DK0626070T3 - Fremgangsmåde til bestemmelse af hirudin og syntetiske thrombininhibitorer - Google Patents

Fremgangsmåde til bestemmelse af hirudin og syntetiske thrombininhibitorer

Info

Publication number
DK0626070T3
DK0626070T3 DK93903232.2T DK93903232T DK0626070T3 DK 0626070 T3 DK0626070 T3 DK 0626070T3 DK 93903232 T DK93903232 T DK 93903232T DK 0626070 T3 DK0626070 T3 DK 0626070T3
Authority
DK
Denmark
Prior art keywords
pct
hirudin
determination
synthetic thrombin
thrombin inhibitors
Prior art date
Application number
DK93903232.2T
Other languages
Danish (da)
English (en)
Inventor
Goetz Nowak
Elke Bucha
Jutta Hoffmann
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of DK0626070T3 publication Critical patent/DK0626070T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/4609—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
    • G01N2333/4613—Snake venom
    • G01N2333/4633—Snake venom from Echis carinatus; Ecarin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK93903232.2T 1992-02-11 1993-01-25 Fremgangsmåde til bestemmelse af hirudin og syntetiske thrombininhibitorer DK0626070T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4203980A DE4203980A1 (de) 1992-02-11 1992-02-11 Verfahren zur bestimmung von hirudin und synthetischen thrombininhibitoren

Publications (1)

Publication Number Publication Date
DK0626070T3 true DK0626070T3 (da) 1996-05-06

Family

ID=6451420

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93903232.2T DK0626070T3 (da) 1992-02-11 1993-01-25 Fremgangsmåde til bestemmelse af hirudin og syntetiske thrombininhibitorer

Country Status (8)

Country Link
US (1) US5547850A (ja)
EP (1) EP0626070B1 (ja)
JP (1) JP3198111B2 (ja)
AT (1) ATE136367T1 (ja)
DE (2) DE4203980A1 (ja)
DK (1) DK0626070T3 (ja)
ES (1) ES2087715T3 (ja)
WO (1) WO1993016390A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4203965A1 (de) * 1992-02-11 1993-08-12 Max Planck Gesellschaft Antidot fuer hirudin und synthetische thrombininhibitoren
DE19755682A1 (de) * 1997-12-15 1999-06-17 Knoll Ag Verfahren zur Ermittlung eines Dosierungschemas für Thrombininhibitoren
DE19904674A1 (de) 1999-02-04 2000-08-31 Haemosys Gmbh Verfahren zur Bestimmung der Konzentration von Thrombininhibitoren
US7422905B2 (en) 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US7439069B2 (en) 2004-02-27 2008-10-21 Nippoldt Douglas D Blood coagulation test cartridge, system, and method
US7399637B2 (en) 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
WO2005111231A2 (en) * 2004-05-11 2005-11-24 Heptest Laboratories, Inc. Compositions, kit and one-step method for monitoring compounds having anti-factor xa and/or anti factor iia activities
GB2433592A (en) * 2005-12-23 2007-06-27 Pentapharm Ag Assay for thrombin inhibitors
ES2907190T3 (es) * 2014-07-31 2022-04-22 Haemonetics Corp Detección de la reversión de un anticoagulante mediante pruebas de coagulación por ecarina y factor Xa

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
DE3038163A1 (de) * 1980-10-09 1982-05-06 Boehringer Mannheim Gmbh, 6800 Mannheim Thrombininhibitor, seine herstellung und verwendung
EP0049877B1 (de) * 1980-10-09 1984-05-23 Roche Diagnostics GmbH Verfahren und Reagenz zur Bestimmung von Antithrombin-BM
DE3330699A1 (de) * 1983-08-25 1985-03-07 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma
NL8902406A (nl) * 1989-09-27 1991-04-16 Hendrik Coenraad Hemker Prof D Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit.
DE59109048D1 (de) * 1990-02-14 1998-10-15 Pentapharm Ag Inhibitoren zur antikoagulierenden Vorbehandung von Blutproben
JP3094165B2 (ja) * 1990-11-05 2000-10-03 バクスター、ダイアグノスチックス、インコーポレイテッド 抗凝固剤濃度測定方法

Also Published As

Publication number Publication date
DE59302119D1 (de) 1996-05-09
JP3198111B2 (ja) 2001-08-13
DE4203980A1 (de) 1993-08-12
EP0626070B1 (de) 1996-04-03
EP0626070A1 (de) 1994-11-30
ATE136367T1 (de) 1996-04-15
JPH07503373A (ja) 1995-04-13
WO1993016390A1 (de) 1993-08-19
ES2087715T3 (es) 1996-07-16
US5547850A (en) 1996-08-20

Similar Documents

Publication Publication Date Title
DK0509086T3 (da) Fremgangsmåde til bestemmelse af koncentrationen af antikoagulanter
Lange et al. Ecarin chromogenic assay–a new method for quantitative determination of direct thrombin inhibitors like hirudin
US20090087870A1 (en) Hematological assay and kit
DK163671C (da) Reagens og fremgangsmaade til fotometrisk bestemmelse af thromboplastintiden, reagensets fremstilling og anvendelse
ATE315233T1 (de) Verfahren zur bestimmung des antikoagulatorischen potentials einer probe und verfahren zur bestimmung der glykosilierung von thrombomodulin
DK0626070T3 (da) Fremgangsmåde til bestemmelse af hirudin og syntetiske thrombininhibitorer
ATE85131T1 (de) Verfahren zur spezifischen bestimmung des serumfructosamingehalts sowie hierfuer geeignetes reagenzgemisch.
ATE78519T1 (de) Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet.
Lindhoff-Last et al. Hirudin Determination in Plasma Can Be Strongly Influenced by the Prothrombin Level☆
DK0830608T3 (da) Thromboseriskotest
ATE115728T1 (de) Verfahren zur verminderung von störungen in einer fluoreszenzbestimmung.
ATE333091T1 (de) Verfahren zur messung von blutersatzstoffen
US4918001A (en) Method for the determination of protease inhibitors
ATE226322T1 (de) Verfahren zum durchführen von bluttests
ATE40718T1 (de) Verfahren zur bestimmung von fibrinmonomer in plasma.
ATE16944T1 (de) Reagens zur optischen bestimmung des blutgerinnungsverhaltens.
DK164512C (da) Fremgangsmaade til simultan bestemmelse af prokallikrein og den partielle thromboplastintid
KR920704117A (ko) 피브리노겐 직접 분석 방법
Vinazzer Photometric assay of antithrombin III with a chromogenic substrate
Nowak et al. Process for determining hirudin and synthetic thrombin inhibitors
ATE199781T1 (de) Verfahren zur beseitigung von hämoglobin- störungen bei der bestimmung von albumin
ATE491945T1 (de) Verfahren zur bestimmung des vorhandenseins von thrombozyteninhibitoren in einer blutprobe