DK0715618T3 - Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser - Google Patents
Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaserInfo
- Publication number
- DK0715618T3 DK0715618T3 DK94927162T DK94927162T DK0715618T3 DK 0715618 T3 DK0715618 T3 DK 0715618T3 DK 94927162 T DK94927162 T DK 94927162T DK 94927162 T DK94927162 T DK 94927162T DK 0715618 T3 DK0715618 T3 DK 0715618T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- hydroxyethylaminosulfonamides
- retroviral proteases
- retroviral
- proteases
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/41—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/110,911 US5843946A (en) | 1992-08-25 | 1993-08-24 | α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US08/204,827 US6060476A (en) | 1992-08-25 | 1994-03-02 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
PCT/US1994/009139 WO1995006030A1 (fr) | 1993-08-24 | 1994-08-23 | Hydroxyethylamino-sulfonamides aptes a etre utilises comme inhibiteurs de protease retrovirale |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0715618T3 true DK0715618T3 (da) | 1999-08-23 |
Family
ID=26808496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94927162T DK0715618T3 (da) | 1993-08-24 | 1994-08-23 | Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0715618B1 (fr) |
AT (1) | ATE174587T1 (fr) |
AU (1) | AU7669794A (fr) |
DE (1) | DE69415326T2 (fr) |
DK (1) | DK0715618T3 (fr) |
ES (1) | ES2127938T3 (fr) |
GR (1) | GR3029378T3 (fr) |
WO (1) | WO1995006030A1 (fr) |
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US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
US6878728B1 (en) | 1999-06-11 | 2005-04-12 | Vertex Pharmaceutical Incorporated | Inhibitors of aspartyl protease |
ES2123065T3 (es) | 1992-08-25 | 1999-01-01 | Searle & Co | Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas. |
US7141609B2 (en) | 1992-08-25 | 2006-11-28 | G.D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6861539B1 (en) | 1995-03-10 | 2005-03-01 | G. D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6407134B1 (en) | 1995-03-10 | 2002-06-18 | G. D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6169085B1 (en) | 1995-03-10 | 2001-01-02 | G. D. Searle & Company | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6667307B2 (en) | 1997-12-19 | 2003-12-23 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5985870A (en) * | 1995-03-10 | 1999-11-16 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6150556A (en) * | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
RU2174519C2 (ru) | 1995-03-10 | 2001-10-10 | Джи. Ди. Сирл Энд Ко. | Гидроксиэтиламино сульфонамиды гетероциклокарбонил аминокислоты, ингибирующие ретровирусную протеазу |
US7339078B2 (en) | 1995-03-10 | 2008-03-04 | G.D. Searle Llc | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
EP1188766A1 (fr) | 1995-03-10 | 2002-03-20 | G.D. Searle & Co. | Hydroxyethylamino sulfonamide de bis-aminoacide comme inhibiteurs de proteases de retrovirus |
US6143788A (en) * | 1995-03-10 | 2000-11-07 | G.D. Searle & Co. | Bis-amino acid hydroxyethlamino sulfonamide retroviral protease inhibitors |
US5776971A (en) | 1995-03-10 | 1998-07-07 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
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WO1997018205A1 (fr) * | 1995-11-15 | 1997-05-22 | G.D. Searle & Co. | Inhibiteurs de proteases retrovirales a base de sulfonylalcanoylamino hydroxyethylamino sulfonamides substitues |
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US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
BR9814484A (pt) * | 1997-12-24 | 2000-10-10 | Vertex Pharma | "pró-drogas de inibidores de aspartil protease" |
AU2010299A (en) * | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
DK1086076T3 (da) | 1998-06-19 | 2005-03-29 | Vertex Pharma | Sulfonamidinhibitorer af aspartylprotease |
WO1999067417A2 (fr) | 1998-06-23 | 1999-12-29 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Analyse de potentiel biochimique et methodes associees |
AU2007203321C1 (en) * | 1998-06-23 | 2011-12-08 | The Board Of Trustees Of The University Of Illinois | Method of treating HIV infections |
WO1999067254A2 (fr) * | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Inhibiteurs de protease retrovirale resistant a l'action de plusieurs medicaments et procedes associes |
JP2002536298A (ja) * | 1999-01-13 | 2002-10-29 | デュポン ファーマシューティカルズ カンパニー | Hivプロテアーゼ阻害剤としてn末端置換ベンジル基を含むビス−アミノ酸スルホンアミド |
US6319946B1 (en) | 1999-02-12 | 2001-11-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of aspartyl protease |
AR031520A1 (es) * | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
OA12053A (en) * | 1999-10-06 | 2006-05-02 | Tibotec Pharm Ltd | HexahydrofuroÄ2,3-bÜfuran-3-yl-N-ä3-Ä(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)aminoÜ-1-benzyl-2-hydroxypropylücarbamate as retroviral protease inhibitor. |
EP1244610B1 (fr) * | 1999-12-23 | 2008-07-16 | Ampac Fine Chemicals LLC | Preparation amelioree de 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide chlorydrate et autres derives de diamines 2-hydroxy-1,3 |
US6391919B1 (en) | 2000-01-12 | 2002-05-21 | Bristol-Myers Squibb Pharma Company | Bis-amino acid sulfonamides containing substituted benzyl amines HIV protease inhibitors |
PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
EP1666452A2 (fr) | 2000-06-30 | 2006-06-07 | Elan Pharmaceuticals, Inc. | Composés pour le traitement de la maladie d'Alzheimer |
US6617310B2 (en) | 2000-07-19 | 2003-09-09 | Bristol-Myers Squibb Pharma Company | Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines |
BR0207862A (pt) * | 2001-02-14 | 2004-06-22 | Tibotec Pharm Ltd | Inibidores de protease de hiv 2-(amino-substituìda)-benzotiazol-sulfonamida de amplo espectro |
CZ303139B6 (cs) * | 2001-04-09 | 2012-04-25 | Tibotec Pharmaceuticals Ltd. | 2-(substituovaný amino)-benzoxazolsulfonamidový derivát, farmaceutická kompozice s jeho obsahem a zpusob in vitro inhibice retrovirové replikace |
AR035970A1 (es) * | 2001-05-11 | 2004-07-28 | Tibotec Pharm Ltd | 2-amino-benzoxazol sulfonamidas inhibidoras de amplio espectro de la hiv proteasa, composicion farmaceutica, metodo "in vitro" para inhibir la replicacion retroviral, y utilizacion de estos compuestos en la manufactura de medicamentos |
DE60234952D1 (de) | 2001-09-10 | 2010-02-11 | Tibotec Pharm Ltd | VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROc2,3-BÜFURAN-3-OL |
US6562848B1 (en) | 2001-09-18 | 2003-05-13 | Bristol-Myers Squibb Company | Bis-amino acid sulfonamides as HIV protease inhibitors |
AU2002361235B2 (en) | 2001-12-21 | 2008-07-24 | Tibotec Pharmaceuticals Ltd. | Broadspectrum heterocyclic substituted phenyl containing sulfonamide HIV protease inhibitors |
MY142238A (en) | 2002-03-12 | 2010-11-15 | Tibotec Pharm Ltd | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors |
US7157489B2 (en) * | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
DK2767539T3 (en) * | 2002-05-16 | 2017-09-11 | Janssen Sciences Ireland Uc | Pseudopolymorphic forms of an HIV protease inhibitor |
SI1517899T1 (sl) | 2002-05-17 | 2008-02-29 | Tibotec Pharm Ltd | Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji |
KR20050025647A (ko) * | 2002-08-02 | 2005-03-14 | 티보텍 파마슈티칼즈 리미티드 | 광범위 2-아미노-벤조티아졸 설폰아미드 hiv프로테아제 저해제 |
CN101445493A (zh) * | 2002-08-02 | 2009-06-03 | 泰博特克药品有限公司 | 广谱2-氨基-苯并噻唑磺酰胺类hiv蛋白酶抑制剂 |
WO2004016619A1 (fr) | 2002-08-14 | 2004-02-26 | Tibotec Pharmaceuticals Ltd. | Oxindole sulfonamides substitues inhibiteurs a large spectre de la protease du vih |
AU2003268550A1 (en) | 2002-09-06 | 2004-03-29 | Elan Pharmaceuticals, Inc. | 1, 3-diamino-2-hydroxypropane prodrug derivatives |
GB0228410D0 (en) | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
US20080234288A1 (en) * | 2003-09-30 | 2008-09-25 | Kenneth Alan Simmen | Hcv Inhibiting Sulfonamides |
US20050131042A1 (en) * | 2003-12-11 | 2005-06-16 | Flentge Charles A. | HIV protease inhibiting compounds |
US8193227B2 (en) | 2003-12-11 | 2012-06-05 | Abbott Laboratories | HIV protease inhibiting compounds |
US7772411B2 (en) | 2003-12-23 | 2010-08-10 | Tibotec Pharmaceuticals Ltd. | Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate |
WO2005087728A1 (fr) | 2004-03-11 | 2005-09-22 | Sequoia Pharmaceuticals, Inc. | Inhibiteurs de la protease retrovirale inhibant la resistance |
TWI383975B (zh) | 2004-03-31 | 2013-02-01 | Tibotec Pharm Ltd | 製備(3R,3aS,6aR)六氫-呋喃并〔2,3-b〕呋喃-3-醇之方法 |
SI2089371T1 (sl) | 2006-11-09 | 2011-05-31 | Tibotec Pharm Ltd | Postopki za pripravo heksahidrofuro(2,3-b)furan-3-ola |
AU2008244306A1 (en) | 2007-04-27 | 2008-11-06 | Tibotec Pharmaceuticals Ltd. | Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives |
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US8592487B2 (en) | 2007-10-26 | 2013-11-26 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
TWI482775B (zh) | 2008-09-01 | 2015-05-01 | Tibotec Pharm Ltd | 用於製備(3r,3as,6ar)-六氫呋喃并〔2,3-b〕呋喃-3-基(1s,2r)-3-〔〔(4-胺基苯基)磺醯基〕(異丁基)胺基〕-1-苯甲基-2-羥基丙基胺基甲酸酯之方法 |
CA2750774A1 (fr) | 2009-01-29 | 2010-08-05 | Mapi Pharma Hk Limited | Polymorphes de darunavir |
US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
WO2011061590A1 (fr) | 2009-11-17 | 2011-05-26 | Hetero Research Foundation | Nouveaux dérivés carboxamides comme inhibiteurs du vih |
CN102686594A (zh) | 2009-12-16 | 2012-09-19 | 熙德隆研究基金会 | 地瑞那韦的多晶型物 |
JP2013516397A (ja) | 2010-01-05 | 2013-05-13 | シプラ・リミテッド | ダルナビルの多形及びその製造方法 |
ES2516916T3 (es) | 2010-01-28 | 2014-10-31 | Mapi Pharma Limited | Procedimiento para la preparación de darunavir e intermedios de darunavir |
EP2571355B1 (fr) * | 2010-05-20 | 2016-09-07 | Hetero Research Foundation | Sel de chlorhydrate cristallin de darunavir |
WO2012107889A1 (fr) | 2011-02-10 | 2012-08-16 | Ranbaxy Laboratories Limited | Procédé destiné à la préparation de darunavir amorphe |
AU2012280277B2 (en) | 2011-07-07 | 2017-02-09 | Janssen Sciences Ireland Uc | Darunavir formulations |
ES2651212T3 (es) | 2011-07-07 | 2018-01-25 | Janssen Sciences Ireland Uc | Formulaciones combinadas de darunavir |
CN104478830B (zh) * | 2014-12-31 | 2016-06-22 | 中国医学科学院医药生物技术研究所 | 一组叔胺类拟肽衍生物及其在抑制hiv-1蛋白酶中的应用 |
EP3303343A1 (fr) | 2015-06-05 | 2018-04-11 | Amneal Pharmaceuticals Company GmbH | Procédé pour la préparation de darunavir |
ES2881949T3 (es) | 2016-10-27 | 2021-11-30 | Gilead Sciences Inc | Forma cristalina de base libre de darunavir |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3635907A1 (de) * | 1986-10-22 | 1988-04-28 | Merck Patent Gmbh | Hydroxy-aminosaeurederivate |
TW225540B (fr) * | 1990-06-28 | 1994-06-21 | Shionogi & Co | |
ES2123065T3 (es) * | 1992-08-25 | 1999-01-01 | Searle & Co | Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas. |
-
1994
- 1994-08-23 DE DE69415326T patent/DE69415326T2/de not_active Expired - Lifetime
- 1994-08-23 AT AT94927162T patent/ATE174587T1/de active
- 1994-08-23 DK DK94927162T patent/DK0715618T3/da active
- 1994-08-23 WO PCT/US1994/009139 patent/WO1995006030A1/fr active IP Right Grant
- 1994-08-23 AU AU76697/94A patent/AU7669794A/en not_active Abandoned
- 1994-08-23 EP EP94927162A patent/EP0715618B1/fr not_active Expired - Lifetime
- 1994-08-23 ES ES94927162T patent/ES2127938T3/es not_active Expired - Lifetime
-
1999
- 1999-02-12 GR GR990400462T patent/GR3029378T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2127938T3 (es) | 1999-05-01 |
EP0715618B1 (fr) | 1998-12-16 |
AU7669794A (en) | 1995-03-21 |
DE69415326D1 (de) | 1999-01-28 |
DE69415326T2 (de) | 1999-06-02 |
GR3029378T3 (en) | 1999-05-28 |
WO1995006030A1 (fr) | 1995-03-02 |
EP0715618A1 (fr) | 1996-06-12 |
ATE174587T1 (de) | 1999-01-15 |
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