases |
| US7907679B2 (en) * | 2007-01-12 | 2011-03-15 | General Dynamics C4 Systems, Inc. | Methods and systems for acquiring signals using coherent match filtering |
| US8139680B2 (en) | 2007-01-12 | 2012-03-20 | General Dynamics C4 Systems, Inc. | Signal acquisition methods and apparatus in wireless communication systems |
| WO2008109613A1 (fr) * | 2007-03-05 | 2008-09-12 | Wyeth | Dérivés de benzo[c][2,7]naphtyridine et leur utilisation en tant qu'inhibiteurs de kinase |
| CA2689934A1 (fr) * | 2007-06-08 | 2008-12-18 | Helicon Therapeutics, Inc. | Derives de pyrazolonaphtyridine therapeutiques |
| WO2009123537A1 (fr) * | 2008-04-04 | 2009-10-08 | Forskarpatent I Syd Ab | Modulateurs des récepteurs gaba<sb>a</sb> |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| WO2009139916A1 (fr) * | 2008-05-16 | 2009-11-19 | Synta Pharmaceuticals Corp. | Composés triazoles tricycliques modulant l'activité hsp90 |
| EP2303890A4 (fr) * | 2008-06-19 | 2012-04-11 | Progenics Pharm Inc | Inhibiteurs de phosphatidylinositol 3 kinase |
| WO2010054968A1 (fr) | 2008-11-14 | 2010-05-20 | F. Hoffmann-La Roche Ag | Dérivés de quinazoline comme antagonistes des récepteurs nk3 |
| US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| WO2011146591A1 (fr) | 2010-05-19 | 2011-11-24 | Millennium Pharmaceuticals, Inc. | Acides hydroxamiques substitués et leurs utilisations |
| WO2013151876A1 (fr) * | 2012-04-04 | 2013-10-10 | Merck Sharp & Dohme Corp. | Inhibiteurs d'aldostérone synthase |
| CN104838122B (zh) | 2012-12-04 | 2018-01-02 | 沃尔沃卡车集团 | 用于控制燃料喷射的方法和系统 |
| CN103073547A (zh) * | 2013-02-06 | 2013-05-01 | 上海药明康德新药开发有限公司 | 一种(3aS,9bR)-叔丁基-3,3a,4,5-四氢吡咯[3,4-c]喹啉-2(9bH)酯的合成方法 |
| MX363258B (es) | 2013-04-05 | 2019-03-19 | Eisai R&D Man Co Ltd | Compuestos piridinilpirazoloquinolina. |
| EP2982675B1 (fr) | 2013-04-05 | 2017-08-16 | Eisai R&D Management Co., Ltd. | Sel de dérivé de pyrazoloquinoline et son cristal |
| CN104447736B (zh) * | 2014-10-14 | 2016-06-08 | 雅安职业技术学院 | 一种veranamine的合成方法 |
| AU2018276565A1 (en) | 2017-06-01 | 2019-11-07 | Eisai R&D Management Co., Ltd. | Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil |
| MX2019013383A (es) | 2017-06-01 | 2020-02-20 | Eisai R&D Man Co Ltd | Agente terapeutico para la demencia que combina derivado de pirazoloquinolina y memantina. |
| US11484502B2 (en) | 2017-06-01 | 2022-11-01 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition comprising PDE9 inhibitor |
| IL270357B2 (en) | 2017-06-01 | 2024-02-01 | Eisai R&D Man Co Ltd | A therapeutic agent in Lewy body disease containing pyrazoloquinoline compounds |
| WO2024012554A1 (fr) * | 2022-07-14 | 2024-01-18 | 上海日馨医药科技股份有限公司 | Agoniste de tpk et procédé de traitement de maladies neurodégénératives l'utilisant |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL66835A (en) * | 1981-09-24 | 1988-05-31 | Roussel Uclaf | 1,4-disubstituted(1,2,4)triazolo(4,3-alpha)quinazolin-5(4h)-one derivatives and their salts,their preparation and pharmaceutical compositions containing them |
| US4713383A (en) * | 1984-10-01 | 1987-12-15 | Ciba-Geigy Corporation | Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses |
| ATE128136T1 (de) * | 1990-05-31 | 1995-10-15 | Merck Sharp & Dohme | Dioxo-tetrahydrochinolinderivate. |
-
1995
- 1995-05-16 JP JP7530032A patent/JP2828506B2/ja not_active Expired - Fee Related
- 1995-05-16 ES ES95920816T patent/ES2149989T3/es not_active Expired - Lifetime
- 1995-05-16 CA CA002189776A patent/CA2189776A1/fr not_active Abandoned
- 1995-05-16 DE DE69518075T patent/DE69518075T2/de not_active Expired - Fee Related
- 1995-05-16 AT AT95920816T patent/ATE194841T1/de not_active IP Right Cessation
- 1995-05-16 EP EP95920816A patent/EP0760819B1/fr not_active Expired - Lifetime
- 1995-05-16 BR BR9507672A patent/BR9507672A/pt not_active IP Right Cessation
- 1995-05-16 PT PT95920816T patent/PT760819E/pt unknown
- 1995-05-16 CN CN95193244A patent/CN1044245C/zh not_active Expired - Fee Related
- 1995-05-16 US US08/737,240 patent/US5688803A/en not_active Expired - Fee Related
- 1995-05-16 AU AU26130/95A patent/AU688515B2/en not_active Ceased
- 1995-05-16 RU RU96124496/04A patent/RU2145606C1/ru not_active IP Right Cessation
- 1995-05-16 WO PCT/EP1995/001856 patent/WO1995032205A1/fr active IP Right Grant
- 1995-05-16 NZ NZ287413A patent/NZ287413A/en unknown
- 1995-05-16 DK DK95920816T patent/DK0760819T3/da active
-
2000
- 2000-10-13 GR GR20000402311T patent/GR3034625T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0760819A1 (fr) | 1997-03-12 |
| JP2828506B2 (ja) | 1998-11-25 |
| EP0760819B1 (fr) | 2000-07-19 |
| ATE194841T1 (de) | 2000-08-15 |
| AU2613095A (en) | 1995-12-18 |
| CN1149295A (zh) | 1997-05-07 |
| GR3034625T3 (en) | 2001-01-31 |
| ES2149989T3 (es) | 2000-11-16 |
| US5688803A (en) | 1997-11-18 |
| RU2145606C1 (ru) | 2000-02-20 |
| CN1044245C (zh) | 1999-07-21 |
| DE69518075D1 (de) | 2000-08-24 |
| WO1995032205A1 (fr) | 1995-11-30 |
| PT760819E (pt) | 2000-11-30 |
| JPH09506634A (ja) | 1997-06-30 |
| AU688515B2 (en) | 1998-03-12 |
| BR9507672A (pt) | 1997-08-19 |
| CA2189776A1 (fr) | 1995-11-30 |
| NZ287413A (en) | 1998-02-26 |
| DE69518075T2 (de) | 2001-03-22 |
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