DE69230882D1 - Cytosindeaminase negatives selektionssystem zur genübertragung und therapien - Google Patents

Cytosindeaminase negatives selektionssystem zur genübertragung und therapien

Info

Publication number
DE69230882D1
DE69230882D1 DE69230882T DE69230882T DE69230882D1 DE 69230882 D1 DE69230882 D1 DE 69230882D1 DE 69230882 T DE69230882 T DE 69230882T DE 69230882 T DE69230882 T DE 69230882T DE 69230882 D1 DE69230882 D1 DE 69230882D1
Authority
DE
Germany
Prior art keywords
therapies
cytosindeaminase
communication
selection system
negative selection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69230882T
Other languages
English (en)
Other versions
DE69230882T2 (de
Inventor
A Mullen
Michael Blaese
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of DE69230882D1 publication Critical patent/DE69230882D1/de
Application granted granted Critical
Publication of DE69230882T2 publication Critical patent/DE69230882T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Brushes (AREA)
  • Exchange Systems With Centralized Control (AREA)
  • Devices For Checking Fares Or Tickets At Control Points (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69230882T 1991-07-03 1992-06-30 Cytosindeaminase negatives selektionssystem zur genübertragung und therapien Expired - Fee Related DE69230882T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/725,076 US5358866A (en) 1991-07-03 1991-07-03 Cytosine deaminase negative selection system for gene transfer techniques and therapies
PCT/US1992/005385 WO1993001281A1 (en) 1991-07-03 1992-06-30 Cytosine deaminase negative selection system for gene transfer techniques and therapies

Publications (2)

Publication Number Publication Date
DE69230882D1 true DE69230882D1 (de) 2000-05-11
DE69230882T2 DE69230882T2 (de) 2000-11-09

Family

ID=24913069

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230882T Expired - Fee Related DE69230882T2 (de) 1991-07-03 1992-06-30 Cytosindeaminase negatives selektionssystem zur genübertragung und therapien

Country Status (12)

Country Link
US (2) US5358866A (de)
EP (1) EP0595873B1 (de)
JP (1) JP3386461B2 (de)
AT (1) ATE191505T1 (de)
AU (1) AU667820B2 (de)
CA (1) CA2112395C (de)
DE (1) DE69230882T2 (de)
DK (1) DK0595873T3 (de)
ES (1) ES2152929T3 (de)
GR (1) GR3033909T3 (de)
SG (1) SG52475A1 (de)
WO (1) WO1993001281A1 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6337209B1 (en) 1992-02-26 2002-01-08 Glaxo Wellcome Inc. Molecular constructs containing a carcinoembryonic antigen regulatory sequence
CA2042093C (en) * 1990-05-09 2002-12-24 Gyula Hadlaczky Cell line carrying an excess of mammalian centromeres
US6555370B1 (en) * 1990-11-13 2003-04-29 Immunex Corporation Bifunctional selectable fusion genes
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
WO1993010218A1 (en) * 1991-11-14 1993-05-27 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Vectors including foreign genes and negative selective markers
FR2683725B1 (fr) * 1991-11-15 1995-07-07 Pasteur Institut Composition cellulaire pour le traitement des organismes humains ou animaux.
EP0637966B1 (de) * 1992-05-01 1997-08-27 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Warte-effekt bei tumorzerstörender therapie
EP0804590A1 (de) * 1993-05-21 1997-11-05 Targeted Genetics Corporation Bifunktionelle selektierbare fusionsgene auf dem cytosin-deaminase (cd) gen beruhend
EP0758387B1 (de) * 1994-05-02 2001-12-19 University of Washington Thymidin-kinase-mutanten
US6451571B1 (en) 1994-05-02 2002-09-17 University Of Washington Thymidine kinase mutants
EP0772689B1 (de) 1994-05-09 2007-12-19 Oxford Biomedica (UK) Limited Retrovirale vektoren mit verminderter rekombinationsrate
US6013517A (en) 1994-05-09 2000-01-11 Chiron Corporation Crossless retroviral vectors
US5856153A (en) * 1994-11-17 1999-01-05 Cayla Suicide genes and new associations of pyrimidine nucleobase and nucleoside analogs with new suicide genes for gene therapy of acquired diseases
US6638762B1 (en) * 1994-11-28 2003-10-28 Genetic Therapy, Inc. Tissue-vectors specific replication and gene expression
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
US20020068049A1 (en) * 1998-09-10 2002-06-06 Henderson Daniel R. Tissue specific adenoviral vectors
WO1997015668A2 (en) * 1995-10-23 1997-05-01 Board Of Regents, The University Of Texas System Methods and compositions comprising glut-2 and glut-2 chimeras
WO1997029201A2 (de) * 1996-02-07 1997-08-14 Max-Delbrück-Centrum für Molekulare Medizin Retroviraler vektor für den gentransfer eines il6-antagonisten in humane hämatopoetische stammzellen
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US20020160970A1 (en) * 1996-04-10 2002-10-31 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US20030033617A1 (en) * 1996-04-10 2003-02-13 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6566089B1 (en) * 1996-09-04 2003-05-20 Tularik Inc. Cell-based drug screens for regulators of gene expression
WO1999042593A1 (en) * 1998-02-19 1999-08-26 St. Jude Children's Research Hospital Compositions and methods for sensitizing and inhibiting growth of human tumor cells
GB9810752D0 (en) * 1998-05-19 1998-07-15 Glaxo Group Ltd Cystosine deaminase gene
US7186409B2 (en) 1998-08-14 2007-03-06 The Children's Medical Center Corporation Neural stem cells and use thereof for brain tumor therapy
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
US20020115213A1 (en) * 1998-08-14 2002-08-22 Northeastern Ohio Universities Of Medicine Engraftable neural progenitor & stem cells for brain tumor therapy
FR2794025A1 (fr) * 1999-05-25 2000-12-01 Transgene Sa Composition destinee a la mise en oeuvre d'un traitement antitumoral ou antiviral chez un mammifere
US6656917B1 (en) 1999-06-30 2003-12-02 Marker Gene Technologies, Inc. Compositions and methods for targeted enzymatic release of cell regulatory compounds
US8716558B2 (en) 1999-06-30 2014-05-06 Marker Gene Technologies, Inc. Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase
AU4744201A (en) * 2000-03-15 2001-09-24 Childrens Medical Center Systemic gene delivery vehicles for the treatment of tumors
US6579522B1 (en) 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
AU2002218447C9 (en) * 2000-09-28 2008-04-17 Bioriginal Food & Science Corporation Fad4, Fad5, Fad5-2, and Fad6, fatty acid desaturase family members and uses thereof
EP1264891A1 (de) * 2001-05-31 2002-12-11 Plant Research International B.V. Veränderung des Pflanzen Genoms durch induzierbaren, ortsspezifischen Rekombination von Transgenen
DE60237696D1 (de) * 2001-08-01 2010-10-28 Univ Utah Am n-terminus trunkierte isoformen von zyklischen phosphodiesterasen pde3a
US20030086903A1 (en) * 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
CA2493364A1 (en) * 2002-07-26 2004-02-12 Basf Plant Science Gmbh Inversion of the negative-selective effect of negative marker proteins using selection methods
US20040149174A1 (en) * 2003-02-05 2004-08-05 Mbt Holding Ag Accelerating admixture for concrete
WO2005007857A1 (en) 2003-07-21 2005-01-27 Transgene S.A. Polypeptide having an improved cytosine deaminase activity
ATE500267T1 (de) 2003-07-21 2011-03-15 Transgene Sa Multifunktionelle cytokine
ATE458500T1 (de) * 2003-11-14 2010-03-15 Genvec Inc Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc).
WO2005090581A1 (en) * 2004-03-17 2005-09-29 Basf Plant Science Gmbh Improved constructs for marker excision based on dual-function selection marker
CA2558273A1 (en) * 2004-03-17 2005-09-29 Basf Plant Science Gmbh Post harvest control of genetically modified crop growth employing d-amino acid compounds
ATE491799T1 (de) 2004-05-26 2011-01-15 Bayer Schering Pharma Ag Chimäre adenoviren zur verwendung in der krebsbehandlung
CA2834275A1 (en) 2004-08-02 2006-02-09 Basf Plant Science Gmbh Method for isolation of transcription termination sequences
CN101198701B (zh) 2005-04-19 2013-04-24 巴斯福植物科学有限公司 单子叶植物中的淀粉胚乳特异性和/或萌芽胚特异性表达
US20070026012A1 (en) 2005-08-01 2007-02-01 Cornell Research Foundation, Inc. Compositions and methods for monitoring and altering protein folding and solubility
WO2007024877A2 (en) 2005-08-22 2007-03-01 Cornell Research Foundation, Inc. Compositions and methods for analyzing protein interactions
WO2008099013A1 (en) 2007-02-16 2008-08-21 Basf Plant Science Gmbh Nucleic acid sequences for regulation of embryo-specific expression in monocotyledonous plants
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
NZ592070A (en) 2008-09-26 2012-07-27 Tocagen Inc Gene therapy vectors and humanized yeast cytosine deaminase triple mutant
EP2248903A1 (de) 2009-04-29 2010-11-10 Universitat Autònoma De Barcelona Verfahren und Reagenzien zum effizienten und gezielten Gentransfer in Monozyten und Makrophagen
US9605844B2 (en) * 2009-09-01 2017-03-28 Cree, Inc. Lighting device with heat dissipation elements
EP2796555B1 (de) * 2011-12-21 2018-08-29 Cj Cheiljedang Corporation Verfahren zur herstellung von l-lysin mit mikroorganismen mit fähigkeit zur herstellung von l-lysin
US9862932B2 (en) 2012-07-24 2018-01-09 The General Hospital Corporation Oncolytic virus therapy for resistant tumors
SG11201602887QA (en) 2013-10-25 2016-05-30 Psioxus Therapeutics Ltd Oncolytic adenoviruses armed with heterologous genes
EP3082834B1 (de) 2013-12-11 2020-03-11 The General Hospital Corporation DBA Massachusetts Von stammzellen abgegebener onkolytischer herpes-simplex-virus und verfahren zur behandlung von hirntumoren
CA2943871A1 (en) 2014-04-10 2015-10-15 Transgene S.A. Poxviral oncolytic vectors
WO2016168601A1 (en) 2015-04-17 2016-10-20 Khalid Shah Agents, systems and methods for treating cancer
CN108396015B (zh) 2015-04-30 2022-02-18 皮斯奥克斯治疗公司 编码b7蛋白质的溶瘤腺病毒
KR20180107105A (ko) 2015-12-17 2018-10-01 싸이오서스 테라퓨틱스 엘티디. 항-tcr-복합체 항체 또는 단편을 암호화하는 군 b 아데노바이러스
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
KR102371151B1 (ko) 2020-03-13 2022-03-07 주식회사 큐로셀 항-bcma 결합 영역, 이를 포함하는 융합단백질, 및 이를 포함하는 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4975278A (en) * 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
CA2018273C (en) * 1989-06-09 1999-04-06 Peter D. Senter Thermally stable cytosine deaminase
GB8919607D0 (en) * 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies

Also Published As

Publication number Publication date
EP0595873B1 (de) 2000-04-05
CA2112395C (en) 2008-04-22
US5624830A (en) 1997-04-29
JP3386461B2 (ja) 2003-03-17
WO1993001281A1 (en) 1993-01-21
AU667820B2 (en) 1996-04-18
ES2152929T3 (es) 2001-02-16
EP0595873A1 (de) 1994-05-11
DK0595873T3 (da) 2000-07-10
AU2295992A (en) 1993-02-11
US5358866A (en) 1994-10-25
GR3033909T3 (en) 2000-11-30
DE69230882T2 (de) 2000-11-09
SG52475A1 (en) 1998-09-28
JPH07501925A (ja) 1995-03-02
ATE191505T1 (de) 2000-04-15
CA2112395A1 (en) 1993-01-21
EP0595873A4 (de) 1994-12-07

Similar Documents

Publication Publication Date Title
DE69230882D1 (de) Cytosindeaminase negatives selektionssystem zur genübertragung und therapien
DK0500917T3 (da) Vacciner og fremgangsmåder baseret på rekombinante herpes simplex virusser.
EP0846160A4 (de) Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon
ZA942719B (en) Expression of heterologous genes
ES2121794T3 (es) Procedimiento de transferencia de genes por medio de retrotransposones.
AU7945682A (en) Rennin from recombinant dna
DE60303810D1 (de) Kontrollierte bakterielle lyse zur verabreichung von dna vakzinvektoren und impfantigen
ATE270342T1 (de) Endosomolytisch wirksame partikel
ES8705036A1 (es) Procedimiento para preparar una vacuna que comprende un polipeptido fijado a una membrana
MXPA03000634A (es) Metodos para el reemplazo, el desplazamiento y acumulacion de adn en genomas eucarioticos.
HK1018078A1 (en) Recombinant sendai virus
DK0617736T3 (da) Anvendelse af Bacillus thuringiensis isolater til bekæmpelse af skadedyr i familien Aphididae
DE69734829D1 (de) Infektiöse pseudovirale papillomavirus partikel
DE69033961D1 (de) Zellinien, die einen biologisch aktiven faktor-ix exprimieren
DE69736838D1 (de) Herpesvirus saimiri als viraler vektor
Doersen et al. Cytoplasmic inheritance of erythromycin resistance in human cells.
HUP0401585A2 (hu) Fertőző, marhában előforduló, vírusos hasmenés vírusklónja
IL148360A0 (en) A herpes viral mutant and pharmaceutical compositions containing the same
EP0914422A4 (de) Säugetiergene, die an viraler infektion und tumorunterdrückung beteiligt sind
AU2190288A (en) Vector for the expression of proteins of the HIV-2 virus, one of the casual agents of AIDS, cell culture infected or transformed by this vector, proteins obtained, vaccine and antibodies obtained
AU6262786A (en) Growing aids virus in cell lines lacking human class ii histocompatability antigens
Mullen et al. Cytosine deaminase negative selection system for gene transfer techniques and therapies
DK204586D0 (da) Hybridceller, der producerer et karakteristisk antigen for hepatitis b-virus, opnaaet ud fra hepatocytter og celler, der er tilvejebragt fra aber, fremgangsmaade til opnaaelse af hybridcellerne og anvendelse af disse til produktion af antigenet

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee