DK0698012T3 - - Google Patents
Info
- Publication number
- DK0698012T3 DK0698012T3 DK94916021.2T DK94916021T DK0698012T3 DK 0698012 T3 DK0698012 T3 DK 0698012T3 DK 94916021 T DK94916021 T DK 94916021T DK 0698012 T3 DK0698012 T3 DK 0698012T3
- Authority
- DK
- Denmark
- Prior art keywords
- novel
- alkyl
- deoxygalactonojirimycin
- useful
- carbon atoms
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/131—Amines acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/061,645 US5399567A (en) | 1993-05-13 | 1993-05-13 | Method of treating cholera |
US08/102,654 US6291657B1 (en) | 1993-05-13 | 1993-08-05 | Deoxygalactonojirimycin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0698012T3 true DK0698012T3 (de) | 1997-02-17 |
Family
ID=26741316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94916021.2T DK0698012T3 (de) | 1993-05-13 | 1994-05-11 |
Country Status (11)
Country | Link |
---|---|
US (3) | US6291657B1 (de) |
EP (1) | EP0698012B1 (de) |
JP (1) | JP3636363B2 (de) |
AT (1) | ATE148456T1 (de) |
AU (1) | AU6783294A (de) |
CA (1) | CA2159988C (de) |
DE (1) | DE69401658T2 (de) |
DK (1) | DK0698012T3 (de) |
ES (1) | ES2097653T3 (de) |
GR (1) | GR3022554T3 (de) |
WO (1) | WO1994026714A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5798366A (en) * | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
AU1734600A (en) * | 1998-11-17 | 2000-06-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Identification of glycosphingolipids that promote hiv-1 entry into cells |
US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
US20050032841A1 (en) * | 1999-04-20 | 2005-02-10 | Steven Walkley | Therapeutic compositions and methods of treating glycolipid storage related disorders |
GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
WO2001007078A1 (en) | 1999-07-26 | 2001-02-01 | G.D. Searle & Co. | Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of medicament for the treatment of glycolipid storage diseases |
US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
DE60037664T2 (de) * | 1999-08-10 | 2008-12-24 | The Chancellor, Masters And Scholars Of The University Of Oxford | Langkettige n-alkyl verbindungen und deren oxa-derivate zur verwendung als anitvirale mittel |
ES2393331T3 (es) | 2002-07-17 | 2012-12-20 | Actelion Pharmaceuticals Ltd. | Derivados de piperidintriol como inhibidores de la glucosiliceramida sintasa |
AU2003248960B2 (en) | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase |
GB0229476D0 (en) * | 2002-12-17 | 2003-01-22 | Oxford Glycosciences Uk Ltd | Novel process |
PT2444102E (pt) | 2003-01-31 | 2015-09-17 | Sinai School Medicine | Terapia combinada para o tratamento de distúrbios de deficiência proteica |
GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
WO2005046612A2 (en) * | 2003-11-12 | 2005-05-26 | Amicus Therapeutics Inc. | Hydroxy piperidine derivatives to treat gaucher disease |
US20050256168A1 (en) * | 2004-04-28 | 2005-11-17 | Block Timothy M | Compositions for oral administration for the treatment of interferon-responsive disorders |
WO2005123055A2 (en) * | 2004-06-14 | 2005-12-29 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
MX2007014470A (es) | 2005-05-17 | 2008-02-06 | Amicus Therapeutics Inc | Metodo para el tratamiento de enfermedad de pompe usando derivados de 1-desoxinojirimicina. |
GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
EP2049126A2 (de) | 2006-08-02 | 2009-04-22 | United Therapeutics Corporation | Liposomen-behandlung von virusinfektionen |
WO2009118658A2 (en) * | 2008-03-26 | 2009-10-01 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
WO2010109330A2 (en) * | 2009-03-27 | 2010-09-30 | University Of Oxford | Cholesterol level lowering liposomes |
EP2411526A4 (de) * | 2009-03-27 | 2012-09-19 | Zacharon Pharmaceuticals Inc | Modulatoren der gangliosidenbiosynthese |
JP5861194B2 (ja) | 2010-12-23 | 2016-02-16 | アレクトス・セラピューティクス・インコーポレイテッド | 選択的グルコシダーゼインヒビターおよびその使用 |
US9718854B2 (en) | 2011-03-31 | 2017-08-01 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
US9701693B2 (en) | 2011-06-27 | 2017-07-11 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
EP2890678A4 (de) * | 2012-08-31 | 2016-01-27 | Alectos Therapeutics Inc | Glycosidasehemmer und verwendungen davon |
US9670195B2 (en) | 2012-08-31 | 2017-06-06 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
US9809537B2 (en) | 2012-08-31 | 2017-11-07 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
WO2014067003A1 (en) | 2012-10-31 | 2014-05-08 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
AU2014205378B2 (en) * | 2013-01-09 | 2018-08-30 | Amicus Therapeutics, Inc. | Stable parenteral DNJ compositions |
UA125938C2 (uk) | 2017-06-01 | 2022-07-13 | Ідорсія Фармасьютікалз Лтд | Кристалічна форма n-бутилдеоксигалактоноджириміцину |
EP4034256A1 (de) | 2019-09-25 | 2022-08-03 | Teva Pharmaceuticals International GmbH | Festkörperformen von lucarastatsalzen und herstellungsverfahren dafür |
US11623916B2 (en) | 2020-12-16 | 2023-04-11 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade migalastat and methods of producing the same |
WO2022132992A1 (en) | 2020-12-16 | 2022-06-23 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade 1-deoxygalactonojirimycin compounds |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1555654A (en) | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
US4065562A (en) | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
GB2020278B (en) | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
DE3650377T2 (de) | 1985-12-23 | 1996-02-22 | Hutchinson Fred Cancer Res | Regulierung der retroviralen replikation, infektion und pathogenese. |
US4849430A (en) | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
US5011829A (en) * | 1989-06-02 | 1991-04-30 | G. D. Searle & Co. | Pharmaceutical composition and method of inhibiting virus |
US5030638A (en) | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
EP0536402A4 (en) | 1990-06-29 | 1993-05-12 | Nippon Shinyaku Company, Limited | Piperidine derivative |
US5128347A (en) * | 1990-10-18 | 1992-07-07 | Monsanto Company | Glycosidase inhibiting 1,4-dideoxy-4-fluoronojirimycin |
-
1993
- 1993-08-05 US US08/102,654 patent/US6291657B1/en not_active Expired - Lifetime
-
1994
- 1994-05-11 DE DE69401658T patent/DE69401658T2/de not_active Expired - Fee Related
- 1994-05-11 WO PCT/US1994/004974 patent/WO1994026714A1/en active IP Right Grant
- 1994-05-11 EP EP94916021A patent/EP0698012B1/de not_active Expired - Lifetime
- 1994-05-11 JP JP52554194A patent/JP3636363B2/ja not_active Expired - Fee Related
- 1994-05-11 CA CA002159988A patent/CA2159988C/en not_active Expired - Fee Related
- 1994-05-11 ES ES94916021T patent/ES2097653T3/es not_active Expired - Lifetime
- 1994-05-11 AU AU67832/94A patent/AU6783294A/en not_active Abandoned
- 1994-05-11 DK DK94916021.2T patent/DK0698012T3/da active
- 1994-05-11 AT AT94916021T patent/ATE148456T1/de not_active IP Right Cessation
-
1995
- 1995-03-01 US US08/396,989 patent/US5580884A/en not_active Expired - Lifetime
-
1996
- 1996-01-17 US US08/588,027 patent/US5786368A/en not_active Expired - Fee Related
-
1997
- 1997-02-12 GR GR970400244T patent/GR3022554T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2159988A1 (en) | 1994-11-24 |
JPH08510244A (ja) | 1996-10-29 |
EP0698012A1 (de) | 1996-02-28 |
ATE148456T1 (de) | 1997-02-15 |
DE69401658D1 (de) | 1997-03-13 |
WO1994026714A1 (en) | 1994-11-24 |
US5580884A (en) | 1996-12-03 |
DE69401658T2 (de) | 1997-06-12 |
ES2097653T3 (es) | 1997-04-01 |
US6291657B1 (en) | 2001-09-18 |
GR3022554T3 (en) | 1997-05-31 |
EP0698012B1 (de) | 1997-01-29 |
JP3636363B2 (ja) | 2005-04-06 |
CA2159988C (en) | 2007-01-09 |
AU6783294A (en) | 1994-12-12 |
US5786368A (en) | 1998-07-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0698012T3 (de) | ||
ZA955466B (en) | Stereochemical wortmannin derivatives | |
ZA976705B (en) | Process for the synthesis of protected esters of (S)-3,4-dihydroxybutric acid. | |
GB2301106B (en) | Synergistic stabilizer mixture | |
HU9302335D0 (en) | 9-|(substituted glycyl)-amido¨-6-desmethyl-6-desoxy-tetracyclines | |
EP0477531A3 (en) | Process for inhibiting and destroying peroxides in dialkyl ethers | |
HK1019878A1 (en) | Total synthesis of antitumor acylfulvenes. | |
HU9503370D0 (en) | N-alkylthio polyamine derivatives as radioprotective agents | |
ZA858169B (en) | New adamantanamine derivatives,processes for their preparation and drugs in which they are present | |
HU9500559D0 (en) | New mercapto-acetamide tricyclic derivatives as enkephalinase-inhibitors | |
MX9801190A (es) | Inhibidores de prolil endopeptidasa. | |
UA66866C2 (uk) | Синтез морфолінових похідних | |
AP9400632A0 (en) | Ether derivatives. | |
IL128951A0 (en) | Tricyclic compounds useful for inhibition of farnesyl protein transferase | |
GR1002598B (el) | Παραγωγα επι-επιβατιδινης. | |
HU906010D0 (en) | New substituted alkyl-piperidine derivatives | |
FI951588A (fi) | Öljykoostumuksia | |
ZA9811380B (de) | ||
YU71400A (sh) | Poboljšani postupak za pripremanje farmaceutski dragocenih derivata norbenzomorfana | |
ES2023760A6 (es) | Procedimiento para la preparacion de derivados benzotiazinicos. | |
MX9801130A (es) | Tiamacrolidos. | |
IL138373A0 (en) | New compounds | |
AU6663596A (en) | One pot synthesis of 2-oxazolidinone derivatives | |
GR3029453T3 (en) | NOVEL PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PLATELET CLYCOPROTEIN IIb/IIIa INHIBITORS | |
TW333554B (en) | Benzidine derivative and electrophotosensitive material using the same |