DK0641218T4 - Anvendelse af angiotensinantagonist (AT1) til formindskelse af postmyocardial infarktmorbiditet og -mortalitet - Google Patents

Anvendelse af angiotensinantagonist (AT1) til formindskelse af postmyocardial infarktmorbiditet og -mortalitet

Info

Publication number
DK0641218T4
DK0641218T4 DK93912155T DK93912155T DK0641218T4 DK 0641218 T4 DK0641218 T4 DK 0641218T4 DK 93912155 T DK93912155 T DK 93912155T DK 93912155 T DK93912155 T DK 93912155T DK 0641218 T4 DK0641218 T4 DK 0641218T4
Authority
DK
Denmark
Prior art keywords
mortality
reduce
postmyocardial infarction
angiotensin antagonist
infarction morbidity
Prior art date
Application number
DK93912155T
Other languages
Danish (da)
English (en)
Other versions
DK0641218T3 (da
Inventor
Eugene Braunwald
Marc A Pfeffer
Janice M Pfeffer
Original Assignee
Brigham & Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27127973&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0641218(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/866,827 external-priority patent/US5977160A/en
Application filed by Brigham & Womens Hospital filed Critical Brigham & Womens Hospital
Publication of DK0641218T3 publication Critical patent/DK0641218T3/da
Application granted granted Critical
Publication of DK0641218T4 publication Critical patent/DK0641218T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK93912155T 1992-04-10 1993-04-09 Anvendelse af angiotensinantagonist (AT1) til formindskelse af postmyocardial infarktmorbiditet og -mortalitet DK0641218T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/866,827 US5977160A (en) 1992-04-10 1992-04-10 Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US07/981,196 US5972990A (en) 1992-04-10 1992-11-25 Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
PCT/US1993/003318 WO1993020839A2 (en) 1992-04-10 1993-04-09 Use of renin-angiotensin antagonist for reducing post myocardial infarct mobidity and mortality

Publications (2)

Publication Number Publication Date
DK0641218T3 DK0641218T3 (da) 2004-03-29
DK0641218T4 true DK0641218T4 (da) 2008-01-02

Family

ID=27127973

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93912155T DK0641218T4 (da) 1992-04-10 1993-04-09 Anvendelse af angiotensinantagonist (AT1) til formindskelse af postmyocardial infarktmorbiditet og -mortalitet

Country Status (9)

Country Link
US (2) US5972990A (de)
EP (2) EP0641218B2 (de)
JP (1) JPH07505884A (de)
AU (1) AU4281093A (de)
CA (1) CA2117782C (de)
DE (1) DE69333362T3 (de)
DK (1) DK0641218T4 (de)
ES (1) ES2211867T5 (de)
WO (1) WO1993020839A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1498124B1 (de) * 1997-10-17 2007-07-04 Ark Therapeutics Limited Verwendung von Inhibitoren des Renin-Angiotensin Systems
CN101011390A (zh) 1999-01-26 2007-08-08 诺瓦提斯公司 血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
RU2276997C2 (ru) * 1999-08-30 2006-05-27 Санофи-Авентис Дойчланд Гмбх Применение ингибиторов ренин-ангиотензиновой системы для профилактики сердечно-сосудистых явлений
US20030113330A1 (en) * 1999-11-08 2003-06-19 Uhal Bruce D. Methods for treating pulmonary fibrosis
US6808927B2 (en) * 2001-04-04 2004-10-26 American Diagnostica, Inc. Method of preparation of stabilized thrombin-activatable fibrinolysis inhibitor (TAFI) and methods of use thereof
WO2003035039A1 (en) * 2001-10-25 2003-05-01 Depomed, Inc. Methods of treatment using a gastric retained losartan dosage
US7107198B2 (en) * 2001-11-02 2006-09-12 Sun Microsystems, Inc. Automatic generation of reduced-size circuit models including inductive interaction
FI20020197A0 (fi) * 2002-02-01 2002-02-01 Orion Corp Yhdistelmä akuutin myokardiilisen infarktin hoitoon
US7470519B2 (en) * 2002-08-29 2008-12-30 American Diagnostica, Inc. Methods for detecting TAFIa or TAFIai
WO2014055392A2 (en) * 2012-10-01 2014-04-10 Decimmune Therapeutics, Inc. Method of protecting cardiac function
ITFI20140115A1 (it) * 2014-05-19 2015-11-19 Italmed Srl Composizione ad uso odontoiatrico per il trattamento chirurgico delle perimplantiti
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
JP2021528735A (ja) 2018-06-14 2021-10-21 アストラゼネカ・ユーケイ・リミテッドＡｓｔｒａＺｅｎｅｃａ ＵＫ Ｌｉｍｉｔｅｄ アンジオテンシンｉｉ受容体遮断薬医薬組成物による高血圧症の治療方法

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302386A (en) * 1978-08-25 1981-11-24 The Ohio State University Antigenic modification of polypeptides
US3932624A (en) * 1974-06-17 1976-01-13 Morton-Norwich Products, Inc. Method for prolonging the inhibitory effect of saralasin on angiotensin II
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4316906A (en) * 1978-08-11 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of substituted prolines
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4780401A (en) * 1984-04-09 1988-10-25 Ciba-Geigy Corporation Novel monoclonal antibodies to human renin and hybridoma cells, processes for their preparation and their applications
US4845079A (en) * 1985-01-23 1989-07-04 Luly Jay R Peptidylaminodiols
US5066643A (en) * 1985-02-19 1991-11-19 Sandoz Ltd. Fluorine and chlorine statine or statone containing peptides and method of use
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
US4885292A (en) * 1986-02-03 1989-12-05 E. R. Squibb & Sons, Inc. N-heterocyclic alcohol renin inhibitors
US4816463A (en) * 1986-04-01 1989-03-28 Warner-Lambert Company Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5063053A (en) * 1986-10-20 1991-11-05 The United States Of America As Represented By The Department Of Health & Human Services Isolation and purification of the R18 antigen of HTLV-III
US4772684A (en) * 1987-01-20 1988-09-20 Triton Biosciences, Inc. Peptides affecting blood pressure regulation
US4980283A (en) * 1987-10-01 1990-12-25 Merck & Co., Inc. Renin-inhibitory pepstatin phenyl derivatives
US5034512A (en) * 1987-10-22 1991-07-23 Warner-Lambert Company Branched backbone renin inhibitors
US5063207A (en) * 1987-10-26 1991-11-05 Warner-Lambert Company Renin inhibitors, method for using them, and compositions containing them
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
GB8728561D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
US5081127A (en) * 1988-01-07 1992-01-14 E. I. Du Pont De Nemours And Company Substituted 1,2,3-triazole angiotensin II antagonists
US5036054A (en) * 1988-02-11 1991-07-30 Warner-Lambert Company Renin inhibitors containing alpha-heteroatom amino acids
US5036053A (en) * 1988-05-27 1991-07-30 Warner-Lambert Company Diol-containing renin inhibitors
NZ230808A (en) * 1988-10-24 1993-04-28 Squibb & Sons Inc Pharmaceutical compositions and combinations containing an angiotensin-converting enzyme inhibitor and a thrombolytic agent
DE3841520A1 (de) * 1988-12-09 1990-06-13 Hoechst Ag Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
US5106835A (en) * 1988-12-27 1992-04-21 American Cyanamid Company Renin inhibitors
DE4004820A1 (de) * 1989-08-05 1991-04-25 Bayer Ag Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
US5063208A (en) * 1989-07-26 1991-11-05 Abbott Laboratories Peptidyl aminodiol renin inhibitors
US5098924A (en) * 1989-09-15 1992-03-24 E. R. Squibb & Sons, Inc. Diol sulfonamide and sulfinyl renin inhibitors
US5104869A (en) * 1989-10-11 1992-04-14 American Cyanamid Company Renin inhibitors
US5114937A (en) * 1989-11-28 1992-05-19 Warner-Lambert Company Renin inhibiting nonpeptides
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
US5098471A (en) * 1989-12-06 1992-03-24 Westinghouse Electric Corp. Separation of magnesium from magnesium chloride and zirconium and/or hafnium subchlorides in the production of zirconium and/or hafnium sponge metal
US5095119A (en) * 1990-03-08 1992-03-10 American Home Products Corporation Renin inhibitors
US5075451A (en) * 1990-03-08 1991-12-24 American Home Products Corporation Pyrrolimidazolones useful as renin inhibitors
US5064965A (en) * 1990-03-08 1991-11-12 American Home Products Corporation Renin inhibitors
US5085992A (en) * 1990-07-19 1992-02-04 Merck & Co., Inc. Microbial transformation process for antihypertensive products
US5087634A (en) * 1990-10-31 1992-02-11 G. D. Searle & Co. N-substituted imidazol-2-one compounds for treatment of circulatory disorders
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
SI9210098B (sl) † 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
GB9102804D0 (en) * 1991-02-11 1991-03-27 Ici Plc Heterocyclic derivatives
US5266583A (en) * 1992-09-01 1993-11-30 Merck & Co., Inc. Angitotensin II antagonist
US5264447A (en) * 1992-09-01 1993-11-23 Merck & Co., Inc. Angiotensin II antagonist

Also Published As

Publication number Publication date
DE69333362D1 (de) 2004-01-29
DE69333362T2 (de) 2005-01-27
WO1993020839A3 (en) 1994-02-17
ES2211867T5 (es) 2008-04-01
ES2211867T3 (es) 2004-07-16
JPH07505884A (ja) 1995-06-29
US5952305A (en) 1999-09-14
EP0641218A1 (de) 1995-03-08
EP1262175A2 (de) 2002-12-04
EP0641218B2 (de) 2007-11-14
CA2117782A1 (en) 1993-10-28
CA2117782C (en) 2008-07-08
DE69333362T3 (de) 2008-06-12
AU4281093A (en) 1993-11-18
DK0641218T3 (da) 2004-03-29
WO1993020839A2 (en) 1993-10-28
US5972990A (en) 1999-10-26
EP1262175A3 (de) 2003-04-09
EP0641218B1 (de) 2003-12-17

Similar Documents

Publication Publication Date Title
DK0641218T3 (da) Anvendelse af angiotensinantagonist (AT1) til formindskelse af postmyocardial infarktmorbiditet og -mortalitet
FI932517A0 (fi) Antagonister av angiotensin II
GB2270608B (en) Global management of telephone directory
DE69328439D1 (de) Kühlbare schaufelsstruktur
NO943025D0 (no) Tredjepartsbelastning
DE69311772D1 (de) Nichtwässriger Akkumulator
ID25854A (id) Wadah keranjang yang dapat dilipat-lipat
DE69316812D1 (de) Batterieschutzschaltungen
DE69330530D1 (de) Batterieschutzschaltungen
DE69720546D1 (de) Kaskadierter Anschluss von kommuniziernden Geräten
LV11465A (lv) Heterocikliski amidini panemiens to iegusanai un pielietojums
FI932087A (fi) Staolfiberfoerstaerkt betong med stor boejhaollfasthet
DE69324730D1 (de) Multiplizier-Akkumulator
DK0719281T3 (da) Flergrenede peptidstrukturer til anvendelse mod HIV
DK0689577T3 (da) Anvendelse af ferroncen
DE69840312D1 (de) Aufbewahrung von Kryogengemischen
ID22787A (id) Nitro-benzamida berguna sebagai zat anti - arritimia
KR930014464U (ko) 토목용 비탈면 보호블록
KR940004890U (ko) 작업용 우산
KR940005031U (ko) 휴대용 비눗갑
DE69319595D1 (de) Abbildung von thermoelektrizitaet bei supraleitenden kupraten
KR930024857U (ko) 절첩식 휴대용 물통
ATA235792A (de) Trocken-streifen-mörtel in porösen hüllen, streifenförmig verpackt
KR920007957U (ko) 비탈면 수로 겸용 보호블럭
KR940009224U (ko) 휴대 및 보관이 편리한 상