DK0737208T3 - Monoklonale antistoffer, der er specifikke for PHF-tau, hybridomaer, der secernerer dem, og antigen-genkendelse for disse antistoffer og deres anvendelsesmuligheder - Google Patents

Monoklonale antistoffer, der er specifikke for PHF-tau, hybridomaer, der secernerer dem, og antigen-genkendelse for disse antistoffer og deres anvendelsesmuligheder

Info

Publication number
DK0737208T3
DK0737208T3 DK95903798T DK95903798T DK0737208T3 DK 0737208 T3 DK0737208 T3 DK 0737208T3 DK 95903798 T DK95903798 T DK 95903798T DK 95903798 T DK95903798 T DK 95903798T DK 0737208 T3 DK0737208 T3 DK 0737208T3
Authority
DK
Denmark
Prior art keywords
pro
applications
antigen recognition
thr
peptide
Prior art date
Application number
DK95903798T
Other languages
English (en)
Inventor
De Voorde Andre Van
Marc Vandermeeren
Eugeen Vanmechelen
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Application granted granted Critical
Publication of DK0737208T3 publication Critical patent/DK0737208T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK95903798T 1993-12-21 1994-12-14 Monoklonale antistoffer, der er specifikke for PHF-tau, hybridomaer, der secernerer dem, og antigen-genkendelse for disse antistoffer og deres anvendelsesmuligheder DK0737208T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93403133 1993-12-21

Publications (1)

Publication Number Publication Date
DK0737208T3 true DK0737208T3 (da) 2006-11-27

Family

ID=8214780

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95903798T DK0737208T3 (da) 1993-12-21 1994-12-14 Monoklonale antistoffer, der er specifikke for PHF-tau, hybridomaer, der secernerer dem, og antigen-genkendelse for disse antistoffer og deres anvendelsesmuligheder

Country Status (11)

Country Link
US (4) US6008024A (da)
EP (1) EP0737208B1 (da)
JP (2) JP3992729B2 (da)
AT (1) ATE335007T1 (da)
AU (1) AU698383B2 (da)
CA (1) CA2178212C (da)
DE (1) DE69434811T2 (da)
DK (1) DK0737208T3 (da)
ES (1) ES2270421T3 (da)
PT (1) PT737208E (da)
WO (1) WO1995017429A1 (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3909084B2 (ja) * 1991-10-25 2007-04-25 エヌ・ブイ・インノジェネティクス・ソシエテ・アノニム 微小管結合タンパク質タウに対するモノクローナル抗体
WO1996004309A1 (en) * 1994-07-29 1996-02-15 Innogenetics N.V. Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications
US6797478B1 (en) * 1998-03-05 2004-09-28 University Of Cincinnati Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies
ATE342509T1 (de) * 2000-01-24 2006-11-15 Innogenetics Nv Diagnose von tauopathien durch bestimmung des verhältnisses von tau/phospho-tau
JP4851052B2 (ja) * 2000-06-30 2012-01-11 イノジェネティックス・ナムローゼ・フェンノートシャップ 神経学的疾患の分別診断
DE60141752D1 (de) 2000-06-30 2010-05-20 Innogenetics Nv Differentielle diagnose von neurologischen krankheiten
US20030162230A1 (en) 2000-09-27 2003-08-28 Reagan Kevin J. Method for quantifying phosphokinase activity on proteins
US6919173B2 (en) * 2001-09-10 2005-07-19 Meso Scale Technologies, Llc. Assay buffer, compositions containing the same, and methods of using the same
AU2003257850A1 (en) * 2002-08-14 2004-03-03 Mitsubishi Kagaku Iatron, Inc. ANTIBODY SPECIFIC TO CENTRAL Tau-PROTEIN
JP5179011B2 (ja) * 2002-10-09 2013-04-10 ディーエムアイ バイオサイエンシズ インコーポレイテッド 胎盤虚血および多臓器不全のモニタリング
WO2005080986A1 (en) * 2004-02-18 2005-09-01 University Of Iowa Research Foundation Antibodies to phosphorylated tau, methods of making and methods of use
CA2599731A1 (en) * 2005-03-03 2006-09-08 Dmi Biosciences, Inc. Quantification of proteins
US7368712B2 (en) * 2005-12-06 2008-05-06 International Business Machines Corporation Y-shaped carbon nanotubes as AFM probe for analyzing substrates with angled topography
US20100167948A1 (en) * 2007-05-22 2010-07-01 The Brigham And Women's Hospital, Inc. MicroRNA Expression Profiling of Cerebrospinal Fluid
WO2011053565A2 (en) * 2009-10-29 2011-05-05 Biomedical Sciences Research Centre "Alexander Fleming" Compositions and methods for detecting a tauopathy
PT2556176T (pt) 2010-04-09 2020-05-12 Southwire Co Dispositivo ultrassónico com sistema integrado de entrega de gás
US8652397B2 (en) 2010-04-09 2014-02-18 Southwire Company Ultrasonic device with integrated gas delivery system
EA031698B1 (ru) 2010-10-11 2019-02-28 Байоджен Интернэшнл Нейросайенз Гмбх Человеческие анти-тау антитела
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
WO2012151093A1 (en) * 2011-04-30 2012-11-08 Marv Enterprises Llc Treatment for tauopathies
GB201112056D0 (en) 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
AU2012359039B2 (en) 2011-12-20 2017-08-24 Janssen Biotech, Inc. Anti-PHF-tau antibodies and their uses
BR112015003326A2 (pt) 2012-08-16 2017-07-04 Ipierian Inc métodos de tratamento de uma tauopatia
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
US9598484B2 (en) 2012-12-21 2017-03-21 Biogen Ma Inc. Human anti-tau antibodies
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
US20160355573A1 (en) 2013-09-05 2016-12-08 Cornell University Gene therapy for alzheimer's and other neurodegenerative diseases and conditions
US10400018B2 (en) 2014-02-14 2019-09-03 Ipierian, Inc. Tau peptides, anti-tau antibodies, and methods of use thereof
WO2015165961A1 (en) 2014-04-29 2015-11-05 Affiris Ag Treatment and prevention of alzheimer's disease (ad)
DE102014013571A1 (de) * 2014-09-18 2016-03-24 Aj Roboscreen Gmbh Monoklonaler Antikörper gegen humanes TAU-Protein
MX2017015908A (es) 2015-07-06 2018-03-15 Ucb Biopharma Sprl Anticuerpos de union a tau.
US10233515B1 (en) 2015-08-14 2019-03-19 Southwire Company, Llc Metal treatment station for use with ultrasonic degassing system
JOP20180021A1 (ar) * 2017-03-16 2019-01-30 Janssen Biotech Inc الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها
JP7029718B2 (ja) 2017-07-31 2022-03-04 国立研究開発法人量子科学技術研究開発機構 リン酸化タウタンパク質の測定方法
TW201946654A (zh) * 2018-03-05 2019-12-16 比利時商健生藥品公司 抗ＰＨＦ－Ｔａｕ抗體及其用途
AU2019232630A1 (en) 2018-03-05 2020-09-24 Janssen Pharmaceutica Nv Assays to detect neurodegeneration
WO2019213245A1 (en) * 2018-05-03 2019-11-07 Hough Ear Institute Methods for reducing accumulated pathologic tau protein
WO2020105700A1 (ja) 2018-11-22 2020-05-28 富士レビオ株式会社 抗体コンジュゲート
CN111349617B (zh) * 2020-05-25 2020-09-22 苏州仁端生物医药科技有限公司 一种分泌抗Tau或pTau-181/231/396单克隆抗体杂交瘤细胞株及其应用
CN111349151B (zh) * 2020-05-25 2020-10-02 苏州仁端生物医药科技有限公司 一种磷酸化多肽和截短蛋白的共价偶联方法及其应用
US20240101654A1 (en) 2020-12-29 2024-03-28 Neurimmune Ag Human anti-tau antibodies
CN113005096B (zh) * 2021-01-19 2022-10-14 华中科技大学 分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株
CN114539400B (zh) * 2022-02-15 2024-06-07 武汉天德生物科技有限公司 一种磷酸化Tau pT217蛋白单克隆抗体、ELISA试剂盒及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733734A (en) * 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
JP3909084B2 (ja) * 1991-10-25 2007-04-25 エヌ・ブイ・インノジェネティクス・ソシエテ・アノニム 微小管結合タンパク質タウに対するモノクローナル抗体
EP0911390B1 (en) * 1991-12-06 2009-08-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Protein kinases as tools for the diagnosis and treatment of Alzheimer's disease
EP0544942A1 (en) * 1991-12-06 1993-06-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Novel tools for the diagnosis and treatment of Alzheimer disease

Also Published As

Publication number Publication date
US20030138972A1 (en) 2003-07-24
CA2178212A1 (en) 1995-06-29
AU698383B2 (en) 1998-10-29
ATE335007T1 (de) 2006-08-15
AU1273695A (en) 1995-07-10
WO1995017429A1 (en) 1995-06-29
US6008024A (en) 1999-12-28
JP2004045417A (ja) 2004-02-12
PT737208E (pt) 2006-12-29
ES2270421T3 (es) 2007-04-01
JP3992729B2 (ja) 2007-10-17
JP4110057B2 (ja) 2008-07-02
US20040038430A1 (en) 2004-02-26
EP0737208A1 (en) 1996-10-16
US6500674B1 (en) 2002-12-31
JPH09506771A (ja) 1997-07-08
CA2178212C (en) 2011-06-14
DE69434811D1 (de) 2006-09-14
EP0737208B1 (en) 2006-08-02
DE69434811T2 (de) 2007-03-01

Similar Documents

Publication Publication Date Title
DK0737208T3 (da) Monoklonale antistoffer, der er specifikke for PHF-tau, hybridomaer, der secernerer dem, og antigen-genkendelse for disse antistoffer og deres anvendelsesmuligheder
DK532284A (da) Fremgangsmaade til bestemmelse af antigenaktive aminosyresekvenser
EP0330506A3 (en) Vla proteins
CA2143491A1 (en) A novel peptide related to human programmed cell death and dna encoding it
CA1306961C (en) Production and characterization of hybridoma antibodies directedspecifically against common determinant(s) present among closely related, but distinct proteins
AU564620B2 (en) Peptides and protein-peptide complexes
US7713712B2 (en) Antibodies active against a fusion polypeptide comprising a histidine portion
EP0769696A3 (en) Antibodies and proteins useful for assaying virus infection in grape plants
US6309863B1 (en) Methods for generating phosphorylation site-specific immunological reagents
Sledge et al. Antibody structure: amino terminal sequences of nurse shark light and heavy chains
GB2246780B (en) Immunodiagnostic assay for rheumatoid arthritis
Schluter et al. Conservation among vertebrate immunoglobulin chains detected by antibodies to a synthetic joining segment peptide
DK0418590T3 (da) Antistoffer, fremstilling deraf og anvendelse deraf
Bluestone et al. Anti-idiotypes against anti-H-2 monoclonal antibodies: structural analysis of the molecules induced by in vivo anti-idiotype treatment.
NO910479D0 (no) Syntetiske polypeptider og antistoffer relatert til epstein-barr-virus-kjerneantigen.
Pousette Mouse monoclonal antibodies against ovine prolactin
Park et al. Production and Characteriuation of Monoclonal Antibodies against Human Interferon-$\alpha$
EP0859010A1 (en) Anti-tpo monoclonal antibody
COUSIN et al. Use of Monoclonal Antibodies for Discrimination Between Natural and Recombinant Human Interferon-т
Francotte et al. Monoclonal Antibodies Against Human Growth Hormone Releasing Factor, hGRF (1–44) NH2
Butler et al. Antigenic sites on mouse 2.5 S nerve growth factor
ATE196362T1 (de) Verfahren zur immunologischen identifizierung oder bestimmung von polypeptid-antigenen