DK0583579T3 - Nye cardiovasculært aktive 17-hydroxyimiomethyl5beta, 14beta-androstanderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater med inhold deraf - Google Patents

Nye cardiovasculært aktive 17-hydroxyimiomethyl5beta, 14beta-androstanderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater med inhold deraf

Info

Publication number
DK0583579T3
DK0583579T3 DK93110189.3T DK93110189T DK0583579T3 DK 0583579 T3 DK0583579 T3 DK 0583579T3 DK 93110189 T DK93110189 T DK 93110189T DK 0583579 T3 DK0583579 T3 DK 0583579T3
Authority
DK
Denmark
Prior art keywords
preparation
pharmaceutical compositions
hydroxyimiomethyl
14beta
5beta
Prior art date
Application number
DK93110189.3T
Other languages
Danish (da)
English (en)
Inventor
Piero Melloni
Luigi Bernardi
Alberto Cerri
Giuseppe Bianchi
Elena Folpini
Monica Florio
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK0583579T3 publication Critical patent/DK0583579T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK93110189.3T 1992-08-20 1993-06-25 Nye cardiovasculært aktive 17-hydroxyimiomethyl5beta, 14beta-androstanderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater med inhold deraf DK0583579T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4227605A DE4227605C2 (de) 1992-08-20 1992-08-20 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten

Publications (1)

Publication Number Publication Date
DK0583579T3 true DK0583579T3 (da) 1998-04-27

Family

ID=6465986

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93110189.3T DK0583579T3 (da) 1992-08-20 1993-06-25 Nye cardiovasculært aktive 17-hydroxyimiomethyl5beta, 14beta-androstanderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater med inhold deraf

Country Status (12)

Country Link
US (1) US5444055A (xx)
EP (1) EP0583579B1 (xx)
JP (1) JP3510651B2 (xx)
KR (1) KR100276527B1 (xx)
AT (1) ATE160784T1 (xx)
CA (1) CA2103825C (xx)
DE (2) DE4227605C2 (xx)
DK (1) DK0583579T3 (xx)
ES (1) ES2110030T3 (xx)
GR (1) GR3026265T3 (xx)
HK (1) HK1004919A1 (xx)
ZA (1) ZA935866B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4227626C2 (de) * 1992-08-20 1994-11-17 Sigma Tau Ind Farmaceuti 17-Hydrazonomethyl-14ß-hydroxy-5ß-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE4232656C2 (de) * 1992-09-29 1995-01-12 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
DE4420501A1 (de) 1994-06-13 1995-12-14 Sigma Tau Ind Farmaceuti Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
IT1279386B1 (it) * 1994-11-07 1997-12-10 Sigma Tau Ind Farmaceuti 1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
DE4442486A1 (de) * 1994-11-29 1996-05-30 Sigma Tau Ind Farmaceuti Neue 17-(3-Imino-2-alkylpropylen)-5ß,14ß-androstan-Derivate, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
IT1282286B1 (it) * 1995-05-11 1998-03-16 Sigma Tau Ind Farmaceuti Seco-d steroidi sul sistema cardiovascolare, processi per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1282289B1 (it) * 1995-06-23 1998-03-16 Sigma Tau Ind Farmaceuti 17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare,
DE19633376A1 (de) * 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue Seco-D-Steroide, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
DE19633349A1 (de) * 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3019242A (en) * 1960-07-01 1962-01-30 Upjohn Co 3, 20-dioximes of 11-hydroxyprogesterones

Also Published As

Publication number Publication date
DE69315501D1 (de) 1998-01-15
DE69315501T2 (de) 1998-04-16
KR100276527B1 (ko) 2001-02-01
DE4227605C2 (de) 1995-02-16
CA2103825A1 (en) 1994-02-21
CA2103825C (en) 1999-01-12
ES2110030T3 (es) 1998-02-01
ATE160784T1 (de) 1997-12-15
EP0583579B1 (en) 1997-12-03
JP3510651B2 (ja) 2004-03-29
US5444055A (en) 1995-08-22
KR940005661A (ko) 1994-03-22
GR3026265T3 (en) 1998-05-29
EP0583579A2 (en) 1994-02-23
DE4227605A1 (de) 1994-03-10
HK1004919A1 (en) 1998-12-11
JPH06184188A (ja) 1994-07-05
ZA935866B (en) 1994-03-09
EP0583579A3 (en) 1995-03-22

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