DK0707591T3 - Methylphosphonsyreestere, fremgangsmåde til deres fremstilling samt deres anvendelse - Google Patents
Methylphosphonsyreestere, fremgangsmåde til deres fremstilling samt deres anvendelseInfo
- Publication number
- DK0707591T3 DK0707591T3 DK94919670T DK94919670T DK0707591T3 DK 0707591 T3 DK0707591 T3 DK 0707591T3 DK 94919670 T DK94919670 T DK 94919670T DK 94919670 T DK94919670 T DK 94919670T DK 0707591 T3 DK0707591 T3 DK 0707591T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- acid esters
- pct
- phosphonic acid
- methyl phosphonic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4321946A DE4321946A1 (de) | 1993-07-01 | 1993-07-01 | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| PCT/EP1994/002121 WO1995001363A1 (de) | 1993-07-01 | 1994-06-29 | Methylphosphonsäureester, verfahren zu deren herstellung und deren verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0707591T3 true DK0707591T3 (da) | 2002-01-21 |
Family
ID=6491730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94919670T DK0707591T3 (da) | 1993-07-01 | 1994-06-29 | Methylphosphonsyreestere, fremgangsmåde til deres fremstilling samt deres anvendelse |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6028182A (ja) |
| EP (1) | EP0707591B1 (ja) |
| JP (1) | JP3831407B2 (ja) |
| AT (1) | ATE206130T1 (ja) |
| AU (1) | AU698928B2 (ja) |
| CA (1) | CA2165971C (ja) |
| DE (2) | DE4321946A1 (ja) |
| DK (1) | DK0707591T3 (ja) |
| ES (1) | ES2165391T3 (ja) |
| FI (1) | FI115399B (ja) |
| NO (1) | NO319860B1 (ja) |
| PT (1) | PT707591E (ja) |
| WO (1) | WO1995001363A1 (ja) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458772B1 (en) | 1909-10-07 | 2002-10-01 | Medivir Ab | Prodrugs |
| DE4331670A1 (de) * | 1993-09-17 | 1995-03-23 | Hoechst Ag | Neue Antisense-Oligonucleotide gegen HSV-1 sowie deren Herstellung |
| DE4338704A1 (de) | 1993-11-12 | 1995-05-18 | Hoechst Ag | Stabilisierte Oligonucleotide und deren Verwendung |
| DE19502912A1 (de) * | 1995-01-31 | 1996-08-01 | Hoechst Ag | G-Cap Stabilisierte Oligonucleotide |
| PT739898E (pt) * | 1995-03-13 | 2002-03-28 | Aventis Pharma Gmbh | Mono-esteres de acidos fosfonucleicos processo para a sua preparacao e sua utilizacao |
| US5821354A (en) * | 1996-11-26 | 1998-10-13 | Angiogene Inc. | Radiolabeled DNA oligonucleotide and method of preparation |
| US6248878B1 (en) | 1996-12-24 | 2001-06-19 | Ribozyme Pharmaceuticals, Inc. | Nucleoside analogs |
| EP0948511B1 (en) * | 1996-12-24 | 2006-10-18 | Sirna Therapeutics, Inc. | Chemical synthesis of nucleosides analogs and their incorporation into polynucleotides |
| NZ513935A (en) | 1999-02-17 | 2004-02-27 | Csl Ltd | Immunogenic complexes and methods relating thereto |
| DE19935303A1 (de) | 1999-07-28 | 2001-02-08 | Aventis Pharma Gmbh | Oligonukleotide zur Inhibierung der Expression von humanem eg5 |
| US20020119178A1 (en) * | 2001-02-23 | 2002-08-29 | Luc Levesque | Drug eluting device for treating vascular diseases |
| GB0110732D0 (en) * | 2001-05-02 | 2001-06-27 | Psl Technology Ltd | Apparatus and method |
| AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| EP2241325B1 (en) | 2002-10-29 | 2012-02-08 | Coley Pharmaceutical Group, Inc. | Use of CPG oligonucleotides in the treatment of hepatitis C virus infection |
| CA2555390C (en) | 2004-02-19 | 2014-08-05 | Coley Pharmaceutical Group, Inc. | Immunostimulatory viral rna oligonucleotides |
| KR20100018029A (ko) | 2004-07-18 | 2010-02-16 | 씨에스엘 리미티드 | 면역자극 복합체 및 향상된 인터페론-감마 반응을 유도하기 위한 올리고뉴클레오티드 제제 |
| CA2642152C (en) | 2006-02-15 | 2016-11-01 | Coley Pharmaceutical Gmbh | Compositions and methods for oligonucleotide formulations |
| PT2078080E (pt) | 2006-09-27 | 2015-09-18 | Coley Pharm Gmbh | Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada |
| RU2009142211A (ru) * | 2007-05-17 | 2011-05-27 | Коли Фармасьютикал Груп, Инк. (Us) | Класс олигонуклеотидов с иммуностимулирующей активностью |
| CN101820908A (zh) | 2007-10-09 | 2010-09-01 | 科利制药公司 | 包含改性糖部分的免疫刺激寡核苷酸类似物 |
| DK2306986T3 (en) | 2008-06-26 | 2018-06-18 | Prolynx Llc | PRODRUGS AND PHARMACEUTICAL Macromolecule Conjugates with Controlled Drug Release Rates |
| JP5209800B2 (ja) | 2008-12-09 | 2013-06-12 | ファイザー バクシーンズ エルエルシー | ＩｇＥＣＨ３ペプチドワクチン |
| AU2009325926B2 (en) | 2008-12-09 | 2013-05-16 | Coley Pharmaceutical Group, Inc. | Immunostimulatory oligonucleotides |
| CA2768346A1 (en) | 2009-07-30 | 2011-02-03 | Pfizer Vaccines Llc | Antigenic tau peptides and uses thereof |
| PT2575878T (pt) | 2010-05-28 | 2018-10-03 | Zoetis Belgium S A | Vacinas compreendendo colesterol e cpg como moléculas únicas adjuvante-portador |
| WO2011154878A1 (en) | 2010-06-07 | 2011-12-15 | Pfizer Vaccines Llc | Ige ch3 peptide vaccine |
| SG11201406592QA (en) | 2012-05-04 | 2014-11-27 | Pfizer | Prostate-associated antigens and vaccine-based immunotherapy regimens |
| JP6885867B2 (ja) | 2014-12-31 | 2021-06-16 | チェックメイト ファーマシューティカルズ， インコーポレイテッド | 組合せ腫瘍免疫療法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993010140A1 (en) * | 1991-11-21 | 1993-05-27 | Pharmagenics, Inc. | Oligonucleotides having modified anionic moieties |
-
1993
- 1993-07-01 DE DE4321946A patent/DE4321946A1/de not_active Withdrawn
-
1994
- 1994-06-29 CA CA002165971A patent/CA2165971C/en not_active Expired - Fee Related
- 1994-06-29 AT AT94919670T patent/ATE206130T1/de not_active IP Right Cessation
- 1994-06-29 US US08/578,686 patent/US6028182A/en not_active Expired - Fee Related
- 1994-06-29 DE DE59409880T patent/DE59409880D1/de not_active Expired - Fee Related
- 1994-06-29 DK DK94919670T patent/DK0707591T3/da active
- 1994-06-29 EP EP94919670A patent/EP0707591B1/de not_active Expired - Lifetime
- 1994-06-29 JP JP50326995A patent/JP3831407B2/ja not_active Expired - Fee Related
- 1994-06-29 ES ES94919670T patent/ES2165391T3/es not_active Expired - Lifetime
- 1994-06-29 WO PCT/EP1994/002121 patent/WO1995001363A1/de active IP Right Grant
- 1994-06-29 PT PT94919670T patent/PT707591E/pt unknown
- 1994-06-29 AU AU70735/94A patent/AU698928B2/en not_active Ceased
-
1995
- 1995-12-29 NO NO19955352A patent/NO319860B1/no unknown
- 1995-12-29 FI FI956341A patent/FI115399B/fi active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995001363A1 (de) | 1995-01-12 |
| ATE206130T1 (de) | 2001-10-15 |
| DE59409880D1 (de) | 2001-10-31 |
| JPH08512039A (ja) | 1996-12-17 |
| DE4321946A1 (de) | 1995-01-12 |
| EP0707591A1 (de) | 1996-04-24 |
| FI956341A (fi) | 1996-02-19 |
| NO955352L (no) | 1996-02-14 |
| NO955352D0 (no) | 1995-12-29 |
| CA2165971C (en) | 2006-05-30 |
| AU7073594A (en) | 1995-01-24 |
| AU698928B2 (en) | 1998-11-12 |
| FI115399B (fi) | 2005-04-29 |
| FI956341A0 (fi) | 1995-12-29 |
| ES2165391T3 (es) | 2002-03-16 |
| EP0707591B1 (de) | 2001-09-26 |
| JP3831407B2 (ja) | 2006-10-11 |
| CA2165971A1 (en) | 1995-01-12 |
| US6028182A (en) | 2000-02-22 |
| NO319860B1 (no) | 2005-09-26 |
| PT707591E (pt) | 2002-03-28 |
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