DK0578728T3 - Inhibitorer for aggregering af blodplader, hvilke inhibitorer har høj specificitet for GP IIbIIIa - Google Patents
Inhibitorer for aggregering af blodplader, hvilke inhibitorer har høj specificitet for GP IIbIIIaInfo
- Publication number
- DK0578728T3 DK0578728T3 DK92909119T DK92909119T DK0578728T3 DK 0578728 T3 DK0578728 T3 DK 0578728T3 DK 92909119 T DK92909119 T DK 92909119T DK 92909119 T DK92909119 T DK 92909119T DK 0578728 T3 DK0578728 T3 DK 0578728T3
- Authority
- DK
- Denmark
- Prior art keywords
- iibiiia
- platelet aggregation
- high specificity
- aggregation inhibitors
- inhibitors
- Prior art date
Links
- 229940127218 antiplatelet drug Drugs 0.000 title 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68180291A | 1991-04-05 | 1991-04-05 | |
PCT/US1992/002731 WO1992017492A1 (en) | 1991-04-05 | 1992-04-03 | PLATELET AGGREGATION INHIBITORS HAVING HIGH SPECIFICITY FOR GP IIbIII¿a? |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0578728T3 true DK0578728T3 (da) | 1999-04-12 |
Family
ID=24736888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92909119T DK0578728T3 (da) | 1991-04-05 | 1992-04-03 | Inhibitorer for aggregering af blodplader, hvilke inhibitorer har høj specificitet for GP IIbIIIa |
Country Status (8)
Country | Link |
---|---|
US (2) | US5493007A (de) |
EP (1) | EP0578728B1 (de) |
JP (1) | JPH06509551A (de) |
AU (1) | AU666853B2 (de) |
CA (1) | CA2106314A1 (de) |
DE (1) | DE69226077T2 (de) |
DK (1) | DK0578728T3 (de) |
WO (1) | WO1992017492A1 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
JPH05509294A (ja) * | 1990-04-06 | 1993-12-22 | ラ ホヤ キャンサー リサーチ ファウンデーション | 血栓症治療のための方法および組成物 |
US5612311A (en) | 1990-04-06 | 1997-03-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6017877A (en) * | 1990-04-06 | 2000-01-25 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6521594B1 (en) * | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
CA2106314A1 (en) * | 1991-04-05 | 1992-10-06 | John P. Burnier | Platelet aggregation inhibitors having high specification for gpiibiiia |
AU687080B2 (en) * | 1993-04-08 | 1998-02-19 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
DE69332203T2 (de) * | 1992-10-02 | 2003-05-28 | Diatide Inc | Multimerische mehrzweckwirkstoffe gegen thrombose |
US5744120A (en) * | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
US6872803B1 (en) | 1993-09-21 | 2005-03-29 | Kyowa Hakko Kogyo Co., Ltd. | Peptides |
DE4415310A1 (de) * | 1994-04-30 | 1995-11-02 | Merck Patent Gmbh | Cyclopeptide |
AU2958195A (en) * | 1994-06-29 | 1996-01-25 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
CA2216162A1 (en) * | 1995-04-26 | 1996-10-31 | Takeda Chemical Industries, Ltd. | Piperazinones useful as inhibitors of platelet aggregation |
JP2000509014A (ja) | 1996-03-11 | 2000-07-18 | フォーカル,インコーポレイテッド | 放射性核種および放射性医薬品のポリマー送達 |
US5879659A (en) * | 1996-03-13 | 1999-03-09 | Dupont Pharmaceuticals Company | Ternary radiopharmaceutical complexes |
US6087332A (en) * | 1997-12-23 | 2000-07-11 | Galler; Lawrence Isaac | Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy |
AU3192299A (en) * | 1998-03-18 | 1999-10-11 | Wake Forest University | Improved implantable biomaterials, compositions and methods for their preparation and uses thereof |
US6251393B1 (en) * | 1998-10-23 | 2001-06-26 | The Brigham And Women's Hospital, Inc. | Conformation-specific anti-von Willebrand Factor antibodies |
US6235877B1 (en) | 1999-08-04 | 2001-05-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
US6605648B1 (en) * | 1999-04-06 | 2003-08-12 | Phillips Plastics Corporation | Sinterable structures and method |
US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
EP2110381A1 (de) | 1999-05-17 | 2009-10-21 | ConjuChem Biotechnologies Inc. | Lang wirkende Peptidinhibitoren der Virusfusion mit Körperzellen bei viralen Infektionen |
US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
US6514500B1 (en) | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
EP1180121B9 (de) | 1999-05-17 | 2004-09-08 | Conjuchem, Inc. | Lang wirkende insulinotrope peptide |
US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
EP1105409B1 (de) | 1999-05-17 | 2006-03-01 | Conjuchem, Inc. | Schutz endogener, therapeutisch aktiver peptide vor peptidaseaktivität durch konjugation an blutbestandteile |
US6706892B1 (en) | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
AU2002233082B2 (en) * | 2001-02-02 | 2005-11-10 | Conjuchem Biotechnologies Inc. | Long lasting growth hormone releasing factor derivatives |
DK1360202T3 (da) | 2001-02-16 | 2008-09-22 | Conjuchem Biotechnologies Inc | Langvarigt glucagon-lignende peptid 2 (GLP-2) til behandling af gastrointestinale sygdomme og lidelser |
AU2003275116A1 (en) | 2002-09-24 | 2004-04-19 | Frontier Biotechnologies Co., Ltd | Peptide derivative fusion inhibitors of hiv infection |
ATE465172T1 (de) * | 2004-03-05 | 2010-05-15 | Univ Illinois | Peptidträger für die verabreichung von arzneimitteln |
PL1745078T3 (pl) * | 2004-04-23 | 2009-12-31 | Conjuchem Biotechnologies Inc | Sposób oczyszczania koniugatów albumin |
CN100406468C (zh) * | 2004-09-09 | 2008-07-30 | 井健 | 抗栓剂kgd-环七肽的设计、制备及应用 |
WO2007003010A1 (en) * | 2005-07-05 | 2007-01-11 | Baker Medical Research Institute | Anticoagulation agent and uses thereof |
US8039432B2 (en) * | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
JP2009520469A (ja) * | 2005-12-22 | 2009-05-28 | コンジュクヘム ビオテクフノロギエス インコーポレイテッド | アルブミンと治療薬との前もって形成された抱合体の産生のための方法 |
EP1984391A4 (de) * | 2006-01-19 | 2009-08-12 | Eyegene Inc | Peptidhaltige pharmazeutische zusammensetzung zur behandlung von mit dem gefässsystem in zusammenhang stehenden krankheiten |
EP2114437A2 (de) * | 2006-10-16 | 2009-11-11 | ConjuChem Biotechnologies Inc. | Modifizierte peptide mit corticotropinfreisetzungsfaktor und verwendungen davon |
US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
US20090186819A1 (en) * | 2007-12-11 | 2009-07-23 | Marieve Carrier | Formulation of insulinotropic peptide conjugates |
US9273093B2 (en) * | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
EP4091624A1 (de) | 2013-03-15 | 2022-11-23 | Protagonist Therapeutics, Inc. | Hepcidin-analoga und verwendungen davon |
US20140294902A1 (en) * | 2013-04-02 | 2014-10-02 | Protagonist Therapeutics, Inc. | Novel a4b7 peptide antagonists |
DK3143037T3 (da) | 2014-05-16 | 2021-09-20 | Protagonist Therapeutics Inc | Alpha4beta7-integrin-thioether-peptidantagonister |
RU2736637C9 (ru) | 2014-07-17 | 2021-02-08 | Протагонист Терепьютикс, Инк. | Пептидные ингибиторы рецептора интерлейкина-23 для перорального приема и их применение для лечения воспалительных заболеваний кишечника |
JP2017535527A (ja) | 2014-10-01 | 2017-11-30 | プロタゴニスト セラピューティクス, インコーポレイテッド | 新規のα4β7ペプチド単量体及び二量体拮抗薬 |
WO2016054445A1 (en) | 2014-10-01 | 2016-04-07 | Protagonist Therapeutics, Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
CA3009834A1 (en) | 2015-12-30 | 2017-07-06 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
US10407468B2 (en) | 2016-03-23 | 2019-09-10 | Protagonist Therapeutics, Inc. | Methods for synthesizing α4β7 peptide antagonists |
CA3073806A1 (en) | 2017-09-11 | 2019-03-14 | Protagonist Therapeutics, Inc. | Opioid agonist peptides and uses thereof |
WO2019157268A1 (en) | 2018-02-08 | 2019-08-15 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
CN113993882A (zh) | 2019-06-11 | 2022-01-28 | 富士胶片株式会社 | 环肽、细胞支架材料、细胞分离材料及培养基 |
EP3967703B1 (de) | 2019-06-11 | 2023-07-26 | FUJIFILM Corporation | Zyklisches peptid, zellgerüstmaterial, zelltrennmaterial und kulturmedium |
EP3997105A4 (de) | 2019-07-10 | 2023-09-13 | Protagonist Therapeutics, Inc. | Peptidinhibitoren des interleukin-23-rezeptors und deren verwendung zur behandlung entzündlicher erkrankungen |
CN118005737A (zh) | 2020-01-15 | 2024-05-10 | 詹森生物科技公司 | 介白素-23受体的肽抑制剂及其治疗炎性疾病的用途 |
CA3202226A1 (en) | 2020-11-20 | 2022-05-27 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of interleukin-23 receptor |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4792525A (en) * | 1982-08-04 | 1988-12-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4589881A (en) * | 1982-08-04 | 1986-05-20 | La Jolla Cancer Research Foundation | Polypeptide |
US4661111A (en) * | 1982-08-04 | 1987-04-28 | La Jolla Cancer Research Foundation | Polypeptide |
US4578079A (en) * | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4517686A (en) * | 1982-08-04 | 1985-05-21 | La Jolla Cancer Research Foundation | Polypeptide |
US4614517A (en) * | 1982-08-04 | 1986-09-30 | La Jolla Cancer Research Foundation | Tetrapeptide |
US5041380A (en) * | 1982-08-04 | 1991-08-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4683291A (en) * | 1985-10-28 | 1987-07-28 | Scripps Clinic And Research Foundation | Platelet binding inhibitors |
EP0275748B1 (de) * | 1986-12-15 | 1992-08-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Peptid-Derivate und deren Verwendung in der Therapie |
US5114842A (en) * | 1987-07-08 | 1992-05-19 | The Scripps Research Institute | Peptides and antibodies that inhibit platelet adhesion |
IT1222437B (it) * | 1987-08-04 | 1990-09-05 | Ellem Ind Farmaceutica | Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione |
EP0317053B1 (de) * | 1987-11-18 | 1993-12-08 | Temple University of the Commonwealth System of Higher Education | Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt |
FR2623509B1 (fr) * | 1987-11-19 | 1990-04-20 | Centre Nat Rech Scient | Proteine de 17 kd a action angiogenique, son procede d'isolement a partir de lait de mammiferes, compositions therapeutiques la contenant, procede de detection et/ou de dosage et reactifs immunologiques de detection et de dosage des angiogenines de mammiferes, de leurs homologues et de leurs fragments |
US4857508A (en) * | 1987-12-03 | 1989-08-15 | Monsanto Company | Novel platelet-aggregation inhibitor peptide derivatives |
AU639409B2 (en) * | 1987-12-10 | 1993-07-29 | La Jolla Cancer Research Foundation | Conformationally stabilized cell adhesion peptides |
WO1989007609A1 (en) * | 1988-02-22 | 1989-08-24 | The Upjohn Company | Homoarginine-based peptides as platelet aggregation inhibitors |
NZ228710A (en) * | 1988-04-22 | 1992-10-28 | Merck & Co Inc | Modified "echistatin" and anti-clotting pharmaceutical composition |
ZW6189A1 (en) * | 1988-05-09 | 1990-05-09 | Smithkline Beckman Corp | Anti-aggregatory peptides |
JP2892726B2 (ja) * | 1988-06-30 | 1999-05-17 | コア セラピューティクス,インコーポレイティド | 血小板阻止ペプチド |
US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
US5037808A (en) * | 1988-07-20 | 1991-08-06 | Monsanto Co. | Indolyl platelet-aggregation inhibitors |
US5169836A (en) * | 1988-11-10 | 1992-12-08 | Trustees Of The University Of Penna. | Inhibitors of platelet binding |
DE3841753A1 (de) * | 1988-12-12 | 1990-06-13 | Basf Ag | Neue tnf-peptide |
US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
US5395609A (en) * | 1989-06-19 | 1995-03-07 | Antisoma Limited | Synthetic peptides for use in tumor detection |
US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
US5023233A (en) * | 1989-07-28 | 1991-06-11 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5643872A (en) * | 1989-10-23 | 1997-07-01 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
JPH05509294A (ja) * | 1990-04-06 | 1993-12-22 | ラ ホヤ キャンサー リサーチ ファウンデーション | 血栓症治療のための方法および組成物 |
CA2106314A1 (en) * | 1991-04-05 | 1992-10-06 | John P. Burnier | Platelet aggregation inhibitors having high specification for gpiibiiia |
-
1992
- 1992-04-03 CA CA002106314A patent/CA2106314A1/en not_active Abandoned
- 1992-04-03 AU AU19822/92A patent/AU666853B2/en not_active Expired
- 1992-04-03 DK DK92909119T patent/DK0578728T3/da active
- 1992-04-03 WO PCT/US1992/002731 patent/WO1992017492A1/en active IP Right Grant
- 1992-04-03 JP JP4508865A patent/JPH06509551A/ja active Pending
- 1992-04-03 EP EP92909119A patent/EP0578728B1/de not_active Expired - Lifetime
- 1992-04-03 DE DE69226077T patent/DE69226077T2/de not_active Expired - Lifetime
-
1994
- 1994-09-23 US US08/311,835 patent/US5493007A/en not_active Expired - Lifetime
-
1995
- 1995-12-06 US US08/567,977 patent/US5756452A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2106314A1 (en) | 1992-10-06 |
WO1992017492A1 (en) | 1992-10-15 |
AU1982292A (en) | 1992-11-02 |
JPH06509551A (ja) | 1994-10-27 |
DE69226077D1 (de) | 1998-08-06 |
US5756452A (en) | 1998-05-26 |
AU666853B2 (en) | 1996-02-29 |
EP0578728A1 (de) | 1994-01-19 |
DE69226077T2 (de) | 1998-12-03 |
US5493007A (en) | 1996-02-20 |
EP0578728B1 (de) | 1998-07-01 |
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