DK0646596T3 - Nucleinsyre-bindende oligomerer med C-forgrening til terapi og diagnostik - Google Patents
Nucleinsyre-bindende oligomerer med C-forgrening til terapi og diagnostikInfo
- Publication number
- DK0646596T3 DK0646596T3 DK94113573T DK94113573T DK0646596T3 DK 0646596 T3 DK0646596 T3 DK 0646596T3 DK 94113573 T DK94113573 T DK 94113573T DK 94113573 T DK94113573 T DK 94113573T DK 0646596 T3 DK0646596 T3 DK 0646596T3
- Authority
- DK
- Denmark
- Prior art keywords
- branching
- nucleic acid
- diagnostics
- therapy
- binding oligomers
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4331011A DE4331011A1 (de) | 1993-09-13 | 1993-09-13 | Nukleinsäuren-bindende Oligomere mit C-Verzweigung für Therapie und Diagnostik |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0646596T3 true DK0646596T3 (da) | 1999-11-29 |
Family
ID=6497575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94113573T DK0646596T3 (da) | 1993-09-13 | 1994-08-31 | Nucleinsyre-bindende oligomerer med C-forgrening til terapi og diagnostik |
Country Status (11)
Country | Link |
---|---|
US (1) | US5849893A (da) |
EP (1) | EP0646596B1 (da) |
JP (1) | JPH07112969A (da) |
AT (1) | ATE180494T1 (da) |
AU (1) | AU7161994A (da) |
CA (1) | CA2131760A1 (da) |
DE (2) | DE4331011A1 (da) |
DK (1) | DK0646596T3 (da) |
ES (1) | ES2131612T3 (da) |
GR (1) | GR3030708T3 (da) |
SI (1) | SI0646596T1 (da) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7825215B1 (en) * | 1993-04-26 | 2010-11-02 | Peter E. Nielsen | Substituted nucleic acid mimics |
DE4331012A1 (de) * | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
US6133444A (en) * | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
US5539083A (en) * | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
AU4159396A (en) * | 1994-11-14 | 1996-06-06 | Chiron Corporation | Synthesis of peptide nucleic acids (pnas) and analogues via submonomer approach |
EP0840741B1 (en) * | 1995-06-07 | 2004-04-28 | Perseptive Biosystems, Inc. | Pna-dna chimeras and pna synthons for their preparation |
GB9621367D0 (en) | 1996-10-14 | 1996-12-04 | Isis Innovation | Chiral peptide nucleic acids |
US6054568A (en) * | 1998-01-16 | 2000-04-25 | The Perkin-Elmer Corporation | Nucleobase oligomers |
US6030997A (en) * | 1998-01-21 | 2000-02-29 | Eilat; Eran | Acid labile prodrugs |
HUP0203338A2 (hu) * | 1999-04-13 | 2003-03-28 | Abbott Gmbh & Co. Kg | Integrin receptor ligandumok |
HUP9902217A3 (en) * | 1999-06-29 | 2002-07-29 | Szegoe Peter | Polycation based bioconjugates and process for producing thereof |
US6716961B2 (en) | 2001-10-30 | 2004-04-06 | Isis Innovation Limited | Chiral peptide nucleic acids with a N-aminoethyl-d-proline backbone |
DK1513871T3 (da) * | 2002-02-04 | 2009-02-23 | Isis Innovation | Pyrrolidinyl peptid nucleinsyrer |
ATE449103T1 (de) * | 2002-09-08 | 2009-12-15 | Applera Corp | Festphasengebundene pna-dimere und deren synthese |
WO2008070525A1 (en) * | 2006-12-04 | 2008-06-12 | Luminex Corporation | Oxocarbonamide peptide nucleic acids and methods of using same |
CN105555756B (zh) | 2013-06-28 | 2018-12-07 | 奥克兰联合服务有限公司 | 氨基酸缀合物和肽缀合物及缀合方法 |
AU2015370479B2 (en) | 2014-12-23 | 2020-07-23 | Auckland Uniservices Limited | Amino acid and peptide conjugates and uses thereof |
JP7161404B2 (ja) | 2016-02-26 | 2022-10-26 | オークランド ユニサービシーズ リミティド | アミノ酸及びペプチド接合体及び接合方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3650349T2 (de) * | 1985-03-15 | 1995-12-14 | Antivirals Inc | Immunotestmittel für polynukleotid und verfahren. |
US4994368A (en) * | 1987-07-23 | 1991-02-19 | Syntex (U.S.A.) Inc. | Amplification method for polynucleotide assays |
US5539082A (en) * | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
EP0666923A1 (en) * | 1991-09-05 | 1995-08-16 | The University Of Connecticut | Targeted delivery of poly- or oligonucleotides to cells |
-
1993
- 1993-09-13 DE DE4331011A patent/DE4331011A1/de not_active Withdrawn
-
1994
- 1994-08-31 DK DK94113573T patent/DK0646596T3/da active
- 1994-08-31 EP EP94113573A patent/EP0646596B1/de not_active Expired - Lifetime
- 1994-08-31 DE DE59408308T patent/DE59408308D1/de not_active Expired - Fee Related
- 1994-08-31 ES ES94113573T patent/ES2131612T3/es not_active Expired - Lifetime
- 1994-08-31 AT AT94113573T patent/ATE180494T1/de active
- 1994-08-31 SI SI9430250T patent/SI0646596T1/xx unknown
- 1994-09-01 AU AU71619/94A patent/AU7161994A/en not_active Abandoned
- 1994-09-07 JP JP6238619A patent/JPH07112969A/ja active Pending
- 1994-09-09 CA CA002131760A patent/CA2131760A1/en not_active Abandoned
-
1996
- 1996-09-24 US US08/719,048 patent/US5849893A/en not_active Expired - Fee Related
-
1999
- 1999-07-07 GR GR990401791T patent/GR3030708T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE180494T1 (de) | 1999-06-15 |
ES2131612T3 (es) | 1999-08-01 |
DE4331011A1 (de) | 1995-03-16 |
DE59408308D1 (de) | 1999-07-01 |
EP0646596A1 (de) | 1995-04-05 |
SI0646596T1 (en) | 1999-08-31 |
EP0646596B1 (de) | 1999-05-26 |
JPH07112969A (ja) | 1995-05-02 |
US5849893A (en) | 1998-12-15 |
AU7161994A (en) | 1995-03-23 |
GR3030708T3 (en) | 1999-11-30 |
CA2131760A1 (en) | 1995-03-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0646595T3 (da) | Nukleinsyrer-bindende oligomerer med N-forgrening til terapi og diagnostik | |
DK0646596T3 (da) | Nucleinsyre-bindende oligomerer med C-forgrening til terapi og diagnostik | |
GR3018541T3 (en) | Condensed heterocyclic compounds and their use in therapy. | |
DK0624595T3 (da) | Nor-galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidler | |
ATE280160T1 (de) | Substituierte aryl-oder heteroarylamide mit retinoid-ähnlicher biologischer aktivität | |
ATE141946T1 (de) | Hiv-2-virusvarianten | |
ATE206409T1 (de) | N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide | |
IS4237A (is) | Hliðstæð aðferð til framleiðslu ediksýru afleiða og notkunar þeirra sem lyfja | |
ATE495240T1 (de) | Ligand des zelleintritt-vermittelnden proteins von herpes simplex virus und methoden zu dessen verwendung | |
DK0509398T3 (da) | Quinoxaliner, fremgangsmåder til deres fremstilling samt deres anvendelse | |
ATE248184T1 (de) | Dns-sequenzen des humanen cytomegaloviruses | |
TR199801039T2 (xx) | Yeni fenilamidin t�revlerinin elde edilmesine y�nelik usul. | |
DK0638068T3 (da) | Fremgangsmåde til fremstilling af (S)-3-amino-1-substitueret-pyrrolidiner | |
DK0579968T3 (da) | 4-Iminoquinoliner, fremgangsmåde til deres fremstilling og deres anvendelse | |
NO930205D0 (no) | Benzimidazoler, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling | |
DK446381A (da) | Saccharose-mutase immobiliseret saccharose-mutase og anvendelse heraf til fremstilling af isomaltulose (6-0-alfa-d-glucopyranosidod-fructose). | |
DK1005532T3 (da) | Isolerede nukleinsyremolekyler kodende for SSX familiemedlemmer og anvendelser deraf | |
ES2165358T3 (es) | Utilizaciones de la proteinquinasa de neurofilamento/tau pk40. | |
DK1674575T3 (da) | Ligand for Herpes simplex-indgangsmediator og fremgangsmåder til anvendelse | |
DE69421665T2 (de) | Anomere Fluorribosylamine | |
DE69407533T2 (de) | Verwendung von 2,5-substituierten Tetrahydrofuranen als anionische Initiatormodifiziermittel | |
BR9407232A (pt) | Compostos de tiocarbamoíla | |
ES2068040T3 (es) | Sales de 3-(cis-2,6-dimetilpiperidino)-sidnonimina. | |
ITAQ930006A0 (it) | Idrogeli morbidi o semirigidi per uso biomedico. | |
ITRM920224A1 (it) | Sistema ottico per la combinazione di due cammini ottici, in particolare i cammini ottici di uno strumento di diagnostica oculare e di un altro strumento. |