DE69518075D1 - Tricyclische dicarbonylderivate - Google Patents

Tricyclische dicarbonylderivate

Info

Publication number
DE69518075D1
DE69518075D1 DE69518075T DE69518075T DE69518075D1 DE 69518075 D1 DE69518075 D1 DE 69518075D1 DE 69518075 T DE69518075 T DE 69518075T DE 69518075 T DE69518075 T DE 69518075T DE 69518075 D1 DE69518075 D1 DE 69518075D1
Authority
DE
Germany
Prior art keywords
lower alkyl
pct
disease
amino
signify
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69518075T
Other languages
English (en)
Other versions
DE69518075T2 (de
Inventor
Bernd Buettelmann
Thierry Godel
Laurence Gross
Neidhart Marie-Paule Heitz
Claus Riemer
Rene Wyler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69518075D1 publication Critical patent/DE69518075D1/de
Publication of DE69518075T2 publication Critical patent/DE69518075T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69518075T 1994-05-24 1995-05-16 Tricyclische dicarbonylderivate Expired - Fee Related DE69518075T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH160294 1994-05-24
CH47795 1995-02-17
PCT/EP1995/001856 WO1995032205A1 (en) 1994-05-24 1995-05-16 Tricyclic dicarbonyl derivatives

Publications (2)

Publication Number Publication Date
DE69518075D1 true DE69518075D1 (de) 2000-08-24
DE69518075T2 DE69518075T2 (de) 2001-03-22

Family

ID=25684688

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69518075T Expired - Fee Related DE69518075T2 (de) 1994-05-24 1995-05-16 Tricyclische dicarbonylderivate

Country Status (16)

Country Link
US (1) US5688803A (de)
EP (1) EP0760819B1 (de)
JP (1) JP2828506B2 (de)
CN (1) CN1044245C (de)
AT (1) ATE194841T1 (de)
AU (1) AU688515B2 (de)
BR (1) BR9507672A (de)
CA (1) CA2189776A1 (de)
DE (1) DE69518075T2 (de)
DK (1) DK0760819T3 (de)
ES (1) ES2149989T3 (de)
GR (1) GR3034625T3 (de)
NZ (1) NZ287413A (de)
PT (1) PT760819E (de)
RU (1) RU2145606C1 (de)
WO (1) WO1995032205A1 (de)

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US5243049A (en) * 1992-01-22 1993-09-07 Neurogen Corporation Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
US5955465A (en) * 1996-03-22 1999-09-21 Neurogen Corporation 1,2,4-triazolo 4,3-c!quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones
GB2346883B (en) * 1996-09-02 2001-02-14 Lilly Industries Ltd GluR5 receptor binding assay
FR2773153A1 (fr) * 1997-12-29 1999-07-02 Rhone Poulenc Agrochimie Nouveaux composes fongicides
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
AU2220801A (en) * 1999-12-22 2001-07-03 Kyorin Pharmaceutical Co. Ltd. Tricyclic compounds and addition salts thereof
DE10004572A1 (de) * 2000-02-02 2001-08-09 Boehringer Ingelheim Pharma Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
GB0223730D0 (en) * 2002-10-11 2002-11-20 Novartis Ag Organic compounds
EP1719771A1 (de) 2004-02-19 2006-11-08 Takeda Pharmaceutical Company Limited Pyrazolochinolonderivat und dessen verwendung
JO3077B1 (ar) * 2005-07-28 2017-03-15 Janssen Pharmaceutica Nv مشتقات كوينولين مضادة للبكتيريا
TW200806670A (en) * 2006-04-25 2008-02-01 Merck & Co Inc Inhibitors of checkpoint kinases
US7907679B2 (en) * 2007-01-12 2011-03-15 General Dynamics C4 Systems, Inc. Methods and systems for acquiring signals using coherent match filtering
US8139680B2 (en) 2007-01-12 2012-03-20 General Dynamics C4 Systems, Inc. Signal acquisition methods and apparatus in wireless communication systems
WO2008109613A1 (en) * 2007-03-05 2008-09-12 Wyeth Benzo[c][2,7]naphthyridine derivatives, and their use as kinase inhibitors
WO2008154447A1 (en) * 2007-06-08 2008-12-18 Helicon Therapeutics, Inc. Therapeutic pyrazolonaphthyridine derivatives
WO2009123537A1 (en) * 2008-04-04 2009-10-08 Forskarpatent I Syd Ab GABAa RECEPTOR MODULATORS
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
WO2009139916A1 (en) * 2008-05-16 2009-11-19 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate hsp90 activity
EP2303890A4 (de) * 2008-06-19 2012-04-11 Progenics Pharm Inc Inhibitoren von phosphatidylinosit-3-kinase
JP5362839B2 (ja) 2008-11-14 2013-12-11 エフ．ホフマン−ラ ロシュ アーゲー Ｎｋ３受容体アンタゴニストとしてのキナゾリン誘導体
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
WO2011146591A1 (en) 2010-05-19 2011-11-24 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
EP2861071B1 (de) 2012-04-04 2017-03-15 Merck Sharp & Dohme Corp. Aldosteronsynthasehemmer
EP2929169B1 (de) 2012-12-04 2019-02-13 Volvo Truck Corporation Verfahren und vorrichtung zur steuerung einer kraftstoffinjektion
CN103073547A (zh) * 2013-02-06 2013-05-01 上海药明康德新药开发有限公司 一种(3aS,9bR)-叔丁基-3,3a,4,5-四氢吡咯[3,4-c]喹啉-2(9bH)酯的合成方法
EP2982675B1 (de) 2013-04-05 2017-08-16 Eisai R&D Management Co., Ltd. Salz eines pyrazolochinolinderivats und kristall daraus
AU2014250391B2 (en) 2013-04-05 2017-11-02 Eisai R&D Management Co., Ltd. Pyridinylpyrazoloquinoline compound
CN104447736B (zh) * 2014-10-14 2016-06-08 雅安职业技术学院 一种veranamine的合成方法
RU2019135261A (ru) 2017-06-01 2021-07-09 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Фармацевтическая композиция, содержащая ингибитор pde9
CN110603039B (zh) 2017-06-01 2023-02-28 卫材R&D管理有限公司 组合吡唑并喹啉衍生物和美金刚的痴呆治疗剂
AU2018278422B2 (en) 2017-06-01 2022-03-17 Eisai R&D Management Co., Ltd. Lewy body disease therapeutic agent containing pyrazoloquinoline derivative
JP7079777B2 (ja) 2017-06-01 2022-06-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロキノリン誘導体とドネペジルの併用による認知症治療剤
WO2024012554A1 (zh) * 2022-07-14 2024-01-18 上海日馨医药科技股份有限公司 Tpk激动剂及使用其治疗神经退行性疾病的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
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IL66835A (en) * 1981-09-24 1988-05-31 Roussel Uclaf 1,4-disubstituted(1,2,4)triazolo(4,3-alpha)quinazolin-5(4h)-one derivatives and their salts,their preparation and pharmaceutical compositions containing them
US4713383A (en) * 1984-10-01 1987-12-15 Ciba-Geigy Corporation Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
DE69113115T2 (de) * 1990-05-31 1996-06-13 Merck Sharp & Dohme Dioxo-tetrahydrochinolinderivate.

Also Published As

Publication number Publication date
ATE194841T1 (de) 2000-08-15
EP0760819B1 (de) 2000-07-19
WO1995032205A1 (en) 1995-11-30
NZ287413A (en) 1998-02-26
CN1149295A (zh) 1997-05-07
DK0760819T3 (da) 2000-10-09
RU2145606C1 (ru) 2000-02-20
AU688515B2 (en) 1998-03-12
AU2613095A (en) 1995-12-18
JP2828506B2 (ja) 1998-11-25
GR3034625T3 (en) 2001-01-31
CA2189776A1 (en) 1995-11-30
BR9507672A (pt) 1997-08-19
ES2149989T3 (es) 2000-11-16
PT760819E (pt) 2000-11-30
DE69518075T2 (de) 2001-03-22
CN1044245C (zh) 1999-07-21
US5688803A (en) 1997-11-18
JPH09506634A (ja) 1997-06-30
EP0760819A1 (de) 1997-03-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee