DE69333362D1 - Verwendung von angiotensin antagonisten (at1) zur verminderung des erkrankungs- und todesfallrisikos nach myokardinfarkt - Google Patents

Verwendung von angiotensin antagonisten (at1) zur verminderung des erkrankungs- und todesfallrisikos nach myokardinfarkt

Info

Publication number
DE69333362D1
DE69333362D1 DE69333362T DE69333362T DE69333362D1 DE 69333362 D1 DE69333362 D1 DE 69333362D1 DE 69333362 T DE69333362 T DE 69333362T DE 69333362 T DE69333362 T DE 69333362T DE 69333362 D1 DE69333362 D1 DE 69333362D1
Authority
DE
Germany
Prior art keywords
myocardinal
infect
disease
reduce
death risk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69333362T
Other languages
English (en)
Other versions
DE69333362T3 (de
DE69333362T2 (de
Inventor
A Pfeffer
M Pfeffer
Eugene Braunwald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27127973&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69333362(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/866,827 external-priority patent/US5977160A/en
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Publication of DE69333362D1 publication Critical patent/DE69333362D1/de
Application granted granted Critical
Publication of DE69333362T2 publication Critical patent/DE69333362T2/de
Publication of DE69333362T3 publication Critical patent/DE69333362T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69333362T 1992-04-10 1993-04-09 Verwendung von angiotensin antagonisten (at1) zur verminderung des erkrankungs- und todesfallrisikos nach myokardinfarkt Expired - Lifetime DE69333362T3 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US866827 1986-05-23
US07/866,827 US5977160A (en) 1992-04-10 1992-04-10 Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US981196 1992-11-25
US07/981,196 US5972990A (en) 1992-04-10 1992-11-25 Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
PCT/US1993/003318 WO1993020839A2 (en) 1992-04-10 1993-04-09 Use of renin-angiotensin antagonist for reducing post myocardial infarct mobidity and mortality

Publications (3)

Publication Number Publication Date
DE69333362D1 true DE69333362D1 (de) 2004-01-29
DE69333362T2 DE69333362T2 (de) 2005-01-27
DE69333362T3 DE69333362T3 (de) 2008-06-12

Family

ID=27127973

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69333362T Expired - Lifetime DE69333362T3 (de) 1992-04-10 1993-04-09 Verwendung von angiotensin antagonisten (at1) zur verminderung des erkrankungs- und todesfallrisikos nach myokardinfarkt

Country Status (9)

Country Link
US (2) US5972990A (de)
EP (2) EP1262175A3 (de)
JP (1) JPH07505884A (de)
AU (1) AU4281093A (de)
CA (1) CA2117782C (de)
DE (1) DE69333362T3 (de)
DK (1) DK0641218T4 (de)
ES (1) ES2211867T5 (de)
WO (1) WO1993020839A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1023067T4 (da) * 1997-10-17 2011-12-12 Ark Therapeutics Ltd Anvendelse af inhibitorer af renin-angiotensin-systemet til behandling af hypoxi eller svækket metabolisk funktion
CN101011390A (zh) 1999-01-26 2007-08-08 诺瓦提斯公司 血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
EE05670B1 (et) * 1999-08-30 2013-08-15 Aventis Pharma Deutschland Gmbh Ramipriil kardiovaskulaarsete haigusjuhtude „rahoidmiseks
US20030113330A1 (en) * 1999-11-08 2003-06-19 Uhal Bruce D. Methods for treating pulmonary fibrosis
EP1383885A4 (de) * 2001-04-04 2005-11-30 American Diagnostica Inc Verfahren zur herstellung eines stabilisierten, mit thrombin aktivierbaren fibrinolyseinhibitors (tafi) sowie verfahren zu dessen verwendung
CA2464561A1 (en) * 2001-10-25 2003-05-01 Depomed, Inc. Methods of treatment using a gastric retained losartan dosage
US7107198B2 (en) * 2001-11-02 2006-09-12 Sun Microsystems, Inc. Automatic generation of reduced-size circuit models including inductive interaction
FI20020197A0 (fi) * 2002-02-01 2002-02-01 Orion Corp Yhdistelmä akuutin myokardiilisen infarktin hoitoon
DE60332129D1 (de) * 2002-08-29 2010-05-27 American Diagnostica Inc Diagnostischer assay für den mit thrombin aktivierbaren fibrinolyse-inhibitor (tafi)
WO2014055392A2 (en) * 2012-10-01 2014-04-10 Decimmune Therapeutics, Inc. Method of protecting cardiac function
ITFI20140115A1 (it) * 2014-05-19 2015-11-19 Italmed Srl Composizione ad uso odontoiatrico per il trattamento chirurgico delle perimplantiti
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
US11081240B2 (en) 2018-06-14 2021-08-03 Astrazeneca Uk Limited Methods for treatment of hypertension with an angiotensin II receptor blocker pharmaceutical composition

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302386A (en) * 1978-08-25 1981-11-24 The Ohio State University Antigenic modification of polypeptides
US3932624A (en) * 1974-06-17 1976-01-13 Morton-Norwich Products, Inc. Method for prolonging the inhibitory effect of saralasin on angiotensin II
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4316906A (en) * 1978-08-11 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of substituted prolines
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4780401A (en) * 1984-04-09 1988-10-25 Ciba-Geigy Corporation Novel monoclonal antibodies to human renin and hybridoma cells, processes for their preparation and their applications
US4845079A (en) * 1985-01-23 1989-07-04 Luly Jay R Peptidylaminodiols
US5066643A (en) * 1985-02-19 1991-11-19 Sandoz Ltd. Fluorine and chlorine statine or statone containing peptides and method of use
EP0218688B1 (de) * 1985-04-19 1990-09-12 The Upjohn Company Substituierte dihalo-statin-reninhemmungsmittel
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
US4885292A (en) * 1986-02-03 1989-12-05 E. R. Squibb & Sons, Inc. N-heterocyclic alcohol renin inhibitors
US4816463A (en) * 1986-04-01 1989-03-28 Warner-Lambert Company Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5063053A (en) * 1986-10-20 1991-11-05 The United States Of America As Represented By The Department Of Health & Human Services Isolation and purification of the R18 antigen of HTLV-III
US4772684A (en) * 1987-01-20 1988-09-20 Triton Biosciences, Inc. Peptides affecting blood pressure regulation
US4980283A (en) * 1987-10-01 1990-12-25 Merck & Co., Inc. Renin-inhibitory pepstatin phenyl derivatives
US5034512A (en) * 1987-10-22 1991-07-23 Warner-Lambert Company Branched backbone renin inhibitors
US5063207A (en) * 1987-10-26 1991-11-05 Warner-Lambert Company Renin inhibitors, method for using them, and compositions containing them
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
GB8728561D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
US5081127A (en) * 1988-01-07 1992-01-14 E. I. Du Pont De Nemours And Company Substituted 1,2,3-triazole angiotensin II antagonists
US5036054A (en) * 1988-02-11 1991-07-30 Warner-Lambert Company Renin inhibitors containing alpha-heteroatom amino acids
US5036053A (en) * 1988-05-27 1991-07-30 Warner-Lambert Company Diol-containing renin inhibitors
NZ230808A (en) * 1988-10-24 1993-04-28 Squibb & Sons Inc Pharmaceutical compositions and combinations containing an angiotensin-converting enzyme inhibitor and a thrombolytic agent
DE3841520A1 (de) * 1988-12-09 1990-06-13 Hoechst Ag Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
US5106835A (en) * 1988-12-27 1992-04-21 American Cyanamid Company Renin inhibitors
DE4004820A1 (de) * 1989-08-05 1991-04-25 Bayer Ag Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
US5063208A (en) * 1989-07-26 1991-11-05 Abbott Laboratories Peptidyl aminodiol renin inhibitors
US5098924A (en) * 1989-09-15 1992-03-24 E. R. Squibb & Sons, Inc. Diol sulfonamide and sulfinyl renin inhibitors
US5104869A (en) * 1989-10-11 1992-04-14 American Cyanamid Company Renin inhibitors
US5114937A (en) * 1989-11-28 1992-05-19 Warner-Lambert Company Renin inhibiting nonpeptides
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
US5098471A (en) * 1989-12-06 1992-03-24 Westinghouse Electric Corp. Separation of magnesium from magnesium chloride and zirconium and/or hafnium subchlorides in the production of zirconium and/or hafnium sponge metal
US5064965A (en) * 1990-03-08 1991-11-12 American Home Products Corporation Renin inhibitors
US5095119A (en) * 1990-03-08 1992-03-10 American Home Products Corporation Renin inhibitors
US5075451A (en) * 1990-03-08 1991-12-24 American Home Products Corporation Pyrrolimidazolones useful as renin inhibitors
US5085992A (en) * 1990-07-19 1992-02-04 Merck & Co., Inc. Microbial transformation process for antihypertensive products
US5087634A (en) * 1990-10-31 1992-02-11 G. D. Searle & Co. N-substituted imidazol-2-one compounds for treatment of circulatory disorders
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
SI9210098B (sl) † 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
GB9102804D0 (en) * 1991-02-11 1991-03-27 Ici Plc Heterocyclic derivatives
US5264447A (en) * 1992-09-01 1993-11-23 Merck & Co., Inc. Angiotensin II antagonist
US5266583A (en) * 1992-09-01 1993-11-30 Merck & Co., Inc. Angitotensin II antagonist

Also Published As

Publication number Publication date
AU4281093A (en) 1993-11-18
ES2211867T5 (es) 2008-04-01
US5952305A (en) 1999-09-14
DK0641218T3 (da) 2004-03-29
DE69333362T3 (de) 2008-06-12
CA2117782A1 (en) 1993-10-28
WO1993020839A3 (en) 1994-02-17
JPH07505884A (ja) 1995-06-29
EP0641218B1 (de) 2003-12-17
EP1262175A3 (de) 2003-04-09
EP0641218B2 (de) 2007-11-14
ES2211867T3 (es) 2004-07-16
DK0641218T4 (da) 2008-01-02
WO1993020839A2 (en) 1993-10-28
EP0641218A1 (de) 1995-03-08
EP1262175A2 (de) 2002-12-04
CA2117782C (en) 2008-07-08
DE69333362T2 (de) 2005-01-27
US5972990A (en) 1999-10-26

Similar Documents

Publication Publication Date Title
DE69333362D1 (de) Verwendung von angiotensin antagonisten (at1) zur verminderung des erkrankungs- und todesfallrisikos nach myokardinfarkt
DE69729646D1 (de) Formulierung zur verwendung in der vorbeugung von pathogen-induzierten erkrankungen, einschliesslich hiv und hsv
FR2739255B1 (fr) Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
ID29198A (id) Pemakaian uridin 5'-difosfat dan persamaannya untuk mengobati penyakit paru-paru
DE69609353D1 (de) In der therapie verwendbare chinolin- und chinazolinverbindungen
DE69530003D1 (de) Verwendung von koniferylaldehyd und alpha-hexyl cinnamaldehyd zur bekämpfung von insekten und milben
DE59406374D1 (de) Hydroxamsäuren und hydroxamsäureether sowie ihre verwendung als komplexbildner
DE69418203D1 (de) Zementiermittel und ihre verwendung
DE69432595D1 (de) Antagonisten des angiotensin ii-rezeptors zur behandlung von chronischen entzündlichen erkrankungen
DE69033636D1 (de) Verwendung von 4-Acyloxychinolin-Derivate als Insektizide und Akarizide
DE69301529D1 (de) Methode zur Reduktion der Stoff- und Reibungsempfindlichkeit von Tetrazolen
DE69333264D1 (de) 3-Phenyl-5-pyridyl-Triazole und ihre Verwendung als Insektizide
DE69434777D1 (de) Verwendung von Relaxin zur Herstellung von therapeutischen Mitteln
DE122007000051I2 (de) Kristallmodifikation von 1-(2,6-difluorbenzyl) -1h-1,2,3-triazol-4-carbonsäureamid und seine verwendung als antiepileptikum
DE69133390D1 (de) Verwendung von angiotensin-ii-rezeptorantagonisten in der behandlung von hämorragischem schlaganfall
DE69327537T2 (de) 17-beta-arylester carboxylate von 4-aza-5-alpha-androstan-3-one
DE69332815T2 (de) Polyglyzidyl-Äthern und ihre Verwendung
DK0604254T3 (da) Kanister til strå
DE59307471D1 (de) Neue lederfettungsmittel und ihre verwendung (ii)
DE69702817D1 (de) Verwendung von N-Acetonylbenzamiden zur Bekämpfung von resistenten Pilzen
DE69029899D1 (de) "Pour-on"-Formulierungen zur Bekämpfung von internen und externen Parasiten bei homoöthermen Tieren
DE59502325D1 (de) Arzneimittelszusammensetzung aus S-Milchsäure und dessen Verwendung
ES529570A0 (es) Procedimiento de intensificar cultivos agricolas y similares
DE59606574D1 (de) Para-Hydroxyphenylessigsäure zur Reduktion der Repellenz von Insektiziden
FR2771900B1 (fr) Composition pour la lutte contre les organismes vivants nuisibles et son procede d'utilisation

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings