DK0663825T3 - Anvendelse af melatonin i orale doser til fremkaldelse af søvn - Google Patents

Anvendelse af melatonin i orale doser til fremkaldelse af søvn

Info

Publication number
DK0663825T3
DK0663825T3 DK93923164T DK93923164T DK0663825T3 DK 0663825 T3 DK0663825 T3 DK 0663825T3 DK 93923164 T DK93923164 T DK 93923164T DK 93923164 T DK93923164 T DK 93923164T DK 0663825 T3 DK0663825 T3 DK 0663825T3
Authority
DK
Denmark
Prior art keywords
melatonin
oral doses
induce sleep
sleep
individual
Prior art date
Application number
DK93923164T
Other languages
Danish (da)
English (en)
Inventor
Richard J Wurtman
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of DK0663825T3 publication Critical patent/DK0663825T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DK93923164T 1992-10-01 1993-09-29 Anvendelse af melatonin i orale doser til fremkaldelse af søvn DK0663825T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95530492A 1992-10-01 1992-10-01
US08/093,317 US5449683A (en) 1992-10-01 1993-07-16 Methods of inducing sleep using melatonin
PCT/US1993/009273 WO1994007487A1 (en) 1992-10-01 1993-09-29 Use of melatonin to induce sleep

Publications (1)

Publication Number Publication Date
DK0663825T3 true DK0663825T3 (da) 1999-05-25

Family

ID=26787395

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93923164T DK0663825T3 (da) 1992-10-01 1993-09-29 Anvendelse af melatonin i orale doser til fremkaldelse af søvn

Country Status (9)

Country Link
US (2) US5449683A (de)
EP (1) EP0663825B1 (de)
JP (1) JP3133760B2 (de)
AT (1) ATE169816T1 (de)
CA (1) CA2146151C (de)
DE (1) DE69320485T2 (de)
DK (1) DK0663825T3 (de)
ES (1) ES2123064T3 (de)
WO (1) WO1994007487A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242941A (en) * 1990-12-04 1993-09-07 State Of Oregon Methods of treating circadian rhythm disorders
US6638963B1 (en) 1990-12-04 2003-10-28 Oregon Health And Science University Methods for treating circadian rhythm disorders
US5449683A (en) * 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin
US6180657B1 (en) * 1993-11-18 2001-01-30 Eli Lilly And Company Melatonin derivatives for use in treating desynchronization disorders
US5654325A (en) * 1993-11-18 1997-08-05 Eli Lilly And Company Melatonin derivatives for use in treating sleep disorders
US5541228A (en) * 1994-10-14 1996-07-30 Bristol-Myers Squibb Co. Melatonergic agents
DE4443175A1 (de) * 1994-12-05 1996-06-13 Jenapharm Gmbh Neue pulsatile Arzneiform
US5530012A (en) 1994-12-22 1996-06-25 Bristol-Myers Squibb Co. 3-alkoxybenzylpiperidine derivatives as melatonergic agents
US6469044B1 (en) 1995-02-01 2002-10-22 Neurim Pharmaceuticals (1991) Ltd. Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies
US5661186A (en) * 1995-02-24 1997-08-26 Bristol-Myers Squibb Co. Tetralinyl-and indanyl-ethylamides
AU4569496A (en) * 1995-02-24 1996-09-05 Bristol-Myers Squibb Company Tetralinyl- and indanyl-ethylamides
US5736578A (en) * 1995-06-06 1998-04-07 Bristol-Myers Squibb Company Ethylamido fluorenes and improved method of making same
US5753709A (en) * 1995-06-07 1998-05-19 Bristol-Myers Squibb Company N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
US5596019A (en) * 1995-06-07 1997-01-21 Bristol-Myers Squibb Company N-acyl-cycloalkylamine derivatives as melatonergics
AU6241796A (en) * 1995-06-27 1997-01-30 Takeda Chemical Industries Ltd. 4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists
CA2186412A1 (en) 1995-10-31 1997-05-01 Katherine S. Takaki Ethylamino carbazole melatonergic agents
DE19713141A1 (de) * 1996-03-29 1997-10-30 Labtec Gmbh Transdermales System mit Melatonin
US5808151A (en) * 1996-04-17 1998-09-15 Bristol-Myers Squibb Company Biphenylamido derivatives as melatonergic agents
NZ335910A (en) * 1996-12-10 2000-11-24 Bristol Myers Squibb Co Benzodioxole, benzofuran, dihydrobenzofuran and benzodioxane melatonergic agents useful in treating sleep disorders and circadian rhthym related disorders
WO1998038991A1 (en) * 1997-03-05 1998-09-11 Bristol-Myers Squibb Company Polycyclic ethyl alkylamide melatonergic agents
AU750361B2 (en) * 1997-03-26 2002-07-18 Franciscus W.H.M. Merkus Nasal melatonin composition
EP0867181A1 (de) * 1997-03-26 1998-09-30 Franciscus Wilhelmus Henricus Maria Merkus Melatoninhaltiges Nasalpräparat
FR2762993B1 (fr) * 1997-05-06 1999-08-13 Inst Rech Biolog Sa Nouvelle utilisation de phospholipides d'origine animale en therapeutique et/ou dietetique
US6028112A (en) * 1997-05-23 2000-02-22 Bristol-Myers Squibb Company Spirocyclopropyl fluorenes as melatonergic agents
AU2333099A (en) * 1998-03-20 1999-10-18 Bristol-Myers Squibb Company Aryloxyanilides and related compounds
JP2002516859A (ja) 1998-06-05 2002-06-11 ブリストルーマイヤーズ スクイブ カンパニー メラトニン作動性薬剤であるヘテロ環シスシクロプロパン誘導体
ATE257834T1 (de) 1999-06-30 2004-01-15 Bristol Myers Squibb Co Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffe
CA2357114C (en) * 2001-03-22 2010-06-29 Pooger Properties Ltd. Use of melatonin in the manufacture of a medicament for treating attention deficit hyperactive disorder
IL144900A (en) * 2001-08-14 2013-12-31 Neurim Pharma 1991 Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
US6569894B1 (en) 2001-10-04 2003-05-27 Bristol-Myers Squibb Company Arylalkylbenzofuran derivatives as melatonergic agents
US6737431B2 (en) 2002-03-12 2004-05-18 Bristol-Myers Squibb Company Benzoxazole derivatives as novel melatonergic agents
ES2287512T3 (es) * 2002-09-26 2007-12-16 Pooger Properties Limited Utilizacion combinada de metilfenidato y melatonina para el tratamiento de la enfermedad de hiperactividad con deficit de atencion.
US6703412B1 (en) * 2002-09-27 2004-03-09 Holly A. Rosenthal Method of treating sleeplessness with melatonin on an acute basis
US9119846B2 (en) 2003-04-29 2015-09-01 Neurim Pharmaceuticals (1991) Ltd. Method and composition for enhancing cognition in alzheimer's patients
IL155666A (en) * 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
WO2005094849A1 (ja) * 2004-03-31 2005-10-13 Calpis Co., Ltd. 内因性メラトニン分泌リズム改善用機能性食品、及び概日リズム改善用機能性食品
ATE477809T1 (de) * 2004-04-06 2010-09-15 Taiyokagaku Co Ltd Verwendung einer kombination von theanin und serotonin gegen schlafstörung
US7364583B2 (en) 2004-04-23 2008-04-29 Physician Engineered Products Inc. Head mounted photoeffective device
US7546165B2 (en) * 2005-12-19 2009-06-09 Cardiac Pacemakers, Inc. Interconnections of implantable lead conductors and electrodes and reinforcement therefor
WO2007095716A1 (en) 2006-02-23 2007-08-30 Iomedix Sleep International Srl Compositions and methods for the induction and maintenance of quality sleep
US20080171085A1 (en) * 2007-01-11 2008-07-17 Natrol, Inc. Novel biphasic delivery system for a pharmaceutical or nutraceutical composition and method of administration
WO2008122102A1 (en) * 2007-04-05 2008-10-16 Iomedix Development International Srl Melatonin-based composition for improved sleep
US20080248106A1 (en) 2007-04-05 2008-10-09 Marvin Heuer Melatonin-based composition for improved sleep
US20100256197A1 (en) * 2009-04-02 2010-10-07 Silver Eagle Labs Nv, Llc Nicotine Dissolving Film With Or Without Menthol
US20100256215A1 (en) * 2009-04-02 2010-10-07 Silver Eagle Labs Nv, Llc Menthol-Melatonin Dissolving Film
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
US8691275B2 (en) 2011-01-28 2014-04-08 Zx Pharma, Llc Controlled-release melatonin compositions and related methods
US10369310B2 (en) * 2014-03-05 2019-08-06 ResMed Pty Ltd Method and apparatus for treatment of respiratory disorders
US10849856B2 (en) 2016-10-31 2020-12-01 Neurim Pharmaceuticals Ltd. Melatonin mini-tablets and method of manufacturing the same
RS61024B1 (sr) 2016-10-31 2020-12-31 Neurim Pharma 1991 Mini-tablete melatonina i postupak za njihovu proizvodnju
IT201900002913A1 (it) 2019-03-01 2020-09-01 Nicola Pescosolido Composto utile per il trattamento del glaucoma
US11833182B2 (en) 2021-08-10 2023-12-05 Shaklee Corporation Sleep product

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5557563A (en) * 1978-10-21 1980-04-28 Hoechst Ag Melatonine nasal application composition
US4600723A (en) * 1983-05-18 1986-07-15 Monash University Method for minimizing disturbances in circadian rhythms of bodily performance and function
EP0126630B1 (de) * 1983-05-18 1987-09-16 Monash University Verwendung von Melatonin zur Herstellung eines Arzneimittels
JPS6045513A (ja) * 1983-05-18 1985-03-12 モナシユ　ユニバ−シテイ 身体行動および機能の日周期の不調を軽減する薬剤
US4687763A (en) * 1985-02-25 1987-08-18 Massachusetts Institute Of Technology Composition and method for increasing levels or release of brain serotonin
JPH0418034A (ja) * 1990-05-11 1992-01-22 Kanegafuchi Chem Ind Co Ltd 点眼組成物
JPH0474135A (ja) * 1990-07-13 1992-03-09 Kanegafuchi Chem Ind Co Ltd 点眼組成物
IT1243193B (it) * 1990-08-10 1994-05-24 Medea Res Srl Composizioni farmaceutiche orali a base di melatonina
US5242941A (en) * 1990-12-04 1993-09-07 State Of Oregon Methods of treating circadian rhythm disorders
IT1251544B (it) * 1991-05-13 1995-05-17 Gabriele Biella Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico
AU660336B2 (en) * 1991-10-18 1995-06-22 Alza Corporation Device for the transdermal administration of melatonin
IT1254995B (it) * 1992-06-24 1995-10-11 Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
US5449683A (en) * 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin

Also Published As

Publication number Publication date
JPH08502259A (ja) 1996-03-12
DE69320485T2 (de) 1999-04-01
DE69320485D1 (de) 1998-09-24
US5449683A (en) 1995-09-12
ATE169816T1 (de) 1998-09-15
US5641801A (en) 1997-06-24
CA2146151C (en) 1997-09-02
JP3133760B2 (ja) 2001-02-13
EP0663825B1 (de) 1998-08-19
EP0663825A1 (de) 1995-07-26
ES2123064T3 (es) 1999-01-01
WO1994007487A1 (en) 1994-04-14

Similar Documents

Publication Publication Date Title
DK0663825T3 (da) Anvendelse af melatonin i orale doser til fremkaldelse af søvn
DE69735581D1 (de) Dosierungsform für eine verzögerte und zunehmende wirkstoffsfreisetzung
NO934487D0 (no) Doseringsanordning med forsinket medikamentavgivelse
NO952469D0 (no) Terapautisk kombinasjon som inneholder interferon
NO20061094L (no) Antistoff samt anvendelse derav til fremstilling av medikamenter til behandling av B-celle-lymfom
SE7701662L (sv) Patientstol, serskilt tandlekarstol
DK0562041T3 (da) Undermættet transdermal lægemiddeludleveringsanordning, der udviser forøget lægemiddelflux
DK0494972T3 (da) Brusedosisform samt fremgangsmåde til administration heraf
DK162986D0 (da) Terapeutisk middel i enhedsdosisform
DK0713701T3 (da) 2-Brommelatonin til behandling af søvnforstyrrelser
DE68910159D1 (de) Dosierform für Verabreichung in der Humanmedizin.
YU49026B (sh) UPOTREBA 17 Гџ -(N-TERC-BUTILKARBAMOIL)-4-AZA-5-ALFA-ANDROST-1-3-ON ZA PROIZVODNJU LEKA ZA TRETIRANJE ANDROGENE ALOPECIJE
DK1365808T3 (da) Sammensætninger til antitumorbehandling indeholdende ecteinascidin 743
FI851686A0 (fi) Redskap foer anvaendning vid behandling av osteoporosis.
SE9701161D0 (sv) New use I
SE429402B (sv) Patientstol for tandbehandlingsendamal
KR900009029A (ko) 가축병 치료용 약물을 투여하는 장치
EA199800770A1 (ru) Лекарственный препарат для терапевтического лечения вирусного гепатита
SE7901863L (sv) Medicinsk behandlingsstol, isynnerhet tandlekarstol
ES2051788T3 (es) Un producto farmaceutico.
ES2096081T3 (es) Utilizacion de interleuquina 10 para la preparacion de medicamentos con una actividad inhibidora de tumores.
PL203416A1 (pl) Pulpit jednostanowiskowy do pracy,zabaw i posilkow dla dzieci w okresie rehabilitacji leczniczej
IT8011954V0 (it) Manipolo per apparecchi terapeutici e di trattamenti estetici
NO920306L (no) Nye indolonaftyridiner med terapeutisk virkning
ITRM920486A1 (it) Dispositivo per pulire i denti dalla placca in formazione.