DK0582338T3 - 17-spiromethylensteroider - Google Patents
17-spiromethylensteroiderInfo
- Publication number
- DK0582338T3 DK0582338T3 DK93202204T DK93202204T DK0582338T3 DK 0582338 T3 DK0582338 T3 DK 0582338T3 DK 93202204 T DK93202204 T DK 93202204T DK 93202204 T DK93202204 T DK 93202204T DK 0582338 T3 DK0582338 T3 DK 0582338T3
- Authority
- DK
- Denmark
- Prior art keywords
- carbon atom
- spiromethylene
- steroids
- skeleton
- steroid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Toxicology (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92202339 | 1992-07-29 | ||
EP93201657 | 1993-06-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0582338T3 true DK0582338T3 (da) | 2000-03-20 |
Family
ID=26131593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93202204T DK0582338T3 (da) | 1992-07-29 | 1993-07-26 | 17-spiromethylensteroider |
Country Status (17)
Country | Link |
---|---|
US (2) | US5712264A (xx) |
EP (1) | EP0582338B1 (xx) |
JP (1) | JP3418428B2 (xx) |
KR (1) | KR100341169B1 (xx) |
CN (1) | CN1054133C (xx) |
AT (1) | ATE185812T1 (xx) |
AU (1) | AU665430B2 (xx) |
CA (1) | CA2100514C (xx) |
DE (1) | DE69326805T2 (xx) |
DK (1) | DK0582338T3 (xx) |
ES (1) | ES2140436T3 (xx) |
FI (1) | FI113371B (xx) |
GR (1) | GR3032257T3 (xx) |
HK (1) | HK1002011A1 (xx) |
MX (1) | MX9304541A (xx) |
NO (1) | NO303338B1 (xx) |
NZ (1) | NZ248260A (xx) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2126573T3 (es) * | 1991-04-22 | 1999-04-01 | Otsuka Pharma Co Ltd | Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado. |
DE4417880A1 (de) * | 1994-05-18 | 1995-11-23 | Schering Ag | 19,11beta-Überbrückte 18-Nor-Steroide, Verfahren zu ihrer Herstellung, diese Steroide enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln |
IL119649A (en) * | 1995-11-30 | 2002-03-10 | Akzo Nobel Nv | Preparation of Cyclic Kills of History - 3 keto- (5) 10, (-9) 11 steroidadians |
US6020328A (en) * | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
ATE473759T1 (de) | 1998-05-22 | 2010-07-15 | Univ Leland Stanford Junior | Bifunktionelle moleküle sowie darauf basierende therapien. |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
KR101255074B1 (ko) | 2003-10-01 | 2013-04-16 | 아돌로 코포레이션 | 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법 |
TW200531977A (en) | 2004-03-25 | 2005-10-01 | Akzo Nobel Nv | Progesterone receptor modulators |
US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
CN103259027A (zh) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | 药物信息系统 |
JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Crを含むタンパク質に対して特異的な受容体−結合タンパク質(rap)変異体を含む組成物およびその使用 |
DK1989218T3 (da) | 2006-02-17 | 2010-04-26 | Janssen Pharmaceutica Nv | 17-phosphor-steroidderivater, der er anvendelige som progesteronreceptormodulatorer |
AU2007217094A1 (en) * | 2006-02-17 | 2007-08-30 | Janssen Pharmaceutica N.V. | 11-phosphorous steroid derivatives useful as progesterone receptor modulators |
US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
DE102006054535A1 (de) * | 2006-11-15 | 2008-05-21 | Bayer Schering Pharma Aktiengesellschaft | Progesteronrezeptorantagonisten |
PT2398500T (pt) | 2009-02-20 | 2019-06-14 | 2 Bbb Medicines B V | Sistema de entrega de medicamentos à base de glutationas |
US8673968B2 (en) * | 2009-04-06 | 2014-03-18 | Evestra, Inc. | Progesterone antagonists |
TWI556839B (zh) | 2009-05-06 | 2016-11-11 | 研究室護膚股份有限公司 | 包含活性劑-磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法 |
DE102009034362A1 (de) * | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034367A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102009034366A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034368A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034526A1 (de) | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102009034525A1 (de) | 2009-07-21 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102010007719A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
DE102010007722A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
US20130272956A1 (en) | 2010-06-17 | 2013-10-17 | Franciscus Theodorus Leonardus Brands | (11beta, 17alpha)-11-(4-(2-11C-ACETYL)PHENYL)-17,23-EPOXY-19,24-DINORCHOLA-4,9,20-TRIEN-3-ONE |
US9096641B2 (en) * | 2013-06-05 | 2015-08-04 | Evestra, Inc. | Imidazolyl progesterone antagonists |
CN105237606B (zh) * | 2014-07-11 | 2018-08-24 | 上海创诺制药有限公司 | 一种用于合成去氧孕烯的中间体及其制备方法和应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE623844A (xx) * | ||||
US2744122A (en) * | 1951-11-22 | 1956-05-01 | Syntex Sa | delta 4-19-nor-17alpha-ethinylandrosten-17beta-ol-3-one and process |
US3338892A (en) * | 1964-11-24 | 1967-08-29 | Lilly Co Eli | Steroidal carbamic acid-gamma-lactones |
US3280157A (en) * | 1965-10-22 | 1966-10-18 | Schering Corp | Peroxy steroids and methods for their manufacture |
NL129874C (xx) * | 1966-03-15 | |||
US3764596A (en) * | 1971-06-22 | 1973-10-09 | Sandoz Ag | 17-dihydrofuranyl-substituted steroids |
US3833621A (en) * | 1972-03-20 | 1974-09-03 | Richardson Merrell Inc | 3-keto-7(alpha,beta)-loweralkyl-delta5 steroids and process for preparing same |
US3927046A (en) * | 1972-12-09 | 1975-12-16 | Akzona Inc | Novel 11,11-alkylidene steroids |
US4081537A (en) * | 1975-10-10 | 1978-03-28 | Schering Aktiengesellschaft | Δ15 -Steroids and pharmaceutical compositions thereof |
ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
DE3461090D1 (en) * | 1983-02-18 | 1986-12-04 | Schering Ag | 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them |
FR2596395B1 (fr) * | 1986-03-26 | 1989-05-26 | Roussel Uclaf | Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
DE3702383A1 (de) * | 1987-01-23 | 1988-08-04 | Schering Ag | 11ss-alkinylestrene und -estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
US5272140A (en) * | 1987-01-23 | 1993-12-21 | Akzo N.V. | 11-aryl steroid derivatives |
DE3866410D1 (de) * | 1987-04-24 | 1992-01-09 | Akzo Nv | 11-arylestranderivate und 11-arylpregnanderivate. |
FR2620707B1 (fr) * | 1987-09-18 | 1989-12-08 | Roussel Uclaf | Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
ES2053714T3 (es) * | 1987-12-12 | 1994-08-01 | Akzo Nv | Proceso para la preparacion de 11-arilesteroides. |
DE3921059A1 (de) * | 1989-06-23 | 1991-01-10 | Schering Ag | 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
IT1230907B (it) * | 1989-06-23 | 1991-11-08 | Ocean Spa | Macchina lavabiancheria perfezionata |
ZA929315B (en) * | 1991-12-20 | 1993-05-24 | Akzo Nv | 17-spirofuran-3'-ylidene steroids. |
-
1993
- 1993-07-14 CA CA002100514A patent/CA2100514C/en not_active Expired - Fee Related
- 1993-07-16 AU AU42037/93A patent/AU665430B2/en not_active Ceased
- 1993-07-26 AT AT93202204T patent/ATE185812T1/de not_active IP Right Cessation
- 1993-07-26 ES ES93202204T patent/ES2140436T3/es not_active Expired - Lifetime
- 1993-07-26 EP EP93202204A patent/EP0582338B1/en not_active Expired - Lifetime
- 1993-07-26 DE DE69326805T patent/DE69326805T2/de not_active Expired - Fee Related
- 1993-07-26 DK DK93202204T patent/DK0582338T3/da active
- 1993-07-27 FI FI933363A patent/FI113371B/fi active
- 1993-07-27 NZ NZ248260A patent/NZ248260A/en not_active IP Right Cessation
- 1993-07-28 US US08/098,665 patent/US5712264A/en not_active Expired - Fee Related
- 1993-07-28 NO NO932723A patent/NO303338B1/no not_active IP Right Cessation
- 1993-07-28 CN CN93108470A patent/CN1054133C/zh not_active Expired - Fee Related
- 1993-07-28 MX MX9304541A patent/MX9304541A/es not_active IP Right Cessation
- 1993-07-28 KR KR1019930014397A patent/KR100341169B1/ko not_active IP Right Cessation
- 1993-07-29 JP JP18846093A patent/JP3418428B2/ja not_active Expired - Fee Related
-
1997
- 1997-11-03 US US08/962,798 patent/US5854235A/en not_active Expired - Fee Related
-
1998
- 1998-02-11 HK HK98101025A patent/HK1002011A1/xx not_active IP Right Cessation
-
1999
- 1999-12-23 GR GR990403342T patent/GR3032257T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI933363A0 (fi) | 1993-07-27 |
FI113371B (fi) | 2004-04-15 |
JPH06157587A (ja) | 1994-06-03 |
GR3032257T3 (en) | 2000-04-27 |
HK1002011A1 (en) | 1998-07-24 |
KR940005663A (ko) | 1994-03-22 |
FI933363A (fi) | 1994-01-30 |
EP0582338A3 (en) | 1995-08-23 |
NO303338B1 (no) | 1998-06-29 |
MX9304541A (es) | 1994-05-31 |
CA2100514A1 (en) | 1994-01-30 |
CN1084857A (zh) | 1994-04-06 |
AU665430B2 (en) | 1996-01-04 |
AU4203793A (en) | 1994-02-03 |
ATE185812T1 (de) | 1999-11-15 |
JP3418428B2 (ja) | 2003-06-23 |
CA2100514C (en) | 2005-03-29 |
US5712264A (en) | 1998-01-27 |
DE69326805D1 (de) | 1999-11-25 |
DE69326805T2 (de) | 2000-05-31 |
EP0582338A2 (en) | 1994-02-09 |
US5854235A (en) | 1998-12-29 |
CN1054133C (zh) | 2000-07-05 |
NO932723D0 (no) | 1993-07-28 |
NO932723L (no) | 1994-01-31 |
NZ248260A (en) | 1995-07-26 |
EP0582338B1 (en) | 1999-10-20 |
KR100341169B1 (ko) | 2002-10-25 |
ES2140436T3 (es) | 2000-03-01 |
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