DK0737208T3 - Monoklonale antistoffer, der er specifikke for PHF-tau, hybridomaer, der secernerer dem, og antigen-genkendelse for disse antistoffer og deres anvendelsesmuligheder - Google Patents

Monoklonale antistoffer, der er specifikke for PHF-tau, hybridomaer, der secernerer dem, og antigen-genkendelse for disse antistoffer og deres anvendelsesmuligheder

Info

Publication number
DK0737208T3
DK0737208T3 DK95903798T DK95903798T DK0737208T3 DK 0737208 T3 DK0737208 T3 DK 0737208T3 DK 95903798 T DK95903798 T DK 95903798T DK 95903798 T DK95903798 T DK 95903798T DK 0737208 T3 DK0737208 T3 DK 0737208T3
Authority
DK
Denmark
Prior art keywords
pro
applications
antigen recognition
thr
peptide
Prior art date
Application number
DK95903798T
Other languages
Danish (da)
English (en)
Inventor
De Voorde Andre Van
Marc Vandermeeren
Eugeen Vanmechelen
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Application granted granted Critical
Publication of DK0737208T3 publication Critical patent/DK0737208T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK95903798T 1993-12-21 1994-12-14 Monoklonale antistoffer, der er specifikke for PHF-tau, hybridomaer, der secernerer dem, og antigen-genkendelse for disse antistoffer og deres anvendelsesmuligheder DK0737208T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93403133 1993-12-21

Publications (1)

Publication Number Publication Date
DK0737208T3 true DK0737208T3 (da) 2006-11-27

Family

ID=8214780

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95903798T DK0737208T3 (da) 1993-12-21 1994-12-14 Monoklonale antistoffer, der er specifikke for PHF-tau, hybridomaer, der secernerer dem, og antigen-genkendelse for disse antistoffer og deres anvendelsesmuligheder

Country Status (11)

Country Link
US (4) US6008024A (fr)
EP (1) EP0737208B1 (fr)
JP (2) JP3992729B2 (fr)
AT (1) ATE335007T1 (fr)
AU (1) AU698383B2 (fr)
CA (1) CA2178212C (fr)
DE (1) DE69434811T2 (fr)
DK (1) DK0737208T3 (fr)
ES (1) ES2270421T3 (fr)
PT (1) PT737208E (fr)
WO (1) WO1995017429A1 (fr)

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WO1993008302A1 (fr) * 1991-10-25 1993-04-29 Itt Automotive Europe Gmbh Anticorps monoclonaux diriges contre la proteine tau associee aux microtubules
DE69529906D1 (de) * 1994-07-29 2003-04-17 Innogenetics Nv Monoklonale antikörper gegen ein epitop einer gewissen unterklasse oder form von phosphoryliertem tau, hybridome die diese sezernieren,antigenerkennung durch diese antikörper und deren verwendung
US6797478B1 (en) * 1998-03-05 2004-09-28 University Of Cincinnati Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies
ES2274869T3 (es) * 2000-01-24 2007-06-01 Innogenetics N.V. Diagnostico de tauopatias determinando la relacion tau/fosfotau.
PT1295129E (pt) * 2000-06-30 2010-06-21 Innogenetics Nv Diagnóstico diferencial de doenças neurológicas
DE60141752D1 (de) 2000-06-30 2010-05-20 Innogenetics Nv Differentielle diagnose von neurologischen krankheiten
US20030162230A1 (en) * 2000-09-27 2003-08-28 Reagan Kevin J. Method for quantifying phosphokinase activity on proteins
CA2460114C (fr) * 2001-09-10 2012-11-06 Meso Scale Technologies, Llc Tampon de dosage, compositions contenant ce tampon et procedes d'utilisation correspondants
WO2004016655A1 (fr) * 2002-08-14 2004-02-26 Mitsubishi Chemical Corporation Anticorps specifique a une proteine-$g(t) centrale
WO2004032711A2 (fr) * 2002-10-09 2004-04-22 Dmi Biosciences, Inc. Diagnostic et surveillance d'une inflammation, d'une ischemie et d'une appendicite
US7238788B2 (en) * 2004-02-18 2007-07-03 University Of Iowa Foundation Antibodies to phosphorylated tau, methods of making and methods of use
WO2006094185A2 (fr) * 2005-03-03 2006-09-08 Dmi Biosciences Inc. Quantification de proteines
US7368712B2 (en) * 2005-12-06 2008-05-06 International Business Machines Corporation Y-shaped carbon nanotubes as AFM probe for analyzing substrates with angled topography
US20100167948A1 (en) * 2007-05-22 2010-07-01 The Brigham And Women's Hospital, Inc. MicroRNA Expression Profiling of Cerebrospinal Fluid
WO2011053565A2 (fr) * 2009-10-29 2011-05-05 Biomedical Sciences Research Centre "Alexander Fleming" Compositions et méthodes de détection d'une tauopathie
US8652397B2 (en) 2010-04-09 2014-02-18 Southwire Company Ultrasonic device with integrated gas delivery system
KR20130091640A (ko) 2010-04-09 2013-08-19 사우쓰와이어 컴퍼니 용융 금속의 초음파 가스 제거
ES2686550T3 (es) 2010-10-11 2018-10-18 Biogen International Neuroscience Gmbh Anticuerpos anti-tau humanos
WO2012142301A2 (fr) 2011-04-12 2012-10-18 Quanterix Corporation Procédé de détermination d'un protocole de traitement et/ou d'un pronostic de rétablissement d'un patient à la suite d'un traumatisme cérébral
WO2012151093A1 (fr) * 2011-04-30 2012-11-08 Marv Enterprises Llc Traitement des tauopathies
GB201112056D0 (en) 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
CA2859665C (fr) 2011-12-20 2024-05-21 Janssen Biotech, Inc. Anticorps anti-phf-tau et leurs utilisations
KR102076384B1 (ko) 2012-08-16 2020-02-11 아이피어리언 인코포레이티드 타우병증을 치료하는 방법
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
LT2935326T (lt) 2012-12-21 2020-12-10 Biogen Ma Inc. Žmogaus antikūnai prieš tau baltymą
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
US20160355573A1 (en) 2013-09-05 2016-12-08 Cornell University Gene therapy for alzheimer's and other neurodegenerative diseases and conditions
EP3104870A4 (fr) 2014-02-14 2017-09-13 Ipierian, Inc. Peptides tau, anticorps anti-tau, et leurs procédés d'utilisation
WO2015165961A1 (fr) 2014-04-29 2015-11-05 Affiris Ag Traitement et prévention de la maladie d'alzheimer
DE102014013571A1 (de) * 2014-09-18 2016-03-24 Aj Roboscreen Gmbh Monoklonaler Antikörper gegen humanes TAU-Protein
TN2017000543A1 (en) 2015-07-06 2019-04-12 Ucb Biopharma Sprl Tau-binding antibodies
US10233515B1 (en) 2015-08-14 2019-03-19 Southwire Company, Llc Metal treatment station for use with ultrasonic degassing system
JOP20180021A1 (ar) 2017-03-16 2019-01-30 Janssen Biotech Inc الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها
JP7029718B2 (ja) 2017-07-31 2022-03-04 国立研究開発法人量子科学技術研究開発機構 リン酸化タウタンパク質の測定方法
WO2019171258A1 (fr) 2018-03-05 2019-09-12 Janssen Pharmaceutica Nv Dosages pour détecter la neurodégénérescence
AU2019232631A1 (en) * 2018-03-05 2020-09-24 Janssen Pharmaceutica Nv Anti-PHF-tau antibodies and uses thereof
JP2021523126A (ja) * 2018-05-03 2021-09-02 ハフ イアー インスティテュート 蓄積した病理学的Ｔａｕタンパク質を低減する方法
US20220018856A1 (en) 2018-11-22 2022-01-20 Fujirebio Inc. Antibody conjugate
CN111349617B (zh) * 2020-05-25 2020-09-22 苏州仁端生物医药科技有限公司 一种分泌抗Tau或pTau-181/231/396单克隆抗体杂交瘤细胞株及其应用
CN111349151B (zh) * 2020-05-25 2020-10-02 苏州仁端生物医药科技有限公司 一种磷酸化多肽和截短蛋白的共价偶联方法及其应用
US20240101654A1 (en) 2020-12-29 2024-03-28 Neurimmune Ag Human anti-tau antibodies
CN113005096B (zh) * 2021-01-19 2022-10-14 华中科技大学 分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733734A (en) * 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
WO1993008302A1 (fr) * 1991-10-25 1993-04-29 Itt Automotive Europe Gmbh Anticorps monoclonaux diriges contre la proteine tau associee aux microtubules
EP0544942A1 (fr) * 1991-12-06 1993-06-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Nouveaux outils pour le diagnostic et le traitement de la maladie d'Alzheimer
DK0618968T3 (da) * 1991-12-06 2000-04-10 Max Planck Gesellschaft Midler til diagnostisering og behandling af Alzheimer's sygdom

Also Published As

Publication number Publication date
CA2178212C (fr) 2011-06-14
JP4110057B2 (ja) 2008-07-02
DE69434811T2 (de) 2007-03-01
JP3992729B2 (ja) 2007-10-17
AU698383B2 (en) 1998-10-29
US20040038430A1 (en) 2004-02-26
WO1995017429A1 (fr) 1995-06-29
ES2270421T3 (es) 2007-04-01
JPH09506771A (ja) 1997-07-08
US20030138972A1 (en) 2003-07-24
US6500674B1 (en) 2002-12-31
ATE335007T1 (de) 2006-08-15
AU1273695A (en) 1995-07-10
US6008024A (en) 1999-12-28
CA2178212A1 (fr) 1995-06-29
PT737208E (pt) 2006-12-29
EP0737208B1 (fr) 2006-08-02
EP0737208A1 (fr) 1996-10-16
DE69434811D1 (de) 2006-09-14
JP2004045417A (ja) 2004-02-12

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