DK0737685T5 - Pyrinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger, der indeholder disse - Google Patents

Pyrinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger, der indeholder disse

Info

Publication number
DK0737685T5
DK0737685T5 DK96400778T DK96400778T DK0737685T5 DK 0737685 T5 DK0737685 T5 DK 0737685T5 DK 96400778 T DK96400778 T DK 96400778T DK 96400778 T DK96400778 T DK 96400778T DK 0737685 T5 DK0737685 T5 DK 0737685T5
Authority
DK
Denmark
Prior art keywords
alkyl
aryl
substd
arylalkyl
cycloalkyl
Prior art date
Application number
DK96400778T
Other languages
Danish (da)
English (en)
Other versions
DK0737685T3 (da
Inventor
Marie-Claude Viaud
Daniel Mazeas
Herve Vandepoel
Pierre Renard
Bruno Pfeiffer
Philippe Delagrange
Gerald Guillaumet
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of DK0737685T3 publication Critical patent/DK0737685T3/da
Publication of DK0737685T5 publication Critical patent/DK0737685T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
DK96400778T 1995-04-14 1996-04-11 Pyrinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger, der indeholder disse DK0737685T5 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9504504A FR2732969B1 (fr) 1995-04-14 1995-04-14 Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DK0737685T3 DK0737685T3 (da) 2000-10-09
DK0737685T5 true DK0737685T5 (da) 2001-01-02

Family

ID=9478127

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96400778T DK0737685T5 (da) 1995-04-14 1996-04-11 Pyrinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger, der indeholder disse

Country Status (16)

Country Link
US (1) US5714495A (pt)
EP (1) EP0737685B1 (pt)
JP (1) JP3723274B2 (pt)
CN (1) CN1058967C (pt)
AT (1) ATE194839T1 (pt)
AU (1) AU700071B2 (pt)
CA (1) CA2174033C (pt)
DE (1) DE69609371T2 (pt)
DK (1) DK0737685T5 (pt)
ES (1) ES2150642T3 (pt)
FR (1) FR2732969B1 (pt)
GR (1) GR3034620T3 (pt)
NO (1) NO305988B1 (pt)
NZ (1) NZ286360A (pt)
PT (1) PT737685E (pt)
ZA (1) ZA962934B (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1178045T3 (da) * 1997-04-09 2003-06-23 Pfizer Azaindol-ethylaminderivater som nikotinacetylcholinreceptor-bindingsmidler
US5977131A (en) * 1997-04-09 1999-11-02 Pfizer Inc. Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents
FR2763335B1 (fr) * 1997-05-16 2000-11-24 Adir Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU745579B2 (en) 1997-10-20 2002-03-21 F. Hoffmann-La Roche Ag Bicyclic kinase inhibitors
US6228867B1 (en) 1998-04-02 2001-05-08 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6025366A (en) * 1998-04-02 2000-02-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1999051231A1 (en) * 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP2002510631A (ja) * 1998-04-02 2002-04-09 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬
JP2002510629A (ja) * 1998-04-02 2002-04-09 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬
AU3210799A (en) * 1998-04-02 1999-10-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6110931A (en) * 1998-04-02 2000-08-29 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
US6696439B1 (en) 1999-02-26 2004-02-24 Eli Lilly And Company 5-HT1F agonists
IL144355A0 (en) * 1999-02-26 2002-05-23 Lilly Co Eli 5-ht1f agonists
FR2799757B1 (fr) * 1999-10-15 2001-12-14 Adir Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IL150388A0 (en) * 1999-12-24 2002-12-01 Aventis Pharma Ltd Azaindoles
GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
US6921762B2 (en) 2001-11-16 2005-07-26 Amgen Inc. Substituted indolizine-like compounds and methods of use
EP1474420B1 (en) * 2002-02-01 2012-03-14 AstraZeneca AB Quinazoline compounds
JP2005534619A (ja) 2002-03-28 2005-11-17 エーザイ株式会社 Ｃ−ｊｕｎｎ−末端キナーゼ阻害剤としてのアザインドール
IL164187A0 (en) 2002-03-28 2005-12-18 Eisai Co Ltd 7-Azaindole derivatives and pharmaceutical compositions containing the same
ES2294330T3 (es) 2002-08-02 2008-04-01 MERCK & CO., INC. Derivados de furo(2,3-b)piridina sustituidos.
GB0305142D0 (en) * 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
EP2295433A3 (en) * 2003-03-06 2011-07-06 Eisai R&D Management Co., Ltd. JNK inhibitors
EP1628975A2 (en) 2003-05-16 2006-03-01 Eisai Co., Ltd. Jnk inhibitors
GB0405055D0 (en) * 2004-03-05 2004-04-07 Eisai London Res Lab Ltd JNK inhibitors
KR100958829B1 (ko) * 2004-09-03 2010-05-25 주식회사유한양행 피롤로[2,3-ｃ]피리딘 유도체 및 그의 제조방법
ES2426920T3 (es) * 2004-09-03 2013-10-25 Yuhan Corporation Derivados de pirrolo[3,2-B]piridina y procesos para su preparación
US20060183758A1 (en) * 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
GB0516156D0 (en) * 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
JP2009507024A (ja) * 2005-09-01 2009-02-19 アレイ バイオファーマ、インコーポレイテッド Ｒａｆ阻害剤化合物およびその使用方法
CL2007002617A1 (es) 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
EP2100895B1 (en) * 2006-12-08 2012-03-07 Takeda Pharmaceutical Company Limited Tricyclic compound and medical use thereof
WO2011109932A1 (en) * 2010-03-09 2011-09-15 F.Hoffmann-La Roche Ag Novel process for the manufacture of 5-halogenated-7-azaindoles
EP2940022B1 (en) * 2014-04-30 2020-09-02 Masarykova Univerzita Furopyridines as inhibitors of protein kinases
CN106045995B (zh) * 2016-06-13 2017-07-11 菏泽学院 一种5‑溴‑1H‑吡咯并[2,3‑b]吡啶的合成方法
CN113874015B (zh) 2018-12-21 2024-05-24 细胞基因公司 Ripk2的噻吩并吡啶抑制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5552428A (en) * 1992-06-24 1996-09-03 Instituto Farmacologico Lombardo-Iflo, S.A.S. Compounds effective in the treatment of circadian rhythms and related disorders, the novel pharmaceutical preparations and novel method of application
WO1995033748A1 (en) * 1994-06-09 1995-12-14 Smithkline Beecham Corporation Endothelin receptor antagonists
US5965582A (en) * 1994-08-03 1999-10-12 Asta Medica Aktiengesellschaft N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect
US5541228A (en) * 1994-10-14 1996-07-30 Bristol-Myers Squibb Co. Melatonergic agents

Also Published As

Publication number Publication date
GR3034620T3 (en) 2001-01-31
CA2174033C (fr) 2001-07-24
ES2150642T3 (es) 2000-12-01
NO961457L (no) 1996-10-15
NO961457D0 (no) 1996-04-12
AU5062996A (en) 1996-10-24
CN1058967C (zh) 2000-11-29
ATE194839T1 (de) 2000-08-15
JPH08291172A (ja) 1996-11-05
DE69609371D1 (de) 2000-08-24
DK0737685T3 (da) 2000-10-09
PT737685E (pt) 2000-10-31
EP0737685B1 (fr) 2000-07-19
NO305988B1 (no) 1999-08-30
FR2732969B1 (fr) 1997-05-16
DE69609371T2 (de) 2001-02-22
NZ286360A (en) 1997-09-22
FR2732969A1 (fr) 1996-10-18
CN1139111A (zh) 1997-01-01
EP0737685A1 (fr) 1996-10-16
US5714495A (en) 1998-02-03
AU700071B2 (en) 1998-12-17
CA2174033A1 (fr) 1996-10-15
JP3723274B2 (ja) 2005-12-07
ZA962934B (en) 1996-10-17

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