DK0644904T3 - Bærere med azlactonfunktionelle overflader, adduktbærere og fremgangsmåder til fremstilling deraf - Google Patents

Bærere med azlactonfunktionelle overflader, adduktbærere og fremgangsmåder til fremstilling deraf

Info

Publication number
DK0644904T3
DK0644904T3 DK93911302T DK93911302T DK0644904T3 DK 0644904 T3 DK0644904 T3 DK 0644904T3 DK 93911302 T DK93911302 T DK 93911302T DK 93911302 T DK93911302 T DK 93911302T DK 0644904 T3 DK0644904 T3 DK 0644904T3
Authority
DK
Denmark
Prior art keywords
carriers
processes
preparation
adduct
functional surfaces
Prior art date
Application number
DK93911302T
Other languages
Danish (da)
English (en)
Inventor
Patrick L Coleman
Dean S Milbrath
Gary J Drtina
David R Gagnon
Oh-Seung Kwon
Christopher S Lyons
Jerald K Rasmussen
Julie B Stahl
Original Assignee
Minnesota Mining & Mfg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minnesota Mining & Mfg filed Critical Minnesota Mining & Mfg
Application granted granted Critical
Publication of DK0644904T3 publication Critical patent/DK0644904T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28023—Fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3276—Copolymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3278—Polymers being grafted on the carrier
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/328—Polymers on the carrier being further modified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/084—Polymers containing vinyl alcohol units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249954—With chemically effective material or specified gas other than air, N, or carbon dioxide in void-containing component
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249955—Void-containing component partially impregnated with adjacent component
    • Y10T428/249958—Void-containing component is synthetic resin or natural rubbers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249955—Void-containing component partially impregnated with adjacent component
    • Y10T428/249959—Void-containing component is wood or paper
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249978—Voids specified as micro
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249987—With nonvoid component of specified composition
    • Y10T428/249991—Synthetic resin or natural rubbers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
DK93911302T 1992-06-09 1993-05-13 Bærere med azlactonfunktionelle overflader, adduktbærere og fremgangsmåder til fremstilling deraf DK0644904T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/896,107 US5344701A (en) 1992-06-09 1992-06-09 Porous supports having azlactone-functional surfaces

Publications (1)

Publication Number Publication Date
DK0644904T3 true DK0644904T3 (da) 1998-02-23

Family

ID=25405637

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93911302T DK0644904T3 (da) 1992-06-09 1993-05-13 Bærere med azlactonfunktionelle overflader, adduktbærere og fremgangsmåder til fremstilling deraf

Country Status (8)

Country Link
US (2) US5344701A (fr)
EP (1) EP0644904B1 (fr)
JP (1) JPH07507587A (fr)
CA (1) CA2136004A1 (fr)
DE (1) DE69312294T2 (fr)
DK (1) DK0644904T3 (fr)
IL (1) IL105848A (fr)
WO (1) WO1993025594A1 (fr)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328758A (en) * 1991-10-11 1994-07-12 Minnesota Mining And Manufacturing Company Particle-loaded nonwoven fibrous article for separations and purifications
US5554501A (en) * 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
GB9310241D0 (en) * 1993-05-18 1993-06-30 Unilever Plc Cosmetic treatment of substrates
WO1995005400A1 (fr) * 1993-08-19 1995-02-23 Minnesota Mining And Manufacturing Company Supports d'affinite fonctionnelle de l'heparine
US5408002A (en) * 1993-09-09 1995-04-18 Minnesota Mining And Manufacturing Company Azlactone-functional polymer blends, articles produced therefrom and methods for preparing both
US5547760A (en) * 1994-04-26 1996-08-20 Ibc Advanced Technologies, Inc. Compositions and processes for separating and concentrating certain ions from mixed ion solutions using ion-binding ligands bonded to membranes
FR2726286B1 (fr) * 1994-10-28 1997-01-17 Genset Sa Procede d'amplification d'acides nucleiques en phase solide et trousse de reactifs utile pour la mise en oeuvre de ce procede
US5507804A (en) * 1994-11-16 1996-04-16 Alcon Laboratories, Inc. Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices
CN1052915C (zh) * 1995-11-27 2000-05-31 中国医学科学院生物医学工程研究所 用于携载基因的蛋白质涂层医用载体及其制作方法
US5764355A (en) * 1996-01-12 1998-06-09 Gagnon; David R. Spectroscopic sample holder
DE19611936C2 (de) * 1996-03-27 2003-02-13 Leica Microsystems Verfahren zur Erzeugung einer haftfesten Beschichtung mit optischen und/oder mechanischen Funktionen auf einer Polymethylmetacrylat-Substratoberfläche
US5780112A (en) * 1996-05-15 1998-07-14 Lrc Products, Ltd. Power-free latex articles and methods of making the same
EP0910601B1 (fr) * 1996-07-06 2000-03-08 MERCK PATENT GmbH Polyamides derives d'azlactone
AR009439A1 (es) * 1996-12-23 2000-04-12 Novartis Ag Un articulo que comprende un sustrato con un recubrimiento polimerico primario que porta grupos reactivos predominantemente en su superficie, unmetodo para preparar dicho articulo, un articulo que posee un recubrimiento de tipo hibrido y una lente de contacto
US6295474B1 (en) 1998-03-13 2001-09-25 Intermedics Inc. Defibrillator housing with conductive polymer coating
US6376619B1 (en) 1998-04-13 2002-04-23 3M Innovative Properties Company High density, miniaturized arrays and methods of manufacturing same
US6183516B1 (en) * 1998-10-08 2001-02-06 Sulzer Orthopedics Inc. Method for improved bonding of prosthetic devices to bone
US6156478A (en) 1998-10-30 2000-12-05 3M Innovative Properties Company Photocurable and photopatternable hydrogel matrix based on azlactone copolymers
US6379952B1 (en) 1999-02-01 2002-04-30 3M Innovative Properties Company Method for cell selection utilizing azlactone-functional supports
US6440571B1 (en) 1999-05-20 2002-08-27 Bausch & Lomb Incorporated Surface treatment of silicone medical devices with reactive hydrophilic polymers
US6630243B2 (en) 1999-05-20 2003-10-07 Bausch & Lomb Incorporated Surface treatment of silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating
US6451191B1 (en) * 1999-11-18 2002-09-17 3M Innovative Properties Company Film based addressable programmable electronic matrix articles and methods of manufacturing and using the same
US6482638B1 (en) * 1999-12-09 2002-11-19 3M Innovative Properties Company Heat-relaxable substrates and arrays
US6881538B1 (en) 2000-03-05 2005-04-19 3M Innovative Properties Company Array comprising diamond-like glass film
US6599559B1 (en) * 2000-04-03 2003-07-29 Bausch & Lomb Incorporated Renewable surface treatment of silicone medical devices with reactive hydrophilic polymers
AUPR259301A0 (en) * 2001-01-18 2001-02-15 Polymerat Pty Ltd Polymers having co-continuous architecture
US6787635B2 (en) * 2001-04-05 2004-09-07 3M Innovative Properties Company Solid phase synthesis supports and methods
US6794458B2 (en) * 2001-05-18 2004-09-21 3M Innovative Properties Company Azlactone-functional hydrophilic coatings and hydrogels
JP3990880B2 (ja) * 2001-07-10 2007-10-17 キヤノン株式会社 ポリヒドロキシアルカノエート被覆リポソームの製造方法
US20030040125A1 (en) * 2001-08-21 2003-02-27 3M Innovative Properties Company Methods for performing immunological assays
US20050164188A1 (en) * 2002-01-24 2005-07-28 Jeffrey Kane Analysis device
US8273403B2 (en) 2002-05-10 2012-09-25 Bio-Layer Pty Ltd. Generation of surface coating diversity
GB0307011D0 (en) 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
WO2005007819A2 (fr) 2003-07-09 2005-01-27 Wisconsin Alumni Research Foundation Polymeres a charge dynamique et transport de composes anioniques
US7247387B1 (en) 2003-07-24 2007-07-24 Sepax Technologies Inc. Material and process for controlled thin polymeric coatings on plastic surface
US7176268B2 (en) * 2003-12-05 2007-02-13 Bausch & Lomb Incorporated Prepolymers for improved surface modification of contact lenses
US7084188B2 (en) * 2003-12-05 2006-08-01 Bausch & Lomb Incorporated Surface modification of contact lenses
US7881871B2 (en) * 2003-12-12 2011-02-01 Bio-Layer Pty Limited Method for designing surfaces
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US7727710B2 (en) 2003-12-24 2010-06-01 3M Innovative Properties Company Materials, methods, and kits for reducing nonspecific binding of molecules to a surface
WO2006002472A1 (fr) 2004-07-02 2006-01-12 Bio-Layer Pty Ltd Usage de complexes métalliques
US7556858B2 (en) * 2004-09-30 2009-07-07 3M Innovative Properties Company Substrate with attached dendrimers
US20110177492A1 (en) * 2005-06-16 2011-07-21 3M Innovative Properties Company Method of classifying chemically crosslinked cellular samples using mass spectra
US7306729B2 (en) * 2005-07-18 2007-12-11 Gore Enterprise Holdings, Inc. Porous PTFE materials and articles produced therefrom
KR20080081001A (ko) * 2005-12-30 2008-09-05 쓰리엠 이노베이티브 프로퍼티즈 컴파니 기능화 기판의 제조 방법
WO2007076580A1 (fr) * 2005-12-30 2007-07-12 Bio-Layer Pty Limited Fixation de molécules
JP5567327B2 (ja) * 2006-04-03 2014-08-06 インテグリス・インコーポレーテッド 常圧マイクロ波プラズマ処理多孔性膜
US20080002146A1 (en) * 2006-06-28 2008-01-03 Stachowski Mark J Biocompatible, surface modified materials
US7842214B2 (en) * 2007-03-28 2010-11-30 3M Innovative Properties Company Process for forming microporous membranes
US20090105375A1 (en) * 2007-10-09 2009-04-23 Lynn David M Ultrathin Multilayered Films for Controlled Release of Anionic Reagents
US8071210B2 (en) * 2007-10-09 2011-12-06 Wiscousin Alumni Research Foundation Covalent assembly of ultrathin polymeric films
JP2011523965A (ja) 2008-05-30 2011-08-25 スリーエム イノベイティブ プロパティズ カンパニー リガンド官能化基材
EP2522692B1 (fr) 2008-05-30 2014-06-18 3M Innovative Properties Company Ligand monomères et copolymères correspondants
WO2009158071A2 (fr) 2008-06-26 2009-12-30 3M Innovative Properties Company Support solide à chaîne greffée
EP2168666A1 (fr) * 2008-09-25 2010-03-31 Gambro Lundia AB Membrane irradiée pour expansion cellulaire
JP5416222B2 (ja) * 2008-12-23 2014-02-12 スリーエム イノベイティブ プロパティズ カンパニー 官能化不織布物品
WO2010077646A2 (fr) 2008-12-30 2010-07-08 Bausch & Lomb Incorporated Procédé d'application d'un revêtement polymère renouvelable de lentille
US20100209693A1 (en) * 2009-02-18 2010-08-19 3M Innovative Properties Company Hydrophilic porous substrates
US20100210160A1 (en) * 2009-02-18 2010-08-19 3M Innovative Properties Company Hydrophilic porous substrates
JP5681166B2 (ja) 2009-03-31 2015-03-04 スリーエム イノベイティブ プロパティズ カンパニー 疎水性モノマー、疎水的に誘導体化された支持体、並びにその製造及び使用方法
JP2012531531A (ja) 2009-06-23 2012-12-10 スリーエム イノベイティブ プロパティズ カンパニー 官能化不織布物品
WO2011062949A1 (fr) * 2009-11-17 2011-05-26 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Traitement de plaques de microtitration pour des chimies d'immobilisation covalente
US8377672B2 (en) 2010-02-18 2013-02-19 3M Innovative Properties Company Ligand functionalized polymers
EP2889625B1 (fr) 2010-03-03 2016-09-14 3M Innovative Properties Company Polymères fonctionnalisés par ligand guanidinyle
DE102010027936A1 (de) 2010-04-19 2011-10-20 Institut für Biochemie Ernst-Moritz-Arndt-Universität Greifswald Immobilisierung von Enzym unter Verwendung von Plasmen
JP2016503486A (ja) * 2012-09-27 2016-02-04 スリーエム イノベイティブ プロパティズ カンパニー リガンドグラフト化基材
FR2997082B1 (fr) * 2012-10-18 2015-02-13 Centre Nat Rech Scient Reactifs de couplage multifonctionnels a fonction azlactone.
US10562997B2 (en) 2015-03-24 2020-02-18 3M Innovative Properties Company Method of purifying a biological composition and article therefor
CN108367079B (zh) 2015-11-12 2022-11-22 灰色视觉公司 用于治疗的聚集性微粒
US20170298092A1 (en) * 2016-04-19 2017-10-19 Clarcor Inc. Fine fiber web with chemically functional species
US20170342211A1 (en) 2016-05-31 2017-11-30 Robert Bosch Gmbh Azlactone functionalized substrates for conjugation of biomolecules
DE202017007538U1 (de) 2017-01-24 2022-08-19 Sartorius Stedim Biotech Gmbh Chromatographiemedium mit gebundenen Mikroglobuli
DE102017000631A1 (de) * 2017-01-24 2018-07-26 Sartorius Stedim Biotech Gmbh Chromatographiemedium mit gebundenen Mikroglobuli und Verfahren zu dessen Herstellung
EP3621654A4 (fr) 2017-05-10 2021-02-17 Graybug Vision, Inc. Microparticules à libération prolongée et suspensions de celles-ci destinées à une thérapie médicale
EP4134158B1 (fr) 2018-12-17 2024-05-15 Solventum Intellectual Properties Company Substrat de liaison de ligand
DE102019105192A1 (de) 2019-02-28 2020-09-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Funktionalisierung einer Oberfläche, Erzeugnis mit einer nach dem Verfahren funktionalisierten Oberfläche und Verwendungen derselben

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3488327A (en) * 1967-06-30 1970-01-06 Roehm & Haas Gmbh Preparation of coating materials
DE1745348A1 (de) * 1967-12-01 1971-09-09 Roehm Gmbh Azlactongruppen enthaltende Mischpolymerisate
US3598790A (en) * 1966-07-01 1971-08-10 Roehm & Haas Gmbh Azlactone copolymers
US3634218A (en) * 1967-10-31 1972-01-11 Japan Atomic Energy Res Inst Process for the radiation grafting of butadiene and other co-graft monomers onto polyolefin substrates
US3941718A (en) * 1972-10-03 1976-03-02 Gaf Corporation Insoluble crosslinked homopolymers and copolymers, polymerized on an inert substrate
JPS5247355B2 (fr) * 1974-10-15 1977-12-01
AU529368B2 (en) * 1978-05-15 1983-06-02 Pall Corporation Preparing polyamide membrane filter media and product
US4280970A (en) * 1979-01-19 1981-07-28 Puropore Inc. Polyoxyethylene grafted membrane materials with grafting links derived from a diisocyanate
JPS55106239A (en) * 1979-02-05 1980-08-14 Japan Atom Energy Res Inst Preparation of hydrophilic membrane based on polyethylene membrane
US4304705A (en) * 1980-01-02 1981-12-08 Minnesota Mining And Manufacturing Company Radiation-curable polymers containing pendant unsaturated peptide groups derived from azlactone polymers
US4777276A (en) * 1981-10-29 1988-10-11 Minnesota Mining And Manufacturing Company Acrylamidoacylated oligomers
US4914223A (en) * 1981-10-29 1990-04-03 Minnesota Mining And Manufacturing Company Acrylamidoacylated oligomers
SE8200751L (sv) * 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
US4451619A (en) * 1982-09-30 1984-05-29 Minnesota Mining And Manufacturing Company Method of hydrophilizing or hydrophobizing polymers
US5059654A (en) * 1983-02-14 1991-10-22 Cuno Inc. Affinity matrices of modified polysaccharide supports
US4563388A (en) * 1983-03-28 1986-01-07 Minnesota Mining And Manufacturing Company Polyolefin substrate coated with acrylic-type normally tacky and pressure-sensitive adhesive and a method of making same
NO843527L (no) * 1983-09-06 1985-03-07 Chlorine Eng Corp Ltd Fremgangsmaate for fremstilling av en membran av podepolymer
US4695608A (en) * 1984-03-29 1987-09-22 Minnesota Mining And Manufacturing Company Continuous process for making polymers having pendant azlactone or macromolecular moieties
US4705753A (en) * 1984-06-08 1987-11-10 Gregor Harry P Biologically active acrylonitrile-based copolymeric membrane
JPS6115687A (ja) * 1984-06-29 1986-01-23 Japan Atom Energy Res Inst 固定化増殖微生物およびその製造方法
US4693985A (en) * 1984-08-21 1987-09-15 Pall Corporation Methods of concentrating ligands and active membranes used therefor
US4595726A (en) * 1984-10-04 1986-06-17 Hercules Incorporated N-alkyl methacrylate modified polypropylene
JPS6283885A (ja) * 1985-10-08 1987-04-17 Nitto Electric Ind Co Ltd 酵素固定膜及びその製造方法
US4757014A (en) * 1985-11-08 1988-07-12 Minnesota Mining And Manufacturing Company Immobilization of biologically active protein on a polymeric fibrous support
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
ES2059339T3 (es) * 1986-10-23 1994-11-16 Behringwerke Ag Fases solidas porosas bioafines, un procedimiento para la preparacion de fases solidas porosas bioafines y su utilizacion.
US5037656A (en) * 1986-12-04 1991-08-06 Millipore Corporation Porous membrane having hydrophilic and cell growth promotions surface and process
US4726989A (en) * 1986-12-11 1988-02-23 Minnesota Mining And Manufacturing Microporous materials incorporating a nucleating agent and methods for making same
GB2199946A (en) * 1987-01-12 1988-07-20 Pall Corp Diagnostic device,
US5292840A (en) * 1987-03-13 1994-03-08 Minnesota Mining And Manufacturing Company Polymeric supports
US4871824A (en) * 1987-03-13 1989-10-03 Minnesota Mining And Manufacturing Company Variably crosslinked polymeric supports
US4737560A (en) * 1987-03-13 1988-04-12 Minnesota Mining And Manufacturing Company Polymer beads
US4961954A (en) * 1987-04-10 1990-10-09 University Of Florida Surface modified surgical instruments, devices, implants, contact lenses and the like
US4950549A (en) * 1987-07-01 1990-08-21 Minnesota Mining And Manufacturing Company Polypropylene articles and method for preparing same
US4824870A (en) * 1987-09-14 1989-04-25 Gelman Sciences, Inc. Polyaldehyde activated membranes
JP2561309B2 (ja) * 1988-03-28 1996-12-04 テルモ株式会社 医療用材料およびその製造方法
US4874822A (en) * 1988-04-07 1989-10-17 Minnesota Mining And Manufacturing Company Process for the acrylamidoacylation of alcohols
CA2001720C (fr) * 1988-10-31 2001-10-02 Randal A. Goffe Appareil a affinite de membrane et methodes de purification
JP2749094B2 (ja) * 1989-01-13 1998-05-13 日本原子力研究所 イミノジ酢酸基を有する複合機能ろ過膜の製造方法
US5013795A (en) * 1989-04-10 1991-05-07 Minnesota Mining And Manufacturing Company Azlactone graft copolymers
US4981933A (en) * 1989-06-23 1991-01-01 Polaroid Corporation Azlactone copolymers
GB8915974D0 (en) * 1989-07-12 1989-08-31 Gore W L & Ass Uk Hydrophilic semi-permeable ptfe membranes and their manufacture
US5053133A (en) * 1990-02-09 1991-10-01 Elias Klein Affinity separation with activated polyamide microporous membranes
JP2954275B2 (ja) * 1990-05-10 1999-09-27 日本原子力研究所 アミノ酸を有する複合機能▲ろ▼過膜の製造方法
JP3063769B2 (ja) * 1990-07-17 2000-07-12 イーシー化学株式会社 大気圧プラズマ表面処理法
US5081197A (en) * 1990-10-23 1992-01-14 Minnesota Mining And Manufacturing Company Oligo(2-alkenyl azlactones)
US5155144A (en) * 1990-10-29 1992-10-13 Manganaro James L Polysaccharide-based porous sheets
WO1992007899A2 (fr) * 1990-10-30 1992-05-14 Minnesota Mining And Manufacturing Company Articles possedant une enveloppe polymere hydrophile et procede de preparation desdits articles
US5993935A (en) * 1991-10-11 1999-11-30 3M Innovative Properties Company Covalently reactive particles incorporated in a continous porous matrix
US5292514A (en) * 1992-06-24 1994-03-08 Minnesota Mining And Manufacturing Company Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof

Also Published As

Publication number Publication date
JPH07507587A (ja) 1995-08-24
US5344701A (en) 1994-09-06
EP0644904A1 (fr) 1995-03-29
CA2136004A1 (fr) 1993-12-23
EP0644904B1 (fr) 1997-07-16
IL105848A0 (en) 1993-09-22
US5451453A (en) 1995-09-19
IL105848A (en) 1997-02-18
DE69312294T2 (de) 1998-02-26
WO1993025594A1 (fr) 1993-12-23
DE69312294D1 (de) 1997-08-21

Similar Documents

Publication Publication Date Title
DK0644904T3 (da) Bærere med azlactonfunktionelle overflader, adduktbærere og fremgangsmåder til fremstilling deraf
DE69331903D1 (de) Veränderte Antikörper, damit zusammenhängende Produkte und Verfahren
DE3688715D1 (de) Druckverfahren vom abtastaufzeichnungstyp und dessen verwirklichungsvorrichtung.
MX24568A (es) 3-arilcarbonil-1h-indoles y procedimiento para su preparacion.
DK0850909T3 (da) Stilbenforbindelser med adamantylgruppe, præparater indeholdende disse og anvendelser heraf
ES2017922B3 (es) 3-amino-4,5-dihidroxipiperidinas, procedimiento para su preparacion, y su empleo.
DK524485D0 (da) Fremgangsmaade og apparat til sproejtning, isaer til anvendelse i land- og havebrug
DK298789A (da) Blaesestoebt flaske i et stykke og fremgangsmaade til fremstilling af samme
DK16386A (da) Taepperenser og beholder til brug med samme
MX26267A (es) Aminobenzodiacepinas y procedimiento para su prepaacion.
DK0562583T3 (da) Hidtil ukendte alkylendiammoniumdiclavulanatderivater, fremgangsmåde til fremstilling deraf samt anvendelse deraf
DK484887D0 (da) Boejelig overtrukket genstand og fremgangsmaade til fremstilling af samme
DK0635004T3 (da) 4-Diphenylmethylpiperidinderivater og fremgangsmåde til fremstilling deraf
NO893748L (no) Forbedret nedslipbart belegg og fremgangsmaate til dets fremstilling.
DK0564830T3 (da) Monolitisk bærerkatalysator, fremgangsmåde til dens fremstilling og dens anvendelse
DK80889A (da) Badeanlaeg og fremgangsmaade til anvendelse af samme
NO870210L (no) Fremgangsmaate og anordning for avskinning.
DK502086D0 (da) Asbestfrit vaadformet inorganisk produkt og fremgangsmaade til fremstilling af produktet
ES553373A0 (es) Procedimiento para aislar y purificar x-interferones plasmidogenos.
DK0814077T3 (da) Benzoylguanidiner, fremgangsmåde til deres fremstilling samt lægemidler med indhold heraf
DK122185A (da) Fremgangsmaader, forbindelser og midler til behandling af protozo-infektioner
ATA20290A (de) Bauelementensatz zum abdichten von kanaelen u.dgl.
DK367887D0 (da) Arylethanolhydroxylaminer, deres fremstilling og anvendelse samt mellemprodukter til fremstilling ogdisses fremstilling
DK98386A (da) Fremgangsmaade og mellemprodukter til fremstilling af 4-alkoxy-6-alkyl-2-cyanamino-1,3,5-triaziner samt mellemprodukternes fremstilling
IT206328Z2 (it) Dispositivo di bloccaggio e taglio per gruppo di applicazione e tensionamento di reggia.