DK0577648T3 - Nye protein-polykation-konjugater - Google Patents

Nye protein-polykation-konjugater

Info

Publication number
DK0577648T3
DK0577648T3 DK92906855T DK92906855T DK0577648T3 DK 0577648 T3 DK0577648 T3 DK 0577648T3 DK 92906855 T DK92906855 T DK 92906855T DK 92906855 T DK92906855 T DK 92906855T DK 0577648 T3 DK0577648 T3 DK 0577648T3
Authority
DK
Denmark
Prior art keywords
protein
cell surface
complexes
surface protein
polycation conjugates
Prior art date
Application number
DK92906855T
Other languages
English (en)
Inventor
Matthew Cotten
Ernst Wagner
Max L Birnstiel
Original Assignee
Boehringer Ingelheim Int
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Genentech Inc filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of DK0577648T3 publication Critical patent/DK0577648T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DK92906855T 1991-03-29 1992-03-24 Nye protein-polykation-konjugater DK0577648T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4110409A DE4110409C2 (de) 1991-03-29 1991-03-29 Neue Protein-Polykation-Konjugate
PCT/EP1992/000642 WO1992017210A1 (de) 1991-03-29 1992-03-24 Neue protein-polykation-konjugate

Publications (1)

Publication Number Publication Date
DK0577648T3 true DK0577648T3 (da) 2001-08-27

Family

ID=6428515

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92906855T DK0577648T3 (da) 1991-03-29 1992-03-24 Nye protein-polykation-konjugater

Country Status (10)

Country Link
US (1) US20030027773A1 (da)
EP (1) EP0577648B1 (da)
JP (1) JP3556214B2 (da)
AT (1) ATE202485T1 (da)
CA (1) CA2101332C (da)
DE (2) DE4110409C2 (da)
DK (1) DK0577648T3 (da)
ES (1) ES2157900T3 (da)
GR (1) GR3036634T3 (da)
WO (1) WO1992017210A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972901A (en) * 1994-03-23 1999-10-26 Case Western Reserve University Serpin enzyme complex receptor--mediated gene transfer
JPH0889278A (ja) * 1994-09-29 1996-04-09 Ajinomoto Co Inc 遺伝子導入用修飾蛋白質及びその製法
GB9422495D0 (en) * 1994-11-08 1995-01-04 Medical Res Council DNA transfer method
DE69636122T2 (de) 1995-11-13 2006-12-07 Takara Bio Inc., Otsu Verfahren zum gentransfer in zielzellen mit einem retrovirus
GB9709421D0 (en) 1997-05-10 1997-07-02 Zeneca Ltd Chemical compounds
GB9908195D0 (en) 1999-04-09 1999-06-02 Microbiological Res Authority Treatment of intracellular infection
WO2009026122A1 (en) * 2007-08-17 2009-02-26 Amgen Inc. Formulations of antibodies and fc-fusion molecules using polycations
CN102046481A (zh) * 2008-03-28 2011-05-04 欧瑞亚轴环有限责任公司 复合式可堆叠托盘装置
EP2646470B1 (en) 2010-11-30 2017-03-01 F. Hoffmann-La Roche AG Low affinity anti-transferrin receptor antibodies and their use to transfer therapeutic scfv across the blood brain barrier
AU2013346767B2 (en) 2012-11-15 2019-04-11 Roche Innovation Center Copenhagen A/S Oligonucleotide conjugates
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
SG11201805420SA (en) 2015-12-30 2018-07-30 Kodiak Sciences Inc Antibodies and conjugates thereof
CN114786731A (zh) 2019-10-10 2022-07-22 科达制药股份有限公司 治疗眼部病症的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273085A1 (en) * 1986-12-29 1988-07-06 IntraCel Corporation A method for internalizing nucleic acids into eukaryotic cells
US5149782A (en) * 1988-08-19 1992-09-22 Tanox Biosystems, Inc. Molecular conjugates containing cell membrane-blending agents
US5354844A (en) * 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
WO1991004753A1 (en) * 1989-10-02 1991-04-18 Cetus Corporation Conjugates of antisense oligonucleotides and therapeutic uses thereof
DK0532525T3 (da) * 1990-05-18 1995-12-04 Genentech Inc Nye protein-polykationkonjugater

Also Published As

Publication number Publication date
ES2157900T3 (es) 2001-09-01
WO1992017210A1 (de) 1992-10-15
GR3036634T3 (en) 2001-12-31
EP0577648A1 (de) 1994-01-12
ATE202485T1 (de) 2001-07-15
CA2101332C (en) 2003-09-23
JP3556214B2 (ja) 2004-08-18
US20030027773A1 (en) 2003-02-06
DE4110409A1 (de) 1992-10-01
EP0577648B1 (de) 2001-06-27
CA2101332A1 (en) 1992-09-30
DE59209905D1 (de) 2001-08-02
JPH06505980A (ja) 1994-07-07
DE4110409C2 (de) 1999-05-27

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