DK0595873T3 - Negativt cytosindeaminaseselektionssystem til gentransferteknikker og -terapier - Google Patents

Negativt cytosindeaminaseselektionssystem til gentransferteknikker og -terapier

Info

Publication number
DK0595873T3
DK0595873T3 DK92915347T DK92915347T DK0595873T3 DK 0595873 T3 DK0595873 T3 DK 0595873T3 DK 92915347 T DK92915347 T DK 92915347T DK 92915347 T DK92915347 T DK 92915347T DK 0595873 T3 DK0595873 T3 DK 0595873T3
Authority
DK
Denmark
Prior art keywords
cytosine deaminase
therapies
negative
gene transfer
selection system
Prior art date
Application number
DK92915347T
Other languages
Danish (da)
English (en)
Inventor
Craig A Mullen
R Michael Blaese
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of DK0595873T3 publication Critical patent/DK0595873T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Brushes (AREA)
  • Exchange Systems With Centralized Control (AREA)
  • Devices For Checking Fares Or Tickets At Control Points (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK92915347T 1991-07-03 1992-06-30 Negativt cytosindeaminaseselektionssystem til gentransferteknikker og -terapier DK0595873T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/725,076 US5358866A (en) 1991-07-03 1991-07-03 Cytosine deaminase negative selection system for gene transfer techniques and therapies
PCT/US1992/005385 WO1993001281A1 (fr) 1991-07-03 1992-06-30 Systeme de selection negative de cytosine desaminase pour techniques et therapies de transfert de gene

Publications (1)

Publication Number Publication Date
DK0595873T3 true DK0595873T3 (da) 2000-07-10

Family

ID=24913069

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92915347T DK0595873T3 (da) 1991-07-03 1992-06-30 Negativt cytosindeaminaseselektionssystem til gentransferteknikker og -terapier

Country Status (12)

Country Link
US (2) US5358866A (fr)
EP (1) EP0595873B1 (fr)
JP (1) JP3386461B2 (fr)
AT (1) ATE191505T1 (fr)
AU (1) AU667820B2 (fr)
CA (1) CA2112395C (fr)
DE (1) DE69230882T2 (fr)
DK (1) DK0595873T3 (fr)
ES (1) ES2152929T3 (fr)
GR (1) GR3033909T3 (fr)
SG (1) SG52475A1 (fr)
WO (1) WO1993001281A1 (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6337209B1 (en) 1992-02-26 2002-01-08 Glaxo Wellcome Inc. Molecular constructs containing a carcinoembryonic antigen regulatory sequence
CA2042093C (fr) * 1990-05-09 2002-12-24 Gyula Hadlaczky Lignee de cellules renfermant un exces de centromeres mammaliens
US6555370B1 (en) * 1990-11-13 2003-04-29 Immunex Corporation Bifunctional selectable fusion genes
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
WO1993010218A1 (fr) * 1991-11-14 1993-05-27 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Vecteurs comprenant des genes etrangers et des marqueurs selectifs negatifs
FR2683725B1 (fr) * 1991-11-15 1995-07-07 Pasteur Institut Composition cellulaire pour le traitement des organismes humains ou animaux.
DK0637966T3 (da) * 1992-05-01 1998-05-04 Us Health Tumoricid terapi med "tilskuer-virkning"
CA2163427A1 (fr) * 1993-05-21 1994-12-08 Stephen D. Lupton Genes hybrides bifonctionnels selectables, a base du gene de la cytosine desaminase (cd)
US6451571B1 (en) 1994-05-02 2002-09-17 University Of Washington Thymidine kinase mutants
AU2434195A (en) * 1994-05-02 1995-11-29 University Of Washington Thymidine kinase mutants
US6013517A (en) * 1994-05-09 2000-01-11 Chiron Corporation Crossless retroviral vectors
JP4303315B2 (ja) 1994-05-09 2009-07-29 オックスフォード バイオメディカ（ユーケー）リミテッド 非交差性レトロウイルスベクター
US5856153A (en) * 1994-11-17 1999-01-05 Cayla Suicide genes and new associations of pyrimidine nucleobase and nucleoside analogs with new suicide genes for gene therapy of acquired diseases
US6638762B1 (en) * 1994-11-28 2003-10-28 Genetic Therapy, Inc. Tissue-vectors specific replication and gene expression
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
US20020068049A1 (en) * 1998-09-10 2002-06-06 Henderson Daniel R. Tissue specific adenoviral vectors
WO1997015668A2 (fr) * 1995-10-23 1997-05-01 Board Of Regents, The University Of Texas System Procedes et compositions comprenant glut-2 et des chimeres de glut-2
DE19704979A1 (de) * 1996-02-07 1997-08-14 Max Delbrueck Centrum Retroviraler Vektor für den Gentransfer eines IL6-Antagonisten in humane hämatopoetische Stammzellen
US20020160970A1 (en) * 1996-04-10 2002-10-31 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US20030033617A1 (en) 1996-04-10 2003-02-13 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6566089B1 (en) * 1996-09-04 2003-05-20 Tularik Inc. Cell-based drug screens for regulators of gene expression
CN1303436A (zh) * 1998-02-19 2001-07-11 圣朱迪儿童研究医院 致敏和抑制人肿瘤细胞生长的组合物和方法
GB9810752D0 (en) * 1998-05-19 1998-07-15 Glaxo Group Ltd Cystosine deaminase gene
US5958767A (en) * 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
US20020115213A1 (en) * 1998-08-14 2002-08-22 Northeastern Ohio Universities Of Medicine Engraftable neural progenitor & stem cells for brain tumor therapy
US7186409B2 (en) 1998-08-14 2007-03-06 The Children's Medical Center Corporation Neural stem cells and use thereof for brain tumor therapy
FR2794025A1 (fr) * 1999-05-25 2000-12-01 Transgene Sa Composition destinee a la mise en oeuvre d'un traitement antitumoral ou antiviral chez un mammifere
US6656917B1 (en) 1999-06-30 2003-12-02 Marker Gene Technologies, Inc. Compositions and methods for targeted enzymatic release of cell regulatory compounds
US8716558B2 (en) 1999-06-30 2014-05-06 Marker Gene Technologies, Inc. Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase
AU4744201A (en) * 2000-03-15 2001-09-24 Childrens Medical Center Systemic gene delivery vehicles for the treatment of tumors
US6579522B1 (en) 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
EP1322752B2 (fr) * 2000-09-28 2015-02-11 Bioriginal Food & Science Corp. Fad4, fad5, fad5-2, and fad6, membres de la famille des desaturases d'acides gras et utilisations associees
EP1264891A1 (fr) * 2001-05-31 2002-12-11 Plant Research International B.V. Modification du génome vegetal par recombinaison dirigée inductible des transgenes
AU2002312543A1 (en) * 2001-08-01 2003-02-17 University Of Utah, Technology Transfer Office Isoform-selective inhibitors and activators of pde3 cyclic
US20030086903A1 (en) * 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
US7786344B2 (en) * 2002-07-26 2010-08-31 Basf Plant Science Gmbh Selection method
US20040149174A1 (en) * 2003-02-05 2004-08-05 Mbt Holding Ag Accelerating admixture for concrete
ATE405654T1 (de) 2003-07-21 2008-09-15 Transgene Sa Polypeptid mit verbesserter cytosin-deaminase- aktivität
EP1925626A1 (fr) 2003-07-21 2008-05-28 Transgene S.A. Nouvelles cytokines multifonctionnelles
DE602004025726D1 (de) * 2003-11-14 2010-04-08 Genvec Inc Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc).
WO2005090582A1 (fr) * 2004-03-17 2005-09-29 Basf Plant Science Gmbh Controle post-recolte de culture genetiquement modifiee utilisant des composes d'acides amines d
AU2005224324B2 (en) * 2004-03-17 2009-12-24 Basf Plant Science Gmbh Improved constructs for marker excision based on dual-function selection marker
BR122013008865B8 (pt) 2004-05-26 2021-05-25 Psioxus Therapeutics Ltd adenovírus oncolítico de replicação competente
AU2005268917B2 (en) 2004-08-02 2010-05-20 Basf Plant Science Gmbh Method for isolation of transcription termination sequences
CA2606220A1 (fr) 2005-04-19 2006-12-21 Basf Plant Science Gmbh Expression specifique de l'albumen farineux et/ou de l'embryon en germination dans des plantes monocotyledonees
US20070026012A1 (en) 2005-08-01 2007-02-01 Cornell Research Foundation, Inc. Compositions and methods for monitoring and altering protein folding and solubility
AU2006283130B2 (en) 2005-08-22 2012-02-09 Cornell Research Foundation, Inc. Compositions and methods for analyzing protein interactions
CA2675926A1 (fr) 2007-02-16 2008-08-21 Basf Plant Science Gmbh Sequences d'acides nucleiques pour la regulation de l'expression specifique de l'embryon dans des plantes monocotyles
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
JP5771147B2 (ja) 2008-09-26 2015-08-26 トカジェン インコーポレーテッド 遺伝子治療ベクターおよびシトシンデアミナーゼ
EP2248903A1 (fr) 2009-04-29 2010-11-10 Universitat Autònoma De Barcelona Procédés et réactifs pour le transfert génétique efficace et ciblé vers des monocytes et macrophages
US9605844B2 (en) * 2009-09-01 2017-03-28 Cree, Inc. Lighting device with heat dissipation elements
RU2588665C2 (ru) * 2011-12-21 2016-07-10 СиДжей ЧеилДжеданг Корпорейшн Способ получения l-лизина с использованием микроорганизмов, обладающих способностью продуцировать l-лизин
WO2014018113A1 (fr) 2012-07-24 2014-01-30 The General Hospital Corporation Traitement par virus oncolytique de tumeurs résistantes
PL3021859T3 (pl) 2013-10-25 2018-06-29 Psioxus Therapeutics Limited Adenowirusy onkolityczne wyposażone w geny heterolityczne
WO2015089280A1 (fr) 2013-12-11 2015-06-18 The General Hospital Corporation Virus herpes simplex oncolytique délivré par une cellule souche et procédés de traitement de tumeurs du cerveau
KR102457060B1 (ko) 2014-04-10 2022-10-19 트랜스진 폭스바이러스 종양용해 벡터
US20180112006A1 (en) 2015-04-17 2018-04-26 The General Hospital Corporation Agents, systems and methods for treating cancer
MX2017013684A (es) 2015-04-30 2018-08-28 Psioxus Therapeutics Ltd Adenovirus oncolitico que codifica una proteina b7.
CA3006859A1 (fr) 2015-12-17 2017-06-22 Psioxus Therapeutics Limited Adenovirus du groupe b codant pour un anticorps ou fragment contre le complexe tcr
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
CN109862912B (zh) 2016-08-29 2024-08-02 阿卡米斯生物公司 携带双特异性t细胞衔接器的腺病毒
KR102371151B1 (ko) 2020-03-13 2022-03-07 주식회사 큐로셀 항-bcma 결합 영역, 이를 포함하는 융합단백질, 및 이를 포함하는 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4975278A (en) * 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
CA2018273C (fr) * 1989-06-09 1999-04-06 Peter D. Senter Cytosine deaminase thermostable
GB8919607D0 (en) * 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies

Also Published As

Publication number Publication date
ES2152929T3 (es) 2001-02-16
EP0595873B1 (fr) 2000-04-05
JP3386461B2 (ja) 2003-03-17
EP0595873A1 (fr) 1994-05-11
WO1993001281A1 (fr) 1993-01-21
GR3033909T3 (en) 2000-11-30
CA2112395A1 (fr) 1993-01-21
CA2112395C (fr) 2008-04-22
US5358866A (en) 1994-10-25
EP0595873A4 (fr) 1994-12-07
ATE191505T1 (de) 2000-04-15
AU667820B2 (en) 1996-04-18
DE69230882D1 (de) 2000-05-11
AU2295992A (en) 1993-02-11
US5624830A (en) 1997-04-29
SG52475A1 (en) 1998-09-28
DE69230882T2 (de) 2000-11-09
JPH07501925A (ja) 1995-03-02

Similar Documents

Publication Publication Date Title
DK0595873T3 (da) Negativt cytosindeaminaseselektionssystem til gentransferteknikker og -terapier
EP0500917A4 (en) Recombinant herpes simplex viruses vaccines and methods
ES2121794T3 (es) Procedimiento de transferencia de genes por medio de retrotransposones.
EP0846160A4 (fr) Procede d'amelioration de la production de vaccins antiviraux dans une culture cellulaire par suppression d'interferon
DE60303810D1 (de) Kontrollierte bakterielle lyse zur verabreichung von dna vakzinvektoren und impfantigen
ATE270342T1 (de) Endosomolytisch wirksame partikel
HK1018078A1 (en) Recombinant sendai virus
DK160998C (da) Plasmid indeholdende dna fra en plasmidfraktion af b.thuringiensis, e.coli bakteriestamme indeholdende plasmidet, gensplejset e.coli bakteriestamme, fremgangsmaade til fremstilling af plasmidet, fremgangsmaade til at skabe en gensplejset e.coli bakteriestamme, fremgangsmaade til fremstilling af bacillus thuringiensis krystalprotein og fremgangsmaade til at opnaa insekticid virkning i et miljoe
AU8067698A (en) Chimeric vectors comprising a phage packaging site and a portion derived from a genome of a eukaryotic virus
DK0617736T3 (da) Anvendelse af Bacillus thuringiensis isolater til bekæmpelse af skadedyr i familien Aphididae
ATE365205T1 (de) Virale partikel, die nach infektion durch humanes cytomegalovirus freigesetzt werden und ihre verwendung als impfstoff
DE69033961D1 (de) Zellinien, die einen biologisch aktiven faktor-ix exprimieren
ATE342997T1 (de) Herpesvirus saimiri als viraler vektor
Doersen et al. Cytoplasmic inheritance of erythromycin resistance in human cells.
DE60016429D1 (de) Zell- und/oder tumor-spezifische promotor-abhängige änderung der gezielten expression des herpes gamma 34.5 gens
Schuessler et al. Charge cluster-to-alanine scanning of UL128 for fine tuning of the endothelial cell tropism of human cytomegalovirus
Dulbecco Transformation of cells in vitro by DNA-containing viruses
Welsh et al. Lymphocyte-dependent ‘natural’immunity to virus infections mediated by both natural killer cells and memory T cells
Mullen et al. Cytosine deaminase negative selection system for gene transfer techniques and therapies
Xiao et al. Efficient Strategy for Synthesizing Vector-Free and Oncolytic Herpes Simplex Type 1 Viruses
GB9506298D0 (en) Diagnostic system
DK0635061T3 (da) Fremgangsmåde til begrænsning af genetisk manipulerede organismers overlevelse i deres miljø
DK204586D0 (da) Hybridceller, der producerer et karakteristisk antigen for hepatitis b-virus, opnaaet ud fra hepatocytter og celler, der er tilvejebragt fra aber, fremgangsmaade til opnaaelse af hybridcellerne og anvendelse af disse til produktion af antigenet
WO2000008192A3 (fr) Vecteurs d'herpesvirus utilises pour l'apport de genes
GEP19981481B (en) Means for Function Disturbance Recovery of Immunomodulated Action and Regulating System of Cells Reproduction