DK0637244T3 - En stamme af Streptomyces avermilitis glycosylerer avermectinforbindelser - Google Patents

En stamme af Streptomyces avermilitis glycosylerer avermectinforbindelser

Info

Publication number
DK0637244T3
DK0637244T3 DK93907514T DK93907514T DK0637244T3 DK 0637244 T3 DK0637244 T3 DK 0637244T3 DK 93907514 T DK93907514 T DK 93907514T DK 93907514 T DK93907514 T DK 93907514T DK 0637244 T3 DK0637244 T3 DK 0637244T3
Authority
DK
Denmark
Prior art keywords
cir
compounds
hydroxy
avermectin
strain
Prior art date
Application number
DK93907514T
Other languages
Danish (da)
English (en)
Inventor
Byron H Arison
Tanya Macneil
Marvin D Schulman
Douglas J Macneil
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/855,311 external-priority patent/US5312753A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0637244T3 publication Critical patent/DK0637244T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/58Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623Avermectin; Milbemycin; Ivermectin; C-076
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK93907514T 1992-03-23 1993-03-16 En stamme af Streptomyces avermilitis glycosylerer avermectinforbindelser DK0637244T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85531092A 1992-03-23 1992-03-23
US07/855,311 US5312753A (en) 1992-03-23 1992-03-23 Strain of streptomyces avermitilis capable of glycosylating avermectin compounds at the 13- and 14A positions
PCT/US1993/002366 WO1993018779A1 (fr) 1992-03-23 1993-03-16 Souche de streptomyces avermitilis utilisee pour glycosyler des composes d'avermectine

Publications (1)

Publication Number Publication Date
DK0637244T3 true DK0637244T3 (da) 2001-01-29

Family

ID=27127288

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93907514T DK0637244T3 (da) 1992-03-23 1993-03-16 En stamme af Streptomyces avermilitis glycosylerer avermectinforbindelser

Country Status (10)

Country Link
EP (1) EP0637244B1 (fr)
JP (1) JP3263076B2 (fr)
AT (1) ATE198493T1 (fr)
AU (1) AU3809393A (fr)
DE (1) DE69329821T2 (fr)
DK (1) DK0637244T3 (fr)
ES (1) ES2152947T3 (fr)
GR (1) GR3035187T3 (fr)
PT (1) PT637244E (fr)
WO (1) WO1993018779A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101372681B (zh) * 2003-06-11 2011-09-07 社团法人北里研究所 一种非奈马克丁产生微生物菌株
DE102007007750A1 (de) 2006-08-17 2008-02-21 Bayer Cropscience Ag Avermectinderivate
CN103772458B (zh) * 2012-10-25 2016-05-04 北大方正集团有限公司 一种尼莫克汀的提纯方法
CN105624229B (zh) * 2014-10-30 2019-01-08 牡丹江佰佳信生物科技有限公司 一种提高尼莫克汀产量的方法
CN108774626B (zh) * 2018-02-01 2020-11-17 上海莫息生物科技有限公司 一种生产尼莫克汀的方法和菌株

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4206205A (en) * 1977-10-03 1980-06-03 Merck & Co., Inc. Monosaccharide and aglycone derivatives of C-076
US4666937A (en) * 1985-03-04 1987-05-19 Merck & Co., Inc. Avermectin bioconversion products
CA1339481C (fr) * 1988-10-18 1997-09-30 Shieh-Shung Tom Chen Produits de bioconversion anthelmintiques
US5188944A (en) * 1990-06-22 1993-02-23 Merck & Co., Inc. Process for the glycosylation of avermectin agylcones
NZ238521A (en) * 1990-06-22 1992-12-23 Merck & Co Inc Process for the conversion of avermectin glycone to avermectin mono- and disaccharides by fermentation with streptomyces avermitilis ma6078
US5192671A (en) * 1991-06-26 1993-03-09 Merck & Co., Inc. Process for the glycosylation of avermectin compounds

Also Published As

Publication number Publication date
ES2152947T3 (es) 2001-02-16
EP0637244A1 (fr) 1995-02-08
DE69329821D1 (de) 2001-02-08
AU3809393A (en) 1993-10-21
ATE198493T1 (de) 2001-01-15
WO1993018779A1 (fr) 1993-09-30
EP0637244A4 (fr) 1995-07-12
PT637244E (pt) 2001-04-30
JPH07505280A (ja) 1995-06-15
GR3035187T3 (en) 2001-04-30
EP0637244B1 (fr) 2001-01-03
JP3263076B2 (ja) 2002-03-04
DE69329821T2 (de) 2001-07-19

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