DE69320485T2 - VERWENDUNG VON MELATONIN in niedrigen oralen Dosen ZUM HERBEIFÜHREN VON SCHLAF - Google Patents

VERWENDUNG VON MELATONIN in niedrigen oralen Dosen ZUM HERBEIFÜHREN VON SCHLAF

Info

Publication number
DE69320485T2
DE69320485T2 DE69320485T DE69320485T DE69320485T2 DE 69320485 T2 DE69320485 T2 DE 69320485T2 DE 69320485 T DE69320485 T DE 69320485T DE 69320485 T DE69320485 T DE 69320485T DE 69320485 T2 DE69320485 T2 DE 69320485T2
Authority
DE
Germany
Prior art keywords
melatonin
oral doses
low oral
induce sleep
sleep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69320485T
Other languages
English (en)
Other versions
DE69320485D1 (de
Inventor
Richard J Wurtman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of DE69320485D1 publication Critical patent/DE69320485D1/de
Publication of DE69320485T2 publication Critical patent/DE69320485T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
DE69320485T 1992-10-01 1993-09-29 VERWENDUNG VON MELATONIN in niedrigen oralen Dosen ZUM HERBEIFÜHREN VON SCHLAF Expired - Fee Related DE69320485T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95530492A 1992-10-01 1992-10-01
US08/093,317 US5449683A (en) 1992-10-01 1993-07-16 Methods of inducing sleep using melatonin
PCT/US1993/009273 WO1994007487A1 (en) 1992-10-01 1993-09-29 Use of melatonin to induce sleep

Publications (2)

Publication Number Publication Date
DE69320485D1 DE69320485D1 (de) 1998-09-24
DE69320485T2 true DE69320485T2 (de) 1999-04-01

Family

ID=26787395

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69320485T Expired - Fee Related DE69320485T2 (de) 1992-10-01 1993-09-29 VERWENDUNG VON MELATONIN in niedrigen oralen Dosen ZUM HERBEIFÜHREN VON SCHLAF

Country Status (9)

Country Link
US (2) US5449683A (de)
EP (1) EP0663825B1 (de)
JP (1) JP3133760B2 (de)
AT (1) ATE169816T1 (de)
CA (1) CA2146151C (de)
DE (1) DE69320485T2 (de)
DK (1) DK0663825T3 (de)
ES (1) ES2123064T3 (de)
WO (1) WO1994007487A1 (de)

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US6638963B1 (en) 1990-12-04 2003-10-28 Oregon Health And Science University Methods for treating circadian rhythm disorders
US5242941A (en) * 1990-12-04 1993-09-07 State Of Oregon Methods of treating circadian rhythm disorders
US5449683A (en) * 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin
US5654325A (en) * 1993-11-18 1997-08-05 Eli Lilly And Company Melatonin derivatives for use in treating sleep disorders
US6180657B1 (en) * 1993-11-18 2001-01-30 Eli Lilly And Company Melatonin derivatives for use in treating desynchronization disorders
US5541228A (en) * 1994-10-14 1996-07-30 Bristol-Myers Squibb Co. Melatonergic agents
DE4443175A1 (de) * 1994-12-05 1996-06-13 Jenapharm Gmbh Neue pulsatile Arzneiform
US5530012A (en) 1994-12-22 1996-06-25 Bristol-Myers Squibb Co. 3-alkoxybenzylpiperidine derivatives as melatonergic agents
US6469044B1 (en) 1995-02-01 2002-10-22 Neurim Pharmaceuticals (1991) Ltd. Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies
US5661186A (en) * 1995-02-24 1997-08-26 Bristol-Myers Squibb Co. Tetralinyl-and indanyl-ethylamides
JPH08268987A (ja) * 1995-02-24 1996-10-15 Bristol Myers Squibb Co テトラリニル−，及びインダニル−エチルアミド誘導体
US5736578A (en) * 1995-06-06 1998-04-07 Bristol-Myers Squibb Company Ethylamido fluorenes and improved method of making same
US5596019A (en) * 1995-06-07 1997-01-21 Bristol-Myers Squibb Company N-acyl-cycloalkylamine derivatives as melatonergics
US5753709A (en) * 1995-06-07 1998-05-19 Bristol-Myers Squibb Company N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
ATE275132T1 (de) * 1995-06-27 2004-09-15 Takeda Chemical Industries Ltd 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten
CA2186412A1 (en) * 1995-10-31 1997-05-01 Katherine S. Takaki Ethylamino carbazole melatonergic agents
DE19713141A1 (de) * 1996-03-29 1997-10-30 Labtec Gmbh Transdermales System mit Melatonin
US5808151A (en) * 1996-04-17 1998-09-15 Bristol-Myers Squibb Company Biphenylamido derivatives as melatonergic agents
PL190499B1 (pl) * 1996-12-10 2005-12-30 Bristol Myers Squibb Co Pochodna benzodioksolu, benzofuranu, dihydrobenzofuranu lub benzodioksanu, jej zastosowanie i kompozycja farmaceutyczna
AU6540598A (en) * 1997-03-05 1998-09-22 Bristol-Myers Squibb Company Polycyclic ethyl alkylamide melatonergic agents
EP0867181A1 (de) * 1997-03-26 1998-09-30 Franciscus Wilhelmus Henricus Maria Merkus Melatoninhaltiges Nasalpräparat
AU750361B2 (en) * 1997-03-26 2002-07-18 Franciscus W.H.M. Merkus Nasal melatonin composition
FR2762993B1 (fr) * 1997-05-06 1999-08-13 Inst Rech Biolog Sa Nouvelle utilisation de phospholipides d'origine animale en therapeutique et/ou dietetique
US6028112A (en) * 1997-05-23 2000-02-22 Bristol-Myers Squibb Company Spirocyclopropyl fluorenes as melatonergic agents
US6090854A (en) * 1998-03-20 2000-07-18 Bristol-Meyers Company Aryloxyanilides and related compounds
WO1999062515A1 (en) 1998-06-05 1999-12-09 Bristol-Myers Squibb Company Heterocyclic cis cyclopropane derivatives as melatonergic agents
PT1189900E (pt) 1999-06-30 2004-05-31 Bristol Myers Squibb Co Derivados de aminopirrolidina heterociclicos utilizados como agentes melatonergicos
CA2357114C (en) * 2001-03-22 2010-06-29 Pooger Properties Ltd. Use of melatonin in the manufacture of a medicament for treating attention deficit hyperactive disorder
IL144900A (en) 2001-08-14 2013-12-31 Neurim Pharma 1991 Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
US6569894B1 (en) 2001-10-04 2003-05-27 Bristol-Myers Squibb Company Arylalkylbenzofuran derivatives as melatonergic agents
US6737431B2 (en) 2002-03-12 2004-05-18 Bristol-Myers Squibb Company Benzoxazole derivatives as novel melatonergic agents
CA2500198A1 (en) * 2002-09-26 2004-04-08 Pooger Properties Limited Combined use of methylphenidate and melatonin for treating attention-deficit hyperactive disorder
US6703412B1 (en) 2002-09-27 2004-03-09 Holly A. Rosenthal Method of treating sleeplessness with melatonin on an acute basis
IL155666A (en) * 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
US9119846B2 (en) 2003-04-29 2015-09-01 Neurim Pharmaceuticals (1991) Ltd. Method and composition for enhancing cognition in alzheimer's patients
JP4891069B2 (ja) * 2004-03-31 2012-03-07 カルピス株式会社 内因性メラトニン分泌リズムの位相調整又は振幅増強剤、及び概日リズム改善剤
WO2005097101A1 (ja) * 2004-04-06 2005-10-20 Taiyokagaku Co., Ltd. 睡眠改善用組成物
WO2005109080A2 (en) 2004-04-23 2005-11-17 Physician Engineered Products Inc. Head mounted photoeffective device
US7546165B2 (en) * 2005-12-19 2009-06-09 Cardiac Pacemakers, Inc. Interconnections of implantable lead conductors and electrodes and reinforcement therefor
CA2642761A1 (en) * 2006-02-23 2007-08-30 Iomedix Sleep International Srl Compositions and methods for the induction and maintenance of quality sleep
US20080171085A1 (en) * 2007-01-11 2008-07-17 Natrol, Inc. Novel biphasic delivery system for a pharmaceutical or nutraceutical composition and method of administration
US20080248106A1 (en) 2007-04-05 2008-10-09 Marvin Heuer Melatonin-based composition for improved sleep
WO2008122102A1 (en) * 2007-04-05 2008-10-16 Iomedix Development International Srl Melatonin-based composition for improved sleep
US20100256215A1 (en) * 2009-04-02 2010-10-07 Silver Eagle Labs Nv, Llc Menthol-Melatonin Dissolving Film
US20100256197A1 (en) * 2009-04-02 2010-10-07 Silver Eagle Labs Nv, Llc Nicotine Dissolving Film With Or Without Menthol
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
WO2012103411A2 (en) 2011-01-28 2012-08-02 Zx Pharma, Llc Controlled-release melatonin composition and related methods
US10369310B2 (en) * 2014-03-05 2019-08-06 ResMed Pty Ltd Method and apparatus for treatment of respiratory disorders
EP3777842A1 (de) 2016-10-31 2021-02-17 Neurim Pharmaceuticals Ltd. Melatonin-minitabletten und verfahren zur herstellung davon
US10849856B2 (en) 2016-10-31 2020-12-01 Neurim Pharmaceuticals Ltd. Melatonin mini-tablets and method of manufacturing the same
IT201900002913A1 (it) 2019-03-01 2020-09-01 Nicola Pescosolido Composto utile per il trattamento del glaucoma
US11833182B2 (en) 2021-08-10 2023-12-05 Shaklee Corporation Sleep product

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5557563A (en) * 1978-10-21 1980-04-28 Hoechst Ag Melatonine nasal application composition
US4600723A (en) * 1983-05-18 1986-07-15 Monash University Method for minimizing disturbances in circadian rhythms of bodily performance and function
DE3466215D1 (en) * 1983-05-18 1987-10-22 Univ Monash The use of melatonin for the manufacture of a medicament
JPS6045513A (ja) * 1983-05-18 1985-03-12 モナシユ　ユニバ−シテイ 身体行動および機能の日周期の不調を軽減する薬剤
US4687763A (en) * 1985-02-25 1987-08-18 Massachusetts Institute Of Technology Composition and method for increasing levels or release of brain serotonin
JPH0418034A (ja) * 1990-05-11 1992-01-22 Kanegafuchi Chem Ind Co Ltd 点眼組成物
JPH0474135A (ja) * 1990-07-13 1992-03-09 Kanegafuchi Chem Ind Co Ltd 点眼組成物
IT1243193B (it) * 1990-08-10 1994-05-24 Medea Res Srl Composizioni farmaceutiche orali a base di melatonina
US5242941A (en) * 1990-12-04 1993-09-07 State Of Oregon Methods of treating circadian rhythm disorders
IT1251544B (it) * 1991-05-13 1995-05-17 Gabriele Biella Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico
CA2116036A1 (en) * 1991-10-18 1993-04-29 F. Eugene Yates Device for the transdermal administration of melatonin
IT1254995B (it) * 1992-06-24 1995-10-11 Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
US5449683A (en) * 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin

Also Published As

Publication number Publication date
CA2146151C (en) 1997-09-02
EP0663825B1 (de) 1998-08-19
US5641801A (en) 1997-06-24
JPH08502259A (ja) 1996-03-12
ATE169816T1 (de) 1998-09-15
DE69320485D1 (de) 1998-09-24
DK0663825T3 (da) 1999-05-25
WO1994007487A1 (en) 1994-04-14
EP0663825A1 (de) 1995-07-26
JP3133760B2 (ja) 2001-02-13
US5449683A (en) 1995-09-12
ES2123064T3 (es) 1999-01-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee