DK0608178T3 - Fremgangsmåde til 16 alfa-methylering af steroider - Google Patents

Fremgangsmåde til 16 alfa-methylering af steroider

Info

Publication number
DK0608178T3
DK0608178T3 DK94400114.8T DK94400114T DK0608178T3 DK 0608178 T3 DK0608178 T3 DK 0608178T3 DK 94400114 T DK94400114 T DK 94400114T DK 0608178 T3 DK0608178 T3 DK 0608178T3
Authority
DK
Denmark
Prior art keywords
alpha
hydrogen
beta
optionally
residue
Prior art date
Application number
DK94400114.8T
Other languages
Danish (da)
English (en)
Inventor
Patrick Roussel
Michel Vivat
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Application granted granted Critical
Publication of DK0608178T3 publication Critical patent/DK0608178T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94400114.8T 1993-01-20 1994-01-19 Fremgangsmåde til 16 alfa-methylering af steroider DK0608178T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9300519A FR2700548B1 (fr) 1993-01-20 1993-01-20 Nouveau procédé de préparation de stéroïdes 16 alpha-méthylés.

Publications (1)

Publication Number Publication Date
DK0608178T3 true DK0608178T3 (da) 1996-10-07

Family

ID=9443202

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94400114.8T DK0608178T3 (da) 1993-01-20 1994-01-19 Fremgangsmåde til 16 alfa-methylering af steroider

Country Status (17)

Country Link
US (1) US5508452A (ko)
EP (1) EP0608178B1 (ko)
JP (1) JP3535555B2 (ko)
KR (1) KR100284824B1 (ko)
CN (1) CN1040647C (ko)
AT (1) ATE140924T1 (ko)
AU (1) AU667147B2 (ko)
CA (1) CA2113776C (ko)
DE (1) DE69400340T2 (ko)
DK (1) DK0608178T3 (ko)
ES (1) ES2091095T3 (ko)
FR (1) FR2700548B1 (ko)
GR (1) GR3020751T3 (ko)
HU (1) HU221320B1 (ko)
RU (1) RU2127278C1 (ko)
UA (1) UA44887C2 (ko)
ZA (1) ZA94405B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040468A (en) * 1996-10-25 2000-03-21 Alcon Laboratories, Inc. Method of preparing 16α, 17α-dialkylated steroids
US6841665B2 (en) 2000-02-18 2005-01-11 The University Of Hong Kong Method for synthesizing 5β, 6β-epoxides of steroids by a highly β-selective epoxidation of ΔΔ5-unsaturated steroids catalyzed by ketones
EP2444092B1 (en) 2008-05-28 2015-09-02 ReveraGen BioPharma, Inc. Non-hormonal steroid modulators of nf-kb for treatment of disease
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
CN115322242B (zh) * 2022-09-14 2023-09-12 山东赛托生物科技股份有限公司 一种高品质甾体药物中间体的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE28369E (en) * 1957-02-27 1975-03-18 Atcc-zxs
US3080393A (en) * 1960-02-04 1963-03-05 Syntex Corp Process for preparing 16alpha-methyl-17alpha-hydroxy-20-keto-pregnanes from the corresponding 16-dehydro-20-keto pregnanes
JPS504657B1 (ko) * 1968-07-30 1975-02-22
US4022769A (en) * 1974-05-13 1977-05-10 Richardson-Merrell Inc. Androst-4-en-19-ones
NL7607283A (nl) * 1975-07-23 1977-01-25 Merck & Co Inc Werkwijze voor het bereiden van nieuwe pregnaansteroiden.
US4704455A (en) * 1984-06-11 1987-11-03 The Upjohn Company 16α-methylatedΔ17(20)-corticoids
US4990612A (en) * 1984-06-11 1991-02-05 The Upjohn Company 16α-methylation process
JPS611699A (ja) * 1984-06-11 1986-01-07 ジ　アツプジヨン　カンパニー １６α‐メチル化法
KR960011781B1 (ko) * 1986-06-04 1996-08-30 디 엎죤 캄파니 16α-메틸화 공정
US4772755A (en) * 1987-03-19 1988-09-20 Mcneilab, Inc. 1,2-1,4 addition reaction sequence leading to disubstituted acelylenes
FR2643638B1 (fr) * 1989-02-24 1991-06-14 Roussel Uclaf Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2692266B1 (fr) * 1992-06-11 1994-08-05 Roussel Uclaf Nouveau procede de preparation de sterouides 16 alpha-methyles.

Also Published As

Publication number Publication date
ZA94405B (en) 1995-01-20
HU9400156D0 (en) 1994-05-30
AU5384794A (en) 1994-07-28
JPH06293791A (ja) 1994-10-21
EP0608178A1 (fr) 1994-07-27
CA2113776C (fr) 2004-10-05
HU221320B1 (en) 2002-09-28
DE69400340D1 (de) 1996-09-05
EP0608178B1 (fr) 1996-07-31
ES2091095T3 (es) 1996-10-16
GR3020751T3 (en) 1996-11-30
UA44887C2 (uk) 2002-03-15
HUT66233A (en) 1994-10-28
FR2700548A1 (fr) 1994-07-22
CA2113776A1 (fr) 1994-07-21
CN1040647C (zh) 1998-11-11
DE69400340T2 (de) 1997-01-23
ATE140924T1 (de) 1996-08-15
AU667147B2 (en) 1996-03-07
JP3535555B2 (ja) 2004-06-07
US5508452A (en) 1996-04-16
FR2700548B1 (fr) 1995-03-03
KR940018396A (ko) 1994-08-16
KR100284824B1 (ko) 2001-03-15
RU2127278C1 (ru) 1999-03-10
CN1103643A (zh) 1995-06-14

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