ES2087715T3 - Procedimiento para la determinacion de hirudina e inhibidores sinteticos de la trombina. - Google Patents

Procedimiento para la determinacion de hirudina e inhibidores sinteticos de la trombina.

Info

Publication number
ES2087715T3
ES2087715T3 ES93903232T ES93903232T ES2087715T3 ES 2087715 T3 ES2087715 T3 ES 2087715T3 ES 93903232 T ES93903232 T ES 93903232T ES 93903232 T ES93903232 T ES 93903232T ES 2087715 T3 ES2087715 T3 ES 2087715T3
Authority
ES
Spain
Prior art keywords
pct
hirudine
thrombin
determination
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93903232T
Other languages
English (en)
Inventor
Gotz Nowak
Elke Bucha
Jutta Hoffmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Application granted granted Critical
Publication of ES2087715T3 publication Critical patent/ES2087715T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/4609—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
    • G01N2333/4613—Snake venom
    • G01N2333/4633—Snake venom from Echis carinatus; Ecarin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA DETERMINACION DE HIRUDINA E INHIBIDORES DE TROMBINA SINTETICO EN LA SANGRE O EN CONSTITUYENTES DE LA SANGRE. EN ESTE PROCEDIMIENTO, UNA PROTOMBINA INTERMEDIA, UN COMPUESTO QUE SE DIVIDE EN FORMA DE PROTOMBINA DENTRO DE MEIZOTROMBINA, UNA SAL O UNA MEZCLA DE ESTOS COMPUESTOS MAS, ADICIONALMENTE, AMORTIGUADORES Y/O OTROS ADITIVOS ACOSTUMBRADOS SE AÑADEN A LA SANGRE O A LOS CONSTITUYENTES DE LA SANGRE Y SE MIDE EL TIEMPO DESDE LA ADICION HASTA EL PUNTO EN EL QUE EMPIEZA LA COAGULACION. LA INVENCION SE REFIERE TAMBIEN A MEDIOS PARA LA REALIZACION DEL PROCEDIMIENTO, INCLUYENDO LOS MEDIOS UNA PROTOMBINA INTERMEDIA, UN COMPUESTO QUE RAMIFICA LA PROTOMBINA DENTRO DE LA MEIZOTROMBINA, UNA SAL DE ELLA O UNA MEZCLA DE SUS COMPUESTOS MAS, ADICIONALMENTE, AMORTIGUADORES Y/O OTROS ADITIVOS ACOSTUMBRADOS.
ES93903232T 1992-02-11 1993-01-25 Procedimiento para la determinacion de hirudina e inhibidores sinteticos de la trombina. Expired - Lifetime ES2087715T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4203980A DE4203980A1 (de) 1992-02-11 1992-02-11 Verfahren zur bestimmung von hirudin und synthetischen thrombininhibitoren

Publications (1)

Publication Number Publication Date
ES2087715T3 true ES2087715T3 (es) 1996-07-16

Family

ID=6451420

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93903232T Expired - Lifetime ES2087715T3 (es) 1992-02-11 1993-01-25 Procedimiento para la determinacion de hirudina e inhibidores sinteticos de la trombina.

Country Status (8)

Country Link
US (1) US5547850A (es)
EP (1) EP0626070B1 (es)
JP (1) JP3198111B2 (es)
AT (1) ATE136367T1 (es)
DE (2) DE4203980A1 (es)
DK (1) DK0626070T3 (es)
ES (1) ES2087715T3 (es)
WO (1) WO1993016390A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4203965A1 (de) * 1992-02-11 1993-08-12 Max Planck Gesellschaft Antidot fuer hirudin und synthetische thrombininhibitoren
DE19755682A1 (de) * 1997-12-15 1999-06-17 Knoll Ag Verfahren zur Ermittlung eines Dosierungschemas für Thrombininhibitoren
DE19904674A1 (de) 1999-02-04 2000-08-31 Haemosys Gmbh Verfahren zur Bestimmung der Konzentration von Thrombininhibitoren
US7439069B2 (en) 2004-02-27 2008-10-21 Nippoldt Douglas D Blood coagulation test cartridge, system, and method
US7422905B2 (en) 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US7399637B2 (en) 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
AU2005243161A1 (en) * 2004-05-11 2005-11-24 Heptest Laboratories, Inc. Compositions, kit and one-step method for monitoring compounds having anti-factor Xa and/or anti factor iia activities
GB2433592A (en) * 2005-12-23 2007-06-27 Pentapharm Ag Assay for thrombin inhibitors
ES2907190T3 (es) * 2014-07-31 2022-04-22 Haemonetics Corp Detección de la reversión de un anticoagulante mediante pruebas de coagulación por ecarina y factor Xa
EP3971576A1 (en) 2020-09-21 2022-03-23 Instrumentation Laboratory Company Detecting and monitoring oral anticoagulants or intravenous direct thrombin inhibitors in a blood sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
US4496653A (en) * 1980-10-09 1985-01-29 Boehringer Mannheim Gmbh Process for the determination of antithrombin-BM
DE3038163A1 (de) * 1980-10-09 1982-05-06 Boehringer Mannheim Gmbh, 6800 Mannheim Thrombininhibitor, seine herstellung und verwendung
DE3330699A1 (de) * 1983-08-25 1985-03-07 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma
NL8902406A (nl) * 1989-09-27 1991-04-16 Hendrik Coenraad Hemker Prof D Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit.
EP0442843B1 (de) * 1990-02-14 1998-09-09 Pentapharm A.G. Inhibitoren zur antikoagulierenden Vorbehandung von Blutproben
JP3094165B2 (ja) * 1990-11-05 2000-10-03 バクスター、ダイアグノスチックス、インコーポレイテッド 抗凝固剤濃度測定方法

Also Published As

Publication number Publication date
EP0626070B1 (de) 1996-04-03
US5547850A (en) 1996-08-20
DE4203980A1 (de) 1993-08-12
ATE136367T1 (de) 1996-04-15
DE59302119D1 (de) 1996-05-09
WO1993016390A1 (de) 1993-08-19
EP0626070A1 (de) 1994-11-30
JP3198111B2 (ja) 2001-08-13
JPH07503373A (ja) 1995-04-13
DK0626070T3 (da) 1996-05-06

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